verapamil has been researched along with Lung Neoplasms in 95 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human lung carcinoma A549-T27 cells were used to determine the effect of diamide on cadmium accumulation." | 7.68 | Diamide reduces cadmium accumulation by human lung carcinoma A549 cells. ( Enger, MD; Kang, YJ; Liu, MS, 1990) |
| "The effect of the combined administration of doxorubicin (DX) and verapamil (VRP) on the induction of DX resistance of B16 melanoma cells, was investigated both in vitro and in vivo." | 7.67 | Verapamil potentiation of doxorubicin resistance development in B16 melanoma cells both in vitro and in vivo. ( Cleris, L; Formelli, F; Mariani, M; Supino, R, 1988) |
| "Verapamil, a calcium channel antagonist, inhibits murine B16 melanoma and colon adenocarcinoma C26 tumor metastasis by altering platelet aggregation [Tsuruo, T." | 3.68 | Inhibition of tumor cell invasion by verapamil. ( Clothier, JL; Geary, RJ; Hendrix, MJ; Montague, SL; Welch, DR; Winters, AL; Yohem, KH, 1991) |
| "Human lung carcinoma A549-T27 cells were used to determine the effect of diamide on cadmium accumulation." | 3.68 | Diamide reduces cadmium accumulation by human lung carcinoma A549 cells. ( Enger, MD; Kang, YJ; Liu, MS, 1990) |
| " In the present study, the effect of two membrane-acting agents, hyperthermia and the calcium channel blocker verapamil, on the action of adriamycin (ADR) on Lewis lung carcinoma (3LL) was examined." | 3.68 | Combined effect in vitro of chemotherapy with agents acting on the cell membrane of Lewis lung carcinoma. ( Hoenig, S; Leibovici, J; Siegal, A, 1990) |
| "The effect of the combined administration of doxorubicin (DX) and verapamil (VRP) on the induction of DX resistance of B16 melanoma cells, was investigated both in vitro and in vivo." | 3.67 | Verapamil potentiation of doxorubicin resistance development in B16 melanoma cells both in vitro and in vivo. ( Cleris, L; Formelli, F; Mariani, M; Supino, R, 1988) |
| "Dexverapamil was given for six days, 1500 mg a day divided into six doses of 250 mg every four hours starting 24 h prior to chemotherapy." | 2.68 | Randomised trial of vindesine and etoposide +/- dexverapamil in advanced non-small cell lung cancer: first results. ( Gatzemeier, U; Schneider, A; von Pawel, J, 1995) |
| "Verapamil 480 mg day-1 was given for 3 days starting 24 h prior to chemotherapy which consisted of bolus vindesine 7 mg followed by ifosfamide/mesna 5 g m-2 over 24 h, followed by mesna alone for a further 8 h." | 2.67 | Oral verapamil with chemotherapy for advanced non-small cell lung cancer: a randomised study. ( Cantwell, BM; Corris, PA; Harris, AL; Millward, MJ; Munro, NC; Robinson, A, 1993) |
| "Verapamil has been shown to partially restore drug sensitivity in tumour cells rendered resistant in vitro." | 2.67 | A randomised clinical study of verapamil in addition to combination chemotherapy in small cell lung cancer. West of Scotland Lung Cancer Research Group, and the Aberdeen Oncology Group. ( Milroy, R, 1993) |
| " The potential for a pharmacokinetic interaction between the two drugs has therefore been investigated in five patients with small cell lung cancer treated with combination chemotherapy comprising adriamycin, VP16, vincristine and cyclophosphamide." | 2.66 | The effect of verapamil on the pharmacokinetics of adriamycin. ( Brodie, MJ; Cummings, J; Graham, J; Kaye, SB; Kerr, DJ; Morrison, JG; Thompson, GG, 1986) |
| "Lung cancer is one of the foremost tumor-associated cause of death in the world." | 1.48 | Verapamil (VER) Enhances the Cytotoxic Effects of Docetaxel and Vinblastine Combined Therapy Against Non-Small Cell Lung Cancer Cell Lines. ( Daraee, H; Jaferian, S; Soleymaninejad, M, 2018) |
