Page last updated: 2024-10-24

verapamil and Leukemia P388

verapamil has been researched along with Leukemia P388 in 77 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Leukemia P388: An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.

Research Excerpts

ExcerptRelevanceReference
"Experiments were carried out in vitro on adriamycin (ADR) accumulation and cytotoxicity alone and in combination with calcium channel antagonist, verapamil (VRP), in ascites murine tumour models of Ehrlich carcinoma (EAC), sarcoma 180 (S180) and P388 lymphocytic leukaemia (P388)."7.67Modulation of in vitro response to adriamycin by verapamil in murine P388 leukaemia, Ehrlich ascites carcinoma and sarcoma 180. ( Basrur, VS; Chitnis, MP; Pradhan, SG; Tantri, SK, 1987)
"The effects of verapamil on the intracellular pharmacokinetics of daunorubicin (DNR) in blast cells from the bone marrows of patients with acute nonlymphocytic leukemia (ANLL) were studied to determine whether verapamil was capable of enhancing intracellular accumulation and retention of DNR in ANLL, as has been observed in murine P388 cells resistant to DNR."7.67Effects of verapamil on in vitro intracellular accumulation and retention of daunorubicin in blast cells from patients with acute nonlymphocytic leukemia. ( Joneckis, CC; Ross, DD; Schiffer, CA, 1986)
" Most of these compounds increased the intracellular uptake of vinblastine in multidrug-resistant mouse leukemia P388/ADR cells without influence upon the vinblastine accumulation in P388/S cells."3.69Novel inhibitors for multidrug resistance: 1,3,5-triazacycloheptanes. ( Aizawa, T; Miyamoto, K; Murakami, R; Muramatsu, H; Sawanishi, H; Suzuki, H; Takashima, A; Wakusawa, S, 1995)
"Sarcoma 180 (S180) cells pretreated with verapamil increase their resistance to doxorubicin in vitro."3.68Resistance to doxorubicin in tumor cells in vitro and in vivo after pretreatment with verapamil. ( Donenko, FV; Efferth, T; Mattern, J; Moroz, LV; Volm, M, 1991)
"Experiments were carried out in vitro on adriamycin (ADR) accumulation and cytotoxicity alone and in combination with calcium channel antagonist, verapamil (VRP), in ascites murine tumour models of Ehrlich carcinoma (EAC), sarcoma 180 (S180) and P388 lymphocytic leukaemia (P388)."3.67Modulation of in vitro response to adriamycin by verapamil in murine P388 leukaemia, Ehrlich ascites carcinoma and sarcoma 180. ( Basrur, VS; Chitnis, MP; Pradhan, SG; Tantri, SK, 1987)
"The effects of verapamil on the intracellular pharmacokinetics of daunorubicin (DNR) in blast cells from the bone marrows of patients with acute nonlymphocytic leukemia (ANLL) were studied to determine whether verapamil was capable of enhancing intracellular accumulation and retention of DNR in ANLL, as has been observed in murine P388 cells resistant to DNR."3.67Effects of verapamil on in vitro intracellular accumulation and retention of daunorubicin in blast cells from patients with acute nonlymphocytic leukemia. ( Joneckis, CC; Ross, DD; Schiffer, CA, 1986)
