verapamil has been researched along with Mesothelioma in 6 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Mesothelioma: A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study we investigated the ability of ADP, collagen and thrombin to increase cytoplasmic Ca2+ levels in different human tumor cell lines (mesothelioma, DND-1A melanoma, HeLa uterine carcinoma) and we analyzed the effect of the calcium channel blocker verapamil on Ca2+ fluxes and on in vitro tumor cell growth." | 3.69 | Verapamil inhibits to different extents agonist-induced Ca2+ transients in human tumor cells and in vitro tumor cell growth. ( Brocchieri, A; Grignani, G; Moroni, M; Porta, C; Saporiti, A; Tua, A, 1996) |
| "Verapamil has been shown to reverse acquired drug resistance to Adriamycin (ADR) and vinblastine in the P388 leukemia and Ehrlich ascites carcinoma model systems." | 1.27 | Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells. ( Cox, TC; Crowley, J; Goodman, GE; Yen, YP, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Catalano, A | 1 |
| Rodilossi, S | 1 |
| Rippo, MR | 1 |
| Caprari, P | 1 |
| Procopio, A | 1 |
| Saporiti, A | 2 |
| Brocchieri, A | 2 |
| Porta, C | 2 |
| Moroni, M | 2 |
| Grignani, G | 2 |
| Isobe, H | 1 |
| Wellham, L | 1 |
| Sauerteig, A | 1 |
| Sridhar, KS | 1 |
| Ramachandran, C | 1 |
| Krishan, A | 1 |
| Tua, A | 1 |
| Licht, T | 1 |
| Lübbert, M | 1 |
| Martens, C | 1 |
| Bross, KJ | 1 |
| Fiebig, HH | 1 |
| Mertelsmann, R | 1 |
| Herrmann, F | 1 |
| Goodman, GE | 1 |
| Yen, YP | 1 |
| Cox, TC | 1 |
| Crowley, J | 1 |
6 other studies available for verapamil and Mesothelioma
| Article | Year |
|---|---|
Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Separation; Culture Media, Conditioned; Cytokines; Disease Progres | 2004 |
Effect of different platelet agonists on intracellular free Ca++ concentrations in human tumor cells: possible role in tumor growth.
Topics: Adenosine Diphosphate; Adult; Blood Coagulation; Blood Platelets; Calcium; Cell Communication; Cell | 1995 |
Doxorubicin retention and chemoresistance in human mesothelioma cell lines.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Division; DNA, Neopl | 1994 |
Verapamil inhibits to different extents agonist-induced Ca2+ transients in human tumor cells and in vitro tumor cell growth.
Topics: Adenosine Diphosphate; Biological Transport; Calcium; Calcium Channel Blockers; Cell Division; Colla | 1996 |
Modulation of vindesine and doxorubicin resistance in multidrug-resistant pleural mesothelioma cells by tumor necrosis factor-alpha.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Surviva | 1995 |
Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells.
Topics: Breast Neoplasms; Cell Survival; Clone Cells; Colonic Neoplasms; Doxorubicin; Drug Resistance; Esoph | 1987 |