verapamil has been researched along with Leukemia P388 in 77 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Leukemia P388: An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experiments were carried out in vitro on adriamycin (ADR) accumulation and cytotoxicity alone and in combination with calcium channel antagonist, verapamil (VRP), in ascites murine tumour models of Ehrlich carcinoma (EAC), sarcoma 180 (S180) and P388 lymphocytic leukaemia (P388)." | 7.67 | Modulation of in vitro response to adriamycin by verapamil in murine P388 leukaemia, Ehrlich ascites carcinoma and sarcoma 180. ( Basrur, VS; Chitnis, MP; Pradhan, SG; Tantri, SK, 1987) |
| "The effects of verapamil on the intracellular pharmacokinetics of daunorubicin (DNR) in blast cells from the bone marrows of patients with acute nonlymphocytic leukemia (ANLL) were studied to determine whether verapamil was capable of enhancing intracellular accumulation and retention of DNR in ANLL, as has been observed in murine P388 cells resistant to DNR." | 7.67 | Effects of verapamil on in vitro intracellular accumulation and retention of daunorubicin in blast cells from patients with acute nonlymphocytic leukemia. ( Joneckis, CC; Ross, DD; Schiffer, CA, 1986) |
| " Most of these compounds increased the intracellular uptake of vinblastine in multidrug-resistant mouse leukemia P388/ADR cells without influence upon the vinblastine accumulation in P388/S cells." | 3.69 | Novel inhibitors for multidrug resistance: 1,3,5-triazacycloheptanes. ( Aizawa, T; Miyamoto, K; Murakami, R; Muramatsu, H; Sawanishi, H; Suzuki, H; Takashima, A; Wakusawa, S, 1995) |
| "Sarcoma 180 (S180) cells pretreated with verapamil increase their resistance to doxorubicin in vitro." | 3.68 | Resistance to doxorubicin in tumor cells in vitro and in vivo after pretreatment with verapamil. ( Donenko, FV; Efferth, T; Mattern, J; Moroz, LV; Volm, M, 1991) |
| "Experiments were carried out in vitro on adriamycin (ADR) accumulation and cytotoxicity alone and in combination with calcium channel antagonist, verapamil (VRP), in ascites murine tumour models of Ehrlich carcinoma (EAC), sarcoma 180 (S180) and P388 lymphocytic leukaemia (P388)." | 3.67 | Modulation of in vitro response to adriamycin by verapamil in murine P388 leukaemia, Ehrlich ascites carcinoma and sarcoma 180. ( Basrur, VS; Chitnis, MP; Pradhan, SG; Tantri, SK, 1987) |
| "The effects of verapamil on the intracellular pharmacokinetics of daunorubicin (DNR) in blast cells from the bone marrows of patients with acute nonlymphocytic leukemia (ANLL) were studied to determine whether verapamil was capable of enhancing intracellular accumulation and retention of DNR in ANLL, as has been observed in murine P388 cells resistant to DNR." | 3.67 | Effects of verapamil on in vitro intracellular accumulation and retention of daunorubicin in blast cells from patients with acute nonlymphocytic leukemia. ( Joneckis, CC; Ross, DD; Schiffer, CA, 1986) |
| "Lamellarin D (LAM-D) is a marine alkaloid endowed with potent cytotoxic activities against various tumor cells, in particular human prostate cancer cells and leukemia cells." | 1.33 | Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux. ( Bailly, C; Cuevas, C; Kluza, J; Lansiaux, A; Otero, G; Tardy, C; Vanhuyse, M, 2005) |
