verapamil has been researched along with Melanoma in 20 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment of patients with metastatic melanoma with either dacarbazine (DTIC) or interferon-alpha (IFNalpha) as single drugs, or in combination, results in a response rate of approximately 15-20%." | 7.72 | Effects of interferon-alpha, verapamil and dacarbazine in the treatment of advanced malignant melanoma. ( Ake Hofer, P; Andersson, R; Henriksson, R; Riklund-Ahlström, K, 2003) |
| "The effect of the combined administration of doxorubicin (DX) and verapamil (VRP) on the induction of DX resistance of B16 melanoma cells, was investigated both in vitro and in vivo." | 7.67 | Verapamil potentiation of doxorubicin resistance development in B16 melanoma cells both in vitro and in vivo. ( Cleris, L; Formelli, F; Mariani, M; Supino, R, 1988) |
| "Verapamil had previously been shown to increase cellular melphalan uptake and cytotoxicity in fibrosarcomas, and increased the area under the blood concentration versus time curve (AUC) for melphalan in CBA mice." | 7.67 | Effects of verapamil and alcohol on blood flow, melphalan uptake and cytotoxicity, in murine fibrosarcomas and human melanoma xenografts. ( Clutterbuck, RD; McElwain, TJ; Millar, JL; Robinson, BA, 1986) |
| "Treatment of patients with metastatic melanoma with either dacarbazine (DTIC) or interferon-alpha (IFNalpha) as single drugs, or in combination, results in a response rate of approximately 15-20%." | 3.72 | Effects of interferon-alpha, verapamil and dacarbazine in the treatment of advanced malignant melanoma. ( Ake Hofer, P; Andersson, R; Henriksson, R; Riklund-Ahlström, K, 2003) |
| " A model system, consisting of malignant melanoma cells pretreated with the calcium sensitive fluorescent dye, Fluo-3, was used to examine the intracellular calcium dynamics in single-cell photolysis experiments." | 3.70 | Intracellular calcium dynamics during photolysis. ( Busch, NA; Reiken, SR; Toner, M; Yarmush, ML, 1998) |
| " In the present study we investigated the ability of ADP, collagen and thrombin to increase cytoplasmic Ca2+ levels in different human tumor cell lines (mesothelioma, DND-1A melanoma, HeLa uterine carcinoma) and we analyzed the effect of the calcium channel blocker verapamil on Ca2+ fluxes and on in vitro tumor cell growth." | 3.69 | Verapamil inhibits to different extents agonist-induced Ca2+ transients in human tumor cells and in vitro tumor cell growth. ( Brocchieri, A; Grignani, G; Moroni, M; Porta, C; Saporiti, A; Tua, A, 1996) |
| "Verapamil, a calcium channel antagonist, inhibits murine B16 melanoma and colon adenocarcinoma C26 tumor metastasis by altering platelet aggregation [Tsuruo, T." | 3.68 | Inhibition of tumor cell invasion by verapamil. ( Clothier, JL; Geary, RJ; Hendrix, MJ; Montague, SL; Welch, DR; Winters, AL; Yohem, KH, 1991) |
| "The effect of the combined administration of doxorubicin (DX) and verapamil (VRP) on the induction of DX resistance of B16 melanoma cells, was investigated both in vitro and in vivo." | 3.67 | Verapamil potentiation of doxorubicin resistance development in B16 melanoma cells both in vitro and in vivo. ( Cleris, L; Formelli, F; Mariani, M; Supino, R, 1988) |
| "Verapamil had previously been shown to increase cellular melphalan uptake and cytotoxicity in fibrosarcomas, and increased the area under the blood concentration versus time curve (AUC) for melphalan in CBA mice." | 3.67 | Effects of verapamil and alcohol on blood flow, melphalan uptake and cytotoxicity, in murine fibrosarcomas and human melanoma xenografts. ( Clutterbuck, RD; McElwain, TJ; Millar, JL; Robinson, BA, 1986) |
