verapamil has been researched along with Malaria in 12 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A review of all available evidence supports the hypothesis that FP is the receptor for chloroquine and mediator of its antimalarial activity." | 8.77 | Ferriprotoporphyrin IX: role in chloroquine susceptibility and resistance in malaria. ( Fitch, CD, 1989) |
| "Multiple drug resistance in Plasmodium falciparum is already showing evidence of extending to mefloquine, which at present is one of the few alternative antimalarials for the prevention or treatment of infection with such parasites." | 7.68 | The chemotherapy of rodent malaria. XLVI. Reversal of mefloquine resistance in rodent Plasmodium. ( Peters, W; Robinson, BL, 1991) |
| "Racemic verapamil and close structural derivatives gallopamil and devapamil completely reverse chloroquine-resistance in falciparum malaria at 1-2 micromolar concentrations." | 7.67 | Reversal of chloroquine resistance in falciparum malaria independent of calcium channels. ( Van Dyke, K; Ye, ZG, 1988) |
| "A review of all available evidence supports the hypothesis that FP is the receptor for chloroquine and mediator of its antimalarial activity." | 4.77 | Ferriprotoporphyrin IX: role in chloroquine susceptibility and resistance in malaria. ( Fitch, CD, 1989) |
| "Reversal of chloroquine (CQ) resistance by verapamil, a Ca2+ antagonist, has been shown in CQ-resistant human and rodent malaria parasites." | 3.68 | Ultrastructural changes associated with reversal of chloroquine resistance by verapamil in Plasmodium chabaudi. ( Kimata, I; Miki, A; Ohsawa, K; Tanabe, K, 1991) |
| "Multiple drug resistance in Plasmodium falciparum is already showing evidence of extending to mefloquine, which at present is one of the few alternative antimalarials for the prevention or treatment of infection with such parasites." | 3.68 | The chemotherapy of rodent malaria. XLVI. Reversal of mefloquine resistance in rodent Plasmodium. ( Peters, W; Robinson, BL, 1991) |
| "Racemic verapamil and close structural derivatives gallopamil and devapamil completely reverse chloroquine-resistance in falciparum malaria at 1-2 micromolar concentrations." | 3.67 | Reversal of chloroquine resistance in falciparum malaria independent of calcium channels. ( Van Dyke, K; Ye, ZG, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gemma, S | 1 |
| Camodeca, C | 1 |
| Sanna Coccone, S | 1 |
| Joshi, BP | 1 |
| Bernetti, M | 1 |
| Moretti, V | 1 |
| Brogi, S | 1 |
| Bonache de Marcos, MC | 1 |
| Savini, L | 1 |
| Taramelli, D | 1 |
| Basilico, N | 1 |
| Parapini, S | 1 |
| Rottmann, M | 1 |
| Brun, R | 1 |
| Lamponi, S | 1 |
| Caccia, S | 1 |
| Guiso, G | 1 |
| Summers, RL | 1 |
| Martin, RE | 1 |
| Saponara, S | 1 |
| Gorelli, B | 1 |
| Novellino, E | 1 |
| Campiani, G | 1 |
| Butini, S | 1 |
| Joshi, MC | 1 |
| Okombo, J | 1 |
| Nsumiwa, S | 1 |
| Ndove, J | 1 |
| Taylor, D | 1 |
| Wiesner, L | 1 |
| Hunter, R | 1 |
| Chibale, K | 1 |
| Egan, TJ | 1 |
| Mossaad, E | 1 |
| Furuyama, W | 1 |
| Enomoto, M | 1 |
| Kawai, S | 1 |
| Mikoshiba, K | 1 |
| Kawazu, S | 1 |
| Sturm, A | 1 |
| Graewe, S | 1 |
| Franke-Fayard, B | 1 |
| Retzlaff, S | 1 |
| Bolte, S | 1 |
| Roppenser, B | 1 |
| Aepfelbacher, M | 1 |
| Janse, C | 1 |
| Heussler, V | 1 |
| Haynes, RK | 1 |
| Cheu, KW | 1 |
| Li, KY | 1 |
| Tang, MM | 1 |
| Wong, HN | 1 |
| Chen, MJ | 1 |
| Guo, ZF | 1 |
| Guo, ZH | 1 |
| Coghi, P | 1 |
| Monti, D | 1 |
| Hess, FI | 1 |
| Kilian, A | 1 |
| Söllner, W | 1 |
| Nothdurft, HD | 1 |
| Pröll, S | 1 |
| Löscher, T | 1 |
| Platel, DF | 1 |
| Mangou, F | 1 |
| Tribouley-Duret, J | 1 |
| Ohsawa, K | 1 |
| Tanabe, K | 2 |
| Kimata, I | 1 |
| Miki, A | 1 |
| Peters, W | 1 |
| Robinson, BL | 1 |
| Kato, M | 1 |
| Izumo, A | 1 |
| Hagiwara, A | 1 |
| Doi, S | 1 |
| Ye, ZG | 1 |
| Van Dyke, K | 1 |
| Fitch, CD | 1 |
1 review available for verapamil and Malaria
| Article | Year |
|---|---|
Ferriprotoporphyrin IX: role in chloroquine susceptibility and resistance in malaria.