"Lamellarin D (LAM-D) is a marine alkaloid endowed with potent cytotoxic activities against various tumor cells, in particular human prostate cancer cells and leukemia cells."1.33Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux. ( Bailly, C; Cuevas, C; Kluza, J; Lansiaux, A; Otero, G; Tardy, C; Vanhuyse, M, 2005)
"Vinflunine (VFL) is a novel derivative of vinorelbine (NVB, Navelbine), which has shown markedly superior antitumor activity to NVB, in various experimental animal models."1.30Vinflunine (20',20'-difluoro-3',4'-dihydrovinorelbine), a novel Vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro. ( Barret, JM; Etievant, C; Hill, BT; Kruczynski, A; Perrin, D, 1998)
" When simultaneously administered with vinblastine to P388/ADR-bearing mice, NA-382 maintained significantly higher vinblastine levels in the tumour cells for 24 h and gave a larger area under the time-intracellular vinblastine concentration curve (0 to 24 h) than those receiving vinblastine alone, with long retention of the agent in ascitic fluid."1.29Antitumour effects and pharmacokinetics of combination of vinblastine with a staurosporine derivative, NA-382, in P388/ADR-bearing mice. ( Koga, K; Miyamoto, K; Ohshima, T; Takeda, K; Wakusawa, S, 1995)
"Aclacinomycin (ACR) is an anthracycline anticancer drug that shows marked effects in Adriamycin (ADM)-resistant tumors."1.29Difference between the resistance mechanisms of aclacinomycin- and adriamycin-resistant P388 cell lines. ( Dong, J; Johdo, O; Naito, M; Seimiya, H; Tatsuta, T; Tsuruo, T, 1995)
"Menogaril is an anthracycline presently in Phase II clinical trials."1.28P388 leukaemia cells resistant to the anthracycline menogaril lack multidrug resistant phenotype. ( Badiner, GJ; Bhuyan, BK; Groppi, VE; Moy, BC; Smith, KS; Tarpley, WG, 1990)
" These effects of DMDP were greater than those of another calcium channel blocker, verapamil, and occurred at one-half the dosage levels."1.27The effects of verapamil and a tiapamil analogue, DMDP, on adriamycin-induced cytotoxicity in P388 adriamycin-resistant and -sensitive leukemia in vitro and in vivo. ( Bankusli, I; Mayhew, E; Radel, S; Rustum, YM, 1988)
"Cytochalasin B was most effective in VCR- and DAU-sensitive cells; however, the effect in resistant cells was less than that observed for verapamil, suggesting a different mode of action between these drugs in sensitive and resistant cells."1.27Effects of cytochalasins and colchicine on the accumulation and retention of daunomycin and vincristine in drug resistant tumor cells. ( Iida, H; Tsuruo, T, 1986)
" However, when the calcium channel blocker verapamil (75 mg/kg) was administered with VCR at 1."1.27Cure of mice bearing P388 leukemia by vincristine in combination with a calcium channel blocker. ( Iida, H; Sakurai, Y; Tsukagoshi, S; Tsuruo, T, 1985)

