Page last updated: 2024-10-24

verapamil and Medulloblastoma

verapamil has been researched along with Medulloblastoma in 4 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Medulloblastoma: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)

Research Excerpts

ExcerptRelevanceReference
" We report that verapamil reversibly inhibits binding of the nicotinic receptor probe 125I-alpha-bungarotoxin to membranes from rat brain, Torpedo californica, the rat pheochromocytoma cell line PC12 and the human medulloblastoma cell line TE671, with Ki values of 24."3.67Allosteric modification of alpha-bungarotoxin binding by the 'calcium channel antagonist' verapamil. ( Lukas, RJ; Siegel, HN, 1986)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19903 (75.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Miniero, R1
Massara, FM1
Saroglia, EM1
Soldano, S1
Barisone, E1
Leone, L1
Arrighini, A1
Andolina, M1
Brach del Prever, A1
Madon, E1
Huber, KR2
Schmidt, WF2
al-Assaad, B1
Neuberg, RW2
Ettinger, RS2
Siegel, HN1
Lukas, RJ1

Other Studies

4 other studies available for verapamil and Medulloblastoma

ArticleYear
[Use of cyclosporin and verapamil in association with chemotherapy in the treatment of pediatric patients with advanced-stage neoplasms. A pilot study].
    Minerva pediatrica, 1994, Volume: 46, Issue:10

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cerebellar Neoplasms; Ch

1994
Human tumor cells resistant to verapamil.
    Biochemical and biophysical research communications, 1989, Jun-30, Volume: 161, Issue:3

    Topics: Cell Cycle; Cell Division; Cell Line; Cerebellar Neoplasms; Doxorubicin; Drug Resistance; Glioma; Hu

1989
Antiproliferative effect of verapamil alone on brain tumor cells in vitro.
    Cancer research, 1988, Jul-01, Volume: 48, Issue:13

    Topics: Calcium; Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Glioma; Humans; In Vitro Techn

1988
Allosteric modification of alpha-bungarotoxin binding by the 'calcium channel antagonist' verapamil.
    Brain research, 1986, Volume: 387, Issue:1

    Topics: Allosteric Site; Animals; Binding Sites; Binding, Competitive; Brain; Bungarotoxins; Cell Line; Huma

1986