verapamil and Liver Neoplasms studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Research Excerpts

Excerpt	Relevance	Reference
"This study evaluates the clinical effectiveness of targeted arterial infusion of verapamil in interventional treatment of primary hepatocellular carcinoma."	9.15	Clinical evaluation of targeted arterial infusion of verapamil in the interventional chemotherapy of primary hepatocellular carcinoma. ( Duan, Q; Fan, P; Huang, J; Ji, C; Lin, X; Lv, Y; Qian, L; Yu, X, 2011)
"The purpose of the study is to evaluate the protective effects of Verapamil on hepatic ischemia-reperfusion injury in cirrhotic patients with HCC."	9.14	Protective effect of Verapamil on hepatic ischemia-reperfusion injury during hepatectomy in the cirrhotic patients with hepatocellular carcinoma. ( Chen, M; Dong, J; Feng, X; Wang, S; Wang, X; Xia, F, 2009)
"A prospective study was conducted to assess the safety and efficacy of the addition of oral verapamil to intravenous Adriamycin (doxorubicin) for the management of patients with unresectable hepatocellular carcinoma (HCC)."	9.06	Doxorubicin for unresectable hepatocellular carcinoma. A prospective study on the addition of verapamil. ( Cheng, CH; Choi, TK; Fan, ST; Lai, EC; Mok, FP; Tan, ES; Wong, J, 1990)
"This study aimed to investigate the potential role of co-treatment with doxorubicin (DOX) and verapamil (VRP) nanoparticles in experimentally induced hepatocellular carcinoma in mice and to investigate the possible mechanisms behind the potential favorable effect of the co-treatment."	7.96	Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Abo Mansour, HE; Abo-Elmatty, DM; Badawy, NS; El-Batsh, MM; Mehanna, ET; Mesbah, NM, 2020)
"BACKGROUND The aim of this study was to investigate the role of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) in the reversal effect of verapamil (VER) on chemo-resistance to Adriamycin (ADM) in treatment of hepatocellular carcinoma (HCC)."	7.88	Upregulation of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Mediates the Reversal Effect of Verapamil on Chemo-Resistance to Adriamycin of Hepatocellular Carcinoma. ( Cheng, D; Fan, G; Fan, P; Huang, J; Liu, M; Ma, K; Teng, X; Xu, K; Yang, G; Zhang, T, 2018)
"Multidrug resistant H22 (H22/FAP) hepatocellular carcinoma cells were produced in vitro by continuous exposure to increasing doses of doxorubicin, cisplatin and 5-fluorouracil (FAP regimen)."	7.79	Association between reversal of multidrug resistance by methyl jasmonate and P-glycoprotein ATPase activity in hepatocellular carcinoma. ( Huang, FZ; Jiang, XZ; Liu, XY; Nie, WP; Wang, CF; Wang, YQ, 2013)
" In this study we investigated the induction of apoptosis by 4-aminopyridine (4-AP), a K(+) channel blocker, and its mechanism in HepG2 human hepatoblastoma cells."	7.70	Ca2+ influx mediates apoptosis induced by 4-aminopyridine, a K+ channel blocker, in HepG2 human hepatoblastoma cells. ( Jung, MW; Kang, GH; Kang, YS; Kim, JA; Lee, SH; Lee, YS, 2000)
"The data from hepatoma cells show an attenuation of the AAP can result from direct effects of a calcium blocker."	5.29	Diltiazem and superoxide dismutase modulate hepatic acute phase response in gram-negative sepsis. ( Baumann, H; Jahreis, GP; Rose, S; Sayeed, MM, 1994)
"In order to determine the clinical efficacy and adverse reactions of chemotherapy and verapamil infusion through a target artery to treat colorectal cancer patients with metastasis after failure with previous conventional treatments."	5.15	Clinical efficacy of chemotherapy combined with verapamil in metastatic colorectal patients. ( Duan, Q; Fan, P; Hu, B; Hu, L; Li, Y; Liu, Y; Lu, Z; Lv, R; Tong, S; Zhuang, J, 2011)
"This study evaluates the clinical effectiveness of targeted arterial infusion of verapamil in interventional treatment of primary hepatocellular carcinoma."	5.15	Clinical evaluation of targeted arterial infusion of verapamil in the interventional chemotherapy of primary hepatocellular carcinoma. ( Duan, Q; Fan, P; Huang, J; Ji, C; Lin, X; Lv, Y; Qian, L; Yu, X, 2011)