Research

Studies (77)

TimeframeStudies, this research(%)All Research%
pre-199028 (36.36)18.7374
1990's43 (55.84)18.2507
2000's6 (7.79)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dhainaut, A2
Régnier, G2
Atassi, G3
Pierré, A3
Léonce, S3
Kraus-Berthier, L2
Prost, JF1
Sawanishi, H2
Wakusawa, S3
Murakami, R1
Muramatsu, H1
Suzuki, H1
Takashima, A1
Aizawa, T1
Miyamoto, K5
Tizot, A1
Guilbaud, N1
Kobayashi, J1
Hosoyama, H1
Wang, XX1
Shigemori, H1
Sudo, Y2
Tsuruo, T14
Wang, L1
Kitaichi, K1
Hui, CS1
Takagi, K2
Sakai, M1
Yokogawa, K1
Miyamoto, KI1
Hasegawa, T1
Bakken, GA1
Jurs, PC1
Sadzuka, Y2
Egawa, Y1
Sonobe, T2
Vanhuyse, M1
Kluza, J1
Tardy, C1
Otero, G1
Cuevas, C1
Bailly, C1
Lansiaux, A1
Bucher, K1
Belli, S1
Wunderli-Allenspach, H1
Krämer, SD1
Skovsgaard, T2
Danø, K1
Nissen, NI1
Kessel, D2
Wilberding, C1
Yanovich, S1
Preston, L1
Iida, H5
Tsukagoshi, S4
Sakurai, Y4
Yamashiro, M1
Ohsumi, K1
Ohishi, K1
Morinaga, Y1
Nakagawa, R1
Suga, Y1
Sekiyama, T1
Akiyama, Y1
Tsuji, T1
Frey, T1
Yue, S1
Haugland, RP1
Slater, L2
Sweet, P2
Wetzel, M1
Stupecky, M2
Osann, K1
Takeda, K1
Koga, K1
Ohshima, T1
Testi, R1
Mattii, L2
Di Simone, D1
Zaccaro, L1
Malvaldi, G1
Grassi, B1
Petrini, M2
Boesch, D2
Loor, F3
Ramachandran, C1
Yuan, ZK1
Huang, XL1
Krishan, A4
Jachez, B1
Nordmann, R1
Nakamura, S1
Tajima, K1
Hagiwara, M1
Hidaka, H1
Galimberti, S1
Bianchi, F1
Bernardini, N1
Dolfi, A1
Lupetti, M1
Dong, J1
Naito, M3
Tatsuta, T1
Seimiya, H1
Johdo, O1
Pajeva, IK1
Wiese, M1
Cordes, HP1
Seydel, JK1
Quesada, AR2
Barbacid, MM1
Mira, E1
Aracil, M1
Márquez, G1
Homolya, L1
Holló, M1
Müller, M1
Mechetner, EB1
Sarkadi, B1
García Grávalos, MD1
Fernández Puentes, JL1
Nakashima, E1
Matsushita, R1
Negishi, H1
Nomura, M1
Harada, S1
Yamamoto, H1
Ichimura, F1
Elstad, CA1
Thrall, BD1
Raha, G1
Meadows, GG1
Ayesh, S2
Lyubimov, E1
Algour, N1
Stein, WD2
Shao, YM1
Noviello, E1
Allievi, E1
Russo, P1
Parodi, S1
Nanaumi, K1
Tsuchida, K1
Nakaike, S2
Yamagishi, T2
Ichihara, T1
Takahashi, K1
Watajima, H1
Suzuki, Y1
Etievant, C1
Barret, JM1
Kruczynski, A1
Perrin, D1
Hill, BT1
Sugiyama, T1
Anstett, M1
Pérez, V1
Genton, A1
Bizzari, JP1
Soto, F2
Canaves, JM1
Gonzalez-Ros, JM2
Ferragut, JA2
García-Segura, LM1
Planells-Cases, R1
Donenko, FV5
Efferth, T1
Mattern, J1
Moroz, LV5
Volm, M1
Sato, W1
Fukazawa, N1
Suzuki, T1
Yusa, K1
Pourtier-Manzanedo, A1
Kabieva, AO2
Borovkova, NB4
Ramu, A3
Ramu, N3
Gorodetsky, R1
Rosario, LM1
Badiner, GJ1
Moy, BC1
Smith, KS1
Tarpley, WG1
Groppi, VE1
Bhuyan, BK1
Takamori, R1
Tsukahara, S1
Yamabe-Mitsuhashi, J1
Yamazaki, A1
Oh-hara, T1
Adwankar, MK1
Chitnis, MP2
Sitdikova, SM3
Yagen, B1
Vayuvegula, B1
Meador, J1
Gupta, S1
Bose, R1
Lam, HY1
Radel, S1
Bankusli, I1
Mayhew, E1
Rustum, YM1
Kramer, RA1
Zakher, J1
Kim, G1
Sehested, M1
van Deurs, B1
Winther-Nielsen, H1
McGown, A1
Poppitt, DG1
Fox, BW1
Slater, LM1
Murray, SL1
Wetzel, MW1
Streeter, DG2
Johl, JS1
Gordon, GR1
Peters, JH2
Yamaguchi, T1
Nakagawa, M1
Shiraishi, N1
Yoshida, T1
Kiyosue, T1
Arita, M1
Akiyama, S1
Kuwano, M1
Pradhan, SG1
Basrur, VS1
Tantri, SK1
Ross, DD1
Joneckis, CC1
Schiffer, CA1
Capranico, G1
Dasdia, T1
Zunino, F1
Sauerteig, A1
Gordon, K1
Swinkin, C1
Taylor, DL1
Acton, EM1
Kawabata, H1
Nagumo, N1
Kitatani, Y1
Borowitz, JL1
Hadley, R1
Stebbins, G1

Reviews

3 reviews available for verapamil and Leukemia P388

ArticleYear
Chemosensitizers counteracting acquired resistance to anthracyclines and vinca alkaloids in vivo. A new treatment principle.
    Cancer treatment reviews, 1984, Volume: 11 Suppl A