Topics: Animals; Chloroquine; Drug Resistance; Erythrocytes; Heme; Hemin; Hemoglobins; Malaria; Plasmodium; | 1989 |
11 other studies available for verapamil and Malaria
| Article | Year |
|---|---|
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.
Topics: Aminoquinolines; Animals; Antimalarials; Biological Transport; Cell Line; Chloroquine; Clotrimazole; | 2012 |
4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice.
Topics: Administration, Oral; Aminopyridines; Aminoquinolines; Animals; Antimalarials; Cell Membrane Permeab | 2017 |
Simultaneous administration of 2-aminoethyl diphenylborinate and chloroquine reverses chloroquine resistance in malaria parasites.
Topics: Animals; Antimalarials; Chloroquine; Female; Inhibitory Concentration 50; Malaria; Mice; Mice, Inbre | 2015 |
Alteration of the parasite plasma membrane and the parasitophorous vacuole membrane during exo-erythrocytic development of malaria parasites.
Topics: Animals; Calcium Channels; Cell Line; Cell Membrane; Cell Membrane Permeability; Hepatocytes; Humans | 2009 |
A partial convergence in action of methylene blue and artemisinins: antagonism with chloroquine, a reversal with verapamil, and an insight into the antimalarial activity of chloroquine.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Synergism; Flavin-Adenine D | 2011 |
Plasmodium falciparum and Plasmodium berghei: effect of magnesium on the development of parasitemia.
Topics: Analysis of Variance; Animals; Calcium; Chloroquine; Culture Media; Dose-Response Relationship, Drug | 1995 |
High-level chloroquine resistance of Plasmodium berghei is associated with multiple drug resistance and loss of reversal by calcium antagonists.
Topics: Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Drug Resistance; Drug Resistance, Mul | 1998 |
Ultrastructural changes associated with reversal of chloroquine resistance by verapamil in Plasmodium chabaudi.
Topics: Animals; Chloroquine; Cytoplasm; Drug Interactions; Drug Resistance; Endoplasmic Reticulum; Female; | 1991 |
The chemotherapy of rodent malaria. XLVI. Reversal of mefloquine resistance in rodent Plasmodium.
Topics: Animals; Antimalarials; Cyproheptadine; Dose-Response Relationship, Drug; Drug Combinations; Drug Re | 1991 |
Plasmodium chabaudi: in vivo effects of Ca2+ antagonists on chloroquine-resistant and chloroquine-sensitive parasites.
Topics: Animals; Calcium Channel Blockers; Chloroquine; Diltiazem; Dose-Response Relationship, Drug; Drug In | 1990 |
Reversal of chloroquine resistance in falciparum malaria independent of calcium channels.
Topics: Animals; Calcium; Chloroquine; Drug Interactions; Drug Resistance; Gallopamil; Ion Channels; Malaria | 1988 |