"The purpose of the study is to evaluate the protective effects of Verapamil on hepatic ischemia-reperfusion injury in cirrhotic patients with HCC."	5.14	Protective effect of Verapamil on hepatic ischemia-reperfusion injury during hepatectomy in the cirrhotic patients with hepatocellular carcinoma. ( Chen, M; Dong, J; Feng, X; Wang, S; Wang, X; Xia, F, 2009)
"A Phase I trial was performed to determine the maximum tolerable dose (MTD) and dose limiting toxicities of verapamil by hepatic artery infusion, together with doxorubicin, to patients with hepatic metastases of colorectal cancer."	5.07	A phase I trial of intrahepatic verapamil and doxorubicin. Regional therapy to overcome multidrug resistance. ( Bertino, J; Keefe, D; Kelsen, D; Kemeny, N; Murphy, B; O'Brien, JP; Saltz, L; Tao, Y; Tong, W; Tzy-Jun, Y, 1994)
"A prospective study was conducted to assess the safety and efficacy of the addition of oral verapamil to intravenous Adriamycin (doxorubicin) for the management of patients with unresectable hepatocellular carcinoma (HCC)."	5.06	Doxorubicin for unresectable hepatocellular carcinoma. A prospective study on the addition of verapamil. ( Cheng, CH; Choi, TK; Fan, ST; Lai, EC; Mok, FP; Tan, ES; Wong, J, 1990)
"This study aimed to investigate the potential role of co-treatment with doxorubicin (DOX) and verapamil (VRP) nanoparticles in experimentally induced hepatocellular carcinoma in mice and to investigate the possible mechanisms behind the potential favorable effect of the co-treatment."	3.96	Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Abo Mansour, HE; Abo-Elmatty, DM; Badawy, NS; El-Batsh, MM; Mehanna, ET; Mesbah, NM, 2020)
"The aim of the present study was to examine changes in the expression and activity of P-glycoprotein (P-gp) in human hepatocellular carcinoma HepG2 cells after exposure to menthol, and their relationship to the cytotoxicity of and apoptotic responses to doxorubicin (DOX), a substrate of P-gp, in the cells."	3.96	Reduced cytotoxicity in doxorubicin-exposed HepG2 cells pretreated with menthol due to upregulation of P-glycoprotein. ( Fukuno, S; Konishi, H; Miura, T; Nagai, K; Sehara, N; Uchino, Y, 2020)
"BACKGROUND The aim of this study was to investigate the role of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) in the reversal effect of verapamil (VER) on chemo-resistance to Adriamycin (ADM) in treatment of hepatocellular carcinoma (HCC)."	3.88	Upregulation of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Mediates the Reversal Effect of Verapamil on Chemo-Resistance to Adriamycin of Hepatocellular Carcinoma. ( Cheng, D; Fan, G; Fan, P; Huang, J; Liu, M; Ma, K; Teng, X; Xu, K; Yang, G; Zhang, T, 2018)
"Multidrug resistant H22 (H22/FAP) hepatocellular carcinoma cells were produced in vitro by continuous exposure to increasing doses of doxorubicin, cisplatin and 5-fluorouracil (FAP regimen)."	3.79	Association between reversal of multidrug resistance by methyl jasmonate and P-glycoprotein ATPase activity in hepatocellular carcinoma. ( Huang, FZ; Jiang, XZ; Liu, XY; Nie, WP; Wang, CF; Wang, YQ, 2013)
" In this study we investigated the induction of apoptosis by 4-aminopyridine (4-AP), a K(+) channel blocker, and its mechanism in HepG2 human hepatoblastoma cells."	3.70	Ca2+ influx mediates apoptosis induced by 4-aminopyridine, a K+ channel blocker, in HepG2 human hepatoblastoma cells. ( Jung, MW; Kang, GH; Kang, YS; Kim, JA; Lee, SH; Lee, YS, 2000)
"The present study evaluated the efficacy of chemotherapy combined with targeted arterial infusion of verapamil in patients with advanced gastric cancer."	2.79	Efficacy of chemotherapy combined with targeted arterial infusion of verapamil in patients with advanced gastric cancer. ( Chen, D; Duan, Q; Fan, G; Fan, P; Liu, A; Ning, Z; Zhang, T, 2014)
"Primary liver cancer patients (100) were randomly assigned into two groups."	2.77	Basic and clinical research on the therapeutic effect of intervention in primary liver cancer by targeted intra-arterial verapamil infusion. ( Liting, Q; Pingsheng, F; Qiang, H; Qiang, W; Tengyue, Z; Xin, S, 2012)