    Topics: Animals; Antibiotics, Antineoplastic; Calcium Channel Blockers; Calmodulin; Carcinoma, Ehrlich Tumor

1984
[Development of drugs to overcome drug resistance--basic approaches].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:3

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporin

1995
[MDR reversing drugs for clinical development].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:7

    Topics: Animals; Antineoplastic Agents; Cyclosporins; Doxorubicin; Drug Resistance; Drug Synergism; Humans;

1994

Other Studies

74 other studies available for verapamil and Leukemia P388

ArticleYear
New triazine derivatives as potent modulators of multidrug resistance.
    Journal of medicinal chemistry, 1992, Jun-26, Volume: 35, Issue:13

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line;

1992
Novel inhibitors for multidrug resistance: 1,3,5-triazacycloheptanes.
    Journal of medicinal chemistry, 1995, Dec-22, Volume: 38, Issue:26

    Topics: Animals; Antineoplastic Agents; Azepines; Cisplatin; Cycloheptanes; Doxorubicin; Drug Resistance, Mu

1995
New purines and purine analogs as modulators of multidrug resistance.
    Journal of medicinal chemistry, 1996, Sep-27, Volume: 39, Issue:20

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Cha

1996
Modulation of multidrug resistance by taxuspine C and other taxoids from Japanese yew.
    Bioorganic & medicinal chemistry letters, 1998, Jun-16, Volume: 8, Issue:12

    Topics: Animals; Bridged-Ring Compounds; Carcinoma, Squamous Cell; Drug Resistance, Multiple; Drug Resistanc

1998
Reversal of anticancer drug resistance by macrolide antibiotics in vitro and in vivo.
    Clinical and experimental pharmacology & physiology, 2000, Volume: 27, Issue:8

    Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Bindin

2000
Classification of multidrug-resistance reversal agents using structure-based descriptors and linear discriminant analysis.
    Journal of medicinal chemistry, 2000, Nov-16, Volume: 43, Issue:23

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Doxorubicin; Drug Resistance, Multiple;

2000
Effects of xanthine derivatives on the influx and efflux of doxorubicin in P388 and DOX-resistant P388 leukemia cells.
    Toxicology letters, 2002, Sep-05, Volume: 135, Issue:1-2

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Cha

2002
Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux.
    Cancer letters, 2005, Apr-28, Volume: 221, Issue:2

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cass

2005
P-glycoprotein in proteoliposomes with low residual detergent: the effects of cholesterol.
    Pharmaceutical research, 2007, Volume: 24, Issue:11

    Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cholest

2007
Mode of action of calcium antagonists which alter anthracycline resistance.
    Biochemical pharmacology, 1984, Apr-01, Volume: 33, Issue:7

    Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Calcium Channel Blockers; Cell Line; Dau

1984
Effects of verapamil on daunomycin cellular retention and cytotoxicity in P388 leukemic cells.
    Cancer research, 1984, Volume: 44, Issue:5

    Topics: Animals; Biological Transport; Cell Survival; Daunorubicin; Drug Resistance; Kinetics; Leukemia P388

1984
Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.
    Cancer research, 1982, Volume: 42, Issue:11

    Topics: Animals; Calcium Channel Blockers; Calcium-Binding Proteins; Calmodulin; Clomipramine; Doxorubicin;

1982
Enhancement of vincristine- and adriamycin-induced cytotoxicity by verapamil in P388 leukemia and its sublines resistant to vincristine and adriamycin.
    Biochemical pharmacology, 1982, Oct-01, Volume: 31, Issue:19

    Topics: Animals; Doxorubicin; Drug Resistance; Leukemia P388; Leukemia, Experimental; Mice; Verapamil; Vincr

1982
N-alkylated 1,4-dihydropyridines: new agents to overcome multidrug resistance.
    Chemical & pharmaceutical bulletin, 1995, Volume: 43, Issue:5

    Topics: Alkylation; Animals; Chemical Phenomena; Chemistry, Physical; Dihydropyridines; Drug Resistance, Mul

1995
Dyes providing increased sensitivity in flow-cytometric dye-efflux assays for multidrug resistance.
    Cytometry, 1995, Jul-01, Volume: 20, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Burkitt Lymphoma; Calcium Channel

