verapamil has been researched along with Muscle Spasm in 34 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Excerpt | Relevance | Reference |
---|---|---|
"Nicorandil with vasodilator effects by a dual mechanism was effective as the cocktail in preventing radial artery spasm during transradial coronary angiography." | 9.12 | Comparative study of nicorandil and a spasmolytic cocktail in preventing radial artery spasm during transradial coronary angiography. ( Cheon, WS; Cho, GY; Choi, YJ; Kim, EJ; Kim, MK; Kim, SH; Park, WJ; Rhim, CY, 2007) |
"The objective of this study was to evaluate phentolamine as radial artery spasmolytic in transradial catheterization procedures." | 9.11 | Assessment of the efficacy of phentolamine to prevent radial artery spasm during cardiac catheterization procedures: a randomized study comparing phentolamine vs. verapamil. ( Betriu, A; Masotti, M; Mora, R; Ruiz-Salmerón, RJ, 2005) |
"Because of recurrent chest pain, 17 patients with documented spasm in coronary arteries without severe atherosclerotic obstructions were treated with verapamil in an open trial, using doses of 120 mg/day to 480 mg/day (mean, 240 mg/day)." | 9.05 | Coronary spasm management with verapamil (Isoptin). ( Freedman, B; Kelly, DT; Richmond, DR, 1980) |
"Intraluminal CCBs like verapamil may constitute an effective endovascular treatment for mechanically-induced vasospasm in medium to large-sized vessels such as the CCA." | 7.72 | Treatment of mechanically-induced vasospasm of the carotid artery in a primate using intra-arterial verapamil: a technical case report. ( Colby, GP; Coon, AL; Feng, L; Mack, WJ; Meyers, P; Sander Connolly, E, 2004) |
"The antispasmogenic and spasmolytic effects of the calcium entry blocker verapamil were examined on histamine-induced guinea pig tracheal contraction in vitro in comparison with the beta 2-adrenergic agonist salbutamol." | 7.69 | Antispasmogenic and spasmolytic effects of verapamil and salbutamol, alone and in combination, on histamine-induced guinea pig tracheal contraction in vitro. ( Belcheva, A; Valcheva, S, 1994) |
"Nicardipine is a safe and effective alternative of verapamil in preventing spasm of radial artery conduit." | 6.90 | Preventing spasm of the radial artery conduit during coronary artery bypass grafting: Nicardipine versus verapamil. ( Haanschoten, M; Özdemir, AB; Özdemir, HI; Soliman-Hamad, MA; van Dijk, CHB; van Straten, BHM, 2019) |
"This study demonstrates that magnesium is a more effective vasodilator when compared to verapamil, with a reduced hemodynamic effect, and is equally effective at preventing radial artery spasm." | 5.13 | Magnesium sulphate during transradial cardiac catheterization: a new use for an old drug? ( Byrne, J; Della Siega, A; Fretz, E; Haegeli, L; Hilton, D; Kinloch, D; Klinke, P; Mildenberger, R; Spence, M; Williams, M, 2008) |
"Nicorandil with vasodilator effects by a dual mechanism was effective as the cocktail in preventing radial artery spasm during transradial coronary angiography." | 5.12 | Comparative study of nicorandil and a spasmolytic cocktail in preventing radial artery spasm during transradial coronary angiography. ( Cheon, WS; Cho, GY; Choi, YJ; Kim, EJ; Kim, MK; Kim, SH; Park, WJ; Rhim, CY, 2007) |
