verapamil has been researched along with Leukemia in 61 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have previously generated chronic myeloid leukemia (CML) cell lines resistant to the tyrosine kinase inhibitor imatinib mesylate (STI571), and one line (LAMA84-r) showed overexpression not only of the Bcr-Abl protein but also of Pgp." | 7.72 | MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. ( Belloc, F; Chollet, C; Goldman, JM; Lagarde, V; Mahon, FX; Melo, JV; Moreau-Gaudry, F; Reiffers, J, 2003) |
| "The effects of verapamil on the intracellular pharmacokinetics of daunorubicin (DNR) in blast cells from the bone marrows of patients with acute nonlymphocytic leukemia (ANLL) were studied to determine whether verapamil was capable of enhancing intracellular accumulation and retention of DNR in ANLL, as has been observed in murine P388 cells resistant to DNR." | 7.67 | Effects of verapamil on in vitro intracellular accumulation and retention of daunorubicin in blast cells from patients with acute nonlymphocytic leukemia. ( Joneckis, CC; Ross, DD; Schiffer, CA, 1986) |
| "Verapamil pretreatment of cytoplasts from resistant cells revealed the subcellular DNP-sensitive uptake present in parental cytoplasts." | 5.28 | Energy-dependent accumulation of daunorubicin into subcellular compartments of human leukemia cells and cytoplasts. ( Daniel, JC; Lecerf, JM; Levy, SB; Slapak, CA, 1992) |
| " Conceptually, it is accepted that MTX and folic acid are transported by folate receptors (FRs) in cancerous cells, but the exact mechanism of MTX uptake in human leukemia is unknown." | 3.75 | Differential usage of the transport systems for folic acid and methotrexate in normal human T-lymphocytes and leukemic cells. ( Biswal, BK; Verma, RS, 2009) |
| " We have previously generated chronic myeloid leukemia (CML) cell lines resistant to the tyrosine kinase inhibitor imatinib mesylate (STI571), and one line (LAMA84-r) showed overexpression not only of the Bcr-Abl protein but also of Pgp." | 3.72 | MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. ( Belloc, F; Chollet, C; Goldman, JM; Lagarde, V; Mahon, FX; Melo, JV; Moreau-Gaudry, F; Reiffers, J, 2003) |
| "In an attempt to identify the target protein, P-GP or mrp, of each MDR antagonist, verapamyl (Ver), dipyridamole (Dip), or cyclosporin A (Cy-A), this study was designed to compare the activity of the three afore-mentioned drugs and to test their combined effect on the cidal activity of vincristine (VCR) in five types of wild and the corresponding VCR-resistant cultured cell lines from human leukemia and lymphoma." | 3.70 | Effect of MDR antagonists on the cidal activity of vincristine for cells expressing MDR-1 is superior to those expressing MRP. ( Hamano, S; Hirose, M; Hosoi, E; Kuroda, Y; Morimoto, M, 1998) |
| "We studied the effect of verapamil on Pgp expression (Pgp) in MDR human leukemia cell lines, K562/ADR and CEM VLB100." | 3.69 | Verapamil decreases P-glycoprotein expression in multidrug-resistant human leukemic cell lines. ( Bailly, JD; Bordier, C; Goubin, F; Jaffrézou, JP; Laredo, J; Laurent, G; Muller, C, 1994) |