1995
Comparison of cyclosporin A, verapamil, PSC-833 and cremophor EL as enhancing agents of VP-16 in murine lymphoid leukemias.
    Leukemia research, 1995, Volume: 19, Issue:8

    Topics: Animals; Cell Survival; Cyclosporine; Cyclosporins; Drug Synergism; Etoposide; Glycerol; Leukemia L1

1995
Antitumour effects and pharmacokinetics of combination of vinblastine with a staurosporine derivative, NA-382, in P388/ADR-bearing mice.
    The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:6

    Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Resistance, Mu

1995
Evaluation of resistance index of several anticancer agents on parental and resistant P-388 cell lines.
    Leukemia research, 1995, Volume: 19, Issue:4

    Topics: Animals; Biological Transport; DNA Replication; Dose-Response Relationship, Drug; Doxorubicin; Drug

1995
Extent and persistence of P-glycoprotein inhibition in multidrug-resistant P388 cells after exposure to resistance-modifying agents.
    Anti-cancer drugs, 1994, Volume: 5, Issue:2

    Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B,

1994
Doxorubicin resistance in human melanoma cells: MDR-1 and glutathione S-transferase pi gene expression.
    Biochemical pharmacology, 1993, Feb-09, Volume: 45, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Death; Cell Division; Cell Li

1993
Restoration of taxol sensitivity of multidrug-resistant cells by the cyclosporine SDZ PSC 833 and the cyclopeptolide SDZ 280-446.
    Journal of the National Cancer Institute, 1993, Mar-17, Volume: 85, Issue:6

    Topics: Animals; Antineoplastic Agents; CHO Cells; Cricetinae; Cyclosporins; Drug Resistance; Leukemia P388;

1993
Effects of isoquinolinesulphonamide compounds on multidrug-resistant P388 cells.
    The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:4

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Division; C

1993
Scanning electron microscopy of multidrug resistant cells in haematological and mammary malignancies.
    Cellular and molecular biology (Noisy-le-Grand, France), 1993, Volume: 39, Issue:5

    Topics: Acute Disease; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blast Crisis; Breas

1993
Difference between the resistance mechanisms of aclacinomycin- and adriamycin-resistant P388 cell lines.
    Oncology research, 1995, Volume: 7, Issue:5

    Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Me

1995
Membrane interactions of some catamphiphilic drugs and relation to their multidrug-resistance-reversing ability.
    Journal of cancer research and clinical oncology, 1996, Volume: 122, Issue:1

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Breast Neoplasms; Calorimetry, Differential Scanning; D

1996
Chemosensitization and drug accumulation assays as complementary methods for the screening of multidrug resistance reversal agents.
    Cancer letters, 1996, Jan-19, Volume: 99, Issue:1

    Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; ATP Binding C

1996
A new method for a quantitative assessment of P-glycoprotein-related multidrug resistance in tumour cells.
    British journal of cancer, 1996, Volume: 73, Issue:7

    Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Tr

1996
Polyaromatic alkaloids from marine invertebrates as cytotoxic compounds and inhibitors of multidrug resistance caused by P-glycoprotein.
    British journal of cancer, 1996, Volume: 74, Issue:5

    Topics: Adenocarcinoma; Alkaloids; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemoth

1996
Reversal of drug sensitivity in MDR subline of P388 leukemia by gene-targeted antisense oligonucleotide.
    Journal of pharmaceutical sciences, 1995, Volume: 84, Issue:10

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequen

1995
Tyrosine and phenylalanine restriction sensitizes adriamycin-resistant P388 leukemia cells to adriamycin.
    Nutrition and cancer, 1996, Volume: 25, Issue:1

    Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Doxorubicin; Drug Resistance, Neoplasm; Leuk

1996
Reversal of P-glycoprotein is greatly reduced by the presence of plasma but can be monitored by an ex vivo clinical assay.
    Anti-cancer drugs, 1996, Volume: 7, Issue:6

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunorubicin; Drug S

1996
Mutually co-operative interactions between modulators of P-glycoprotein.
    Biochimica et biophysica acta, 1997, Feb-27, Volume: 1360, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Daunorubicin; Drug Resistance, Mul