"The objective of this study was to evaluate phentolamine as radial artery spasmolytic in transradial catheterization procedures." | 5.11 | Assessment of the efficacy of phentolamine to prevent radial artery spasm during cardiac catheterization procedures: a randomized study comparing phentolamine vs. verapamil. ( Betriu, A; Masotti, M; Mora, R; Ruiz-Salmerón, RJ, 2005) |
"Because of recurrent chest pain, 17 patients with documented spasm in coronary arteries without severe atherosclerotic obstructions were treated with verapamil in an open trial, using doses of 120 mg/day to 480 mg/day (mean, 240 mg/day)." | 5.05 | Coronary spasm management with verapamil (Isoptin). ( Freedman, B; Kelly, DT; Richmond, DR, 1980) |
"Patients undergoing transradial access for procedures utilizing moderate sedation can safely receive intra-arterial Verapamil and Nitroglycerine for prevention of radial artery spasm." | 4.12 | Effect of intra-arterial vasodilator administration during radial artery access on systemic blood pressure in patients receiving moderate sedation. ( Foster, HS; Horton, KM; Khan, AA; Sabri, SS; Sivananthan, G; Tabori, NE, 2022) |
" A mixture of verapamil, heparin, and isosorbide dinitrate was administered to reduce spasm." | 3.75 | Transradial coronary angiography in children and adolescents. ( Irving, C; Kirk, R; Zaman, A, 2009) |
"Intraluminal CCBs like verapamil may constitute an effective endovascular treatment for mechanically-induced vasospasm in medium to large-sized vessels such as the CCA." | 3.72 | Treatment of mechanically-induced vasospasm of the carotid artery in a primate using intra-arterial verapamil: a technical case report. ( Colby, GP; Coon, AL; Feng, L; Mack, WJ; Meyers, P; Sander Connolly, E, 2004) |
"The antispasmogenic and spasmolytic effects of the calcium entry blocker verapamil were examined on histamine-induced guinea pig tracheal contraction in vitro in comparison with the beta 2-adrenergic agonist salbutamol." | 3.69 | Antispasmogenic and spasmolytic effects of verapamil and salbutamol, alone and in combination, on histamine-induced guinea pig tracheal contraction in vitro. ( Belcheva, A; Valcheva, S, 1994) |
" Previous studies have shown that therapy for several weeks with the calcium channel blocking drug verapamil or the alpha-1 adrenoceptor blocking drug prazosin can prevent myocardial necrosis due to microvascular spasm." | 3.67 | Prevention of hereditary cardiomyopathy in the Syrian hamster with chronic verapamil therapy. ( Cho, SH; Factor, SM; Malhotra, A; Scheuer, J; Sonnenblick, EH, 1988) |
"Nicardipine is a safe and effective alternative of verapamil in preventing spasm of radial artery conduit." | 2.90 | Preventing spasm of the radial artery conduit during coronary artery bypass grafting: Nicardipine versus verapamil. ( Haanschoten, M; Özdemir, AB; Özdemir, HI; Soliman-Hamad, MA; van Dijk, CHB; van Straten, BHM, 2019) |
"Radial artery spasm is a frequent complication of the transradial approach for coronary angiography and angioplasty." | 1.32 | Evaluation of a spasmolytic cocktail to prevent radial artery spasm during coronary procedures. ( Eccleshall, SC; Kiemeneij, F; Laarman, G; Slagboom, T; Vajifdar, BU; van der Wieken, R, 2003) |
