verapamil has been researched along with Metabolic Acidosis in 24 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Either glycine (2 mM) or extracellular fluid acidosis (pH 7." | 7.68 | Acute phosphate depletion and in vitro rat proximal tubule injury: protection by glycine and acidosis. ( Almeida, AR; Bunnachak, D; Burke, TJ; Chaimovitz, C; Hammond, WS; Schrier, RW; Wetzels, JF, 1992) |
| " Pretreatment of animals with verapamil did not affect the abnormality of glucose metabolism but abolished the associated acidosis." | 7.68 | Verapamil prevents cerebral acidosis during moderate hypoxia and hypotension. ( Lockwood, AH; Yap, EW, 1991) |
| "Metabolic acidosis was produced in two groups of isolated, glucose-perfused beating rat hearts." | 5.27 | Beneficial effects of verapamil during metabolic acidosis in isolated perfused rat hearts. ( Higgins, CB; James, TL; Markiewicz, W; Parmley, WW; Sievers, R; Watters, TA; Wikman-Coffelt, J; Wu, SS, 1988) |
| " Ryanodine (1 microm), a ryanodine receptor blocker, and 10 microm cyclopiazonic acid (CPA; a sarco/endoplasmic reticulum Ca2+ ATPase inhibitor) abolished the transient contraction induced by acidosis." | 3.72 | Mechanism of acidic pH-induced contraction in spontaneously hypertensive rat aorta: role of Ca2+ release from the sarcoplasmic reticulum. ( Ohizumi, Y; Rohra, DK; Saito, SY, 2003) |
| " The effects of diltiazem, verapamil, and nifedipine on extracellular potassium concentration ([K+]e), acidosis, and level of metabolic markers were examined during 30-min global ischemia and postischemic left ventricular (LV) function in isolated guinea pig hearts." | 3.70 | Temporal differences in actions of calcium channel blockers on K+ accumulation, cardiac function, and high-energy phosphate levels in ischemic guinea pig hearts. ( Nagao, T; Sato, R; Yamazaki, J, 1999) |
| " Either glycine (2 mM) or extracellular fluid acidosis (pH 7." | 3.68 | Acute phosphate depletion and in vitro rat proximal tubule injury: protection by glycine and acidosis. ( Almeida, AR; Bunnachak, D; Burke, TJ; Chaimovitz, C; Hammond, WS; Schrier, RW; Wetzels, JF, 1992) |
| " Pretreatment of animals with verapamil did not affect the abnormality of glucose metabolism but abolished the associated acidosis." | 3.68 | Verapamil prevents cerebral acidosis during moderate hypoxia and hypotension. ( Lockwood, AH; Yap, EW, 1991) |
| " These studies have now been extended to compare the relative sensitization by acidosis of verapamil, nifedipine, lidoflazine, perhexilene and diltiazem." | 3.67 | The relative sensitization by acidosis of five calcium blockers in cat papillary muscles. ( Briscoe, MG; Smith, HJ, 1985) |
| " The treatment (ice packs, treatment of acidosis, glucose-insulin, methylprednisolone, lidocaine, verapamil, muscular relaxation and oxygen breathing) was effective." | 3.65 | [A further case of malignant hyperpyrexia and its treatment with lidocaine, methylprednisolone and verapamil (iproveratril) (author's transl)]. ( Bake, I; Buttazzoni, E; Csongrady, A; Pfänder, C; Schneider, M; Tarmann, H, 1976) |
| " The results showed that a temporary relative hypoglycaemia occured in the newborns in short term as well as long term treatment with Partusisten or Partusisten in combination with Isoptin." | 2.64 | [Behaviour of serum concentrations of glucose, immunoreactive insulin and potassium ions in newborns after long term or crash treatments with Partusisten or Partusisten in combination with Isoptin (author's transl)]. ( Haller, K; Hiltmann, WD; Mohr, D; Vogel, M; Weidinger, H, 1976) |