| " Low-dose chemotherapy, which is the long-term administration of relatively low doses of chemotherapeutic agents, has been proposed for targeting tumor angiogenesis in various types of cancers." | 1.42 | Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic effects of low-dose metronomic paclitaxel. ( Akiyama, K; Alam, MT; Hida, K; Hida, Y; Kawamoto, T; Maishi, N; Ohba, Y; Ohga, N; Ohmura, H; Shindoh, M; Torii, C; Yamada, K, 2015) |
| "Treatment with verapamil and siRNA against MDR1 significantly increased the sensitivity to amrubicinol in PC-6/AMR-OH cells with increased cellular accumulation of amrubicinol." | 1.37 | Over-expression of MDR1 in amrubicinol-resistant lung cancer cells. ( Kasai, D; Maeno, K; Miyazaki, M; Oguri, T; Ozasa, H; Sato, S; Takakuwa, O; Uemura, T, 2011) |
| "Only verapamil was effective in the inhibition of MRP1; however, the effects were more pronounced with [(99m)Tc]sestamibi, when compared to [(99m)Tc]tetrofosmin." | 1.35 | P-glycoprotein versus MRP1 on transport kinetics of cationic lipophilic substrates: a comparative study using [99mTc]sestamibi and [99mTc]tetrofosmin. ( Abrunhosa, AJ; Botelho, MF; Gomes, CM; Pauwels, EK, 2009) |
| "The invasion and metastasis process involves degradation of the extracellular matrix mediated by tumor- and host-produced proteolytic enzymes." | 1.30 | Verapamil inhibits tumor protease production, local invasion and metastasis development in murine carcinoma cells. ( Aguirre Ghiso, JA; Bal de Kier Joffé, E; Farías, EF; Ladeda, V, 1998) |
| "Studies were performed in rats bearing tumors bilaterally, a P-gp-negative small cell lung carcinoma (GLC4) and its P-gp-overexpressing subline (GLC4/P-gp)." | 1.30 | A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier. ( de Vries, EG; Eriks-Fluks, L; Franssen, EJ; Hendrikse, NH; Hospers, GA; Vaalburg, W; van der Graaf, WT; Willemsen, AT, 1999) |
| "Murine CT-26 colon cancer cells growing in continuous culture (parental cells) were harvested and injected subcutaneously into the lateral flank (to produce subcutaneous tumors) or the lateral tail vein (to produce experimental lung metastases) of 10 8-week-old syngeneic male BALB/c mice." | 1.29 | Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells. ( Bucana, CD; Dong, Z; Fan, D; Fidler, IJ; Radinsky, R; Tsan, R; Wilmanns, C, 1994) |
| "Etoposide efflux may have been inhibited, not because of (competitive) inhibition by BSO or disturbance of the energy required for this process, but probably because of plasma membrane alterations." | 1.28 | Modulation by D,L-buthionine-S,R-sulphoximine of etoposide cytotoxicity on human non-small cell lung, ovarian and breast carcinoma cell lines. ( Lafleur, MV; Lankelma, J; Mans, DR; Pinedo, HM; Retèl, J; Schuurhuis, GJ; Treskes, M, 1992) |
| "MTS1 is a metastasis-associated gene highly expressed in highly metastatic tumours." | 1.28 | Modulators of intracellular Ca2+ and the calmodulin inhibitor W-7 alter the expression of metastasis-associated genes MTS1 and NM23 in metastatic variants of the B16 murine melanoma. ( Parker, C; Sherbet, GV, 1992) |
| " Dose-response studies indicated that exceedingly high doses of DTIC were necessary to produce antimetastatic effects even when drug treatment was combined with the calcium channel blocker verapamil." | 1.28 | Efficacy of dacarbazine (DTIC) in preventing metastases arising from intraocular melanomas in mice. ( Gamel, JW; Niederkorn, JY; Sanborn, GE, 1992) |
| "When verapamil was administered after irradiation, regrowth of tumours was inhibited." | 1.28 | Modification by vasoactive drugs of tumour destruction by photodynamic therapy with haematoporphyrin derivative. ( Cowled, PA; Forbes, IJ, 1989) |
| "Nifedipine was included as the standard or reference compound." | 1.28 | In vivo characterization of combination antitumor chemotherapy with calcium channel blockers and cis-diamminedichloroplatinum(II). ( Honn, KV; Nelson, KK; Onoda, JM; Taylor, JD, 1989) |
