verapamil has been researched along with Lymphoma in 27 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a controlled trial of dexverapamil, an inhibitor of Pgp, in 45 Hodgkin's (HD) and 154 Non-Hodgkin's (NHL) lymphomas refractory to EPOCH chemotherapy." | 9.08 | Modulation of multidrug resistance by dexverapamil in EPOCH-refractory lymphomas. ( Bates, SE; Chabner, BA; Fojo, A; Wilson, WH, 1995) |
| "Dexverapamil was escalated eight dose levels, from 240 to 1,200 mg/m2/d." | 6.68 | Controlled trial of dexverapamil, a modulator of multidrug resistance, in lymphomas refractory to EPOCH chemotherapy. ( Bates, SE; Bryant, G; Fojo, A; Herdt, J; Jaffe, ES; Regis, J; Steinberg, SM; Wilson, WH; Wittes, RE; Zhan, Z, 1995) |
| "One of 42 newly diagnosed and untreated lymphoma patients (2%) and seven of 11 previously treated and drug-resistant patients (64%) had detectable levels of P-glycoprotein (P less than ." | 5.28 | P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil. ( Dalton, WS; Grogan, TM; Miller, TP; Salmon, SE; Scheper, RJ; Spier, CM, 1991) |
| "We conducted a controlled trial of dexverapamil, an inhibitor of Pgp, in 45 Hodgkin's (HD) and 154 Non-Hodgkin's (NHL) lymphomas refractory to EPOCH chemotherapy." | 5.08 | Modulation of multidrug resistance by dexverapamil in EPOCH-refractory lymphomas. ( Bates, SE; Chabner, BA; Fojo, A; Wilson, WH, 1995) |
| "The novel cucurbitacins, balsaminagenin A and B (1-2) and balsaminoside A (3) and the know cucurbitacin karavelagenin C (4), together with five new mono or diacylated derivatives (5-9) of karavelagenin C were evaluated for multidrug resistance reversing activity on human MDR1 gene transfected mouse lymphoma cells." | 3.75 | New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells. ( Ferreira, MJ; Molnár, J; Mulhovo, S; Ramalhete, C; Rosário, VE, 2009) |
| " Using a concentration of 4mug/mL, these compounds possess 11-43 times the potency of verapamil in reversing MDR in murine L-5178 lymphoma cells transfected with the human MDR1 gene." | 3.74 | 1-[4-(2-Aminoethoxy)phenylcarbonyl]-3,5-bis-(benzylidene)-4-oxopiperidines: a novel series of highly potent revertants of P-glycoprotein associated multidrug resistance. ( Baráth, Z; Bata, Z; Das, U; Dimmock, JR; Molnár, J, 2008) |
| "In an attempt to identify the target protein, P-GP or mrp, of each MDR antagonist, verapamyl (Ver), dipyridamole (Dip), or cyclosporin A (Cy-A), this study was designed to compare the activity of the three afore-mentioned drugs and to test their combined effect on the cidal activity of vincristine (VCR) in five types of wild and the corresponding VCR-resistant cultured cell lines from human leukemia and lymphoma." | 3.70 | Effect of MDR antagonists on the cidal activity of vincristine for cells expressing MDR-1 is superior to those expressing MRP. ( Hamano, S; Hirose, M; Hosoi, E; Kuroda, Y; Morimoto, M, 1998) |
| "Leukemic cells isolated from peripheral blood from 6 patients with chronic lymphocytic leukemia, immunocytoma and prolymphocytic leukemia were incubated with vincristine (10 nM) with and without racemic verapamil and its L- and D-isomers (6." | 3.67 | D-verapamil and L-verapamil are equally effective in increasing vincristine accumulation in leukemic cells in vitro. ( Gruber, A; Peterson, C; Reizenstein, P, 1988) |
| "Dexverapamil is a competitive inhibitor of the P-glycoprotein (Pgp) efflux pump, a potent mechanism of multidrug resistance (mdr-1) in vitro." | 2.68 | Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy. ( Balis, FM; Bates, SE; Bryant, G; Chabner, BA; Jamis-Dow, C; Klecker, RW; Kohler, DR; Steinberg, SM; Wilson, WH; Wittes, RE, 1995) |
| "Dexverapamil was escalated eight dose levels, from 240 to 1,200 mg/m2/d." | 2.68 | Controlled trial of dexverapamil, a modulator of multidrug resistance, in lymphomas refractory to EPOCH chemotherapy. ( Bates, SE; Bryant, G; Fojo, A; Herdt, J; Jaffe, ES; Regis, J; Steinberg, SM; Wilson, WH; Wittes, RE; Zhan, Z, 1995) |
| "One of 42 newly diagnosed and untreated lymphoma patients (2%) and seven of 11 previously treated and drug-resistant patients (64%) had detectable levels of P-glycoprotein (P less than ." | 1.28 | P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil. ( Dalton, WS; Grogan, TM; Miller, TP; Salmon, SE; Scheper, RJ; Spier, CM, 1991) |
