verapamil has been researched along with Leukemia L 1210 in 25 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of calcium antagonist verapamil on the uptake and efflux of Etoposide (VP16), a semi-synthetic derivative of podophylotoxin and a broad spectrum antineoplastic agent, has been investigated and compared in sensitive (UM-UC-2) and resistant (UM-UC-9) human bladder cancer cells, and L1210 leukemia cells, by using both radioisotope (3[H]-VP16) liquid scintillation and high performance liquid chromatography assay with electrochemical detection." | 3.68 | Effect of verapamil on the uptake and efflux of etoposide (VP16) in both sensitive and resistant cancer cells. ( Feng, MR; Grossman, HB; Liebert, M; Mancini, WR; Wagner, JG; Wedemeyer, G; Williams, M, 1991) |
| "Treatment with verapamil (VRP) reduced the resistance to tallimustine, but not to MEN 10710, in MCF7/DX cells." | 1.30 | Cytotoxic and antitumor activity of MEN 10710, a novel alkylating derivative of distamycin. ( Animati, F; Bigioni, M; Lombardi, P; Manzini, S; Palma, C; Pratesi, G; Salvatore, C; Supino, R; Zunino, F, 1997) |
| " Since IAHQ has only modest activity against L1210 leukemia in mice, it was tested in combination with methotrexate (MTX), probenecid, or verapamil in an effort to enhance efficacy." | 1.27 | Effects of 5,8-dideazaisopteroylglutamate (IAHQ) on L1210 leukemia in mice when given alone and in combination with methotrexate, probenecid, or verapamil. ( Gale, GR; Hynes, JB; Smith, AB, 1986) |
| "Verapamil-mediated increase in net VP-16 transport was rapid (1 to 2 min), and allowed for the same elevation of steady-state VP-16 concentration, whether verapamil was added simultaneously with VP-16 or was added after a steady-state level of VP-16 was achieved." | 1.27 | Verapamil-induced augmentation of etoposide accumulation in L1210 cells in vitro. ( Ross, WE; Yalowich, JC, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (32.00) | 18.7374 |
| 1990's | 14 (56.00) | 18.2507 |
| 2000's | 1 (4.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kobayashi, J | 1 |
| Hosoyama, H | 1 |
| Wang, XX | 1 |
| Shigemori, H | 1 |
| Sudo, Y | 1 |
| Tsuruo, T | 1 |
| Breier, A | 5 |
| Stetka, J | 1 |
| Bohacova, V | 1 |
| Macejova, D | 1 |
| Brtko, J | 1 |
| Sulova, Z | 3 |
| Gibalová, L | 2 |
| Sereš, M | 2 |
| Rusnák, A | 1 |
| Ditte, P | 1 |
| Labudová, M | 1 |
| Uhrík, B | 2 |
| Pastorek, J | 1 |
| Sedlák, J | 1 |
| Orlický, J | 1 |
| Fiala, R | 1 |
| Dovinová, I | 1 |
| Yalowich, JC | 2 |
| Ross, WE | 2 |
| Slater, L | 1 |
| Sweet, P | 2 |
| Wetzel, M | 1 |
| Stupecky, M | 2 |
| Osann, K | 1 |
| Pommerenke, E | 1 |
| Mattern, J | 2 |
| Volm, M | 3 |
| Ishikawa, T | 1 |
| Ali-Osman, F | 1 |
| Barancík, M | 2 |
| Stefanková, Z | 1 |
| Bigioni, M | 1 |
| Salvatore, C | 1 |
| Palma, C | 1 |
| Manzini, S | 1 |
| Animati, F | 1 |
| Lombardi, P | 1 |
| Pratesi, G | 1 |
| Supino, R | 1 |
| Zunino, F | 1 |
| Drobná, Z | 1 |
| Desbene, S | 1 |
| Van, HD | 1 |
| Michel, S | 1 |
| Tillequin, F | 1 |
| Koch, M | 1 |
| Schmidt, F | 1 |
| Florent, JC | 1 |
| Monneret, C | 1 |
| Straub, R | 1 |
| Czech, J | 1 |
| Gerken, M | 1 |
| Bosslet, K | 1 |
| Henderson, GB | 1 |
| Lazo, JS | 1 |
| Schisselbauer, JC | 1 |
| Herring, GM | 1 |
| Kennedy, KA | 1 |
| Feng, MR | 1 |
| Liebert, M | 1 |
| Wedemeyer, G | 1 |
| Grossman, HB | 1 |
| Mancini, WR | 1 |
| Williams, M | 1 |