| "Verapamil has been shown to reverse acquired drug resistance to Adriamycin (ADR) and vinblastine in the P388 leukemia and Ehrlich ascites carcinoma model systems." | 1.27 | Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells. ( Cox, TC; Crowley, J; Goodman, GE; Yen, YP, 1987) |
| "NL-44, however, did not form pulmonary metastasis even after the tumor cells had formed heterotypic aggregates with platelets, suggesting that tumor metastasis is dependent on the intrinsic nature of tumor cells." | 1.27 | [Tumor-induced platelet aggregation and growth-promoting factors as determinants of probable tumor metastasis]. ( Tsuruo, T, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (20.00) | 18.7374 |
| 1990's | 49 (51.58) | 18.2507 |
| 2000's | 12 (12.63) | 29.6817 |
| 2010's | 13 (13.68) | 24.3611 |
| 2020's | 2 (2.11) | 2.80 |
| Authors | Studies |
|---|---|
| Yuan, F | 1 |
| Bai, G | 1 |
| Chen, Y | 1 |
| Miao, Y | 1 |
| Chen, J | 1 |
| Li, X | 2 |
| Ai, Y | 1 |
| Zhu, B | 1 |
| Ren, C | 1 |
| Kang, F | 1 |
| Li, J | 1 |
| Huang, Z | 1 |
| Lai, Y | 1 |
| Peng, S | 1 |
| Ding, K | 1 |
| Tian, J | 1 |
| Zhang, Y | 1 |
| Liu, YM | 1 |
| Tu, HJ | 1 |
| Wu, CH | 1 |
| Lai, MJ | 1 |
| Yu, SC | 1 |
| Chao, MW | 1 |
| Wu, YW | 1 |
| Teng, CM | 1 |
| Pan, SL | 1 |
| Liou, JP | 1 |
| Shi, Y | 1 |
| Jin, Y | 1 |
| Liu, F | 2 |
| Jiang, J | 1 |
| Cao, J | 1 |
| Lu, Y | 1 |
| Yang, J | 2 |
| Jaferian, S | 1 |
| Soleymaninejad, M | 1 |
| Daraee, H | 1 |
| Xia, P | 1 |
| Gou, WF | 1 |
| Zhao, S | 1 |
| Zheng, HC | 1 |
| Huang, J | 1 |
| Zhang, T | 1 |
| Ma, K | 1 |
| Fan, P | 1 |
| Liu, Y | 2 |
| Weng, C | 1 |
| Fan, G | 1 |
| Duan, Q | 1 |
| Zhu, X | 1 |
| Yang, B | 1 |
| Ma, YF | 1 |
| Akiyama, K | 1 |
| Maishi, N | 1 |
| Ohga, N | 1 |
| Hida, Y | 1 |
| Ohba, Y | 1 |
| Alam, MT | 1 |
| Kawamoto, T | 1 |
| Ohmura, H | 1 |
| Yamada, K | 1 |
| Torii, C | 1 |
| Shindoh, M | 1 |
| Hida, K | 1 |
| Parumasivam, T | 1 |
| Chan, JG | 1 |
| Pang, A | 1 |
| Quan, DH | 1 |
| Triccas, JA | 1 |
| Britton, WJ | 1 |
| Chan, HK | 1 |
| Chen, YL | 1 |
| Yang, TY | 1 |
| Chen, KC | 1 |
| Wu, CL | 1 |
| Hsu, SL | 1 |
| Hsueh, CM | 1 |
| Zhang, C | 1 |
| Lv, F | 1 |
| Zhou, L | 1 |
| Wu, XX | 1 |
| Hoffman, RM | 1 |
| Gomes, CM | 1 |
| Abrunhosa, AJ | 1 |
| Pauwels, EK | 1 |
| Botelho, MF | 1 |
| Shi, D | 1 |
| Shi, G | 1 |
| Huang, G | 1 |
| Zhang, J | 1 |
| Lartigau, E | 1 |
| Villa, AM | 1 |
| Doglia, SM | 1 |
| Xu, X | 1 |
| Lu, X | 1 |
| Sun, J | 1 |
| Shu, Y | 1 |
| Xia, X | 1 |
| Li, F | 1 |
| Li, Y | 1 |
| Zhou, X | 1 |
| Dai, Y | 1 |
| Wong, ST | 1 |
| Takakuwa, O | 1 |
| Oguri, T | 1 |
| Ozasa, H | 1 |
| Uemura, T | 1 |
| Kasai, D | 1 |
| Miyazaki, M | 1 |
| Maeno, K | 1 |
| Sato, S | 1 |
| Tang, J | 1 |
| Wang, Y | 2 |
| Wang, D | 1 |
| Xu, Z | 1 |
| Racette, K | 1 |
| Hendrikse, NH | 2 |
| Vaalburg, W | 2 |
| Bogush, TA | 1 |
| Konukhova, AV | 1 |
| Ravcheeva, AB | 1 |
| Zabotina, TN | 1 |
| Kadagidze, ZG | 1 |
| Bogush, EA | 1 |
| Komov, DV | 1 |
| Polotskiĭ, BE | 1 |
| Laktionov, KK | 1 |
| Davydov, MI | 1 |
| Catalano, A | 1 |
| Rodilossi, S | 1 |
| Rippo, MR | 1 |
| Caprari, P | 1 |
| Procopio, A | 1 |
| Stehfest, E | 1 |
| Torky, A | 1 |
| Glahn, F | 1 |
| Foth, H | 2 |
| Pesic, M | 1 |
| Markovic, JZ | 1 |
| Jankovic, D | 1 |
| Kanazir, S | 1 |
| Markovic, ID | 1 |
| Rakic, L | 1 |
| Ruzdijic, S | 1 |
| Tsuruo, T | 4 |
| Iida, H | 1 |
| Naganuma, K | 1 |
| Tsukagoshi, S | 1 |
| Sakurai, Y | 1 |
| Binaschi, M | 1 |
| Supino, R | 2 |
| Gambetta, RA | 1 |
| Giaccone, G | 1 |
| Prosperi, E | 1 |
| Capranico, G | 1 |
| Cataldo, I | 1 |
| Zunino, F | 1 |
| Brach Del Prever, A | 1 |
| Massara, FM | 1 |
| Besenzon, L | 1 |
| Bianchi, M | 1 |
| Picci, P | 1 |
| Briccoli, A | 1 |
| Miniero, R | 1 |
| Song, EJ | 2 |
| Yang, VC | 2 |
| Chiang, CD | 2 |
| Chao, CC | 1 |
| Alvarez, M | 1 |
| Paull, K | 1 |
| Monks, A | 1 |
| Hose, C | 1 |
| Lee, JS | 1 |
| Weinstein, J | 1 |
| Grever, M | 1 |
| Bates, S | 1 |
| Fojo, T | 1 |
| Munkonge, FM | 1 |