1997
Effects of Dex-Verapamil on Doxorubicin cytotoxicity in P388 murine leukemia cells.
    Anti-cancer drug design, 1997, Volume: 12, Issue:4

    Topics: Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Res

1997
Overcoming of multidrug resistance by VA-033, a novel derivative of apovincaminic acid ester.
    European journal of pharmacology, 1997, May-30, Volume: 327, Issue:2-3

    Topics: Animals; Cardiovascular System; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Drug Resi

1997
Vinflunine (20',20'-difluoro-3',4'-dihydrovinorelbine), a novel Vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro.
    Investigational new drugs, 1998, Volume: 16, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1;

1998
Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance.
    Toxicology letters, 2000, Apr-03, Volume: 114, Issue:1-3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; ATP Bind

2000
Effects of a new triazinoaminopiperidine derivative on adriamycin accumulation and retention in cells displaying P-glycoprotein-mediated multidrug resistance.
    Biochemical pharmacology, 1992, Nov-03, Volume: 44, Issue:9

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Membe

1992
Rapid kinetics of the interaction between daunomycin and drug-sensitive or drug-resistant P388 leukemia cells.
    FEBS letters, 1992, Apr-13, Volume: 301, Issue:1

    Topics: Animals; Biological Transport; Cell Membrane; Cell Membrane Permeability; Daunorubicin; Drug Resista

1992
Verapamil reverses the ultrastructural alterations in the plasma membrane induced by drug resistance.
    FEBS letters, 1992, Dec-21, Volume: 314, Issue:3

    Topics: Animals; Cell Membrane; Daunorubicin; Drug Resistance; Freeze Fracturing; Leukemia P388; Membrane Gl

1992
Resistance to doxorubicin in tumor cells in vitro and in vivo after pretreatment with verapamil.
    Chemotherapy, 1991, Volume: 37, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Resistance; Leuk

1991
Circumvention of multidrug resistance by a newly synthesized quinoline derivative, MS-073.
    Cancer research, 1991, May-01, Volume: 51, Issue:9

    Topics: Affinity Labels; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Trans

1991
FK-506 (fujimycin) reverses the multidrug resistance of tumor cells in vitro.
    Anti-cancer drugs, 1991, Volume: 2, Issue:3

    Topics: Amiodarone; Animals; Antibiotics, Antineoplastic; Cyclosporine; Doxorubicin; Drug Resistance; Leukem

1991
[Changes in glutathione-S-transferase activity during induction of resistance of leukemia P 388 and Ehrlich ascitic tumor cells to doxorubicin].
    Biulleten' eksperimental'noi biologii i meditsiny, 1991, Volume: 112, Issue:8

    Topics: Animals; Carcinoma, Ehrlich Tumor; Doxorubicin; Drug Resistance; Glutathione Transferase; Leukemia P

1991
Reduced ouabain-sensitive potassium entry as a possible mechanism of multidrug-resistance in P388 cells.
    Biochemical pharmacology, 1991, Oct-09, Volume: 42, Issue:9

    Topics: Animals; Cell Division; Cell Membrane; Drug Resistance; Leukemia P388; Membrane Potentials; Mice; Ou

1991
Circumvention of multidrug-resistance in P388 cells is associated with a rise in the cellular content of phosphatidylcholine.
    Biochemical pharmacology, 1991, May-15, Volume: 41, Issue:10

    Topics: Animals; Cell Membrane; Cell Membrane Permeability; Choline; Digitonin; Dipyridamole; Drug Resistanc

1991
Rapid determination of cellular resistance-related drug efflux in tumor cells.
    Methods in cell biology, 1990, Volume: 33

    Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Chlorpromazine; Doxorubicin; Drug Resist

1990
P388 leukaemia cells resistant to the anthracycline menogaril lack multidrug resistant phenotype.
    British journal of cancer, 1990, Volume: 62, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Dose-Response Relatio

1990
A benzophenazine derivative, N-beta-dimethylaminoethyl 9-carboxy-5-hydroxy-10-methoxy-benzo[a]phenazine-6-carboxamide, as a new antitumor agent against multidrug-resistant and sensitive tumors.
    Cancer chemotherapy and pharmacology, 1990, Volume: 26, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Membrane; Doxorubicin; Drug Resistance; Drug Screening Assays,