| "Vinflunine (VFL) is a novel derivative of vinorelbine (NVB, Navelbine), which has shown markedly superior antitumor activity to NVB, in various experimental animal models." | 1.30 | Vinflunine (20',20'-difluoro-3',4'-dihydrovinorelbine), a novel Vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro. ( Barret, JM; Etievant, C; Hill, BT; Kruczynski, A; Perrin, D, 1998) |
| " When simultaneously administered with vinblastine to P388/ADR-bearing mice, NA-382 maintained significantly higher vinblastine levels in the tumour cells for 24 h and gave a larger area under the time-intracellular vinblastine concentration curve (0 to 24 h) than those receiving vinblastine alone, with long retention of the agent in ascitic fluid." | 1.29 | Antitumour effects and pharmacokinetics of combination of vinblastine with a staurosporine derivative, NA-382, in P388/ADR-bearing mice. ( Koga, K; Miyamoto, K; Ohshima, T; Takeda, K; Wakusawa, S, 1995) |
| "Aclacinomycin (ACR) is an anthracycline anticancer drug that shows marked effects in Adriamycin (ADM)-resistant tumors." | 1.29 | Difference between the resistance mechanisms of aclacinomycin- and adriamycin-resistant P388 cell lines. ( Dong, J; Johdo, O; Naito, M; Seimiya, H; Tatsuta, T; Tsuruo, T, 1995) |
| "Menogaril is an anthracycline presently in Phase II clinical trials." | 1.28 | P388 leukaemia cells resistant to the anthracycline menogaril lack multidrug resistant phenotype. ( Badiner, GJ; Bhuyan, BK; Groppi, VE; Moy, BC; Smith, KS; Tarpley, WG, 1990) |
| " These effects of DMDP were greater than those of another calcium channel blocker, verapamil, and occurred at one-half the dosage levels." | 1.27 | The effects of verapamil and a tiapamil analogue, DMDP, on adriamycin-induced cytotoxicity in P388 adriamycin-resistant and -sensitive leukemia in vitro and in vivo. ( Bankusli, I; Mayhew, E; Radel, S; Rustum, YM, 1988) |
| "Cytochalasin B was most effective in VCR- and DAU-sensitive cells; however, the effect in resistant cells was less than that observed for verapamil, suggesting a different mode of action between these drugs in sensitive and resistant cells." | 1.27 | Effects of cytochalasins and colchicine on the accumulation and retention of daunomycin and vincristine in drug resistant tumor cells. ( Iida, H; Tsuruo, T, 1986) |
| " However, when the calcium channel blocker verapamil (75 mg/kg) was administered with VCR at 1." | 1.27 | Cure of mice bearing P388 leukemia by vincristine in combination with a calcium channel blocker. ( Iida, H; Sakurai, Y; Tsukagoshi, S; Tsuruo, T, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (36.36) | 18.7374 |
| 1990's | 43 (55.84) | 18.2507 |
| 2000's | 6 (7.79) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dhainaut, A | 2 |
| Régnier, G | 2 |
| Atassi, G | 3 |
| Pierré, A | 3 |
| Léonce, S | 3 |
| Kraus-Berthier, L | 2 |
| Prost, JF | 1 |
| Sawanishi, H | 2 |
| Wakusawa, S | 3 |
| Murakami, R | 1 |
| Muramatsu, H | 1 |
| Suzuki, H | 1 |
| Takashima, A | 1 |
| Aizawa, T | 1 |
| Miyamoto, K | 5 |
| Tizot, A | 1 |
| Guilbaud, N | 1 |
| Kobayashi, J | 1 |
| Hosoyama, H | 1 |
| Wang, XX | 1 |
| Shigemori, H | 1 |
| Sudo, Y | 2 |
| Tsuruo, T | 14 |
| Wang, L | 1 |
| Kitaichi, K | 1 |
| Hui, CS | 1 |
| Takagi, K | 2 |
| Sakai, M | 1 |
| Yokogawa, K | 1 |
| Miyamoto, KI | 1 |
| Hasegawa, T | 1 |
| Bakken, GA | 1 |
| Jurs, PC | 1 |
| Sadzuka, Y | 2 |
| Egawa, Y | 1 |
| Sonobe, T | 2 |
