verapamil has been researched along with Nasal Polyps in 7 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Nasal Polyps: Focal accumulations of EDEMA fluid in the NASAL MUCOSA accompanied by HYPERPLASIA of the associated submucosal connective tissue. Polyps may be NEOPLASMS, foci of INFLAMMATION, degenerative lesions, or malformations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inhibition of P-gp enhances the intracellular accumulation of prednisone in nasal polyps." | 3.80 | P-glycoprotein inhibition promotes prednisone retention in human sinonasal polyp explants. ( Bleier, BS; Feldman, R; Han, X; Kocharyan, A; Singleton, A, 2014) |
| " Epithelial cells were isolated from human nasal polyps, cultured for 5-7 days, and used to test the effect of anthracene 9-carboxylate (9-AC), known to inhibit Cl- conductance across the epithelial membrane, on the incorporation and desaturation of [1-14C]linoleic acid (C18:2,n-6) in experiments of up to 4 h duration." | 3.68 | The chloride channel blocker anthracene 9-carboxylate inhibits fatty acid incorporation into phospholipid in cultured human airway epithelial cells. ( Brown, NE; Clandinin, MT; Kang, JX; Labrecque, PA; Man, SF, 1992) |
| "Verapamil is an L-type calcium channel blocker (CCB) that has been shown to have immunomodulatory properties in a variety of tissues." | 1.42 | Verapamil modulates interleukin-5 and interleukin-6 secretion in organotypic human sinonasal polyp explants. ( Bleier, BS; Han, X; Kocharyan, A; Singleton, A, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Workman, AD | 1 |
| Mueller, SK | 1 |
| McDonnell, K | 1 |
| Goldfarb, JW | 1 |
| Bleier, BS | 5 |
| Taha, MS | 1 |
| Nocera, A | 2 |
| Workman, A | 1 |
| Amiji, MM | 1 |
| Kocharyan, A | 2 |
| Feldman, R | 1 |
| Singleton, A | 2 |
| Han, X | 2 |
| Miyake, MM | 1 |
| Levesque, P | 1 |
| Guo, R | 1 |
| Finn, CA | 1 |
| Goldfarb, J | 1 |
| Gray, S | 1 |
| Holbrook, E | 1 |
| Busaba, N | 1 |
| Dolci, JEL | 1 |
| Ostwald, J | 1 |
| Graumüller, S | 1 |
| Dommerich, S | 1 |
| Hoff, M | 1 |
| Kang, JX | 1 |
| Man, SF | 1 |
| Brown, NE | 1 |
| Labrecque, PA | 1 |
| Clandinin, MT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase Ib/II Clinical Trial of Topical Verapamil Hydrochloride for Chronic Rhinosinusitis With Nasal Polyps[NCT03102190] | Phase 1 | 6 participants (Actual) | Interventional | 2017-06-05 | Terminated (stopped due to Phase II funding not available) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Dose Limiting Toxicity will be defined as a development of 2nd or 3rd degree heart block as measured by an EKG. (Phase Ib primary outcome) (NCT03102190)
Timeframe: 1-8 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| Phase Ib | 0 |
1 trial available for verapamil and Nasal Polyps
| Article | Year |
|---|---|
Phase I safety and tolerability study of topical verapamil HCl in chronic rhinosinusitis with nasal polyps.
Topics: Chronic Disease; Humans; Nasal Polyps; Rhinitis; Sinusitis; Verapamil | 2022 |
6 other studies available for verapamil and Nasal Polyps
| Article | Year |
|---|---|
P-glycoprotein inhibition with verapamil overcomes mometasone resistance in Chronic Sinusitis with Nasal Polyps.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member | 2021 |
P-glycoprotein inhibition promotes prednisone retention in human sinonasal polyp explants.
Topics: Anti-Inflammatory Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytoplasm; Dibenz | 2014 |
Verapamil modulates interleukin-5 and interleukin-6 secretion in organotypic human sinonasal polyp explants.
Topics: Calcium Channel Blockers; Cells, Cultured; Chronic Disease; Dexamethasone; Enterotoxins; Humans; Imm | 2015 |
Double-blind placebo-controlled randomized clinical trial of verapamil for chronic rhinosinusitis with nasal polyps.
Topics: Case-Control Studies; Chronic Disease; Humans; Immunologic Factors; Nasal Polyps; Rhinitis; Sinusiti | 2017 |
[Influence of rhinologic usual and unusual drugs on fibroblasts from nasal polyps in cell culture].
Topics: Administration, Topical; Adrenergic beta-Antagonists; Androstadienes; Anti-Inflammatory Agents; Anti | 2003 |
The chloride channel blocker anthracene 9-carboxylate inhibits fatty acid incorporation into phospholipid in cultured human airway epithelial cells.
Topics: Amiloride; Anthracenes; Cells, Cultured; Chloride Channels; Chlorides; Cystic Fibrosis; Electric Con | 1992 |