" The efficacy of MMF as an immunosuppressant and long-term safety in cats of this dosage regimen is unknown."	2.61	( Abrams, G; Adolfsson, E; Agarwal, PK; Akkan, AG; Al Alhareth, NS; Alves, VGL; Armentano, R; Bahroos, E; Baig, M; Baldridge, KK; Barman, S; Bartolucci, C; Basit, A; Bertoli, SV; Bian, L; Bigatti, G; Bobenko, AI; Boix, PP; Bokulic, T; Bolink, HJ; Borowiec, J; Bulski, W; Burciaga, J; Butt, NS; Cai, AL; Campos, AM; Cao, G; Cao, Y; Čapo, I; Caruso, ML; Chao, CT; Cheatum, CM; Chelminski, K; Chen, AJW; Chen, C; Chen, CH; Chen, D; Chen, G; Chen, H; Chen, LH; Chen, R; Chen, RX; Chen, X; Cherdtrakulkiat, R; Chirvony, VS; Cho, JG; Chu, K; Ciurlino, D; Coletta, S; Contaldo, G; Crispi, F; Cui, JF; D'Esposito, M; de Biase, S; Demir, B; Deng, W; Deng, Z; Di Pinto, F; Domenech-Ximenos, B; Dong, G; Drácz, L; Du, XJ; Duan, LJ; Duan, Y; Ekendahl, D; Fan, W; Fang, L; Feng, C; Followill, DS; Foreman, SC; Fortunato, G; Frew, R; Fu, M; Gaál, V; Ganzevoort, W; Gao, DM; Gao, X; Gao, ZW; Garcia-Alvarez, A; Garza, MS; Gauthier, L; Gazzaz, ZJ; Ge, RS; Geng, Y; Genovesi, S; Geoffroy, V; Georg, D; Gigli, GL; Gong, J; Gong, Q; Groeneveld, J; Guerra, V; Guo, Q; Guo, X; Güttinger, R; Guyo, U; Haldar, J; Han, DS; Han, S; Hao, W; Hayman, A; He, D; Heidari, A; Heller, S; Ho, CT; Ho, SL; Hong, SN; Hou, YJ; Hu, D; Hu, X; Hu, ZY; Huang, JW; Huang, KC; Huang, Q; Huang, T; Hwang, JK; Izewska, J; Jablonski, CL; Jameel, T; Jeong, HK; Ji, J; Jia, Z; Jiang, W; Jiang, Y; Kalumpha, M; Kang, JH; Kazantsev, P; Kazemier, BM; Kebede, B; Khan, SA; Kiss, J; Kohen, A; Kolbenheyer, E; Konai, MM; Koniarova, I; Kornblith, E; Krawetz, RJ; Kreouzis, T; Kry, SF; Laepple, T; Lalošević, D; Lan, Y; Lawung, R; Lechner, W; Lee, KH; Lee, YH; Leonard, C; Li, C; Li, CF; Li, CM; Li, F; Li, J; Li, L; Li, S; Li, X; Li, Y; Li, YB; Li, Z; Liang, C; Lin, J; Lin, XH; Ling, M; Link, TM; Liu, HH; Liu, J; Liu, M; Liu, W; Liu, YP; Lou, H; Lu, G; Lu, M; Lun, SM; Ma, Z; Mackensen, A; Majumdar, S; Martineau, C; Martínez-Pastor, JP; McQuaid, JR; Mehrabian, H; Meng, Y; Miao, T; Miljković, D; Mo, J; Mohamed, HSH; Mohtadi, M; Mol, BWJ; Moosavi, L; Mosdósi, B; Nabu, S; Nava, E; Ni, L; Novakovic-Agopian, T; Nyamunda, BC; Nyul, Z; Önal, B; Özen, D; Özyazgan, S; Pajkrt, E; Palazon, F; Park, HW; Patai, Á; Patai, ÁV; Patzke, GR; Payette, G; Pedoia, V; Peelen, MJCS; Pellitteri, G; Peng, J; Perea, RJ; Pérez-Del-Rey, D; Popović, DJ; Popović, JK; Popović, KJ; Posecion, L; Povall, J; Prachayasittikul, S; Prachayasittikul, V; Prat-González, S; Qi, B; Qu, B; Rakshit, S; Ravelli, ACJ; Ren, ZG; Rivera, SM; Salo, P; Samaddar, S; Samper, JLA; Samy El Gendy, NM; Schmitt, N; Sekerbayev, KS; Sepúlveda-Martínez, Á; Sessolo, M; Severi, S; Sha, Y; Shen, FF; Shen, X; Shen, Y; Singh, P; Sinthupoom, N; Siri, S; Sitges, M; Slovak, JE; Solymosi, N; Song, H; Song, J; Song, M; Spingler, B; Stewart, I; Su, BL; Su, JF; Suming, L; Sun, JX; Tantimavanich, S; Tashkandi, JM; Taurbayev, TI; Tedgren, AC; Tenhunen, M; Thwaites, DI; Tibrewala, R; Tomsejm, M; Triana, CA; Vakira, FM; Valdez, M; Valente, M; Valentini, AM; Van de Winckel, A; van der Lee, R; Varga, F; Varga, M; Villarino, NF; Villemur, R; Vinatha, SP; Vincenti, A; Voskamp, BJ; Wang, B; Wang, C; Wang, H; Wang, HT; Wang, J; Wang, M; Wang, N; Wang, NC; Wang, Q; Wang, S; Wang, X; Wang, Y; Wang, Z; Wen, N; Wesolowska, P; Willis, M; Wu, C; Wu, D; Wu, L; Wu, X; Wu, Z; Xia, JM; Xia, X; Xia, Y; Xiao, J; Xiao, Y; Xie, CL; Xie, LM; Xie, S; Xing, Z; Xu, C; Xu, J; Yan, D; Yan, K; Yang, S; Yang, X; Yang, XW; Ye, M; Yin, Z; Yoon, N; Yoon, Y; Yu, H; Yu, K; Yu, ZY; Zhang, B; Zhang, GY; Zhang, H; Zhang, J; Zhang, M; Zhang, Q; Zhang, S; Zhang, W; Zhang, X; Zhang, Y; Zhang, YW; Zhang, Z; Zhao, D; Zhao, F; Zhao, P; Zhao, W; Zhao, Z; Zheng, C; Zhi, D; Zhou, C; Zhou, FY; Zhu, D; Zhu, J; Zhu, Q; Zinyama, NP; Zou, M; Zou, Z, 2019)
"Oleanolic acid (OA) is a triterpenoid, widely found in plants and possesses antitumor activity in many cancer lines."	1.56	P-glycoprotein modulates oleanolic acid effects in hepatocytes cancer cells and zebrafish embryos. ( Greige-Gerges, H; Hamade, A; Kayouka, M; Landy, D; Najjar, F; Saliba, E, 2020)