| Vanhuyse, M | 1 |
| Kluza, J | 1 |
| Tardy, C | 1 |
| Otero, G | 1 |
| Cuevas, C | 1 |
| Bailly, C | 1 |
| Lansiaux, A | 1 |
| Bucher, K | 1 |
| Belli, S | 1 |
| Wunderli-Allenspach, H | 1 |
| Krämer, SD | 1 |
| Skovsgaard, T | 2 |
| Danø, K | 1 |
| Nissen, NI | 1 |
| Kessel, D | 2 |
| Wilberding, C | 1 |
| Yanovich, S | 1 |
| Preston, L | 1 |
| Iida, H | 5 |
| Tsukagoshi, S | 4 |
| Sakurai, Y | 4 |
| Yamashiro, M | 1 |
| Ohsumi, K | 1 |
| Ohishi, K | 1 |
| Morinaga, Y | 1 |
| Nakagawa, R | 1 |
| Suga, Y | 1 |
| Sekiyama, T | 1 |
| Akiyama, Y | 1 |
| Tsuji, T | 1 |
| Frey, T | 1 |
| Yue, S | 1 |
| Haugland, RP | 1 |
| Slater, L | 2 |
| Sweet, P | 2 |
| Wetzel, M | 1 |
| Stupecky, M | 2 |
| Osann, K | 1 |
| Takeda, K | 1 |
| Koga, K | 1 |
| Ohshima, T | 1 |
| Testi, R | 1 |
| Mattii, L | 2 |
| Di Simone, D | 1 |
| Zaccaro, L | 1 |
| Malvaldi, G | 1 |
| Grassi, B | 1 |
| Petrini, M | 2 |
| Boesch, D | 2 |
| Loor, F | 3 |
| Ramachandran, C | 1 |
| Yuan, ZK | 1 |
| Huang, XL | 1 |
| Krishan, A | 4 |
| Jachez, B | 1 |
| Nordmann, R | 1 |
| Nakamura, S | 1 |
| Tajima, K | 1 |
| Hagiwara, M | 1 |
| Hidaka, H | 1 |
| Galimberti, S | 1 |
| Bianchi, F | 1 |
| Bernardini, N | 1 |
| Dolfi, A | 1 |
| Lupetti, M | 1 |
| Dong, J | 1 |
| Naito, M | 3 |
| Tatsuta, T | 1 |
| Seimiya, H | 1 |
| Johdo, O | 1 |
| Pajeva, IK | 1 |
| Wiese, M | 1 |
| Cordes, HP | 1 |
| Seydel, JK | 1 |
| Quesada, AR | 2 |
| Barbacid, MM | 1 |
| Mira, E | 1 |
| Aracil, M | 1 |
| Márquez, G | 1 |
| Homolya, L | 1 |
| Holló, M | 1 |
| Müller, M | 1 |
| Mechetner, EB | 1 |
| Sarkadi, B | 1 |
| García Grávalos, MD | 1 |
| Fernández Puentes, JL | 1 |
| Nakashima, E | 1 |
| Matsushita, R | 1 |
| Negishi, H | 1 |
| Nomura, M | 1 |
| Harada, S | 1 |
| Yamamoto, H | 1 |
| Ichimura, F | 1 |
| Elstad, CA | 1 |
| Thrall, BD | 1 |
| Raha, G | 1 |
| Meadows, GG | 1 |
| Ayesh, S | 2 |
| Lyubimov, E | 1 |
| Algour, N | 1 |
| Stein, WD | 2 |
| Shao, YM | 1 |
| Noviello, E | 1 |
| Allievi, E | 1 |
| Russo, P | 1 |
| Parodi, S | 1 |
| Nanaumi, K | 1 |
| Tsuchida, K | 1 |
| Nakaike, S | 2 |
| Yamagishi, T | 2 |
| Ichihara, T | 1 |
| Takahashi, K | 1 |
| Watajima, H | 1 |
| Suzuki, Y | 1 |
| Etievant, C | 1 |
| Barret, JM | 1 |
| Kruczynski, A | 1 |
| Perrin, D | 1 |
| Hill, BT | 1 |
| Sugiyama, T | 1 |
| Anstett, M | 1 |
| Pérez, V | 1 |
| Genton, A | 1 |
| Bizzari, JP | 1 |
| Soto, F | 2 |
| Canaves, JM | 1 |
| Gonzalez-Ros, JM | 2 |
| Ferragut, JA | 2 |
| García-Segura, LM | 1 |
| Planells-Cases, R | 1 |
| Donenko, FV | 5 |
| Efferth, T | 1 |
| Mattern, J | 1 |
| Moroz, LV | 5 |
| Volm, M | 1 |
| Sato, W | 1 |
| Fukazawa, N | 1 |
| Suzuki, T | 1 |
| Yusa, K | 1 |
| Pourtier-Manzanedo, A | 1 |
| Kabieva, AO | 2 |
| Borovkova, NB | 4 |
| Ramu, A | 3 |
| Ramu, N | 3 |
| Gorodetsky, R | 1 |
| Rosario, LM | 1 |
| Badiner, GJ | 1 |
| Moy, BC | 1 |
| Smith, KS | 1 |
| Tarpley, WG | 1 |
| Groppi, VE | 1 |
| Bhuyan, BK | 1 |
| Takamori, R | 1 |
| Tsukahara, S | 1 |
| Yamabe-Mitsuhashi, J | 1 |
| Yamazaki, A | 1 |
| Oh-hara, T | 1 |
| Adwankar, MK | 1 |
| Chitnis, MP | 2 |
| Sitdikova, SM | 3 |
| Yagen, B | 1 |
| Vayuvegula, B | 1 |
| Meador, J | 1 |
| Gupta, S | 1 |
| Bose, R | 1 |
| Lam, HY | 1 |
| Radel, S | 1 |
| Bankusli, I | 1 |
| Mayhew, E | 1 |
| Rustum, YM | 1 |
| Kramer, RA | 1 |
| Zakher, J | 1 |
| Kim, G | 1 |
| Sehested, M | 1 |
| van Deurs, B | 1 |