| "Metabolic acidosis is associated with various clinical situations including diabetes mellitus and renal diseases." | 1.33 | Acidosis-induced relaxation of human internal mammary artery is due to activation of ATP-sensitive potassium channels. ( Ghayur, MN; Gilani, AH; Rohra, DK; Sarfraz, K; Sharif, HM; Zubairi, HS, 2005) |
| "Metabolic acidosis was produced in two groups of isolated, glucose-perfused beating rat hearts." | 1.27 | Beneficial effects of verapamil during metabolic acidosis in isolated perfused rat hearts. ( Higgins, CB; James, TL; Markiewicz, W; Parmley, WW; Sievers, R; Watters, TA; Wikman-Coffelt, J; Wu, SS, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (54.17) | 18.7374 |
| 1990's | 7 (29.17) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rohra, DK | 2 |
| Saito, SY | 1 |
| Ohizumi, Y | 2 |
| Horai, Y | 1 |
| Furukawa, K | 1 |
| Iwata, S | 1 |
| Sharif, HM | 1 |
| Zubairi, HS | 1 |
| Sarfraz, K | 1 |
| Ghayur, MN | 1 |
| Gilani, AH | 1 |
| Thews, O | 1 |
| Gassner, B | 1 |
| Kelleher, DK | 1 |
| Gekle, M | 1 |
| Enyeart, JJ | 1 |
| Price, WA | 1 |
| Hoffman, DA | 1 |
| Woods, L | 1 |
| Gilmour, RF | 1 |
| Zipes, DP | 1 |
| Patel, R | 1 |
| Lipper, B | 1 |
| Schwartzbard, A | 1 |
| Nelson, C | 1 |
| O'Connor, MA | 1 |
| Frishman, W | 1 |
| Sato, R | 1 |
| Yamazaki, J | 1 |
| Nagao, T | 1 |
| Weidinger, H | 1 |
| Mohr, D | 1 |
| Haller, K | 1 |
| Hiltmann, WD | 1 |
| Vogel, M | 1 |
| Csongrady, A | 1 |
| Bake, I | 1 |
| Pfänder, C | 1 |
| Tarmann, H | 1 |
| Schneider, M | 1 |
| Buttazzoni, E | 1 |
| Pacini, DJ | 1 |
| Boachie-Ansah, G | 1 |
| Kane, KA | 1 |
| Almeida, AR | 1 |
| Wetzels, JF | 1 |
| Bunnachak, D | 1 |
| Burke, TJ | 1 |
| Chaimovitz, C | 1 |
| Hammond, WS | 1 |
| Schrier, RW | 1 |
| Achike, FI | 1 |
| Dai, S | 1 |
| Lockwood, AH | 1 |
| Yap, EW | 1 |
| Quezado, Z | 1 |
| Lippmann, M | 1 |
| Wertheimer, J | 1 |
| Adamantidis, MM | 1 |
| Caron, JF | 1 |
| Dupuis, BA | 1 |
| Mehmel, HC | 1 |
| Robertson, MJ | 1 |
| Lumley, P | 1 |
| Roth, A | 1 |
| Miller, HI | 1 |
| Belhassen, B | 1 |
| Laniado, S | 1 |
| Berger, L | 1 |
| Hakim, AM | 2 |
| Markiewicz, W | 1 |
| Wu, SS | 1 |
| Sievers, R | 1 |
| Parmley, WW | 1 |
| Watters, TA | 1 |
| James, TL | 1 |
| Higgins, CB | 1 |
| Wikman-Coffelt, J | 1 |
| Gende, OA | 1 |
| Camilión de Hurtado, MC | 1 |
| Smith, HJ | 1 |
| Briscoe, MG | 1 |
1 trial available for verapamil and Metabolic Acidosis
| Article | Year |
|---|---|
[Behaviour of serum concentrations of glucose, immunoreactive insulin and potassium ions in newborns after long term or crash treatments with Partusisten or Partusisten in combination with Isoptin (author's transl)].
Topics: Acid-Base Imbalance; Acidosis; Blood Glucose; Ethanolamines; Female; Fenoterol; Glycolysis; Humans; | 1976 |
23 other studies available for verapamil and Metabolic Acidosis
| Article | Year |
|---|---|
Mechanism of acidic pH-induced contraction in spontaneously hypertensive rat aorta: role of Ca2+ release from the sarcoplasmic reticulum.
Topics: Acidosis; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; | 2003 |
Changes in pH increase perfusion pressure of coronary arteries in the rat.
Topics: Acidosis; Animals; Blood Pressure; Coronary Vessels; Cromakalim; Heparin; Hydrogen-Ion Concentration | 2005 |
Acidosis-induced relaxation of human internal mammary artery is due to activation of ATP-sensitive potassium channels.
Topics: Acidosis; Adenosine Triphosphate; Calcium; Glyburide; Humans; Hydrogen-Ion Concentration; In Vitro T | 2005 |
Activity of drug efflux transporters in tumor cells under hypoxic conditions.
Topics: Acidosis; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Ca | 2008 |
Profound hyperglycemia and metabolic acidosis after verapamil overdose.