| "Verapamil, a calcium antagonist, inhibited both experimental (IV inoculation of tumor cells) and spontaneous metastasis (SC inoculation) of the highly metastatic B16 melanoma and colon adenocarcinoma 26 cell lines." | 3.67 | Inhibition of spontaneous and experimental tumor metastasis by the calcium antagonist verapamil. ( Iida, H; Kawabata, H; Makishima, F; Sakurai, Y; Tsukagoshi, S; Tsuruo, T; Yamori, T, 1985) |
| "Malignant melanomas are intrinsically resistant to many conventional treatments, such as radiation and chemotherapy, for reasons that are poorly understood." | 1.35 | Influence of melanosome dynamics on melanoma drug sensitivity. ( Cardarelli, CO; Chen, KG; Gottesman, MM; Hearing, VJ; Lai, B; Leapman, RD; Valencia, JC; Vieira, WD; Zhang, G, 2009) |
| "In particular, in resistant human breast carcinoma cells (MCF-7), adriamycin appeared to be exclusively located within the cytoplasm whereas the nuclei were shown to be completely negative." | 1.29 | Intracellular localization of the antitumour drug adriamycin in living cultured cells: a confocal microscopy study. ( Arancia, G; Calcabrini, A; Citro, G; Meschini, S; Molinari, A, 1994) |
| "Verapamil has been shown to reverse acquired drug resistance to Adriamycin (ADR) and vinblastine in the P388 leukemia and Ehrlich ascites carcinoma model systems." | 1.27 | Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells. ( Cox, TC; Crowley, J; Goodman, GE; Yen, YP, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (35.00) | 18.7374 |
| 1990's | 9 (45.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, J | 1 |
| Ahn, S | 1 |
| Wang, J | 1 |
| Lu, Y | 1 |
| Dalton, JT | 1 |
| Miller, DD | 2 |
| Li, W | 2 |
| Wang, Q | 1 |
| Arnst, KE | 1 |
| Wang, Y | 1 |
| Kumar, G | 1 |
| Ma, D | 1 |
| Chen, H | 1 |
| Wu, Z | 1 |
| Yang, J | 1 |
| White, SW | 1 |
| Chen, KG | 1 |
| Leapman, RD | 1 |
| Zhang, G | 1 |
| Lai, B | 1 |
| Valencia, JC | 1 |
| Cardarelli, CO | 1 |
| Vieira, WD | 1 |
| Hearing, VJ | 1 |
| Gottesman, MM | 1 |
| Andersson, R | 1 |
| Ake Hofer, P | 1 |
| Riklund-Ahlström, K | 1 |
| Henriksson, R | 1 |
| Tsuruo, T | 3 |
| Iida, H | 2 |
| Naganuma, K | 1 |
| Tsukagoshi, S | 2 |
| Sakurai, Y | 2 |
| Saporiti, A | 2 |
| Brocchieri, A | 2 |
| Porta, C | 2 |
| Moroni, M | 2 |
| Grignani, G | 2 |
| Alvarez, M | 1 |
| Paull, K | 1 |
| Monks, A | 1 |
| Hose, C | 1 |
| Lee, JS | 1 |
| Weinstein, J | 1 |
| Grever, M | 1 |
| Bates, S | 1 |
| Fojo, T | 1 |
| Meschini, S | 1 |
| Molinari, A | 1 |
| Calcabrini, A | 1 |
| Citro, G | 1 |
| Arancia, G | 1 |
| Iinuma, S | 1 |
| Farshi, SS | 1 |
| Ortel, B | 1 |
| Hasan, T | 1 |
| Ramachandran, C | 1 |
| Yuan, ZK | 1 |
| Huang, XL | 1 |
| Krishan, A | 1 |
| Tua, A | 1 |
| Busch, NA | 1 |
| Reiken, SR | 1 |
| Toner, M | 1 |
| Yarmush, ML | 1 |
| Anuszewska, EL | 1 |
| Koziorowska, JH | 1 |
| Yohem, KH | 1 |
| Clothier, JL | 1 |
| Montague, SL | 1 |
| Geary, RJ | 1 |
| Winters, AL | 1 |
| Hendrix, MJ | 1 |
| Welch, DR | 1 |
| Formelli, F | 2 |
| Supino, R | 2 |
| Cleris, L | 1 |
| Mariani, M | 2 |
| Goodman, GE | 1 |
| Yen, YP | 1 |
| Cox, TC | 1 |
| Crowley, J | 1 |
| Robinson, BA | 1 |
| Clutterbuck, RD | 1 |
| Millar, JL | 1 |
| McElwain, TJ | 1 |
| Prosperi, E | 1 |
| Parmiani, G | 1 |
| Makishima, F | 1 |
| Yamori, T | 1 |
| Kawabata, H | 1 |
20 other studies available for verapamil and Melanoma
| Article | Year |
|---|---|
Discovery of novel 2-aryl-4-benzoyl-imidazole (ABI-III) analogues targeting tubulin polymerization as antiproliferative agents.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Dr | 2012 |
Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities.