| Osborne, LR | 1 |
| Geddes, DM | 1 |
| Alton, EW | 1 |
| Arvelo, F | 2 |
| Poupon, MF | 2 |
| Goguel, AF | 1 |
| Lizard, G | 1 |
| Bourgeois, Y | 2 |
| Arriagada, R | 1 |
| Le Chevalier, T | 2 |
| Spoelstra, EC | 1 |
| Westerhoff, HV | 2 |
| Pinedo, HM | 4 |
| Dekker, H | 1 |
| Lankelma, J | 5 |
| Dong, Z | 1 |
| Radinsky, R | 1 |
| Fan, D | 1 |
| Tsan, R | 1 |
| Bucana, CD | 1 |
| Wilmanns, C | 1 |
| Fidler, IJ | 1 |
| Zhu, YL | 1 |
| Zhu, YJ | 1 |
| Guo, ZJ | 1 |
| Coley, HM | 3 |
| Amos, WB | 1 |
| Twentyman, PR | 6 |
| Workman, P | 3 |
| Schuurhuis, GJ | 3 |
| van Heijningen, TH | 1 |
| Cervantes, A | 1 |
| de Lange, JH | 1 |
| Keizer, HG | 3 |
| Broxterman, HJ | 2 |
| Baak, JP | 1 |
| Kirk, J | 1 |
| Carmichael, J | 1 |
| Stratford, IJ | 1 |
| Harris, AL | 2 |
| Mülder, HS | 1 |
| van Grondelle, R | 1 |
| Parker, C | 2 |
| Sherbet, GV | 2 |
| Millward, MJ | 1 |
| Cantwell, BM | 1 |
| Munro, NC | 1 |
| Robinson, A | 1 |
| Corris, PA | 1 |
| Ohta, S | 1 |
| Nishio, K | 1 |
| Kubo, S | 1 |
| Nishio, M | 1 |
| Ohmori, T | 1 |
| Takahashi, T | 1 |
| Saijo, N | 1 |
| Schaefer, HI | 1 |
| Höld, KM | 1 |
| Egas-Kenniphaas, JM | 1 |
| van der Laarse, A | 1 |
| Barrand, MA | 1 |
| Rhodes, T | 1 |
| Center, MS | 1 |
| Milroy, R | 2 |
| Bichat, F | 1 |
| Grossin, F | 1 |
| Jacrot, M | 1 |
| Bastian, G | 1 |
| Gatzemeier, U | 1 |
| Schneider, A | 1 |
| von Pawel, J | 1 |
| Quesada, AR | 1 |
| García Grávalos, MD | 1 |
| Fernández Puentes, JL | 1 |
| Zhan, Z | 1 |
| Sandor, VA | 1 |
| Gamelin, E | 1 |
| Regis, J | 1 |
| Dickstein, B | 1 |
| Wilson, W | 1 |
| Fojo, AT | 1 |
| Bates, SE | 1 |
| Heenan, M | 1 |
| O'Driscoll, L | 1 |
| Cleary, I | 2 |
| Connolly, L | 1 |
| Clynes, M | 2 |
| Doherty, G | 1 |
| Moran, E | 1 |
| Cowie, FJ | 1 |
| Pritchard-Jones, K | 1 |
| Renshaw, J | 1 |
| Pinkerton, CR | 1 |
| Van Rensburg, CE | 1 |
| Jooné, G | 1 |
| Anderson, R | 1 |
| Shrivastava, P | 1 |
| Hanibuchi, M | 1 |
| Yano, S | 1 |
| Parajuli, P | 1 |
| Sone, S | 1 |
| Farías, EF | 1 |
| Aguirre Ghiso, JA | 1 |
| Ladeda, V | 1 |
| Bal de Kier Joffé, E | 1 |
| Chan, MW | 1 |
| de Vries, EG | 2 |
| Eriks-Fluks, L | 1 |
| van der Graaf, WT | 1 |
| Hospers, GA | 1 |
| Willemsen, AT | 1 |
| Franssen, EJ | 1 |
| Tachibana, Y | 1 |
| Zhu, XK | 1 |
| Krishnan, P | 1 |
| Lee, KH | 1 |
| Bastow, KF | 1 |
| Matsumori, A | 1 |
| Nunokawa, Y | 1 |
| Sasayama, S | 1 |
| Lehmann, T | 1 |
| Köhler, C | 1 |
| Weidauer, E | 1 |
| Taege, C | 1 |
| Pancrazio, JJ | 2 |
| Oie, HK | 1 |
| Kim, YI | 2 |
| Mans, DR | 1 |
| Treskes, M | 1 |
| Lafleur, MV | 1 |
| Retèl, J | 1 |
| Sanborn, GE | 1 |
| Niederkorn, JY | 1 |
| Gamel, JW | 1 |
| Jensen, PB | 1 |
| Jensen, PS | 1 |
| Demant, EJ | 1 |
| Friche, E | 1 |
| Sørensen, BS | 1 |
| Sehested, M | 1 |
| Wassermann, K | 1 |
| Vindeløv, L | 1 |
| Westergaard, O | 1 |
| Hansen, HH | 1 |
| Yohem, KH | 1 |
| Clothier, JL | 1 |
| Montague, SL | 1 |
| Geary, RJ | 1 |
| Winters, AL | 1 |
| Hendrix, MJ | 1 |
| Welch, DR | 1 |
| Nygren, P | 1 |
| Larsson, R | 1 |
| Gruber, A | 1 |
| Peterson, C | 1 |
| Bergh, J | 1 |
| Schüller, HM | 1 |
| Orloff, M | 1 |
| Reznik, GK | 1 |
| Viglione, MP | 1 |
| Kleiman, RJ | 1 |
| de Jong, S | 1 |
| Zijlstra, JG | 1 |
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| Plumb, JA | 1 |
| Kaye, SB | 3 |
| Bruno, NA | 1 |
| Carver, LA | 1 |
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| Liu, MS | 1 |
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| Arnold, A | 1 |
| Goodyear, M | 1 |
| Findlay, B | 1 |
| Neville, A | 1 |
| Normandeau, R | 1 |
| Jones, A | 1 |
| Zacharski, LR | 1 |
| Moritz, TE | 1 |
| Haakenson, CM | 1 |
| O'Donnell, JF | 1 |
| Ballard, HS | 1 |
| Johnson, GJ | 1 |
| Ringenberg, QS | 1 |
| Schilsky, RL | 1 |
| Spaulding, MB | 1 |
| Tornyos, K | 1 |
| Siegal, A | 1 |
| Hoenig, S | 1 |
| Leibovici, J | 1 |
| Cowled, PA | 1 |
| Forbes, IJ | 1 |
| Joenje, H | 2 |