| Winther-Nielsen, H | 1 |
| McGown, A | 1 |
| Poppitt, DG | 1 |
| Fox, BW | 1 |
| Slater, LM | 1 |
| Murray, SL | 1 |
| Wetzel, MW | 1 |
| Streeter, DG | 2 |
| Johl, JS | 1 |
| Gordon, GR | 1 |
| Peters, JH | 2 |
| Yamaguchi, T | 1 |
| Nakagawa, M | 1 |
| Shiraishi, N | 1 |
| Yoshida, T | 1 |
| Kiyosue, T | 1 |
| Arita, M | 1 |
| Akiyama, S | 1 |
| Kuwano, M | 1 |
| Pradhan, SG | 1 |
| Basrur, VS | 1 |
| Tantri, SK | 1 |
| Ross, DD | 1 |
| Joneckis, CC | 1 |
| Schiffer, CA | 1 |
| Capranico, G | 1 |
| Dasdia, T | 1 |
| Zunino, F | 1 |
| Sauerteig, A | 1 |
| Gordon, K | 1 |
| Swinkin, C | 1 |
| Taylor, DL | 1 |
| Acton, EM | 1 |
| Kawabata, H | 1 |
| Nagumo, N | 1 |
| Kitatani, Y | 1 |
| Borowitz, JL | 1 |
| Hadley, R | 1 |
| Stebbins, G | 1 |
3 reviews available for verapamil and Leukemia P388
| Article | Year |
|---|---|
Chemosensitizers counteracting acquired resistance to anthracyclines and vinca alkaloids in vivo. A new treatment principle.
Topics: Animals; Antibiotics, Antineoplastic; Calcium Channel Blockers; Calmodulin; Carcinoma, Ehrlich Tumor | 1984 |
[Development of drugs to overcome drug resistance--basic approaches].
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporin | 1995 |
[MDR reversing drugs for clinical development].
Topics: Animals; Antineoplastic Agents; Cyclosporins; Doxorubicin; Drug Resistance; Drug Synergism; Humans; | 1994 |
74 other studies available for verapamil and Leukemia P388
| Article | Year |
|---|---|
New triazine derivatives as potent modulators of multidrug resistance.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; | 1992 |
Novel inhibitors for multidrug resistance: 1,3,5-triazacycloheptanes.
Topics: Animals; Antineoplastic Agents; Azepines; Cisplatin; Cycloheptanes; Doxorubicin; Drug Resistance, Mu | 1995 |
New purines and purine analogs as modulators of multidrug resistance.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Cha | 1996 |
Modulation of multidrug resistance by taxuspine C and other taxoids from Japanese yew.
Topics: Animals; Bridged-Ring Compounds; Carcinoma, Squamous Cell; Drug Resistance, Multiple; Drug Resistanc | 1998 |
Reversal of anticancer drug resistance by macrolide antibiotics in vitro and in vivo.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Bindin | 2000 |
Classification of multidrug-resistance reversal agents using structure-based descriptors and linear discriminant analysis.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Doxorubicin; Drug Resistance, Multiple; | 2000 |
Effects of xanthine derivatives on the influx and efflux of doxorubicin in P388 and DOX-resistant P388 leukemia cells.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Cha | 2002 |
Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cass | 2005 |
P-glycoprotein in proteoliposomes with low residual detergent: the effects of cholesterol.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cholest | 2007 |
Mode of action of calcium antagonists which alter anthracycline resistance.
Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Calcium Channel Blockers; Cell Line; Dau | 1984 |
Effects of verapamil on daunomycin cellular retention and cytotoxicity in P388 leukemic cells.
Topics: Animals; Biological Transport; Cell Survival; Daunorubicin; Drug Resistance; Kinetics; Leukemia P388 | 1984 |
Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.