Topics: Animals; Cell Proliferation; Chalcones; Humans; Male; Melanoma; Mice; Mice, Nude; Models, Molecular; | 2018 |
Influence of melanosome dynamics on melanoma drug sensitivity.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Cell Line, Tumor; Cisplatin; Cy | 2009 |
Effects of interferon-alpha, verapamil and dacarbazine in the treatment of advanced malignant melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Calcium Channel Blockers; Dacarbazine; | 2003 |
[Reversal of acquired resistance to vinca alkaloids and anthracycline antibiotics by calcium channel blockers and calmodulin inhibitors].
Topics: Animals; Antibiotics, Antineoplastic; Calcium Channel Blockers; Calmodulin; Drug Resistance; Drug Sy | 1984 |
Promotion by verapamil of vincristine responsiveness in tumor cell lines inherently resistant to the drug.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Synergism; | 1983 |
Effect of different platelet agonists on intracellular free Ca++ concentrations in human tumor cells: possible role in tumor growth.
Topics: Adenosine Diphosphate; Adult; Blood Coagulation; Blood Platelets; Calcium; Cell Communication; Cell | 1995 |
Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cell Surv | 1995 |
Intracellular localization of the antitumour drug adriamycin in living cultured cells: a confocal microscopy study.
Topics: Breast Neoplasms; Cell Nucleus; Cytoplasm; Doxorubicin; Drug Resistance, Multiple; Fluorescence; Hum | 1994 |
A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Division; | 1994 |
Doxorubicin resistance in human melanoma cells: MDR-1 and glutathione S-transferase pi gene expression.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Death; Cell Division; Cell Li | 1993 |
Verapamil inhibits to different extents agonist-induced Ca2+ transients in human tumor cells and in vitro tumor cell growth.
Topics: Adenosine Diphosphate; Biological Transport; Calcium; Calcium Channel Blockers; Cell Division; Colla | 1996 |
Intracellular calcium dynamics during photolysis.
Topics: Aniline Compounds; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Humans; M | 1998 |
Adaptive response towards adriamycin in vitro: circumvention with verapamil.
Topics: Animals; Antineoplastic Agents; Calcium Channel Blockers; CHO Cells; Cricetinae; Dose-Response Relat | 1999 |
Inhibition of tumor cell invasion by verapamil.
Topics: Animals; Cytoskeletal Proteins; Female; Humans; Lung Neoplasms; Matrix Metalloproteinase 9; Melanoma | 1991 |
Verapamil potentiation of doxorubicin resistance development in B16 melanoma cells both in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Resistance; Lung Neoplasm | 1988 |
Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells.
Topics: Breast Neoplasms; Cell Survival; Clone Cells; Colonic Neoplasms; Doxorubicin; Drug Resistance; Esoph | 1987 |
Effects of verapamil and alcohol on blood flow, melphalan uptake and cytotoxicity, in murine fibrosarcomas and human melanoma xenografts.
Topics: Animals; Cinnarizine; Drug Synergism; Ethanol; Female; Fibrosarcoma; Flunarizine; Humans; Male; Mela | 1986 |
Characterization of a doxorubicin-resistant murine melanoma line: studies on cross-resistance and its circumvention.
Topics: Animals; Cell Line; Cell Survival; Clone Cells; Dose-Response Relationship, Drug; Doxorubicin; Drug | 1986 |
Inhibition of spontaneous and experimental tumor metastasis by the calcium antagonist verapamil.
Topics: Animals; Colonic Neoplasms; Melanoma; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Metast | 1985 |