1990
Modulation of in vitro chemosensitivity by extracellular Ca++ in adriamycin sensitive and resistant P388 leukemic cells.
    Neoplasma, 1990, Volume: 37, Issue:1

    Topics: Animals; Calcium; DNA, Neoplasm; Doxorubicin; Drug Resistance; Leukemia P388; Leukemia, Experimental

1990
Verapamil effect on the accumulation of doxorubicin in the leukemia P388 cells with induced antibiotic resistance.
    Archiv fur Geschwulstforschung, 1990, Volume: 60, Issue:2

    Topics: Animals; Doxorubicin; Drug Resistance, Microbial; Leukemia P388; Leukemia, Experimental; Male; Mice;

1990
[The effect of finoptin on doxorubicin accumulation in leukemia P-388 cells with induced resistance to the combination of finoptin and doxorubicin].
    Biulleten' eksperimental'noi biologii i meditsiny, 1990, Volume: 109, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Interactions; Drug Resist

1990
[The effect of finoptin on the accumulation of doxorubicin in leukemia P388 cells with induced resistance to the antibiotic].
    Biulleten' eksperimental'noi biologii i meditsiny, 1989, Volume: 108, Issue:12

    Topics: Animals; Doxorubicin; Drug Interactions; Drug Resistance, Microbial; Drug Screening Assays, Antitumo

1989
The cytotoxicity of T-2 toxin and related 12,13-epoxytrichothecenes to Adriamycin-sensitive and -resistant P388 leukemia cells.
    Cancer chemotherapy and pharmacology, 1989, Volume: 24, Issue:4

    Topics: Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Doxorubicin; Drug Resi

1989
Interactions among membrane transport systems: anthracyclines, calcium antagonists and anti-estrogens.
    Biochemical pharmacology, 1986, Aug-15, Volume: 35, Issue:16

    Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Calcium Channel Blockers; Daunorubicin;

1986
Correction of altered plasma membrane potentials. A possible mechanism of cyclosporin A and verapamil reversal of pleiotropic drug resistance in neoplasia.
    Cancer chemotherapy and pharmacology, 1988, Volume: 22, Issue:2

    Topics: Animals; Antineoplastic Agents; Calcium; Cell Line; Cell Membrane; Cyclosporins; Drug Resistance; Le

1988
Membrane transport changes in an adriamycin-resistant murine leukemia cell line and in its sensitive parental cell line.
    Cancer chemotherapy and pharmacology, 1988, Volume: 21, Issue:1

    Topics: Animals; Biological Transport; Cell Membrane; Doxorubicin; Drug Resistance; Leukemia P388; Leukemia,

1988
The effects of verapamil and a tiapamil analogue, DMDP, on adriamycin-induced cytotoxicity in P388 adriamycin-resistant and -sensitive leukemia in vitro and in vivo.
    Cancer chemotherapy and pharmacology, 1988, Volume: 21, Issue:1

    Topics: Animals; Calcium Channel Blockers; Doxorubicin; Drug Resistance; Drug Synergism; Female; Glycoprotei

1988
Role of the glutathione redox cycle in acquired and de novo multidrug resistance.
    Science (New York, N.Y.), 1988, Aug-05, Volume: 241, Issue:4866

    Topics: Animals; Carmustine; Colonic Neoplasms; Doxorubicin; Drug Resistance; Glutathione; Glutathione Perox

1988
Increased plasma membrane traffic in daunorubicin resistant P388 leukaemic cells. Effect of daunorubicin and verapamil.
    British journal of cancer, 1987, Volume: 56, Issue:6

    Topics: Animals; Cell Membrane; Daunorubicin; Drug Resistance; Endocytosis; Exocytosis; Female; Leukemia P38

1987
Comparison of daunorubicin and anthrapyrazolone sensitivity and transport in resistant cell lines.
    British journal of cancer, 1987, Volume: 56, Issue:6

    Topics: Animals; Anthraquinones; Antineoplastic Agents; Daunorubicin; Dose-Response Relationship, Drug; Drug