| "We studied the effects of two modulators of multidrug resistance (MDR), cyclosporine and verapamil, on the cytotoxicity of etoposide (VP-16) in normal human bone marrow; two human leukemia cell lines, K562 and CEM; their MDR variants, K562/DOX and CEM/VLB; and mixtures of normal marrow and leukemic cells." | 3.68 | Modulation of etoposide (VP-16) cytotoxicity by verapamil or cyclosporine in multidrug-resistant human leukemic cell lines and normal bone marrow. ( Aihara, M; Blume, KG; Chao, NJ; Sikic, BI, 1990) |
| "The effect of a calcium channel blocker, verapamil, on intracellular uptake and cytotoxicity of anthracyclines in vitro was studied on leukemic cells from 32 patients with acute non-lymphoblastic leukemia." | 3.67 | Effects of verapamil on uptake and in vitro toxicity of anthracyclines in human leukemic blast cells. ( Paul, C; Sundman-Engberg, B; Tidefelt, U, 1988) |
| "Leukemic cells isolated from peripheral blood from 6 patients with chronic lymphocytic leukemia, immunocytoma and prolymphocytic leukemia were incubated with vincristine (10 nM) with and without racemic verapamil and its L- and D-isomers (6." | 3.67 | D-verapamil and L-verapamil are equally effective in increasing vincristine accumulation in leukemic cells in vitro. ( Gruber, A; Peterson, C; Reizenstein, P, 1988) |
| "The effects of verapamil on the intracellular pharmacokinetics of daunorubicin (DNR) in blast cells from the bone marrows of patients with acute nonlymphocytic leukemia (ANLL) were studied to determine whether verapamil was capable of enhancing intracellular accumulation and retention of DNR in ANLL, as has been observed in murine P388 cells resistant to DNR." | 3.67 | Effects of verapamil on in vitro intracellular accumulation and retention of daunorubicin in blast cells from patients with acute nonlymphocytic leukemia. ( Joneckis, CC; Ross, DD; Schiffer, CA, 1986) |
| "verapamil, a calcium-influx blocker, enhanced the cytotoxicity of vincristine (VCR) in vitro 6- to 12-fold in eight human hemopoietic tumor cell lines established from acute lymphatic leukemia, acute myelogenous leukemia, and Burkitt's lymphoma." | 3.66 | Potentiation of vincristine and Adriamycin effects in human hemopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors. ( Iida, H; Sakurai, Y; Tsukagoshi, S; Tsuruo, T, 1983) |
| "Verapamil did not increase DNR toxicity in four of these eight cases, but was more efficient in one other MDR1(+) case." | 1.30 | Effect of the multidrug inhibitor GG918 on drug sensitivity of human leukemic cells. ( Faussat, AM; Marie, JP; Simonin, G; Zhou, DC; Zittoun, R, 1997) |
| "Patellamide D at 3." | 1.29 | A marine natural product, patellamide D, reverses multidrug resistance in a human leukemic cell line. ( Jacobs, RS; Williams, AB, 1993) |
| "Verapamil pretreatment of cytoplasts from resistant cells revealed the subcellular DNP-sensitive uptake present in parental cytoplasts." | 1.28 | Energy-dependent accumulation of daunorubicin into subcellular compartments of human leukemia cells and cytoplasts. ( Daniel, JC; Lecerf, JM; Levy, SB; Slapak, CA, 1992) |
| "Pgp was positive in 75% of acute nonlymphoblastic leukemia (ANLL) and 50% of acute lymphoblastic leukemia (ALL)." | 1.28 | P-glycoprotein expression in refractory hematological neoplasms and circumvention of resistance with verapamil or cyclosporine A containing protocols. ( Akan, H; Beksaç, M; Ertürk, S; Güneyli, A; Ikizünal, Y; Ilhan, O; Koç, H; Sardaş, OS, 1992) |