"Target arterial infusion of verapamil combined with chemotherapy drugs for advanced gastric cancer can significantly improve the efficacy of chemotherapy drugs and prolong the survival of patients."	1.48	The clinical observation of verapamil in combination with interventional chemotherapy in advanced gastric cancer. ( Dai, HB; Duan, QH; Fan, GF; Fan, PS; Huang, J; Liu, M; Liu, YB; Pan, JJ; Tang, LL; Weng, CT; Wu, Y; Yang, GH; Zhang, TY; Zhu, ZQ, 2018)
"Verapamil treatment effected particularly E15 cells and immunoexpression of HPCs significantly decreased."	1.39	Hepatic progenitor cell inhibition during embryonic period with high dose verapamil; liable joint to the cancer therapy. ( Bilir, A; Oktem, G; Soner, BC; Uslu, S; Uysal, A, 2013)
" Toxicity studies with Diclofenac, Paracetamol and Verapamil in both cell lines show dose-response characteristics and EC(50) values similar to hHeps."	1.38	Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism. ( Dooley, S; Ehnert, S; Hao, L; Lin, J; Liu, L; Mühl-Benninghaus, R; Neumann, J; Nussler, AK; Nussler, N; Schyschka, L; Stöckle, U, 2012)
" A concentration- or dose-response relationship was shown between the concentration and dose of CH and Rho123 accumulation or the antitumor activity."	1.37	Using rhodamine 123 accumulation in CD8 cells as a surrogate indicator to study the P-glycoprotein modulating effect of cepharanthine hydrochloride in vivo. ( Cai-Hong, Z; Fang, M; Jin-Hua, J; Li, H; Ning, W; Qing-Duan, W; Xiao-Juan, G; Yan, Z, 2011)
"Arsenic trioxide has been used as a therapeutic agent for acute promyelocytic leukemia and recently for some solid tumors."	1.35	The overexpression of multidrug resistance-associated proteins and gankyrin contribute to arsenic trioxide resistance in liver and gastric cancer cells. ( Chen, X; Liu, LX; Zhang, M, 2009)
"18F-fluorodeoxyglucose (FDG) uptake in hepatocellular carcinoma (HCC) is associated with tumor differentiation and expression of P-glycoprotein (P-gp), a drug efflux pump that plays an important role in chemoresistance."	1.35	P-glycoprotein expression affects 18F-fluorodeoxyglucose accumulation in hepatocellular carcinoma in vivo and in vitro. ( Hatano, E; Higashi, T; Ikai, I; Iwaisako, K; Kitamura, K; Nakajima, A; Nakamoto, Y; Seo, S; Tada, M; Tamaki, N; Uemoto, S, 2009)
"Diltiazem was only stimulatory on 125I-LDL processing in leukocytes."	1.30	Effects of antihypertensive drugs on cholesterol metabolism of human mononuclear leukocytes and hepatoma cells. ( Behnke, B; Gebhardt, A; Naegele, H; Strohbeck, M, 1998)
"Mitomycin C pretreatment also significantly increased the sensitivity of cancer cells to subsequent killing by the P-glycoprotein substrate doxorubicin, decreasing the ED50 by 5- to 10-fold."	1.30	Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents. ( Blaxall, JR; Hamilton, JW; Ihnat, MA; La Ronde, N; Lariviere, JP; Pierre, KM; Turpie, BW; Warren, AJ, 1997)
"The innate drug resistance of human hepatocellular carcinoma (HCC) Bel7402 cell line was studied in vitro."	1.30	The study of innate drug resistance of human hepatocellular carcinoma Bel7402 cell line. ( Huang, M; Liu, G, 1999)
"Human and murine hepatoma cells were treated with berberine (0."	1.30	Up-regulation of multidrug resistance transporter expression by berberine in human and murine hepatoma cells. ( Chi, CW; Lin, HL; Liu, TY; Lui, WY, 1999)
"The data from hepatoma cells show an attenuation of the AAP can result from direct effects of a calcium blocker."	1.29	Diltiazem and superoxide dismutase modulate hepatic acute phase response in gram-negative sepsis. ( Baumann, H; Jahreis, GP; Rose, S; Sayeed, MM, 1994)
"These results show that rat hepatoma cells can display elevated levels of functional P-glycoprotein without any prior cytotoxic drug selection and suggest that these cells represent a useful model for analyzing P-glycoprotein regulation in intrinsically clinical drug-resistant cancers."	1.29	Constitutive expression of functional P-glycoprotein in rat hepatoma cells. ( Fardel, O; Glaise, D; Guillouzo, A; Lecureur, V; Loyer, P, 1994)