| Schoonen, WG | 1 |
| van Rijn, J | 1 |
| Onoda, JM | 1 |
| Nelson, KK | 1 |
| Taylor, JD | 1 |
| Honn, KV | 1 |
| Merry, S | 1 |
| Courtney, ER | 1 |
| Fetherston, CA | 1 |
| Freshney, RI | 1 |
| Banham, S | 1 |
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| Burnett, A | 1 |
| Soukop, M | 1 |
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| Kaye, S | 1 |
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| Wright, KA | 1 |
| Bleehen, NM | 2 |
| Kerr, DJ | 1 |
| Graham, J | 1 |
| Cummings, J | 1 |
| Morrison, JG | 1 |
| Thompson, GG | 1 |
| Brodie, MJ | 1 |
| Formelli, F | 1 |
| Cleris, L | 1 |
| Mariani, M | 1 |
| Goodman, GE | 1 |
| Yen, YP | 1 |
| Cox, TC | 1 |
| Crowley, J | 1 |
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| Volm, M | 1 |
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| Simmonds, AP | 1 |
| Moyes, P | 1 |
| Nicol, A | 1 |
| Davidson, KG | 1 |
| Faichney, A | 1 |
5 trials available for verapamil and Lung Neoplasms
| Article | Year |
|---|---|
Clinical evaluation of targeted arterial perfusion of verapamil and chemotherapeutic drugs in interventional therapy of advanced lung cancer.
Topics: Adult; Aged; Antineoplastic Agents; Calcium Channel Blockers; Drug Resistance, Multiple; Drug Resist | 2013 |
Oral verapamil with chemotherapy for advanced non-small cell lung cancer: a randomised study.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Sm | 1993 |
A randomised clinical study of verapamil in addition to combination chemotherapy in small cell lung cancer. West of Scotland Lung Cancer Research Group, and the Aberdeen Oncology Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Pressure; Carcinoma, Small Cell; | 1993 |
Randomised trial of vindesine and etoposide +/- dexverapamil in advanced non-small cell lung cancer: first results.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Calcium Channel Blockers; | 1995 |
The effect of verapamil on the pharmacokinetics of adriamycin.
Topics: Administration, Oral; Carcinoma, Small Cell; Clinical Trials as Topic; Doxorubicin; Drug Interaction | 1986 |
90 other studies available for verapamil and Lung Neoplasms
| Article | Year |
|---|---|
Structure-activity relationships of diverse ACGs against multidrug resistant human lung cancer cell line A549/Taxol.
Topics: Acetogenins; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Drug Resistance, Mult | 2015 |
Discovery of New Monocarbonyl Ligustrazine-Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Curcumin; Dose-Response Relati | 2016 |
Ring-opening of five-membered heterocycles conjugated 4-isopropylresorcinol scaffold-based benzamides as HSP90 inhibitors suppressing tumor growth in vitro and in vivo.
Topics: Afatinib; Animals; Antineoplastic Agents; Benzamides; Cell Cycle Checkpoints; Cell Line; Cell Membra | 2021 |
Ceramide induces the apoptosis of non‑small cell lung cancer cells through the Txnip/Trx1 complex.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Caspase 3; Cell Line, Tumor; Cell Survi | 2021 |
Verapamil (VER) Enhances the Cytotoxic Effects of Docetaxel and Vinblastine Combined Therapy Against Non-Small Cell Lung Cancer Cell Lines.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Non-Small-Cell Lung; | 2018 |
Crizotinib may be used in Lewis lung carcinoma: a novel use for crizotinib.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Calcium Channel Blockers; Carcin | 2013 |
Elevated Expression of Nrf-2 and ABCG2 Involved in Multi-drug Resistance of Lung Cancer SP Cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; ATP Binding Cassette Transporter, Sub | 2015 |
Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic effects of low-dose metronomic paclitaxel.
Topics: Administration, Metronomic; Animals; Anti-Arrhythmia Agents; Antineoplastic Agents, Phytogenic; ATP | 2015 |
In Vitro Evaluation of Inhalable Verapamil-Rifapentine Particles for Tuberculosis Therapy.