Topics: Animals; Calcium Channel Blockers; Calcium-Binding Proteins; Calmodulin; Clomipramine; Doxorubicin; | 1982 |
Enhancement of vincristine- and adriamycin-induced cytotoxicity by verapamil in P388 leukemia and its sublines resistant to vincristine and adriamycin.
Topics: Animals; Doxorubicin; Drug Resistance; Leukemia P388; Leukemia, Experimental; Mice; Verapamil; Vincr | 1982 |
N-alkylated 1,4-dihydropyridines: new agents to overcome multidrug resistance.
Topics: Alkylation; Animals; Chemical Phenomena; Chemistry, Physical; Dihydropyridines; Drug Resistance, Mul | 1995 |
Dyes providing increased sensitivity in flow-cytometric dye-efflux assays for multidrug resistance.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Burkitt Lymphoma; Calcium Channel | 1995 |
Comparison of cyclosporin A, verapamil, PSC-833 and cremophor EL as enhancing agents of VP-16 in murine lymphoid leukemias.
Topics: Animals; Cell Survival; Cyclosporine; Cyclosporins; Drug Synergism; Etoposide; Glycerol; Leukemia L1 | 1995 |
Antitumour effects and pharmacokinetics of combination of vinblastine with a staurosporine derivative, NA-382, in P388/ADR-bearing mice.
Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Resistance, Mu | 1995 |
Evaluation of resistance index of several anticancer agents on parental and resistant P-388 cell lines.
Topics: Animals; Biological Transport; DNA Replication; Dose-Response Relationship, Drug; Doxorubicin; Drug | 1995 |
Extent and persistence of P-glycoprotein inhibition in multidrug-resistant P388 cells after exposure to resistance-modifying agents.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, | 1994 |
Doxorubicin resistance in human melanoma cells: MDR-1 and glutathione S-transferase pi gene expression.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Death; Cell Division; Cell Li | 1993 |
Restoration of taxol sensitivity of multidrug-resistant cells by the cyclosporine SDZ PSC 833 and the cyclopeptolide SDZ 280-446.
Topics: Animals; Antineoplastic Agents; CHO Cells; Cricetinae; Cyclosporins; Drug Resistance; Leukemia P388; | 1993 |
Effects of isoquinolinesulphonamide compounds on multidrug-resistant P388 cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Division; C | 1993 |
Scanning electron microscopy of multidrug resistant cells in haematological and mammary malignancies.
Topics: Acute Disease; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blast Crisis; Breas | 1993 |
Difference between the resistance mechanisms of aclacinomycin- and adriamycin-resistant P388 cell lines.
Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Me | 1995 |
Membrane interactions of some catamphiphilic drugs and relation to their multidrug-resistance-reversing ability.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Breast Neoplasms; Calorimetry, Differential Scanning; D | 1996 |
Chemosensitization and drug accumulation assays as complementary methods for the screening of multidrug resistance reversal agents.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; ATP Binding C | 1996 |
A new method for a quantitative assessment of P-glycoprotein-related multidrug resistance in tumour cells.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Tr | 1996 |
Polyaromatic alkaloids from marine invertebrates as cytotoxic compounds and inhibitors of multidrug resistance caused by P-glycoprotein.
Topics: Adenocarcinoma; Alkaloids; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemoth | 1996 |
Reversal of drug sensitivity in MDR subline of P388 leukemia by gene-targeted antisense oligonucleotide.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequen | 1995 |
Tyrosine and phenylalanine restriction sensitizes adriamycin-resistant P388 leukemia cells to adriamycin.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Doxorubicin; Drug Resistance, Neoplasm; Leuk | 1996 |
Reversal of P-glycoprotein is greatly reduced by the presence of plasma but can be monitored by an ex vivo clinical assay.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunorubicin; Drug S | 1996 |
Mutually co-operative interactions between modulators of P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Daunorubicin; Drug Resistance, Mul | 1997 |
Effects of Dex-Verapamil on Doxorubicin cytotoxicity in P388 murine leukemia cells.
Topics: Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Res | 1997 |
Overcoming of multidrug resistance by VA-033, a novel derivative of apovincaminic acid ester.
Topics: Animals; Cardiovascular System; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Drug Resi | 1997 |
Vinflunine (20',20'-difluoro-3',4'-dihydrovinorelbine), a novel Vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 1998 |
Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; ATP Bind | 2000 |
Effects of a new triazinoaminopiperidine derivative on adriamycin accumulation and retention in cells displaying P-glycoprotein-mediated multidrug resistance.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Membe | 1992 |
Rapid kinetics of the interaction between daunomycin and drug-sensitive or drug-resistant P388 leukemia cells.