"To further assess the effect of Trypanosoma cruzi infection on the microcirculation, we examined the cremaster microvascular model in CD-1 male mice infected with the Brazil strain at 20-25 days postinfection." | 1.29 | Compromised microcirculation in acute murine Trypanosoma cruzi infection. ( Chen, B; Factor, SM; Kaul, DK; Morris, SA; Tanowitz, HB; Weiss, LM; Wittner, M, 1996) |
"Arterial vasospasm is a common problem in microsurgery." | 1.29 | Porcine gastroepiploic artery as an in vitro experimental model to study vasodilators in microsurgery. ( Chen, D; Harakal, C; Kim, DC; Mitra, A; Perrotta, VJ; Shuman, CA; Wendling, WW, 1996) |
"Coronary spasm is due to strong contraction of coronary vascular smooth muscle cells which is triggered by an increase of intracellular calcium ions; hyperventilation plus TRIS-buffer infusion induces coronary spasm by decreasing hydrogen ions which antagonize the action of calcium ions." | 1.26 | Pathophysiology and treatment of coronary arterial spasm. ( Yasue, H, 1980) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 10 (29.41) | 18.7374 |
1990's | 5 (14.71) | 18.2507 |
2000's | 12 (35.29) | 29.6817 |
2010's | 6 (17.65) | 24.3611 |
2020's | 1 (2.94) | 2.80 |
Authors | Studies |
---|---|
Özdemir, HI | 1 |
van Dijk, CHB | 1 |
Özdemir, AB | 1 |
van Straten, BHM | 1 |
Haanschoten, M | 1 |
Soliman-Hamad, MA | 1 |
Foster, HS | 1 |
Tabori, NE | 1 |
Sabri, SS | 1 |
Horton, KM | 1 |
Khan, AA | 1 |
Sivananthan, G | 1 |
Rosencher, J | 1 |
Chaïb, A | 1 |
Barbou, F | 1 |
Arnould, MA | 1 |
Huber, A | 1 |
Salengro, E | 1 |
Jégou, A | 1 |
Allouch, P | 1 |
Zuily, S | 1 |
Mihoub, F | 1 |
Varenne, O | 1 |
Gupta, S | 1 |
Cigarroa, JE | 1 |
Ali, N | 2 |
Alam, H | 1 |
Khan, A | 1 |
Ahmed, G | 2 |
Shah, WA | 1 |
Nabi, M | 1 |
Junaid, M | 1 |
Collet, C | 1 |
Corral, JM | 1 |
Cavalcante, R | 1 |
Tateishi, H | 1 |
Belzarez, O | 1 |
Ribamar Costa, J | 1 |
Costa, R | 1 |
Chamié, D | 1 |
Onuma, Y | 1 |
de Winter, RJ | 1 |
Abizaid, A | 1 |
Serruys, PW | 1 |
Yoshizaki, T | 1 |
Tabuchi, N | 1 |
Toyama, M | 1 |
Zellner, C | 1 |
Boyle, A | 1 |
Yeghiazarians, Y | 1 |
Byrne, J | 1 |
Spence, M | 1 |
Haegeli, L | 1 |
Fretz, E | 1 |
Della Siega, A | 1 |
Williams, M | 1 |
Kinloch, D | 1 |
Mildenberger, R | 1 |
Klinke, P | 1 |
Hilton, D | 1 |
Irving, C | 1 |
Zaman, A | 1 |
Kirk, R | 1 |
Ali Shah, SW | 1 |
Shah, I | 1 |
Ghias, M | 1 |
Khan, I | 1 |
Ali, W | 1 |
Kiemeneij, F | 1 |
Vajifdar, BU | 1 |
Eccleshall, SC | 1 |
Laarman, G | 1 |
Slagboom, T | 1 |
van der Wieken, R | 1 |
Coon, AL | 1 |
Colby, GP | 1 |
Mack, WJ | 1 |
Feng, L | 1 |
Meyers, P | 1 |
Sander Connolly, E | 1 |
Ruiz-Salmerón, RJ | 1 |
Mora, R | 1 |
Masotti, M | 1 |
Betriu, A | 1 |
Chen, CW | 1 |
Lin, CL | 1 |
Lin, TK | 1 |
Lin, CD | 1 |
Kim, SH | 1 |
Kim, EJ | 1 |
Cheon, WS | 1 |
Kim, MK | 1 |
Park, WJ | 1 |
Cho, GY | 1 |
Choi, YJ | 1 |
Rhim, CY | 1 |
Tarhan, IA | 1 |
Kehlibar, T | 1 |
Arslan, Y | 1 |
Yilmaz, M | 1 |
Dumantepe, M | 1 |
Berkoz, K | 1 |
Pancaroglu, C | 1 |
Ozler, A | 1 |
Beinart, C | 1 |
Sos, TA | 1 |
Saddekni, S | 1 |
Weiner, MA | 1 |
Sniderman, KW | 1 |
Yasue, H | 1 |
Freedman, B | 1 |
Richmond, DR | 1 |
Kelly, DT | 1 |
Factor, SM | 3 |
Minase, T | 1 |
Cho, S | 1 |
Dominitz, R | 1 |
Sonnenblick, EH | 2 |
Fuller, CM | 1 |
Raizner, AE | 1 |
Chahine, RA | 1 |
Nahormek, P | 1 |
Ishimori, T | 1 |
Verani, M | 1 |