Topics: Adenocarcinoma; Administration, Inhalation; Aerosols; Anti-Arrhythmia Agents; Antibiotics, Antituber | 2016 |
Hypoxia can impair doxorubicin resistance of non-small cell lung cancer cells by inhibiting MRP1 and P-gp expression and boosting the chemosensitizing effects of MRP1 and P-gp blockers.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; C | 2016 |
Effect of verapamil on the expression of EGFR and NM23 in A549 human lung cancer cells.
Topics: Antineoplastic Agents; Calcium Channel Blockers; Cell Line, Tumor; ErbB Receptors; Humans; Lung Neop | 2009 |
P-glycoprotein versus MRP1 on transport kinetics of cationic lipophilic substrates: a comparative study using [99mTc]sestamibi and [99mTc]tetrofosmin.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line, Tumor; Cyc | 2009 |
Chemosensitivity of radioresistant cells in the multicellular spheroids of A549 lung adenocarcinoma.
Topics: Adenocarcinoma; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Ca | 2009 |
Ethidium bromide as a vital probe of mitochondrial DNA in carcinoma cells.
Topics: Breast; Breast Neoplasms; Calcium Channel Blockers; Cell Line, Tumor; DNA, Mitochondrial; Drug Resis | 2009 |
[microRNA expression profiling of side population cells in human lung cancer and preliminary analysis].
Topics: Calcium Channel Blockers; Cell Line, Tumor; Flow Cytometry; Gene Expression Profiling; Humans; Lung; | 2010 |
Image-based chemical screening identifies drug efflux inhibitors in lung cancer cells.
Topics: Animals; Antineoplastic Agents; ATP-Binding Cassette Transporters; Benzimidazoles; Cell Line, Tumor; | 2010 |
Over-expression of MDR1 in amrubicinol-resistant lung cancer cells.
Topics: Animals; Anthracyclines; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Bl | 2011 |
Key structure of brij for overcoming multidrug resistance in cancer.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; ATP Binding Ca | 2013 |
Dynamics of multidrug resistance: P-glycoprotein analyses with positron emission tomography.
Topics: Adult; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cell; Drug | 2002 |
[Inhibition of ABC-transporter(s)' function in non-small cell lung cancer cells by platinum drugs].
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette | 2003 |
Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Separation; Culture Media, Conditioned; Cytokines; Disease Progres | 2004 |
Non-destructive micromethod for MRP1 functional assay in human lung tumor cells.
Topics: Acetylcysteine; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Buthionin | 2006 |
Induced resistance in the human non small cell lung carcinoma (NCI-H460) cell line in vitro by anticancer drugs.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Curcumin; Doxorubicin; Drug Resistance, Multi | 2006 |
[Reversal of acquired resistance to vinca alkaloids and anthracycline antibiotics by calcium channel blockers and calmodulin inhibitors].
Topics: Animals; Antibiotics, Antineoplastic; Calcium Channel Blockers; Calmodulin; Drug Resistance; Drug Sy | 1984 |
Promotion by verapamil of vincristine responsiveness in tumor cell lines inherently resistant to the drug.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Synergism; | 1983 |
MRP gene overexpression in a human doxorubicin-resistant SCLC cell line: alterations in cellular pharmacokinetics and in pattern of cross-resistance.
Topics: Carcinoma, Small Cell; Doxorubicin; Drug Resistance, Multiple; Gene Expression Regulation, Neoplasti | 1995 |
[Treatment of metastatic osteosarcoma with verapamil, cyclosporine and chemotherapy. A case report].
Topics: Bone Neoplasms; Chemotherapy, Adjuvant; Child; Combined Modality Therapy; Cyclosporine; Femur; Human | 1995 |
Potentiation of growth inhibition due to vincristine by ascorbic acid in a resistant human non-small cell lung cancer cell line.
Topics: Ascorbic Acid; Carcinoma, Non-Small-Cell Lung; Cell Division; Culture Media; Drug Resistance; Drug S | 1995 |
Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cell Surv | 1995 |
Lack of inhibition by dideoxy-forskolin and verapamil of DIDS-sensitive volume-activated Cl- secretion in human squamous lung carcinoma epithelial cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; ATP Binding Cassette Transporter, Subfamily B, Mem | 1994 |
Response of a multidrug-resistant human small-cell lung cancer xenograft to chemotherapy.
Topics: Adult; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Su | 1993 |
The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Carcinoma, No | 1994 |
Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Carrier Proteins; Colon | 1994 |
[Effects of calcium blockers and calmodulin inhibitors on the proliferation of fibroblast in alveolar macrophage condition medium].
Topics: Bronchoalveolar Lavage Fluid; Carcinoma, Bronchogenic; Cell Division; Chlorpromazine; Culture Media, | 1993 |
Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carci | 1993 |
Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carrier Proteins; Cell Nu | 1993 |
Selective toxicity of TGF-alpha-PE40 to EGFR-positive cell lines: selective protection of low EGFR-expressing cell lines by EGF.
Topics: Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; Cell Line; C | 1994 |
A plasma membrane 'vacuum cleaner' for daunorubicin in non-P-glycoprotein multidrug-resistant SW-1573 human non-small cell lung carcinoma cells. A study using fluorescence resonance energy transfer.
