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verapamil and Metabolic Acidosis

verapamil has been researched along with Metabolic Acidosis in 24 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Research Excerpts

ExcerptRelevanceReference
" Either glycine (2 mM) or extracellular fluid acidosis (pH 7."7.68Acute phosphate depletion and in vitro rat proximal tubule injury: protection by glycine and acidosis. ( Almeida, AR; Bunnachak, D; Burke, TJ; Chaimovitz, C; Hammond, WS; Schrier, RW; Wetzels, JF, 1992)
" Pretreatment of animals with verapamil did not affect the abnormality of glucose metabolism but abolished the associated acidosis."7.68Verapamil prevents cerebral acidosis during moderate hypoxia and hypotension. ( Lockwood, AH; Yap, EW, 1991)
"Metabolic acidosis was produced in two groups of isolated, glucose-perfused beating rat hearts."5.27Beneficial effects of verapamil during metabolic acidosis in isolated perfused rat hearts. ( Higgins, CB; James, TL; Markiewicz, W; Parmley, WW; Sievers, R; Watters, TA; Wikman-Coffelt, J; Wu, SS, 1988)
" Ryanodine (1 microm), a ryanodine receptor blocker, and 10 microm cyclopiazonic acid (CPA; a sarco/endoplasmic reticulum Ca2+ ATPase inhibitor) abolished the transient contraction induced by acidosis."3.72Mechanism of acidic pH-induced contraction in spontaneously hypertensive rat aorta: role of Ca2+ release from the sarcoplasmic reticulum. ( Ohizumi, Y; Rohra, DK; Saito, SY, 2003)
" The effects of diltiazem, verapamil, and nifedipine on extracellular potassium concentration ([K+]e), acidosis, and level of metabolic markers were examined during 30-min global ischemia and postischemic left ventricular (LV) function in isolated guinea pig hearts."3.70Temporal differences in actions of calcium channel blockers on K+ accumulation, cardiac function, and high-energy phosphate levels in ischemic guinea pig hearts. ( Nagao, T; Sato, R; Yamazaki, J, 1999)
" Either glycine (2 mM) or extracellular fluid acidosis (pH 7."3.68Acute phosphate depletion and in vitro rat proximal tubule injury: protection by glycine and acidosis. ( Almeida, AR; Bunnachak, D; Burke, TJ; Chaimovitz, C; Hammond, WS; Schrier, RW; Wetzels, JF, 1992)
" Pretreatment of animals with verapamil did not affect the abnormality of glucose metabolism but abolished the associated acidosis."3.68Verapamil prevents cerebral acidosis during moderate hypoxia and hypotension. ( Lockwood, AH; Yap, EW, 1991)
" These studies have now been extended to compare the relative sensitization by acidosis of verapamil, nifedipine, lidoflazine, perhexilene and diltiazem."3.67The relative sensitization by acidosis of five calcium blockers in cat papillary muscles. ( Briscoe, MG; Smith, HJ, 1985)
" The treatment (ice packs, treatment of acidosis, glucose-insulin, methylprednisolone, lidocaine, verapamil, muscular relaxation and oxygen breathing) was effective."3.65[A further case of malignant hyperpyrexia and its treatment with lidocaine, methylprednisolone and verapamil (iproveratril) (author's transl)]. ( Bake, I; Buttazzoni, E; Csongrady, A; Pfänder, C; Schneider, M; Tarmann, H, 1976)
" The results showed that a temporary relative hypoglycaemia occured in the newborns in short term as well as long term treatment with Partusisten or Partusisten in combination with Isoptin."2.64[Behaviour of serum concentrations of glucose, immunoreactive insulin and potassium ions in newborns after long term or crash treatments with Partusisten or Partusisten in combination with Isoptin (author's transl)]. ( Haller, K; Hiltmann, WD; Mohr, D; Vogel, M; Weidinger, H, 1976)
"Metabolic acidosis is associated with various clinical situations including diabetes mellitus and renal diseases."1.33Acidosis-induced relaxation of human internal mammary artery is due to activation of ATP-sensitive potassium channels. ( Ghayur, MN; Gilani, AH; Rohra, DK; Sarfraz, K; Sharif, HM; Zubairi, HS, 2005)
"Metabolic acidosis was produced in two groups of isolated, glucose-perfused beating rat hearts."1.27Beneficial effects of verapamil during metabolic acidosis in isolated perfused rat hearts. ( Higgins, CB; James, TL; Markiewicz, W; Parmley, WW; Sievers, R; Watters, TA; Wikman-Coffelt, J; Wu, SS, 1988)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199013 (54.17)18.7374
1990's7 (29.17)18.2507
2000's4 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rohra, DK2
Saito, SY1
Ohizumi, Y2
Horai, Y1
Furukawa, K1
Iwata, S1
Sharif, HM1
Zubairi, HS1
Sarfraz, K1
Ghayur, MN1
Gilani, AH1
Thews, O1
Gassner, B1
Kelleher, DK1
Gekle, M1
Enyeart, JJ1
Price, WA1
Hoffman, DA1
Woods, L1
Gilmour, RF1
Zipes, DP1
Patel, R1
Lipper, B1
Schwartzbard, A1
Nelson, C1
O'Connor, MA1
Frishman, W1
Sato, R1
Yamazaki, J1
Nagao, T1
Weidinger, H1
Mohr, D1
Haller, K1
Hiltmann, WD1
Vogel, M1
Csongrady, A1
Bake, I1
Pfänder, C1
Tarmann, H1
Schneider, M1
Buttazzoni, E1
Pacini, DJ1
Boachie-Ansah, G1
Kane, KA1
Almeida, AR1
Wetzels, JF1
Bunnachak, D1
Burke, TJ1
Chaimovitz, C1
Hammond, WS1
Schrier, RW1
Achike, FI1
Dai, S1
Lockwood, AH1
Yap, EW1
Quezado, Z1
Lippmann, M1
Wertheimer, J1
Adamantidis, MM1
Caron, JF1
Dupuis, BA1
Mehmel, HC1
Robertson, MJ1
Lumley, P1
Roth, A1
Miller, HI1
Belhassen, B1
Laniado, S1
Berger, L1
Hakim, AM2
Markiewicz, W1
Wu, SS1
Sievers, R1
Parmley, WW1
Watters, TA1
James, TL1
Higgins, CB1
Wikman-Coffelt, J1
Gende, OA1
Camilión de Hurtado, MC1
Smith, HJ1
Briscoe, MG1