"All five hepatoma cell lines were resistant at different levels to these chemicals compared to human KB cells."	1.28	Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression. ( Chin, KV; Gottesman, MM; Lu, YG; Pastan, I; Shen, DW, 1991)
"Verapamil induced an increase in the cellular cholesterol content in preloaded cells."	1.28	Verapamil enhances high-density lipoprotein processing in Hep G2 cells preloaded with cholesterol. ( Auclair, M; Chappey-Gillet, B; Mazière, C; Mazière, JC; Salmon, S, 1990)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (6.38)	18.7374
1990's	17 (36.17)	18.2507
2000's	7 (14.89)	29.6817
2010's	17 (36.17)	24.3611
2020's	3 (6.38)	2.80

Article	Year
Proceedings. Mathematical, physical, and engineering sciences, 2019, Volume: 475, Issue:2227 Topics: Acetylcholine; Acinetobacter baumannii; Actinobacteria; Action Potentials; Adalimumab; Adaptation, P	2019
Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects. Acta pharmacologica Sinica, 2006, Volume: 27, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Ster	2006

Article	Year
Efficacy of chemotherapy combined with targeted arterial infusion of verapamil in patients with advanced gastric cancer. Cell biochemistry and biophysics, 2014, Volume: 68, Issue:1 Topics: Adult; Aged; Antineoplastic Agents; Disease Progression; Drug Therapy, Combination; Female; Humans;	2014
Protective effect of Verapamil on hepatic ischemia-reperfusion injury during hepatectomy in the cirrhotic patients with hepatocellular carcinoma. Langenbeck's archives of surgery, 2009, Volume: 394, Issue:6 Topics: Adult; Aged; Calcium Channel Blockers; Carcinoma, Hepatocellular; Cohort Studies; Drug Administratio	2009
Clinical evaluation of targeted arterial infusion of verapamil in the interventional chemotherapy of primary hepatocellular carcinoma. Cell biochemistry and biophysics, 2011, Volume: 59, Issue:2 Topics: Antineoplastic Agents; Body Weight; Carcinoma, Hepatocellular; Disease Progression; Drug Resistance,	2011
Clinical efficacy of chemotherapy combined with verapamil in metastatic colorectal patients. Cell biochemistry and biophysics, 2011, Volume: 61, Issue:2 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neopl	2011
Basic and clinical research on the therapeutic effect of intervention in primary liver cancer by targeted intra-arterial verapamil infusion. Cell biochemistry and biophysics, 2012, Volume: 62, Issue:1 Topics: Adult; Aged; Alanine Transaminase; alpha-Fetoproteins; Animals; Antineoplastic Agents; Aspartate Ami	2012
A phase I trial of intrahepatic verapamil and doxorubicin. Regional therapy to overcome multidrug resistance. Cancer, 1994, Nov-15, Volume: 74, Issue:10 Topics: Adenocarcinoma; Adult; Aged; Colorectal Neoplasms; Doxorubicin; Drug Resistance, Multiple; Female; H	1994
Doxorubicin for unresectable hepatocellular carcinoma. A prospective study on the addition of verapamil. Cancer, 1990, Oct-15, Volume: 66, Issue:8 Topics: Carcinoma, Hepatocellular; Doxorubicin; Drug Therapy, Combination; Female; Humans; Liver Neoplasms;	1990
Clinical trial of continuous infusion verapamil, bolus vinblastine, and continuous infusion VP-16 in drug-resistant pediatric tumors. Cancer research, 1989, Feb-15, Volume: 49, Issue:4 Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Child; Child,	1989

Article	Year
Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma. Journal of medicinal chemistry, 2018, 02-22, Volume: 61, Issue:4 Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Screening Assays, Antitumor; Heterografts	2018
P-glycoprotein modulates oleanolic acid effects in hepatocytes cancer cells and zebrafish embryos. Chemico-biological interactions, 2020, Jan-05, Volume: 315 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neop	2020
Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice. Human & experimental toxicology, 2020, Volume: 39, Issue:11 Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Calcium Channel Blockers; Carcinoma, Hepatocellular	2020