Topics: Animals; Biological Transport; Cell Membrane; Cell Membrane Permeability; Daunorubicin; Drug Resista | 1992 |
Verapamil reverses the ultrastructural alterations in the plasma membrane induced by drug resistance.
Topics: Animals; Cell Membrane; Daunorubicin; Drug Resistance; Freeze Fracturing; Leukemia P388; Membrane Gl | 1992 |
Resistance to doxorubicin in tumor cells in vitro and in vivo after pretreatment with verapamil.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Resistance; Leuk | 1991 |
Circumvention of multidrug resistance by a newly synthesized quinoline derivative, MS-073.
Topics: Affinity Labels; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Trans | 1991 |
FK-506 (fujimycin) reverses the multidrug resistance of tumor cells in vitro.
Topics: Amiodarone; Animals; Antibiotics, Antineoplastic; Cyclosporine; Doxorubicin; Drug Resistance; Leukem | 1991 |
[Changes in glutathione-S-transferase activity during induction of resistance of leukemia P 388 and Ehrlich ascitic tumor cells to doxorubicin].
Topics: Animals; Carcinoma, Ehrlich Tumor; Doxorubicin; Drug Resistance; Glutathione Transferase; Leukemia P | 1991 |
Reduced ouabain-sensitive potassium entry as a possible mechanism of multidrug-resistance in P388 cells.
Topics: Animals; Cell Division; Cell Membrane; Drug Resistance; Leukemia P388; Membrane Potentials; Mice; Ou | 1991 |
Circumvention of multidrug-resistance in P388 cells is associated with a rise in the cellular content of phosphatidylcholine.
Topics: Animals; Cell Membrane; Cell Membrane Permeability; Choline; Digitonin; Dipyridamole; Drug Resistanc | 1991 |
Rapid determination of cellular resistance-related drug efflux in tumor cells.
Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Chlorpromazine; Doxorubicin; Drug Resist | 1990 |
P388 leukaemia cells resistant to the anthracycline menogaril lack multidrug resistant phenotype.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Dose-Response Relatio | 1990 |
A benzophenazine derivative, N-beta-dimethylaminoethyl 9-carboxy-5-hydroxy-10-methoxy-benzo[a]phenazine-6-carboxamide, as a new antitumor agent against multidrug-resistant and sensitive tumors.
Topics: Animals; Antineoplastic Agents; Cell Membrane; Doxorubicin; Drug Resistance; Drug Screening Assays, | 1990 |
Modulation of in vitro chemosensitivity by extracellular Ca++ in adriamycin sensitive and resistant P388 leukemic cells.
Topics: Animals; Calcium; DNA, Neoplasm; Doxorubicin; Drug Resistance; Leukemia P388; Leukemia, Experimental | 1990 |
Verapamil effect on the accumulation of doxorubicin in the leukemia P388 cells with induced antibiotic resistance.
Topics: Animals; Doxorubicin; Drug Resistance, Microbial; Leukemia P388; Leukemia, Experimental; Male; Mice; | 1990 |
[The effect of finoptin on doxorubicin accumulation in leukemia P-388 cells with induced resistance to the combination of finoptin and doxorubicin].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Interactions; Drug Resist | 1990 |
[The effect of finoptin on the accumulation of doxorubicin in leukemia P388 cells with induced resistance to the antibiotic].
Topics: Animals; Doxorubicin; Drug Interactions; Drug Resistance, Microbial; Drug Screening Assays, Antitumo | 1989 |
The cytotoxicity of T-2 toxin and related 12,13-epoxytrichothecenes to Adriamycin-sensitive and -resistant P388 leukemia cells.
Topics: Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Doxorubicin; Drug Resi | 1989 |
Interactions among membrane transport systems: anthracyclines, calcium antagonists and anti-estrogens.
Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Calcium Channel Blockers; Daunorubicin; | 1986 |
Correction of altered plasma membrane potentials. A possible mechanism of cyclosporin A and verapamil reversal of pleiotropic drug resistance in neoplasia.
Topics: Animals; Antineoplastic Agents; Calcium; Cell Line; Cell Membrane; Cyclosporins; Drug Resistance; Le | 1988 |
Membrane transport changes in an adriamycin-resistant murine leukemia cell line and in its sensitive parental cell line.