Topics: Acidosis; Adult; Dopamine; Electrocardiography; Female; Gastric Lavage; Humans; Hyperglycemia; Hypot | 1983 |
Different electrophysiological responses of canine endocardium and epicardium to combined hyperkalemia, hypoxia, and acidosis.
Topics: Acidosis; Action Potentials; Animals; Dogs; Electrophysiology; Endocardium; Hyperkalemia; Hypoxia; M | 1980 |
Toxic effects of diltiazem in a patient with chronic renal failure.
Topics: Acidosis; Adult; Diltiazem; Heart Failure; Humans; Hyperkalemia; Hypotension; Kidney Failure, Chroni | 1994 |
Temporal differences in actions of calcium channel blockers on K+ accumulation, cardiac function, and high-energy phosphate levels in ischemic guinea pig hearts.
Topics: Acidosis; Adenosine Triphosphate; Animals; Calcium Channel Blockers; Depression, Chemical; Diltiazem | 1999 |
[A further case of malignant hyperpyrexia and its treatment with lidocaine, methylprednisolone and verapamil (iproveratril) (author's transl)].
Topics: Acidosis; Adult; Calcium; Cryotherapy; Glucose; Halothane; Humans; Insulin; Lidocaine; Male; Maligna | 1976 |
Modification by hypoxia, hyperkalaemia and acidosis of the cardiac electrophysiological effects of a range of antiarrhythmic drugs.
Topics: Acidosis; Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Electrocardiography; Ele | 1992 |
Acute phosphate depletion and in vitro rat proximal tubule injury: protection by glycine and acidosis.
Topics: Acidosis; Adenosine Triphosphate; Animals; Glycine; In Vitro Techniques; Kidney Tubules, Proximal; L | 1992 |
Influence of pH changes on the actions of verapamil on cardiac excitation-contraction coupling.
Topics: Acidosis; Alkalosis; Animals; Calcium; Calcium Channels; Epinephrine; Heart; Hydrogen-Ion Concentrat | 1991 |
Verapamil prevents cerebral acidosis during moderate hypoxia and hypotension.
Topics: Acidosis; Animals; Brain; Glucose; Hypotension; Hypoxia; Male; Rats; Rats, Inbred Strains; Verapamil | 1991 |
Severe cardiac, respiratory, and metabolic complications of massive verapamil overdose.
Topics: Acidosis; Adult; Bradycardia; Electrocardiography; Glucagon; Hemodynamics; Humans; Male; Respiratory | 1991 |
Triggered activity induced by combined mild hypoxia and acidosis in guinea-pig Purkinje fibers.
Topics: Acidosis; Animals; Arrhythmias, Cardiac; Calcium; Female; Guinea Pigs; Heart Conduction System; Hypo | 1986 |
[Therapy of acute myocardial infarct].
Topics: Acidosis; Analgesics; Atropine; Bicarbonates; Bradycardia; Cardiac Complexes, Premature; Critical Ca | 1985 |
Effects of hypoxia, elevated K+ and acidosis on the potency of verapamil, diltiazem and nifedipine in the guinea-pig isolated papillary muscle.
Topics: Acidosis; Animals; Cell Hypoxia; Coronary Disease; Diltiazem; Dinitrophenols; Electric Stimulation; | 1989 |
Slow-release verapamil and hyperglycemic metabolic acidosis.
Topics: Acidosis; Aged; Delayed-Action Preparations; Female; Humans; Hyperglycemia; Verapamil | 1989 |
Calcium channel blockers correct acidosis in ischemic rat brain without altering cerebral blood flow.
Topics: Acidosis; Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Epo | 1988 |
Beneficial effects of verapamil during metabolic acidosis in isolated perfused rat hearts.
Topics: Acidosis; Animals; Bicarbonates; Glucose; Heart; Hydrogen-Ion Concentration; Intracellular Fluid; Ma | 1988 |
[Increase of the depressive effect of verapamil in acidosis].
Topics: Acidosis; Animals; Depression, Chemical; Heart Atria; Hydrogen-Ion Concentration; Myocardial Contrac | 1986 |
Cerebral acidosis in focal ischemia: II. Nimodipine and verapamil normalize cerebral pH following middle cerebral artery occlusion in the rat.
Topics: Acidosis; Animals; Arterial Occlusive Diseases; Brain; Brain Diseases; Brain Ischemia; Calcium Chann | 1986 |
The relative sensitization by acidosis of five calcium blockers in cat papillary muscles.
Topics: Acidosis; Animals; Calcium Channel Blockers; Cats; Diltiazem; In Vitro Techniques; Lidoflazine; Myoc | 1985 |