| "Verapamil has been shown to reverse acquired drug resistance to Adriamycin (ADR) and vinblastine in the P388 leukemia and Ehrlich ascites carcinoma model systems." | 1.27 | Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells. ( Cox, TC; Crowley, J; Goodman, GE; Yen, YP, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.11) | 18.7374 |
| 1990's | 14 (51.85) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Hohmann, J | 2 |
| Molnár, J | 6 |
| Rédei, D | 2 |
| Evanics, F | 1 |
| Forgo, P | 2 |
| Kálmán, A | 1 |
| Argay, G | 1 |
| Szabó, P | 1 |
| Dombi, G | 1 |
| Zorig, T | 1 |
| Duarte, N | 1 |
| Varga, A | 1 |
| Cherepnev, G | 1 |
| Radics, R | 1 |
| Ferreira, MJ | 2 |
| Voigt, B | 1 |
| Coburger, C | 1 |
| Monár, J | 1 |
| Hilgeroth, A | 1 |
| Das, U | 1 |
| Baráth, Z | 1 |
| Bata, Z | 1 |
| Dimmock, JR | 1 |
| Ramalhete, C | 2 |
| Mulhovo, S | 2 |
| Rosário, VE | 1 |
| Silva, CD | 1 |
| Spengler, G | 1 |
| Ferreira, MU | 1 |
| McIver, ZA | 1 |
| Kryman, MW | 1 |
| Choi, Y | 1 |
| Coe, BN | 1 |
| Schamerhorn, GA | 1 |
| Linder, MK | 1 |
| Davies, KS | 1 |
| Hill, JE | 1 |
| Sawada, GA | 1 |
| Grayson, JM | 1 |
| Detty, MR | 1 |
| Uozurmi, K | 1 |
| Nakaichi, M | 1 |
| Yamamoto, Y | 1 |
| Une, S | 1 |
| Taura, Y | 1 |
| Wilson, WH | 3 |
| Jamis-Dow, C | 1 |
| Bryant, G | 2 |
| Balis, FM | 1 |
| Klecker, RW | 1 |
| Bates, SE | 4 |
| Chabner, BA | 2 |
| Steinberg, SM | 2 |
| Kohler, DR | 1 |
| Wittes, RE | 2 |
| Fojo, A | 2 |
| Zhan, Z | 2 |
| Regis, J | 2 |
| Jaffe, ES | 1 |
| Herdt, J | 1 |
| Tidefelt, U | 1 |
| Juliusson, G | 1 |
| Elmhorn-Rosenborg, A | 1 |
| Peterson, C | 2 |
| Paul, C | 1 |
| Parekh, H | 1 |
| Simpkins, H | 1 |
| Oonishi, T | 1 |
| Sakashita, K | 1 |
| Suematsu, N | 1 |
| Schechter, AN | 1 |
| Uyesaka, N | 1 |
| Liu, Z | 1 |
| Lheureux, F | 1 |
| Pouliot, JF | 1 |
| Heckel, A | 1 |
| Bamberger, U | 1 |
| Georges, E | 1 |
| Sandor, VA | 1 |
| Gamelin, E | 1 |
| Dickstein, B | 1 |
| Wilson, W | 1 |
| Fojo, AT | 1 |
| Hosoi, E | 1 |
| Hirose, M | 1 |
| Hamano, S | 1 |
| Morimoto, M | 1 |
| Kuroda, Y | 1 |
| Li, M | 1 |
| Kondo, T | 1 |
| Zhao, QL | 1 |
| Li, FJ | 1 |
| Tanabe, K | 1 |
| Arai, Y | 1 |
| Zhou, ZC | 1 |
| Kasuya, M | 1 |
| Lee, WP | 1 |
| Lee, CL | 1 |
| Kao, MC | 1 |
| Miller, TP | 2 |
| Grogan, TM | 2 |
| Dalton, WS | 2 |
| Spier, CM | 1 |
| Scheper, RJ | 1 |
| Salmon, SE | 1 |
| Häussermann, K | 1 |
| Benz, B | 1 |
| Gekeler, V | 1 |
| Schumacher, K | 1 |
| Eichelbaum, M | 1 |
| Ishida, Y | 1 |
| Shimada, Y | 1 |
| Shimoyama, M | 1 |
| Utsunomiya, N | 1 |
| Tsuboi, M | 1 |
| Nakanishi, M | 1 |
| Gruber, A | 1 |
| Reizenstein, P | 1 |
| Goodman, GE | 1 |
| Yen, YP | 1 |
| Cox, TC | 1 |
| Crowley, J | 1 |
1 review available for verapamil and Lymphoma
| Article | Year |
|---|---|
The role of P-glycoprotein in drug-resistant hematologic malignancies.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transpor | 1991 |
3 trials available for verapamil and Lymphoma
| Article | Year |
|---|---|
Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cross-Over Studies; Cyclophosphamide; D | 1995 |
Controlled trial of dexverapamil, a modulator of multidrug resistance, in lymphomas refractory to EPOCH chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfa | 1995 |
Modulation of multidrug resistance by dexverapamil in EPOCH-refractory lymphomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfa | 1995 |
23 other studies available for verapamil and Lymphoma
| Article | Year |
|---|---|
Discovery and biological evaluation of a new family of potent modulators of multidrug resistance: reversal of multidrug resistance of mouse lymphoma cells by new natural jatrophane diterpenoids isolated from Euphorbia species.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Crystallography, X-Ray; Diterpenes | 2002 |
Jatrophane diterpenoids from Euphorbia mongolica as modulators of the multidrug resistance of L5128 mouse lymphoma cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Diterpenes; Drug Resistance, Multiple; Drug Screening As | 2003 |
Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; ATP Binding Cassette Transporter | 2007 |
Structure-activity relationships of novel N-acyloxy-1,4-dihydropyridines as P-glycoprotein inhibitors.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, | 2007 |
1-[4-(2-Aminoethoxy)phenylcarbonyl]-3,5-bis-(benzylidene)-4-oxopiperidines: a novel series of highly potent revertants of P-glycoprotein associated multidrug resistance.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, | 2008 |
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily | 2009 |
Triterpenes from Momordica balsamina (African pumpkin): ABCB1 inhibition and synergistic interaction with doxorubicin in resistant cancer cells.
Topics: Adenocarcinoma; Animals; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Colonic Ne | 2022 |
Selective photodepletion of malignant T cells in extracorporeal photopheresis with selenorhodamine photosensitizers.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Humans; Light; Lymphoma; | 2016 |
Development of multidrug resistance in a canine lymphoma cell line.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, | 2005 |
Increased intracellular concentrations of doxorubicin in resistant lymphoma cells in vivo by concomitant therapy with verapamil and cyclosporin A.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclosporine; Doxorubicin; Drug Interactions; | 1994 |
Cross-resistance and collateral sensitivity to natural product drugs in cisplatin-sensitive and -resistant rat lymphoma and human ovarian carcinoma cells.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine | 1996 |
Quantitative characterization of P-glycoprotein-mediated transport in mdr1-gene-transfected lymphoma cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cattle; Dose-Response Relationship | 1996 |
BIBW22 BS, potent multidrug resistance-reversing agent, binds directly to P-glycoprotein and accumulates in drug-resistant cells.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding S | 1996 |
Expression of the multidrug resistance-associated protein gene in refractory lymphoma: quantitation by a validated polymerase chain reaction assay.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Membe | 1997 |
Effect of MDR antagonists on the cidal activity of vincristine for cells expressing MDR-1 is superior to those expressing MRP.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Bind | 1998 |
Apoptosis induced by cadmium in human lymphoma U937 cells through Ca2+-calpain and caspase-mitochondria- dependent pathways.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; bcl-X Protein; BH3 Interacting Domain Death Agonist Prot | 2000 |
Multidrug resistant HOB1 lymphoma cells express P-glycoprotein that does not play the major role in the development of drug resistance to adriamycin.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Cell Survival; DNA Prob | 1992 |
P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfa | 1991 |
Effects of verapamil enantiomers and major metabolites on the cytotoxicity of vincristine and daunomycin in human lymphoma cell lines.
Topics: Daunorubicin; Drug Resistance; Humans; Lymphoma; Protein Binding; Stereoisomerism; Tumor Cells, Cult | 1991 |
Synergistic effect of cyclosporin A and verapamil in overcoming vincristine resistance of multidrug-resistant cultured human leukemia cells.
Topics: Cyclosporins; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Humans; Leukemia; L | 1990 |
Early transmembrane events in alloimmune cytotoxic T-lymphocyte activation as revealed by stopped-flow fluorometry.
Topics: Animals; Biological Transport; Calcium; Cell Line; Concanavalin A; Cytotoxicity Tests, Immunologic; | 1986 |
D-verapamil and L-verapamil are equally effective in increasing vincristine accumulation in leukemic cells in vitro.
Topics: Calcium; Drug Resistance; Humans; Leukemia; Leukemia, Lymphoid; Leukocytes; Lymphoma; Stereoisomeris | 1988 |
Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells.
Topics: Breast Neoplasms; Cell Survival; Clone Cells; Colonic Neoplasms; Doxorubicin; Drug Resistance; Esoph | 1987 |