Reduced cytotoxicity in doxorubicin-exposed HepG2 cells pretreated with menthol due to upregulation of P-glycoprotein. Die Pharmazie, 2020, 10-01, Volume: 75, Issue:10 Topics: Antibiotics, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Car	2020
Upregulation of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Mediates the Reversal Effect of Verapamil on Chemo-Resistance to Adriamycin of Hepatocellular Carcinoma. Medical science monitor : international medical journal of experimental and clinical research, 2018, Apr-08, Volume: 24 Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tum	2018
The clinical observation of verapamil in combination with interventional chemotherapy in advanced gastric cancer. European review for medical and pharmacological sciences, 2018, Volume: 22, Issue:17 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Calcium Channel Blockers; Female; Follo	2018
Hepatic progenitor cell inhibition during embryonic period with high dose verapamil; liable joint to the cancer therapy. Bratislavske lekarske listy, 2013, Volume: 114, Issue:7 Topics: Animals; Calcium Channel Blockers; Liver; Liver Neoplasms; Mice; Rats; Rats, Wistar; Stem Cells; Ver	2013
Association between reversal of multidrug resistance by methyl jasmonate and P-glycoprotein ATPase activity in hepatocellular carcinoma. The Journal of international medical research, 2013, Volume: 41, Issue:4 Topics: Acetates; Adenosine Triphosphate; Animals; Antineoplastic Agents; Antineoplastic Combined Chemothera	2013
Reversal effect of bufalin on multidrug resistance in human hepatocellular carcinoma BEL-7402/5-FU cells. Oncology reports, 2014, Volume: 31, Issue:1 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter,	2014
Inhibition of Snail Family Transcriptional Repressor 2 (SNAI2) Enhances Multidrug Resistance of Hepatocellular Carcinoma Cells. PloS one, 2016, Volume: 11, Issue:10 Topics: Animals; ATP-Binding Cassette Transporters; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prolif	2016
P-glycoprotein expression affects 18F-fluorodeoxyglucose accumulation in hepatocellular carcinoma in vivo and in vitro. International journal of oncology, 2009, Volume: 34, Issue:5 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Carcinoma, Hepato	2009
The overexpression of multidrug resistance-associated proteins and gankyrin contribute to arsenic trioxide resistance in liver and gastric cancer cells. Oncology reports, 2009, Volume: 22, Issue:1 Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; ATP Binding Cassette Transporter, Subfamily B;	2009
5-Bromotetrandrine enhances the sensitivity of doxorubicin-induced apoptosis in intrinsic resistant human hepatic cancer Bel7402 cells. Cancer letters, 2010, Jun-01, Volume: 292, Issue:1 Topics: Apoptosis; Benzylisoquinolines; Caspase 3; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple;	2010
Development of PLGA nanoparticles simultaneously loaded with vincristine and verapamil for treatment of hepatocellular carcinoma. Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:12 Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug	2010
Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism. Archives of toxicology, 2012, Volume: 86, Issue:1 Topics: Acetaminophen; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Cytochrome P-450 Enzyme	2012
Using rhodamine 123 accumulation in CD8 cells as a surrogate indicator to study the P-glycoprotein modulating effect of cepharanthine hydrochloride in vivo. Journal of biomedicine & biotechnology, 2011, Volume: 2011 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzylisoquinolines; Carcinoma, He	2011
BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo. Molecular pharmaceutics, 2012, Nov-05, Volume: 9, Issue:11 Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apop	2012
MDR1 modulators improve the chemotherapy response of human hepatoblastoma to doxorubicin in vitro. Journal of pediatric surgery, 2002, Volume: 37, Issue:11 Topics: Acridines; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyc	2002