Topics: Biological Transport; Carcinoma, Non-Small-Cell Lung; Cell Membrane; Computer Simulation; Daunorubic | 1993 |
The Ca2+ channel blocker verapamil enhances melanogenesis without altering metastatic potential in the B16 murine melanoma.
Topics: alpha-MSH; Animals; Cell Differentiation; Female; Lung Neoplasms; Melanocytes; Melanoma, Experimenta | 1993 |
Characterisation of a vindesine-resistant human small-cell lung cancer cell line.
Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Carcinoma, Small Cell; Cell Division; | 1993 |
Intracellular calcium signalling after binding of low-density lipoprotein to confluent and nonconfluent cultures of an endothelial cell line, EA.hy 926.
Topics: Calcium; Cell Line, Transformed; Cholesterol Esters; Contact Inhibition; Endothelium, Vascular; Huma | 1993 |
Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein.
Topics: Carcinoma, Non-Small-Cell Lung; Cyclosporine; Cyclosporins; Daunorubicin; Humans; Lung Neoplasms; Me | 1993 |
Adding a reverser (verapamil) to combined chemotherapy overrides resistance in small cell lung cancer xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cisplatin; Cyclophos | 1995 |
Polyaromatic alkaloids from marine invertebrates as cytotoxic compounds and inhibitors of multidrug resistance caused by P-glycoprotein.
Topics: Adenocarcinoma; Alkaloids; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemoth | 1996 |
Expression of the multidrug resistance-associated protein gene in refractory lymphoma: quantitation by a validated polymerase chain reaction assay.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Membe | 1997 |
Isolation from a human MDR lung cell line of multiple clonal subpopulations which exhibit significantly different drug resistance.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell Separation; Clone Cells | 1997 |
The multidrug-resistant human lung tumour cell line, DLKP-A10, expresses novel drug accumulation and sequestration systems.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Su | 1997 |
Multidrug resistance modulation in rhabdomyosarcoma and neuroblastoma cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cel | 1998 |
Alpha-tocopherol antagonizes the multidrug-resistance-reversal activity of cyclosporin A, verapamil, GF120918, clofazimine and B669.
Topics: Acridines; Cell Death; Clofazimine; Cyclosporine; Drug Resistance, Multiple; Humans; Isoquinolines; | 1998 |
Circumvention of multidrug resistance by a quinoline derivative, MS-209, in multidrug-resistant human small-cell lung cancer cells and its synergistic interaction with cyclosporin A or verapamil.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cel | 1998 |
Verapamil inhibits tumor protease production, local invasion and metastasis development in murine carcinoma cells.
Topics: Animals; Calcium Channel Blockers; Cell Division; Dose-Response Relationship, Drug; Endopeptidases; | 1998 |
Effects of cytoskeletal inhibitors on the accumulation of vincristine in a resistant human lung cancer cell line with high level of polymerized tubulin.
Topics: Adenocarcinoma; Cell Survival; Colchicine; Cyclosporine; Cytochalasin B; Cytochalasin D; Cytoskeleto | 1998 |
A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood | 1999 |
Characterization of human lung cancer cells resistant to 4'-O-demethyl-4beta-(2"-nitro-4"-fluoroanilino)-4-desoxypodophyllotoxin , a unique compound in the epipodophyllotoxin antitumor class.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium | 2000 |
Nifedipine inhibits activation of transcription factor NF-kappaB.
Topics: Amlodipine; Calcium Channel Blockers; Cell Migration Inhibition; Diltiazem; Dose-Response Relationsh | 2000 |
Expression of MRP1 and related transporters in human lung cells in culture.
Topics: Adult; Aged; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette | 2001 |
Voltage-sensitive calcium channels in a human small-cell lung cancer cell line.
Topics: Calcium Channels; Carcinoma, Small Cell; Humans; Lambert-Eaton Myasthenic Syndrome; Lung Neoplasms; | 1992 |
Modulation by D,L-buthionine-S,R-sulphoximine of etoposide cytotoxicity on human non-small cell lung, ovarian and breast carcinoma cell lines.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma, Non-Small-Cell | 1992 |
Modulators of intracellular Ca2+ and the calmodulin inhibitor W-7 alter the expression of metastasis-associated genes MTS1 and NM23 in metastatic variants of the B16 murine melanoma.
Topics: Animals; Blotting, Northern; Calcium; Calmodulin; Female; Gene Expression; Genetic Variation; Lung N | 1992 |
Efficacy of dacarbazine (DTIC) in preventing metastases arising from intraocular melanomas in mice.
Topics: Animals; Anterior Eye Segment; Dacarbazine; Eye Enucleation; Eye Neoplasms; Female; Lung Neoplasms; | 1992 |
Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: relationship to DNA integrity and topoisomerase II.
Topics: Aclarubicin; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ehrlich Tumor; Carc | 1991 |
Inhibition of tumor cell invasion by verapamil.
Topics: Animals; Cytoskeletal Proteins; Female; Humans; Lung Neoplasms; Matrix Metalloproteinase 9; Melanoma | 1991 |
Retention of activity by selected anthracyclines in a multidrug resistant human large cell lung carcinoma line without P-glycoprotein hyperexpression.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Dau | 1991 |
Doxorubicin selected multidrug-resistant small cell lung cancer cell lines characterised by elevated cytoplasmic Ca2+ and resistance modulation by verapamil in absence of P-glycoprotein overexpression.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium; Carcinoma, Small Cell; Cell Surviv | 1991 |
Antiproliferative effects of the Ca2+/calmodulin antagonist B859-35 and the Ca(2+)-channel blocker verapamil on human lung cancer cell lines.