Trials

1 trial available for verapamil and Metabolic Acidosis

ArticleYear
[Behaviour of serum concentrations of glucose, immunoreactive insulin and potassium ions in newborns after long term or crash treatments with Partusisten or Partusisten in combination with Isoptin (author's transl)].
    Zeitschrift fur Geburtshilfe und Perinatologie, 1976, Volume: 180, Issue:4

    Topics: Acid-Base Imbalance; Acidosis; Blood Glucose; Ethanolamines; Female; Fenoterol; Glycolysis; Humans;

1976

Other Studies

23 other studies available for verapamil and Metabolic Acidosis

ArticleYear
Mechanism of acidic pH-induced contraction in spontaneously hypertensive rat aorta: role of Ca2+ release from the sarcoplasmic reticulum.
    Acta physiologica Scandinavica, 2003, Volume: 179, Issue:3

    Topics: Acidosis; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases;

2003
Changes in pH increase perfusion pressure of coronary arteries in the rat.
    Journal of pharmacological sciences, 2005, Volume: 97, Issue:3

    Topics: Acidosis; Animals; Blood Pressure; Coronary Vessels; Cromakalim; Heparin; Hydrogen-Ion Concentration

2005
Acidosis-induced relaxation of human internal mammary artery is due to activation of ATP-sensitive potassium channels.
    European journal of pharmacology, 2005, May-09, Volume: 514, Issue:2-3

    Topics: Acidosis; Adenosine Triphosphate; Calcium; Glyburide; Humans; Hydrogen-Ion Concentration; In Vitro T

2005
Activity of drug efflux transporters in tumor cells under hypoxic conditions.
    Advances in experimental medicine and biology, 2008, Volume: 614

    Topics: Acidosis; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Ca

2008
Profound hyperglycemia and metabolic acidosis after verapamil overdose.
    Journal of the American College of Cardiology, 1983, Volume: 2, Issue:6

    Topics: Acidosis; Adult; Dopamine; Electrocardiography; Female; Gastric Lavage; Humans; Hyperglycemia; Hypot

1983
Different electrophysiological responses of canine endocardium and epicardium to combined hyperkalemia, hypoxia, and acidosis.
    Circulation research, 1980, Volume: 46, Issue:6

    Topics: Acidosis; Action Potentials; Animals; Dogs; Electrophysiology; Endocardium; Hyperkalemia; Hypoxia; M

1980
Toxic effects of diltiazem in a patient with chronic renal failure.
    Journal of clinical pharmacology, 1994, Volume: 34, Issue:3

    Topics: Acidosis; Adult; Diltiazem; Heart Failure; Humans; Hyperkalemia; Hypotension; Kidney Failure, Chroni

1994
Temporal differences in actions of calcium channel blockers on K+ accumulation, cardiac function, and high-energy phosphate levels in ischemic guinea pig hearts.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2

    Topics: Acidosis; Adenosine Triphosphate; Animals; Calcium Channel Blockers; Depression, Chemical; Diltiazem