Nitishin, A | 1 |
Mokotoff, D | 1 |
Luchi, RJ | 1 |
Valcheva, S | 1 |
Belcheva, A | 1 |
Winterkorn, JM | 1 |
Kupersmith, MJ | 1 |
Wirtschafter, JD | 1 |
Forman, S | 1 |
Tanowitz, HB | 1 |
Kaul, DK | 1 |
Chen, B | 1 |
Morris, SA | 1 |
Weiss, LM | 1 |
Wittner, M | 1 |
Freeman, L | 1 |
Mazur, LJ | 1 |
Kim, DC | 1 |
Chen, D | 1 |
Perrotta, VJ | 1 |
Shuman, CA | 1 |
Wendling, WW | 1 |
Harakal, C | 1 |
Mitra, A | 1 |
Goding, GS | 1 |
Pernell, KJ | 1 |
Rinaldi, G | 1 |
Navia, D | 1 |
Vaccarino, G | 1 |
Segura, E | 1 |
Albertal, J | 1 |
Hansen, JF | 1 |
Sandøe, E | 1 |
Rippmann, ET | 1 |
LeVeen, RF | 1 |
Wolf, GL | 1 |
Biery, D | 1 |
Cho, SH | 1 |
Scheuer, J | 1 |
Malhotra, A | 1 |
Grey, DP | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Topical Nitroglycerine Treatment for Radial Artery Spasm Prevention[NCT02832115] | Phase 4 | 100 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Change in Radial artery cross sectional area in mm^2 - Before application of topical nitroglycerine / placebo (Pre dilation) vs Prior to arterial puncture after application of topical nitroglycerine / placebo (Post-dilation) (NCT02832115)
Timeframe: Application of nitroglycerine / placebo until prior to arterial puncture. Approximate 60 to 120 minutes
Intervention | mm^2 (Mean) |
---|---|
Study | 2.5 |
Control | -0.2 |
Need to abort procedure or convert to transfemoral access (NCT02832115)
Timeframe: Intraprocedural: From procedure start to application of radial band. Approximate time 30 to 90 minutes.
Intervention | Participants (Count of Participants) |
---|---|
Study | 0 |
Control | 4 |
Patient discomfort or pain during procedure measured using Visual analog scale 0-10, 0 being no discomfort or pain (best) and 10 being worst discomfort or pain (worst) (NCT02832115)
Timeframe: Intraprocedural: From procedure start to application of radial band. Approximate time 30 to 90 minutes.
Intervention | score on a scale (Mean) |
---|---|
Study | 0.792 |
Control | 0.875 |
"Incidence of radial artery spasm indicated by a Radial artery spasm score of 1 or more. Radial artery spasm score is sum of:~Intraprocedural pain in the forearm aggravated by movement of the catheter/sheath - Absent :0; Present:1~Difficulty in manipulating the catheter- Absence :0; Present:1~Difficulty with sheath removal: Absent: 0; Present:1~Additional use of intraarterial nitroglycerine or verapamil after the initial vasodilator cocktail- No:0; Yes:1" (NCT02832115)
Timeframe: Intraprocedural: From procedure start to application of radial band. Approximate time 30 to 90 minutes.
Intervention | Participants (Count of Participants) |
---|---|
Study | 8 |
Control | 15 |
Radial pulse at end of procedure 0- 4+, 0 indicating no palpable pulse (worst); 1 + indicating a faint, but detectable pulse; 2 + suggesting a slightly more diminished pulse than normal; 3 + is a normal pulse; and 4 + indicating a bounding pulse (best). (NCT02832115)
Timeframe: At the end of transradial cardiac catheterization after sheath removal
Intervention | score on a scale (Mean) |
---|---|
Study | 2.208333333 |
Control | 2.166666667 |
9 trials available for verapamil and Muscle Spasm
Article | Year |
---|---|
Preventing spasm of the radial artery conduit during coronary artery bypass grafting: Nicardipine versus verapamil.