| "Trimetrexate (TMQ) is a lipophilic antifolate shown to have antitumor activity in humans." | 1.28 | Multidrug resistance in a human leukemic cell line selected for resistance to trimetrexate. ( Arkin, H; Holland, JF; Kamen, BA; Ohnuma, T; Vallabhajosula, S, 1989) |
| "Cytochalasin B was most effective in VCR- and DAU-sensitive cells; however, the effect in resistant cells was less than that observed for verapamil, suggesting a different mode of action between these drugs in sensitive and resistant cells." | 1.27 | Effects of cytochalasins and colchicine on the accumulation and retention of daunomycin and vincristine in drug resistant tumor cells. ( Iida, H; Tsuruo, T, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (22.95) | 18.7374 |
| 1990's | 34 (55.74) | 18.2507 |
| 2000's | 11 (18.03) | 29.6817 |
| 2010's | 2 (3.28) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ling, T | 1 |
| Maier, J | 1 |
| Das, S | 1 |
| Budhraja, A | 1 |
| Bassett, R | 1 |
| Potts, MB | 1 |
| Shelat, A | 1 |
| Rankovic, Z | 1 |
| Opferman, JT | 1 |
| Rivas, F | 1 |
| Biswal, BK | 1 |
| Verma, RS | 1 |
| Li, J | 1 |
| Hu, XF | 1 |
| Loveland, BE | 1 |
| Xing, PX | 1 |
| Karim, H | 1 |
| Bogason, A | 1 |
| Bhuiyan, H | 1 |
| Fotoohi, AK | 1 |
| Lafolie, P | 1 |
| Vitols, S | 3 |
| Tatidis, L | 1 |
| Masquelier, M | 1 |
| Mahon, FX | 1 |
| Belloc, F | 1 |
| Lagarde, V | 1 |
| Chollet, C | 1 |
| Moreau-Gaudry, F | 1 |
| Reiffers, J | 1 |
| Goldman, JM | 1 |
| Melo, JV | 1 |
| Veuger, MJ | 1 |
| Honders, MW | 1 |
| Spoelder, HE | 1 |
| Willemze, R | 1 |
| Barge, RM | 1 |
| Kappelmayer, J | 1 |
| Simon, A | 1 |
| Kiss, F | 1 |
| Hevessy, Z | 1 |
| Rosati, A | 1 |
| Candussio, L | 1 |
| Crivellato, E | 1 |
| Klugmann, FB | 1 |
| Giraldi, T | 1 |
| Damiani, D | 1 |
| Michelutti, A | 1 |
| Decorti, G | 1 |
| Hong, L | 2 |
| Piao, Y | 1 |
| Han, Y | 1 |
| Wang, J | 1 |
| Zhang, X | 1 |
| Du, Y | 1 |
| Cao, S | 1 |
| Qiao, T | 1 |
| Chen, Z | 1 |
| Fan, D | 2 |
| Sulová, Z | 1 |
| Macejová, D | 1 |
| Seres, M | 1 |
| Sedlák, J | 1 |
| Brtko, J | 1 |
| Breier, A | 1 |
| Li, X | 1 |
| Zhao, Y | 1 |
| Jin, H | 1 |
| Fan, R | 1 |
| Du, R | 1 |
| Xia, L | 1 |
| Luo, G | 1 |
| Tsuruo, T | 3 |
| Iida, H | 2 |
| Tsukagoshi, S | 1 |
| Sakurai, Y | 1 |
| Marks, DC | 1 |
| Davey, MW | 3 |
| Davey, RA | 3 |
| Kidman, AD | 1 |
| Abo, J | 1 |
| Inokuchi, K | 1 |
| Dan, K | 1 |
| Nomura, T | 1 |
| Merlin, JL | 2 |
| Marchal, S | 2 |
| Ramacci, C | 2 |
| Lucas, C | 1 |
| Paraire, M | 1 |
| Poullain, MG | 1 |
| Muller, C | 2 |
| Goubin, F | 2 |
| Ferrandis, E | 1 |
| Cornil-Scharwtz, I | 1 |
| Bailly, JD | 2 |
| Bordier, C | 2 |
| Bénard, J | 1 |
| Sikic, BI | 2 |
| Laurent, G | 2 |
| Laredo, J | 1 |
| Jaffrézou, JP | 1 |
| Guerci, A | 1 |
| Missoum, N | 1 |
| Humbert, JC | 1 |
| Guerci, O | 1 |
| Maslak, P | 1 |
| Hegewisch-Becker, S | 1 |
| Godfrey, L | 1 |
| Andreeff, M | 1 |
| Canitrot, Y | 1 |
| Lautier, D | 1 |
| Viallet, P | 1 |
| Salmon, JM | 1 |
| Galimberti, S | 1 |
| Bianchi, F | 1 |
| Bernardini, N | 1 |
| Mattii, L | 2 |
| Dolfi, A | 1 |
| Lupetti, M | 1 |
| Petrini, M | 2 |
| Visani, G | 1 |
| Fogli, M | 1 |
| Tosi, P | 1 |
| Ottaviani, E | 1 |
| Gamberi, B | 1 |
| Cenacchi, A | 1 |
| Manfroi, S | 1 |
| Tura, S | 1 |
| Williams, AB | 1 |
| Jacobs, RS | 1 |
| Gruber, A | 2 |
| Briese, B | 1 |
| Areström, I | 1 |
| Björkholm, M | 1 |