Verapamil regulates activity and mRNA-expression of human beta-glucuronidase in HepG2 cells. Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 368, Issue:6 Topics: Blotting, Western; Calcium Channel Blockers; Carcinoma, Hepatocellular; Cell Line, Tumor; Down-Regul	2003
Drugs and the liver. Comprehensive therapy, 1984, Volume: 10, Issue:12 Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv	1984
Diltiazem and superoxide dismutase modulate hepatic acute phase response in gram-negative sepsis. Shock (Augusta, Ga.), 1994, Volume: 1, Issue:2 Topics: Acute-Phase Proteins; Acute-Phase Reaction; Animals; Bacteroides fragilis; Bacteroides Infections; B	1994
Constitutive expression of functional P-glycoprotein in rat hepatoma cells. European journal of biochemistry, 1994, Jan-15, Volume: 219, Issue:1-2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Carrier	1994
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verapamil and Liver Neoplasms

Research Excerpts

Research

Studies (47)

Authors

Reviews

Trials

Other Studies

Authors	Studies
Chen, D	3
Soh, CK	1
Goh, WH	1
Wang, H	2
Bobenko, AI	1
Heller, S	1
Schmitt, N	1
Cherdtrakulkiat, R	1
Lawung, R	1
Nabu, S	1
Tantimavanich, S	1
Sinthupoom, N	1
Prachayasittikul, S	1
Prachayasittikul, V	1
Zhang, B	1
Wu, C	1
Zhang, Z	2
Yan, K	1
Li, C	2
Li, Y	5
Li, L	4
Zheng, C	1
Xiao, Y	1
He, D	1
Zhao, F	1
Su, JF	1
Lun, SM	1
Hou, YJ	1
Duan, LJ	1
Wang, NC	1
Shen, FF	1
Zhang, YW	1
Gao, ZW	1
Li, J	5
Du, XJ	1
Zhou, FY	1
Yin, Z	1
Zhu, J	2
Yan, D	1
Lou, H	1
Yu, H	1
Feng, C	1
Wang, Z	1
Wang, Y	4
Hu, X	1
Li, Z	2
Shen, Y	1
Hu, D	1
Chen, H	1
Wu, X	1
Duan, Y	1
Zhi, D	1
Zou, M	2
Zhao, Z	1
Zhang, X	2
Yang, X	2
Zhang, J	2
Popović, KJ	1
Popović, DJ	1
Miljković, D	1
Lalošević, D	1
Čapo, I	1
Popović, JK	1
Liu, M	3
Song, H	2
Xing, Z	1
Lu, G	1
Valentini, AM	1
Di Pinto, F	1
Coletta, S	1
Guerra, V	1
Armentano, R	1
Caruso, ML	1
Gong, J	1
Wang, N	1
Bian, L	1
Wang, M	1
Ye, M	1
Wen, N	1
Fu, M	1
Fan, W	1
Meng, Y	1
Dong, G	1
Lin, XH	1
Liu, HH	1
Gao, DM	1
Cui, JF	1
Ren, ZG	1
Chen, RX	1
Önal, B	1
Özen, D	1
Demir, B	1
Akkan, AG	1
Özyazgan, S	1
Payette, G	1
Geoffroy, V	1
Martineau, C	1
Villemur, R	1
Jameel, T	1
Baig, M	1
Gazzaz, ZJ	1
Tashkandi, JM	1
Al Alhareth, NS	1
Khan, SA	1
Butt, NS	1
Wang, J	3
Geng, Y	1
Zhang, Y	3
Wang, X	3
Liu, J	3
Basit, A	1
Miao, T	1
Liu, W	1
Jiang, W	1
Yu, ZY	1
Wu, L	2
Qu, B	1
Sun, JX	1
Cai, AL	1
Xie, LM	1
Groeneveld, J	1
Ho, SL	1
Mackensen, A	1
Mohtadi, M	1
Laepple, T	1
Genovesi, S	1
Nava, E	1
Bartolucci, C	1
Severi, S	1
Vincenti, A	1
Contaldo, G	1
Bigatti, G	1
Ciurlino, D	1
Bertoli, SV	1
Slovak, JE	1
Hwang, JK	1
Rivera, SM	1
Villarino, NF	1
Li, S	1
Cao, G	1
Ling, M	1
Ji, J	1
Zhao, D	1
Sha, Y	1
Gao, X	1
Liang, C	2
Guo, Q	1
Zhou, C	1
Ma, Z	1
Xu, J	1
Wang, C	1
Zhao, W	1
Xia, X	1
Jiang, Y	1
Peng, J	1
Jia, Z	1
Li, F	1
Chen, X	3
Mo, J	1
Zhang, S	2
Li, X	1
Huang, T	1
Zhu, Q	1
Wang, S	2
Ge, RS	1
Fortunato, G	1
Lin, J	3
Agarwal, PK	1
Kohen, A	1
Singh, P	1
Cheatum, CM	1
Zhu, D	1
Hayman, A	1
Kebede, B	1
Stewart, I	1
Chen, G	1
Frew, R	1
Guo, X	1
Gong, Q	1
Borowiec, J	1
Han, S	1
Zhang, M	2
Willis, M	1
Kreouzis, T	1
Yu, K	1
Chirvony, VS	1
Sekerbayev, KS	1
Pérez-Del-Rey, D	1
Martínez-Pastor, JP	1
Palazon, F	1
Boix, PP	1
Taurbayev, TI	1
Sessolo, M	1
Bolink, HJ	1
Lu, M	1
Lan, Y	1
Xiao, J	1
Song, M	1
Chen, C	1
Huang, Q	1
Cao, Y	1
Ho, CT	1
Qi, B	1
Wang, Q	1
Zhang, W	1
Fang, L	1
Xie, CL	1
Chen, R	1
Yang, S	1
Xia, JM	1
Zhang, GY	1
Chen, CH	1
Yang, XW	1
Domenech-Ximenos, B	1
Garza, MS	1
Prat-González, S	1
Sepúlveda-Martínez, Á	1
Crispi, F	1
Perea, RJ	1
Garcia-Alvarez, A	1
Sitges, M	1
Kalumpha, M	1
Guyo, U	1
Zinyama, NP	1
Vakira, FM	1
Nyamunda, BC	1
Varga, M	1
Drácz, L	1
Kolbenheyer, E	1
Varga, F	1
Patai, ÁV	1
Solymosi, N	1
Patai, Á	1
Kiss, J	1
Gaál, V	1
Nyul, Z	1
Mosdósi, B	1
Valdez, M	1
Moosavi, L	1
Heidari, A	1
Novakovic-Agopian, T	1
Kornblith, E	1
Abrams, G	1
McQuaid, JR	1
Posecion, L	1
Burciaga, J	1
D'Esposito, M	1
Chen, AJW	1
Samy El Gendy, NM	1
Wesolowska, P	1
Georg, D	1
Lechner, W	1
Kazantsev, P	1
Bokulic, T	1
Tedgren, AC	1
Adolfsson, E	1
Campos, AM	1
Alves, VGL	1
Suming, L	1
Hao, W	1
Ekendahl, D	1
Koniarova, I	1
Bulski, W	1