Topics: Animals; Biological Transport; Cell Membrane; Doxorubicin; Drug Resistance; Leukemia P388; Leukemia, | 1988 |
The effects of verapamil and a tiapamil analogue, DMDP, on adriamycin-induced cytotoxicity in P388 adriamycin-resistant and -sensitive leukemia in vitro and in vivo.
Topics: Animals; Calcium Channel Blockers; Doxorubicin; Drug Resistance; Drug Synergism; Female; Glycoprotei | 1988 |
Role of the glutathione redox cycle in acquired and de novo multidrug resistance.
Topics: Animals; Carmustine; Colonic Neoplasms; Doxorubicin; Drug Resistance; Glutathione; Glutathione Perox | 1988 |
Increased plasma membrane traffic in daunorubicin resistant P388 leukaemic cells. Effect of daunorubicin and verapamil.
Topics: Animals; Cell Membrane; Daunorubicin; Drug Resistance; Endocytosis; Exocytosis; Female; Leukemia P38 | 1987 |
Comparison of daunorubicin and anthrapyrazolone sensitivity and transport in resistant cell lines.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Daunorubicin; Dose-Response Relationship, Drug; Drug | 1987 |
Verapamil potentiation of VP-16-213 in acute lymphatic leukemia and reversal of pleiotropic drug resistance.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Daunorubicin; Dose-Response Relation | 1986 |
Effects of cytochalasins and colchicine on the accumulation and retention of daunomycin and vincristine in drug resistant tumor cells.
Topics: Animals; Cell Line; Cell Survival; Colchicine; Cytochalasin B; Cytochalasin D; Cytochalasins; Daunor | 1986 |
Uptake and retention of morpholinyl anthracyclines by adriamycin-sensitive and -resistant P388 cells.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line; Doxorubicin; Drug Resistance; Leukemia P388; Leukem | 1986 |
Overcoming drug resistance in cancer cells with synthetic isoprenoids.
Topics: Animals; Antineoplastic Agents; Calcium; Doxorubicin; Drug Resistance; Ethylenediamines; Lethal Dose | 1986 |
Flow cytometric monitoring of anthracycline transport in tumor cells.
Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Chlorpromazine; Daunorubicin; Flow Cytom | 1986 |
Acquired vs innate multidrug resistance and the effect of calcium channel blockers.
Topics: Animals; Antineoplastic Agents; Calcium Channel Blockers; Cell Line; Doxorubicin; Drug Resistance; D | 1986 |
Modulation of in vitro response to adriamycin by verapamil in murine P388 leukaemia, Ehrlich ascites carcinoma and sarcoma 180.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Cell Survival; Depression, Chemical; DNA, Neoplasm; Do | 1987 |
Effects of verapamil on in vitro intracellular accumulation and retention of daunorubicin in blast cells from patients with acute nonlymphocytic leukemia.
Topics: Acute Disease; Animals; Bone Marrow; Daunorubicin; Drug Resistance; Humans; In Vitro Techniques; Kin | 1986 |
Comparison of doxorubicin-induced DNA damage in doxorubicin-sensitive and -resistant P388 murine leukemia cells.
Topics: Animals; Cell Line; DNA; Doxorubicin; Drug Resistance; Leukemia P388; Leukemia, Experimental; Mathem | 1986 |
Flow cytometric monitoring of cellular anthracycline accumulation in murine leukemic cells.
Topics: Animals; Biological Transport; Cell Line; Chlorpromazine; Daunorubicin; Doxorubicin; Flow Cytometry; | 1986 |
Comparative cytotoxicities of various morpholinyl anthracyclines.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Doxorubicin; Drug Resistance; Drug Synergi | 1985 |
Cure of mice bearing P388 leukemia by vincristine in combination with a calcium channel blocker.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Leukemia P388; Leukemia, Experimental; Mice | 1985 |
Potentiation of antitumor agents by calcium channel blockers with special reference to cross-resistance patterns.
Topics: Animals; Antineoplastic Agents; Calcium Channel Blockers; Cell Line; Doxorubicin; Drug Resistance; D | 1985 |
Effects of calcium and verapamil on normal and tumor murine leukocytes.
Topics: Animals; Calcium; Chlorpromazine; Ethanol; Leukemia P388; Leukemia, Experimental; Leukocytes; Mice; | 1985 |