| Peterson, C | 2 |
| Nagasawa, K | 1 |
| Natazuka, T | 1 |
| Chihara, K | 1 |
| Kitazawa, F | 1 |
| Tsumura, A | 1 |
| Takara, K | 1 |
| Nomiyama, M | 1 |
| Ohnishi, N | 1 |
| Yokoyama, T | 1 |
| Hwang, M | 1 |
| Ahn, CH | 1 |
| Pine, PS | 1 |
| Yin, JJ | 1 |
| Hrycyna, CA | 1 |
| Licht, T | 1 |
| Aszalos, A | 1 |
| Broxterman, HJ | 1 |
| Sonneveld, P | 1 |
| Feller, N | 1 |
| Ossenkoppele, GJ | 1 |
| Währer, DC | 1 |
| Eekman, CA | 1 |
| Schoester, M | 1 |
| Lankelma, J | 1 |
| Pinedo, HM | 1 |
| Löwenberg, B | 1 |
| Schuurhuis, GJ | 1 |
| Ivy, SP | 1 |
| Olshefski, RS | 1 |
| Taylor, BJ | 1 |
| Patel, KM | 1 |
| Reaman, GH | 1 |
| Su, GM | 1 |
| Hargrave, RM | 1 |
| Harvie, RM | 1 |
| Baguley, BC | 1 |
| Zhou, DC | 1 |
| Simonin, G | 1 |
| Faussat, AM | 1 |
| Zittoun, R | 1 |
| Marie, JP | 1 |
| Mankhetkorn, S | 1 |
| Garnier-Suillerot, A | 1 |
| Hosoi, E | 1 |
| Hirose, M | 1 |
| Hamano, S | 1 |
| Morimoto, M | 1 |
| Kuroda, Y | 1 |
| Kessel, M | 1 |
| Gieseler, F | 1 |
| Woodcock, BG | 1 |
| Cullen, KV | 1 |
| Slapak, CA | 1 |
| Lecerf, JM | 1 |
| Daniel, JC | 1 |
| Levy, SB | 1 |
| Beksaç, M | 1 |
| Akan, H | 1 |
| Koç, H | 1 |
| Ilhan, O | 1 |
| Ertürk, S | 1 |
| Güneyli, A | 1 |
| Ikizünal, Y | 1 |
| Sardaş, OS | 1 |
| Kakihara, T | 1 |
| Yamada, T | 1 |
| Fukuda, T | 1 |
| Ohnishi, Y | 1 |
| Kishi, K | 1 |
| Shibata, A | 1 |
| Carulli, G | 1 |
| Sabbatini, A | 1 |
| Pardi, C | 1 |
| Caracciolo, F | 1 |
| Grassi, B | 1 |
| Dalton, WS | 1 |
| Grogan, TM | 1 |
| Miller, TP | 1 |
| Kimmig, A | 1 |
| Gekeler, V | 1 |
| Neumann, M | 1 |
| Frese, G | 1 |
| Handgretinger, R | 1 |
| Kardos, G | 1 |
| Diddens, H | 1 |
| Niethammer, D | 1 |
| Solary, E | 1 |
| Velay, I | 1 |
| Chauffert, B | 1 |
| Bidan, JM | 1 |
| Caillot, D | 1 |
| Dumas, M | 1 |
| Guy, H | 1 |
| Qian, XD | 1 |
| Beck, WT | 5 |
| Kavallaris, M | 1 |
| Haber, M | 1 |
| Norris, MD | 1 |
| Pittman, SM | 1 |
| Reed, C | 1 |
| Stewart, BW | 1 |
| Samuels, BL | 1 |
| Ratain, MJ | 1 |
| Nygren, P | 1 |
| Larsson, R | 1 |
| Ishida, Y | 1 |
| Shimada, Y | 1 |
| Shimoyama, M | 1 |
| Chao, NJ | 1 |
| Aihara, M | 1 |
| Blume, KG | 1 |
| Lee, SC | 1 |
| Deutsch, C | 1 |
| Cairo, MS | 1 |
| Siegel, S | 1 |
| Anas, N | 1 |
| Sender, L | 1 |
| Arkin, H | 1 |
| Ohnuma, T | 1 |
| Kamen, BA | 1 |
| Holland, JF | 1 |
| Vallabhajosula, S | 1 |
| Cirtain, MC | 2 |
| Danks, MK | 1 |
| Felsted, RL | 2 |
| Safa, AR | 2 |
| Wolverton, JS | 1 |
| Suttle, DP | 1 |
| Trent, JM | 1 |
| Glover, CJ | 1 |
| Zamora, JM | 1 |
| Pearce, HL | 1 |
| Tidefelt, U | 1 |
| Sundman-Engberg, B | 1 |
| Paul, C | 1 |
| Reizenstein, P | 1 |
| Weisenthal, LM | 1 |
| Su, YZ | 1 |
| Duarte, TE | 1 |
| Dill, PL | 1 |
| Nagourney, RA | 1 |
| Prischl, F | 1 |
| Pinter, G | 1 |
| Schwarzmeier, J | 1 |
| Andersson, BS | 1 |
| Beran, M | 1 |
| Stuckey, SE | 1 |
| McCredie, KB | 1 |
| Mavligit, GM | 1 |
| Ross, DD | 1 |
| Joneckis, CC | 1 |
| Schiffer, CA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Retrospective Study to Validate Pharmacogenetics Model for Imatinib Metabolism in Patients With Chronic Myeloid Leukemia[NCT01437202] | 100 participants (Actual) | Observational | 2011-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for verapamil and Leukemia
| Article | Year |
|---|---|
Progress in defining multidrug resistance in leukemia.