1987
Verapamil potentiation of VP-16-213 in acute lymphatic leukemia and reversal of pleiotropic drug resistance.
    Cancer chemotherapy and pharmacology, 1986, Volume: 16, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Daunorubicin; Dose-Response Relation

1986
Effects of cytochalasins and colchicine on the accumulation and retention of daunomycin and vincristine in drug resistant tumor cells.
    Biochemical pharmacology, 1986, Apr-01, Volume: 35, Issue:7

    Topics: Animals; Cell Line; Cell Survival; Colchicine; Cytochalasin B; Cytochalasin D; Cytochalasins; Daunor

1986
Uptake and retention of morpholinyl anthracyclines by adriamycin-sensitive and -resistant P388 cells.
    Cancer chemotherapy and pharmacology, 1986, Volume: 16, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Cell Line; Doxorubicin; Drug Resistance; Leukemia P388; Leukem

1986
Overcoming drug resistance in cancer cells with synthetic isoprenoids.
    Journal of the National Cancer Institute, 1986, Volume: 76, Issue:5

    Topics: Animals; Antineoplastic Agents; Calcium; Doxorubicin; Drug Resistance; Ethylenediamines; Lethal Dose

1986
Flow cytometric monitoring of anthracycline transport in tumor cells.
    Annals of the New York Academy of Sciences, 1986, Volume: 468

    Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Chlorpromazine; Daunorubicin; Flow Cytom

1986
Acquired vs innate multidrug resistance and the effect of calcium channel blockers.
    Progress in clinical and biological research, 1986, Volume: 223

    Topics: Animals; Antineoplastic Agents; Calcium Channel Blockers; Cell Line; Doxorubicin; Drug Resistance; D

1986
Modulation of in vitro response to adriamycin by verapamil in murine P388 leukaemia, Ehrlich ascites carcinoma and sarcoma 180.
    European journal of cancer & clinical oncology, 1987, Volume: 23, Issue:4

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Cell Survival; Depression, Chemical; DNA, Neoplasm; Do

1987
Effects of verapamil on in vitro intracellular accumulation and retention of daunorubicin in blast cells from patients with acute nonlymphocytic leukemia.
    Blood, 1986, Volume: 68, Issue:1

    Topics: Acute Disease; Animals; Bone Marrow; Daunorubicin; Drug Resistance; Humans; In Vitro Techniques; Kin

1986
Comparison of doxorubicin-induced DNA damage in doxorubicin-sensitive and -resistant P388 murine leukemia cells.
    International journal of cancer, 1986, Feb-15, Volume: 37, Issue:2

    Topics: Animals; Cell Line; DNA; Doxorubicin; Drug Resistance; Leukemia P388; Leukemia, Experimental; Mathem

1986
Flow cytometric monitoring of cellular anthracycline accumulation in murine leukemic cells.
    Cancer research, 1986, Volume: 46, Issue:4 Pt 1

    Topics: Animals; Biological Transport; Cell Line; Chlorpromazine; Daunorubicin; Doxorubicin; Flow Cytometry;

1986
Comparative cytotoxicities of various morpholinyl anthracyclines.
    Cancer chemotherapy and pharmacology, 1985, Volume: 14, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Doxorubicin; Drug Resistance; Drug Synergi

1985
Cure of mice bearing P388 leukemia by vincristine in combination with a calcium channel blocker.
    Cancer treatment reports, 1985, Volume: 69, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Leukemia P388; Leukemia, Experimental; Mice

1985
Potentiation of antitumor agents by calcium channel blockers with special reference to cross-resistance patterns.
    Cancer chemotherapy and pharmacology, 1985, Volume: 15, Issue:1

    Topics: Animals; Antineoplastic Agents; Calcium Channel Blockers; Cell Line; Doxorubicin; Drug Resistance; D

1985
Effects of calcium and verapamil on normal and tumor murine leukocytes.
    Research communications in chemical pathology and pharmacology, 1985, Volume: 48, Issue:2

    Topics: Animals; Calcium; Chlorpromazine; Ethanol; Leukemia P388; Leukemia, Experimental; Leukocytes; Mice;

1985