Topics: Administration, Topical; Calcium Channel Blockers; Coronary Artery Bypass; Female; Humans; Linear Mo | 2019 |
How to limit radial artery spasm during percutaneous coronary interventions: The spasmolytic agents to avoid spasm during transradial percutaneous coronary interventions (SPASM3) study.
Topics: Aged; Analysis of Variance; Angioplasty, Balloon, Coronary; Cardiac Catheterization; Coronary Angiog | 2014 |
Pressure-mediated versus pharmacologic treatment of radial artery spasm during cardiac catheterisation: a randomised pilot study.
Topics: Aged; Cardiac Catheterization; Female; Humans; Male; Middle Aged; Nitroglycerin; Pilot Projects; Pro | 2017 |
Magnesium sulphate during transradial cardiac catheterization: a new use for an old drug?
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Cardiac Catheterization; Coronary Angiography; Double-Bl | 2008 |
Assessment of the efficacy of phentolamine to prevent radial artery spasm during cardiac catheterization procedures: a randomized study comparing phentolamine vs. verapamil.
Topics: Adrenergic alpha-Antagonists; Angiography; Cardiac Catheterization; Chi-Square Distribution; Female; | 2005 |
A simple and effective regimen for prevention of radial artery spasm during coronary catheterization.
Topics: Aged; Anticoagulants; Blood Pressure; Cardiac Catheterization; Female; Heparin; Humans; Male; Middle | 2006 |
Comparative study of nicorandil and a spasmolytic cocktail in preventing radial artery spasm during transradial coronary angiography.
Topics: Coronary Angiography; Coronary Artery Disease; Double-Blind Method; Female; Humans; Male; Middle Age | 2007 |
Effects of normothermic organ bath and verapamil-nitroglycerin solution alone or in combination on the blood flow of radial artery.
Topics: Adult; Aged; Body Temperature; Drug Combinations; Female; Humans; Hypothermia, Induced; Male; Middle | 2007 |
Coronary spasm management with verapamil (Isoptin).
Topics: Administration, Oral; Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Elec | 1980 |
25 other studies available for verapamil and Muscle Spasm
Article | Year |
---|---|
Effect of intra-arterial vasodilator administration during radial artery access on systemic blood pressure in patients receiving moderate sedation.
Topics: Blood Pressure; Conscious Sedation; Humans; Radial Artery; Spasm; Vasodilator Agents; Verapamil | 2022 |
A stitch in time.
Topics: Angioplasty, Balloon, Coronary; Diltiazem; Female; Humans; Isosorbide Dinitrate; Male; Radial Artery | 2014 |
Antispasmodic and antidiarrhoeal activity of the fruit of Rosa moschata (J).
Topics: Animals; Antidiarrheals; Calcium; Calcium Channel Blockers; Diarrhea; Female; Fruit; Gastrointestina | 2014 |
Verapamil and nitroglycerin improves the patency rate of radial artery grafts.
Topics: Administration, Topical; Aged; Coronary Artery Bypass; Drug Combinations; Female; Graft Occlusion, V | 2008 |
Magnesium sulfate for transradial cardiac catheterization: teaching an old dog new tricks.
Topics: Analgesics; Cardiac Catheterization; Coronary Angiography; Hemodynamics; Humans; Magnesium Sulfate; | 2008 |
Transradial coronary angiography in children and adolescents.
Topics: Adolescent; Anticoagulants; Calcium Channel Blockers; Cardiac Catheterization; Child; Coronary Angio | 2009 |
Anthelmintic and relaxant activities of Verbascum Thapsus Mullein.
Topics: Albendazole; Animals; Anthelmintics; Ascaridia; Atropine; Cestoda; Helminthiasis, Animal; Helminths; | 2012 |
Evaluation of a spasmolytic cocktail to prevent radial artery spasm during coronary procedures.