Topics: Antibodies; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Calcium Channel Bl | 2004 |
The role of P-glycoprotein in drug-resistant hematologic malignancies.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transpor | 1991 |
2 trials available for verapamil and Leukemia
| Article | Year |
|---|---|
[The pleiotropic drug resistance phenotype: role of reverting agents "in vitro" and "in vivo"].
Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transport | 1991 |
Clinical trial of continuous infusion verapamil, bolus vinblastine, and continuous infusion VP-16 in drug-resistant pediatric tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Child; Child, | 1989 |
57 other studies available for verapamil and Leukemia
| Article | Year |
|---|---|
Identification of substituted 5-membered heterocyclic compounds as potential anti-leukemic agents.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Drug Evaluation, Preclinical; | 2019 |
Differential usage of the transport systems for folic acid and methotrexate in normal human T-lymphocytes and leukemic cells.
Topics: Antibodies; Biological Transport; Buffers; Carrier Proteins; Cell Line, Tumor; Folate Receptors, GPI | 2009 |
Pim-1 expression and monoclonal antibody targeting in human leukemia cell lines.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Antineoplastic Agents; Apoptosis; ATP Binding | 2009 |
Comparison of uptake mechanisms for anthracyclines in human leukemic cells.
Topics: Anthracyclines; Antibiotics, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily | 2013 |
Elevated uptake of low density lipoprotein by drug resistant human leukemic cell lines.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Lin | 2002 |
MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamides; Cell Death; Cell Div | 2003 |
Inactivation of deoxycytidine kinase and overexpression of P-glycoprotein in AraC and daunorubicin double resistant leukemic cell lines.
Topics: 2-Chloroadenosine; Alternative Splicing; Animals; ATP Binding Cassette Transporter, Subfamily B, Mem | 2003 |
Bodipy-FL-verapamil: a fluorescent probe for the study of multidrug resistance proteins.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological | 2004 |
Zinc ribbon domain-containing 1 (ZNRD1) mediates multidrug resistance of leukemia cells through regulation of P-glycoprotein and Bcl-2.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; DNA Primers; DNA- | 2005 |
Combined treatment of P-gp-positive L1210/VCR cells by verapamil and all-trans retinoic acid induces down-regulation of P-glycoprotein expression and transport activity.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological | 2008 |
A new apoptosis inhibitor, CIAPIN1 (cytokine-induced apoptosis inhibitor 1), mediates multidrug resistance in leukemia cells by regulating MDR-1, Bcl-2, and Bax.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; bcl-2-Associated X Protein; Blotting, Weste | 2007 |
Potentiation of vincristine and Adriamycin effects in human hemopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors.
Topics: Calcium; Calcium-Binding Proteins; Calmodulin; Cell Line; Cell Survival; Doxorubicin; Drug Synergism | 1983 |
Expression of multidrug resistance in response to differentiation in the K562 human leukaemia cell line.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Butyrates; Butyric Acid; Cell Differentiati | 1995 |
p53 and N-ras mutations in two new leukemia cell lines established from a patient with multilineage CD7-positive acute leukemia.
Topics: Acute Disease; Antigens, CD; Antigens, CD7; Antigens, Differentiation, T-Lymphocyte; Base Sequence; | 1993 |
[Effect of the modality of exposure on the action of S9788 on the modulation of multidrug resistance of human tumor cell lines].
Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Cyclosporine; Daunorubicin; Drug Resistance | 1994 |
Evidence for transcriptional control of human mdr1 gene expression by verapamil in multidrug-resistant leukemic cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Cell Nucleus; Down-Regulatio | 1995 |
Verapamil decreases P-glycoprotein expression in multidrug-resistant human leukemic cell lines.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Diltiazem; Drug Resistanc | 1994 |
Comparative evaluation of S9788, verapamil, and cyclosporine A in K562 human leukemia cell lines and in P-glycoprotein-expressing samples from patients with hematologic malignancies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; ATP Binding Cassette Transporter, | 1994 |
Flow cytometric determination of the multidrug-resistant phenotype in acute leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemoth | 1994 |
Modulation of rhodamine 123 uptake by nigericin in sensitive and multidrug resistant leukemic cells.
Topics: Animals; Antimetabolites, Antineoplastic; Doxorubicin; Drug Interactions; Drug Resistance; Drug Scre | 1994 |
Scanning electron microscopy of multidrug resistant cells in haematological and mammary malignancies.
Topics: Acute Disease; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blast Crisis; Breas | 1993 |
Comparative effects of racemic verapamil vs R-verapamil on normal and leukemic progenitors.
Topics: Bone Marrow Cells; Colony-Forming Units Assay; Daunorubicin; Drug Therapy, Combination; Erythroid Pr | 1993 |
A marine natural product, patellamide D, reverses multidrug resistance in a human leukemic cell line.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Cell Division; Cell Line; Drug Resistance; Huma | 1993 |
Effect of verapamil on daunorubicin accumulation in human leukemic cells with different levels of MDR1 gene expression.
Topics: Adult; Aged; Aged, 80 and over; Daunorubicin; Drug Resistance; Female; Flow Cytometry; Gene Expressi | 1993 |
Transport mechanism of anthracycline derivatives in human leukemia cell lines: uptake and efflux of pirarubicin in HL60 and pirarubicin-resistant HL60 cells.
Topics: Analysis of Variance; Antibiotics, Antineoplastic; Antineoplastic Agents; Biological Transport, Acti | 1996 |
Effect of combination of suboptimal concentrations of P-glycoprotein blockers on the proliferation of MDR1 gene expressing cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Division; Ce | 1996 |
Quality control of multidrug resistance assays in adult acute leukemia: correlation between assays for P-glycoprotein expression and activity.
Topics: Acute Disease; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; | 1996 |
Correlation of P-glycoprotein expression and function in childhood acute leukemia: a children's cancer group study.
Topics: Acute Disease; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subf | 1996 |
The potential of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide to circumvent three multidrug-resistance phenotypes in vitro.
Topics: Acridines; Amsacrine; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1 | 1997 |
Effect of the multidrug inhibitor GG918 on drug sensitivity of human leukemic cells.
Topics: Acridines; Acute Disease; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Membrane Per | 1997 |
The ability of verapamil to restore intracellular accumulation of anthracyclines in multidrug resistant cells depends on the kinetics of their uptake.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; | 1998 |
Effect of MDR antagonists on the cidal activity of vincristine for cells expressing MDR-1 is superior to those expressing MRP.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Bind | 1998 |
Influence of serum protein binding on the uptake and retention of idarubicin by sensitive and multidrug resistant human leukemic cells.
Topics: Anti-Arrhythmia Agents; Blood Proteins; Cell Line; Drug Resistance, Multiple; Humans; Hypersensitivi | 1999 |
Verapamil-stimulated glutathione transport by the multidrug resistance-associated protein (MRP1) in leukaemia cells.
Topics: ATP-Binding Cassette Transporters; Biological Transport; Calcium Channel Blockers; Glutathione; Huma | 2001 |
Energy-dependent accumulation of daunorubicin into subcellular compartments of human leukemia cells and cytoplasts.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Compartmentation; Chloroquine; | 1992 |
P-glycoprotein expression in refractory hematological neoplasms and circumvention of resistance with verapamil or cyclosporine A containing protocols.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, | 1992 |
Vincristine-resistant human leukemia cell line: new monoclonal antibodies to a 65kDa membrane protein.
Topics: Antibodies, Monoclonal; Biological Transport; Dactinomycin; Doxorubicin; Drug Resistance; Enzyme-Lin | 1992 |
Susceptibility of multidrug-resistant human leukemia cell lines to human interleukin 2-activated killer cells.