1999
[A further case of malignant hyperpyrexia and its treatment with lidocaine, methylprednisolone and verapamil (iproveratril) (author's transl)].
    Der Anaesthesist, 1976, Volume: 25, Issue:2

    Topics: Acidosis; Adult; Calcium; Cryotherapy; Glucose; Halothane; Humans; Insulin; Lidocaine; Male; Maligna

1976
Modification by hypoxia, hyperkalaemia and acidosis of the cardiac electrophysiological effects of a range of antiarrhythmic drugs.
    British journal of pharmacology, 1992, Volume: 107, Issue:3

    Topics: Acidosis; Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Electrocardiography; Ele

1992
Acute phosphate depletion and in vitro rat proximal tubule injury: protection by glycine and acidosis.
    Kidney international, 1992, Volume: 41, Issue:6

    Topics: Acidosis; Adenosine Triphosphate; Animals; Glycine; In Vitro Techniques; Kidney Tubules, Proximal; L

1992
Influence of pH changes on the actions of verapamil on cardiac excitation-contraction coupling.
    European journal of pharmacology, 1991, Apr-10, Volume: 196, Issue:1

    Topics: Acidosis; Alkalosis; Animals; Calcium; Calcium Channels; Epinephrine; Heart; Hydrogen-Ion Concentrat

1991
Verapamil prevents cerebral acidosis during moderate hypoxia and hypotension.
    Metabolic brain disease, 1991, Volume: 6, Issue:1

    Topics: Acidosis; Animals; Brain; Glucose; Hypotension; Hypoxia; Male; Rats; Rats, Inbred Strains; Verapamil

1991
Severe cardiac, respiratory, and metabolic complications of massive verapamil overdose.
    Critical care medicine, 1991, Volume: 19, Issue:3

    Topics: Acidosis; Adult; Bradycardia; Electrocardiography; Glucagon; Hemodynamics; Humans; Male; Respiratory

1991
Triggered activity induced by combined mild hypoxia and acidosis in guinea-pig Purkinje fibers.
    Journal of molecular and cellular cardiology, 1986, Volume: 18, Issue:12

    Topics: Acidosis; Animals; Arrhythmias, Cardiac; Calcium; Female; Guinea Pigs; Heart Conduction System; Hypo

1986
[Therapy of acute myocardial infarct].
    Deutsche medizinische Wochenschrift (1946), 1985, May-10, Volume: 110, Issue:19

    Topics: Acidosis; Analgesics; Atropine; Bicarbonates; Bradycardia; Cardiac Complexes, Premature; Critical Ca

1985
Effects of hypoxia, elevated K+ and acidosis on the potency of verapamil, diltiazem and nifedipine in the guinea-pig isolated papillary muscle.
    British journal of pharmacology, 1989, Volume: 98, Issue:3

    Topics: Acidosis; Animals; Cell Hypoxia; Coronary Disease; Diltiazem; Dinitrophenols; Electric Stimulation;

1989
Slow-release verapamil and hyperglycemic metabolic acidosis.
    Annals of internal medicine, 1989, Jan-15, Volume: 110, Issue:2

    Topics: Acidosis; Aged; Delayed-Action Preparations; Female; Humans; Hyperglycemia; Verapamil

1989
Calcium channel blockers correct acidosis in ischemic rat brain without altering cerebral blood flow.
    Stroke, 1988, Volume: 19, Issue:10

    Topics: Acidosis; Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Epo

1988
Beneficial effects of verapamil during metabolic acidosis in isolated perfused rat hearts.
    Cardiovascular drugs and therapy, 1988, Volume: 1, Issue:5

    Topics: Acidosis; Animals; Bicarbonates; Glucose; Heart; Hydrogen-Ion Concentration; Intracellular Fluid; Ma

1988
[Increase of the depressive effect of verapamil in acidosis].
    Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia, 1986, Volume: 36, Issue:4

    Topics: Acidosis; Animals; Depression, Chemical; Heart Atria; Hydrogen-Ion Concentration; Myocardial Contrac

1986
Cerebral acidosis in focal ischemia: II. Nimodipine and verapamil normalize cerebral pH following middle cerebral artery occlusion in the rat.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1986, Volume: 6, Issue:6

    Topics: Acidosis; Animals; Arterial Occlusive Diseases; Brain; Brain Diseases; Brain Ischemia; Calcium Chann

1986
The relative sensitization by acidosis of five calcium blockers in cat papillary muscles.
    Journal of molecular and cellular cardiology, 1985, Volume: 17, Issue:7

    Topics: Acidosis; Animals; Calcium Channel Blockers; Cats; Diltiazem; In Vitro Techniques; Lidoflazine; Myoc

1985