Topics: Aged; Angina Pectoris; Angioplasty; Coronary Angiography; Drug Therapy, Combination; Female; Humans; | 2003 |
Treatment of mechanically-induced vasospasm of the carotid artery in a primate using intra-arterial verapamil: a technical case report.
Topics: Animals; Brachiocephalic Trunk; Carotid Artery Diseases; Carotid Artery, Common; Catheterization; Fe | 2004 |
Arterial spasm during renal angioplasty.
Topics: Adolescent; Adult; Aged; Angioplasty, Balloon; Arterial Occlusive Diseases; Arteriosclerosis; Child; | 1983 |
Pathophysiology and treatment of coronary arterial spasm.
Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Atropine; Calcium; Coronary Disease; Coronary Vess | 1980 |
Microvascular spasm in the cardiomyopathic Syrian hamster: a preventable cause of focal myocardial necrosis.
Topics: Animals; Cardiomyopathies; Coronary Circulation; Cricetinae; Mesocricetus; Microcirculation; Muscle, | 1982 |
Exercise-induced coronary arterial spasm: angiographic demonstration, documentation of ischemia by myocardial scintigraphy and results of pharmacologic intervention.
Topics: Angina Pectoris, Variant; Coronary Disease; Exercise Test; Humans; Indomethacin; Male; Middle Aged; | 1980 |
Antispasmogenic and spasmolytic effects of verapamil and salbutamol, alone and in combination, on histamine-induced guinea pig tracheal contraction in vitro.
Topics: Albuterol; Animals; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle, Smooth; Parasympathol | 1994 |
Brief report: treatment of vasospastic amaurosis fugax with calcium-channel blockers.
Topics: Adult; Aged; Blindness; Carotid Stenosis; Embolism; Female; Humans; Male; Middle Aged; Nifedipine; R | 1993 |
Compromised microcirculation in acute murine Trypanosoma cruzi infection.
Topics: Acute Disease; Animals; Blood Flow Velocity; Chagas Disease; Dilatation, Pathologic; Disease Models, | 1996 |
Verapamil therapy for persistent antral spasms in a child.
Topics: Abdominal Pain; Calcium Channel Blockers; Child; Esophagitis; Gastrointestinal Motility; Humans; Mal | 1996 |
Porcine gastroepiploic artery as an in vitro experimental model to study vasodilators in microsurgery.
Topics: Animals; Arteries; Culture Techniques; Diltiazem; Microsurgery; Nicardipine; Spasm; Swine; Vasodilat | 1996 |
Doxorubicin chemomyectomy: effects on evoked vocal fold tension and mucosal wave.
Topics: Animals; Antibiotics, Antineoplastic; Dogs; Doxorubicin; Drug Therapy, Combination; Laryngeal Mucosa | 2000 |
[Vasodilators in isolated human radial arteries].
Topics: Aged; Coronary Artery Bypass; Diltiazem; Humans; Male; Middle Aged; Nitroglycerin; Radial Artery; Sp | 2000 |
Treatment of Prinzmetal's angina due to coronary artery spasm using verapamil: a report of three cases.
Topics: Angina Pectoris; Angina Pectoris, Variant; Atropine; Coronary Disease; Electrocardiography; Heart Bl | 1978 |
[Beta-sympathomimetics, causal treatment of EPH-gestosis (author's transl)].
Topics: Capillaries; Drug Therapy, Combination; Female; Humans; Pregnancy; Pregnancy Complications, Cardiova | 1976 |
Angioplasty-induced vasospasm in rabbit model. Mechanisms and treatment.
Topics: Angioplasty, Balloon; Animals; Extravasation of Diagnostic and Therapeutic Materials; Femoral Artery | 1985 |
Prevention of hereditary cardiomyopathy in the Syrian hamster with chronic verapamil therapy.
Topics: Adenosine Triphosphatases; Animals; Cardiomyopathies; Cricetinae; Mesocricetus; Myosins; Spasm; Vera | 1988 |
Rebound vasospasm after coronary bypass grafting.
Topics: Humans; Male; Middle Aged; Spasm; Substance Withdrawal Syndrome; Tibia; Vasoconstriction; Verapamil | 1985 |