Topics: Antigens, CD7; Antigens, Differentiation; Antigens, Differentiation, T-Lymphocyte; ATP Binding Casse | 1990 |
Sufficient levels of quinine in the serum circumvent the multidrug resistance of the human leukemic cell line K562/ADM.
Topics: Doxorubicin; Drug Resistance; Feasibility Studies; Humans; Leukemia; Leukemia, Myeloid, Acute; Multi | 1991 |
Binding of an optically pure photoaffinity analogue of verapamil, LU-49888, to P-glycoprotein from multidrug-resistant human leukemic cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Drug Resista | 1990 |
Phenotypic and cytogenetic analysis of atypical multidrug resistance in human leukaemic cells selected with methotrexate at high concentration.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Dactinomycin; Drug Resistanc | 1990 |
Correspondence re: Xiu F. Hu et al., Combined use of cyclosporin A and verapamil in modulating multidrug resistance in human leukemia cell lines. Cancer Res., 50: 2953-2957, 1990.
Topics: Cyclosporins; Dose-Response Relationship, Drug; Drug Resistance; Humans; Leukemia; Tumor Cells, Cult | 1991 |
Differential in vitro sensitivity of human tumor and normal cells to chemotherapeutic agents and resistance modulators.
Topics: Adenocarcinoma; Antineoplastic Agents; Buthionine Sulfoximine; Cell Division; Cell Line; Cell Surviv | 1991 |
Synergistic effect of cyclosporin A and verapamil in overcoming vincristine resistance of multidrug-resistant cultured human leukemia cells.
Topics: Cyclosporins; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Humans; Leukemia; L | 1990 |
Modulation of etoposide (VP-16) cytotoxicity by verapamil or cyclosporine in multidrug-resistant human leukemic cell lines and normal bone marrow.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cell Division; Cell Survival; Cyclospor | 1990 |
Comparison of ion channels in multidrug-resistant and -sensitive human leukemic cells.
Topics: Antineoplastic Agents; Drug Resistance; Electrophysiology; Humans; Ion Channels; Leukemia; Potassium | 1988 |
Multidrug resistance in a human leukemic cell line selected for resistance to trimetrexate.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Doxorubicin; Drug Res | 1989 |
Pharmacological, molecular, and cytogenetic analysis of "atypical" multidrug-resistant human leukemic cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Chloroquine; Chromosome Banding; Chromosome | 1987 |
Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine.
Topics: Affinity Labels; Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Su | 1988 |
Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Line; Chemical Phenomena; Chemistry, Physic | 1988 |
Effects of verapamil on uptake and in vitro toxicity of anthracyclines in human leukemic blast cells.
Topics: Acute Disease; Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Body Fluids; Cell Transformatio | 1988 |
D-verapamil and L-verapamil are equally effective in increasing vincristine accumulation in leukemic cells in vitro.
Topics: Calcium; Drug Resistance; Humans; Leukemia; Leukemia, Lymphoid; Leukocytes; Lymphoma; Stereoisomeris | 1988 |
Effects of cytochalasins and colchicine on the accumulation and retention of daunomycin and vincristine in drug resistant tumor cells.
Topics: Animals; Cell Line; Cell Survival; Colchicine; Cytochalasin B; Cytochalasin D; Cytochalasins; Daunor | 1986 |
Perturbation of in vitro drug resistance in human lymphatic neoplasms by combinations of putative inhibitors of protein kinase C.
Topics: Cell Survival; Chlorpromazine; Drug Resistance; Drug Synergism; Haloperidol; Humans; Imipramine; In | 1987 |
In vitro chemosensitivity testing to predict outcome of therapy in acute leukemia.
Topics: Acute Disease; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; DNA Rep | 1987 |
Sensitivity and resistance to chemotherapy in acute leukemia: correlation with in vitro drug uptake and lack of potentiation by verapamil.
Topics: Acute Disease; Adult; Aged; Amsacrine; Cells, Cultured; Doxorubicin; Drug Resistance; Drug Synergism | 1987 |
Effects of verapamil on in vitro intracellular accumulation and retention of daunorubicin in blast cells from patients with acute nonlymphocytic leukemia.
Topics: Acute Disease; Animals; Bone Marrow; Daunorubicin; Drug Resistance; Humans; In Vitro Techniques; Kin | 1986 |