Topics: Adenocarcinoma; Antineoplastic Agents; Calcium Channel Blockers; Carcinoid Tumor; Cell Division; Dih | 1991 |
Verapamil-induced blockade of voltage-activated K+ current in small-cell lung cancer cells.
Topics: Calcium; Carcinoma, Small Cell; Cell Division; Humans; Kinetics; Lung Neoplasms; Membrane Potentials | 1991 |
Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line.
Topics: Amsacrine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cell; Cell Cycl | 1990 |
The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Doxorubicin; Drug Resista | 1990 |
Isolation and characterization of doxorubicin-resistant Lewis lung carcinoma variants.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell Line; Doxorubi | 1990 |
Diamide reduces cadmium accumulation by human lung carcinoma A549 cells.
Topics: Azo Compounds; Cadmium; Calcium Channels; Carcinoma; Cell Line; Diamide; Glutathione; Humans; Lung N | 1990 |
Voltage-operated calcium channels in small cell lung carcinoma cell lines: pharmacological, functional, and immunological properties.
Topics: Binding Sites; Binding, Competitive; Calcium Channels; Carcinoma, Small Cell; Conotoxins; Humans; Lu | 1990 |
Addition of verapamil and tamoxifen to the initial chemotherapy of small cell lung cancer. A phase I/II study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Doxorubicin; Drug Administrat | 1990 |
Chronic calcium antagonist use in carcinoma of the lung and colon: a retrospective cohort observational study.
Topics: Calcium; Carcinoma, Small Cell; Cohort Studies; Colonic Neoplasms; Diltiazem; Humans; Lung Neoplasms | 1990 |
Combined effect in vitro of chemotherapy with agents acting on the cell membrane of Lewis lung carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cell Membrane; Cell Membrane Per | 1990 |
Modification by vasoactive drugs of tumour destruction by photodynamic therapy with haematoporphyrin derivative.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Hematoporphyrin Derivative; Hematoporphyrin | 1989 |
Identification of anthracyclines and related agents that retain preferential activity over adriamycin in multidrug-resistant cell lines, and further resistance modification by verapamil and cyclosporin A.
Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Small Cell; Cell Line; Coloring Agents; Cyclosporin | 1989 |
Increased cytosolic pH in multidrug-resistant human lung tumor cells: effect of verapamil.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cytosol; Doxorubicin; Dru | 1989 |
Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell Line; Cell Nucleus; Dau | 1989 |
In vivo characterization of combination antitumor chemotherapy with calcium channel blockers and cis-diamminedichloroplatinum(II).
Topics: Animals; Calcium Channel Blockers; Cisplatin; Diltiazem; Drug Evaluation, Preclinical; Drug Resistan | 1989 |
Circumvention of drug resistance in human non-small cell lung cancer in vitro by verapamil.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Resistance; Drug Screening Assays, Antit | 1987 |
The role of VP-16 in the treatment of small-cell lung cancer: studies of the West of Scotland Lung Cancer Group.
Topics: Carcinoma, Small Cell; Cyclophosphamide; Drug Resistance; Drug Therapy, Combination; Etoposide; Fema | 1985 |
Multiform atrial tachycardia.
Topics: Aged; Carcinoma, Small Cell; Heart Atria; Humans; Lung Diseases, Obstructive; Lung Neoplasms; Male; | 1986 |
Derivation and preliminary characterisation of adriamycin resistant lines of human lung cancer cells.
Topics: Adenocarcinoma; Carcinoma, Small Cell; Cell Line; Cytological Techniques; Doxorubicin; Drug Resistan | 1986 |
Drug resistance in human lung cancer cell lines: cross-resistance studies and effects of the calcium transport blocker, verapamil.
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Small Cell; Cell Line; Drug Resistance; Humans; In | 1986 |
Verapamil potentiation of doxorubicin resistance development in B16 melanoma cells both in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Resistance; Lung Neoplasm | 1988 |
Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells.
Topics: Breast Neoplasms; Cell Survival; Clone Cells; Colonic Neoplasms; Doxorubicin; Drug Resistance; Esoph | 1987 |
[Tumor-induced platelet aggregation and growth-promoting factors as determinants of probable tumor metastasis].
Topics: Adenocarcinoma; Animals; Cell Line; Clone Cells; Colonic Neoplasms; Growth Substances; Lung Neoplasm | 1987 |
Occurrence of a multidrug-resistant phenotype in human lung xenografts.
Topics: Animals; Carcinoma, Squamous Cell; Dactinomycin; Doxorubicin; Drug Resistance; Female; Humans; Lung | 1987 |
Verapamil enhances antitumor activity without increasing myeloid toxicity.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Drug Synergism; Drug Therapy, Combination; Female; Fluo | 1987 |
Enhancement of cytotoxicity of vindesine and cis-platinum for human lung tumours by the use of verapamil in vitro.
Topics: Carcinoma, Squamous Cell; Cisplatin; Drug Resistance; Drug Synergism; Humans; In Vitro Techniques; L | 1986 |