Chelminski, K	1
Samper, JLA	1
Vinatha, SP	1
Rakshit, S	1
Siri, S	1
Tomsejm, M	1
Tenhunen, M	1
Povall, J	1
Kry, SF	1
Followill, DS	1
Thwaites, DI	1
Izewska, J	1
Kang, JH	1
Yoon, Y	1
Song, J	1
Van de Winckel, A	1
Gauthier, L	1
Chao, CT	1
Lee, YH	1
Li, CM	1
Han, DS	1
Huang, JW	1
Huang, KC	1
Ni, L	1
Güttinger, R	1
Triana, CA	1
Spingler, B	1
Baldridge, KK	1
Patzke, GR	1
Shen, X	1
Wang, B	1
Xie, S	1
Deng, W	1
Wu, D	1
Zhang, Q	1
Voskamp, BJ	1
Peelen, MJCS	1
Ravelli, ACJ	1
van der Lee, R	1
Mol, BWJ	1
Pajkrt, E	1
Ganzevoort, W	1
Kazemier, BM	1
Tibrewala, R	1
Bahroos, E	1
Mehrabian, H	1
Foreman, SC	1
Link, TM	1
Pedoia, V	1
Majumdar, S	1
Jablonski, CL	1
Leonard, C	1
Salo, P	1
Krawetz, RJ	1
Yoon, N	1
Hong, SN	1
Cho, JG	1
Jeong, HK	1
Lee, KH	1
Park, HW	1
Barman, S	1
Konai, MM	1
Samaddar, S	1
Haldar, J	1
Mohamed, HSH	1
Li, CF	1
Hu, ZY	1
Deng, Z	1
Chen, LH	1
Su, BL	1
Chu, K	1
Liu, YP	1
Li, YB	1
Zhang, H	1
Xu, C	1
Zou, Z	1
Wu, Z	1
Xia, Y	1
Zhao, P	1
Wang, HT	1
de Biase, S	1
Pellitteri, G	1
Gigli, GL	1
Valente, M	1
Kayouka, M	1
Hamade, A	1
Saliba, E	1
Najjar, F	1
Landy, D	1
Greige-Gerges, H	1
Abo Mansour, HE	1
El-Batsh, MM	1
Badawy, NS	1
Mehanna, ET	1
Mesbah, NM	1
Abo-Elmatty, DM	1
Nagai, K	1
Fukuno, S	1
Miura, T	1
Uchino, Y	1
Sehara, N	1
Konishi, H	1
Yang, G	1
Fan, G	2
Zhang, T	2
Ma, K	1
Huang, J	3
Teng, X	1
Xu, K	1
Fan, P	4
Cheng, D	1
Fan, GF	1
Pan, JJ	1
Fan, PS	1
Zhang, TY	1
Liu, YB	1
Weng, CT	1
Duan, QH	1
Wu, Y	1
Tang, LL	1
Yang, GH	1
Dai, HB	1
Zhu, ZQ	1
Ning, Z	1
Liu, A	1
Duan, Q	3
Uslu, S	1
Uysal, A	1
Bilir, A	1
Soner, BC	1
Oktem, G	1
Wang, CF	1
Wang, YQ	1
Huang, FZ	1
Nie, WP	1
Liu, XY	1
Jiang, XZ	1
Gu, W	1
Liu, L	2
Fang, FF	1
Huang, F	1
Cheng, BB	1
Li, B	1
Zhao, XY	1
Wang, XB	1
Fu, RJ	1
Lv, YP	1
Jin, W	1
Meng, C	1
Chen, GQ	1
Huang, L	1
Zhao, KW	1
Xia, F	1
Chen, M	1
Feng, X	1
Dong, J	1
Seo, S	1
Hatano, E	1
Higashi, T	1
Nakajima, A	1
Nakamoto, Y	1
Tada, M	1
Tamaki, N	1
Iwaisako, K	1
Kitamura, K	1
Ikai, I	1
Uemoto, S	1
Liu, LX	1
Liu, XD	1
Sun, H	1
Liu, GT	1
Song, XR	1
Zheng, Y	1
He, G	1
Yang, L	1
Luo, YF	1
He, ZY	1
Li, SZ	1
Li, JM	1
Yu, S	1
Luo, X	1
Hou, SX	1
Wei, YQ	1
Ji, C	1
Lv, Y	1
Lin, X	1
Qian, L	1
Yu, X	1
Liu, Y	1
Lu, Z	1
Tong, S	1
Hu, B	1
Lv, R	1
Hu, L	1
Zhuang, J	1
Schyschka, L	1
Mühl-Benninghaus, R	1
Neumann, J	1
Hao, L	1
Nussler, N	1
Dooley, S	1
Stöckle, U	1
Nussler, AK	1
Ehnert, S	1
Li, H	1
Yan, Z	1
Ning, W	1
Xiao-Juan, G	1
Cai-Hong, Z	1
Jin-Hua, J	1
Fang, M	1
Qing-Duan, W	1
Pingsheng, F	1
Tengyue, Z	1
Qiang, H	1
Qiang, W	1
Xin, S	1
Liting, Q	1
Zhang, DM	1
Shu, C	1
Chen, JJ	1
Sodani, K	1
Bhatnagar, J	1
Lan, P	1
Ruan, ZX	1
Xiao, ZJ	1
Ambudkar, SV	1
Chen, WM	1
Chen, ZS	1
Ye, WC	1
Warmann, S	1
Göhring, G	1
Teichmann, B	1
Geerlings, H	1
Fuchs, J	1
Grube, M	1
Kunert-Keil, C	1
Sperker, B	1
Kroemer, HK	1
Manov, I	1
Motanis, H	1
Frumin, I	1
Iancu, TC	1
Kolts, BE	1
Langfitt, M	1
Rose, S	1
Baumann, H	1
Jahreis, GP	1
Sayeed, MM	1
Fardel, O	1
Loyer, P	1
Lecureur, V	1
Glaise, D	1
Guillouzo, A	1
Park, JG	1
Lee, SK	1
Hong, IG	1
Kim, HS	2
Lim, KH	1
Choe, KJ	1
Kim, WH	1
Kim, YI	1
Tsuruo, T	1
Gottesman, MM	2
Saltz, L	1
Murphy, B	1
Kemeny, N	1
Bertino, J	1
Tong, W	1
Keefe, D	1
Tzy-Jun, Y	1
Tao, Y	1
Kelsen, D	1
O'Brien, JP	1
Matsumoto, J	2
Minami, T	2
Sato, T	2
Onodera, T	2
Kim, JH	1
Chung, JB	1
Park, IS	1
Kim, BS	1
Yoo, NC	1
Choi, JH	1
Roh, JK	1
Kwon, OH	1
Lee, KS	1
Naegele, H	1
Behnke, B	1
Gebhardt, A	1
Strohbeck, M	1
Ihnat, MA	1
Lariviere, JP	1
Warren, AJ	1
La Ronde, N	1
Blaxall, JR	1
Pierre, KM	1
Turpie, BW	1
Hamilton, JW	1
Huang, M	1
Liu, G	1
Gagandeep, S	1
Novikoff, PM	1
Ott, M	1
Gupta, S	1
Lin, HL	1
Liu, TY	1
Lui, WY	1
Chi, CW	1
Kim, JA	1
Kang, YS	1
Jung, MW	1
Kang, GH	1
Lee, SH	1
Lee, YS	1
Sato, C	1
Liu, JH	1
Tang, L	1
Sakai, Y	1
Yauchi, T	1
Izumi, N	1
Takano, T	1
Marumo, F	1
Shen, DW	1
Lu, YG	1
Chin, KV	1
Pastan, I	1
Tzanakakis, GN	1
Agarwal, KC	1
Veronikis, DK	1
Vezeridis, MP	1
Chappey-Gillet, B	1
Salmon, S	1
Mazière, C	1
Auclair, M	1
Mazière, JC	1
Lai, EC	1
Choi, TK	1
Cheng, CH	1
Mok, FP	1
Fan, ST	1
Tan, ES	1
Wong, J	1
Cairo, MS	1
Siegel, S	1
Anas, N	1
Sender, L	1
Corsini, A	1
Granata, A	1
Fumagalli, R	1
Paoletti, R	1