| Wagner, JG | 1 |
| Pommerenke, EW | 2 |
| Traugott, U | 1 |
| Sirotnak, FM | 1 |
| O'Leary, DF | 1 |
| Osswald, H | 1 |
| Hahn, EW | 1 |
| Vassilev, PM | 1 |
| Kanazirska, MP | 1 |
| Charamella, LJ | 1 |
| Dimitrov, NV | 1 |
| Tien, HT | 1 |
| Roberts, DW | 1 |
| Foglesong, PD | 1 |
| Parganas, E | 2 |
| Wiggins, L | 2 |
| Slater, LM | 1 |
| Murray, SL | 1 |
| Wetzel, MW | 1 |
| Rustum, YM | 1 |
| Radel, S | 1 |
| Campbell, J | 1 |
| Mayhew, E | 1 |
| Roberts, D | 1 |
| Lee, T | 1 |
| Yalowich, J | 1 |
| Ashmun, R | 1 |
| Hynes, JB | 1 |
| Smith, AB | 1 |
| Gale, GR | 1 |
25 other studies available for verapamil and Leukemia L 1210
| Article | Year |
|---|---|
Modulation of multidrug resistance by taxuspine C and other taxoids from Japanese yew.
Topics: Animals; Bridged-Ring Compounds; Carcinoma, Squamous Cell; Drug Resistance, Multiple; Drug Resistanc | 1998 |
Effect of 9-cis retinoic acid and all-trans retinoic acid in combination with verapamil on P-glycoprotein expression in L1210 cells.
Topics: Alitretinoin; Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Leukemia | 2014 |
P-glycoprotein depresses cisplatin sensitivity in L1210 cells by inhibiting cisplatin-induced caspase-3 activation.
Topics: Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 2012 |
Expression of P-glycoprotein in L1210 cells is linked with rise in sensitivity to Ca2+.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter | 2005 |
Potentiation of etoposide-induced DNA damage by calcium antagonists in L1210 cells in vitro.
Topics: Animals; Cell Division; Cell Nucleus; Cell Survival; DNA Replication; DNA, Neoplasm; Drug Synergism; | 1984 |
Comparison of cyclosporin A, verapamil, PSC-833 and cremophor EL as enhancing agents of VP-16 in murine lymphoid leukemias.
Topics: Animals; Cell Survival; Cyclosporine; Cyclosporins; Drug Synergism; Etoposide; Glycerol; Leukemia L1 | 1995 |
Modulation of doxorubicin-toxicity by tamoxifen in multidrug-resistant tumor cells in vitro and in vivo.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Female; Leukemia | 1994 |
Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Cell Membrane; Chloramphenicol O-Acetyltransf | 1993 |
Effect of phorbol myristate acetate (PMA) on P-glycoprotein mediated vincristine resistance of L1210 cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Surviva | 1995 |
Cytotoxic and antitumor activity of MEN 10710, a novel alkylating derivative of distamycin.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Calcium Channel Blockers; Cell Su | 1997 |
Direct interaction between verapamil and doxorubicin causes the lack of reversal effect of verapamil on P-glycoprotein mediated resistance to doxorubicin in vitro using L1210/VCR cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, | 1998 |
Application of the ADEPT strategy to the MDR resistance in cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Dipyridamole; Doxorubicin; Dru | 1999 |
Separation and inhibitor specificity of a second unidirectional efflux route for methotrexate in L1210 cells.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Le | 1992 |
Involvement of the cellular vacuolar system with the cytotoxicity of bleomycin-like agents.
Topics: Animals; Bleomycin; Cell Nucleus; Cell Survival; Diltiazem; DNA Damage; Hydrogen-Ion Concentration; | 1990 |
Effect of verapamil on the uptake and efflux of etoposide (VP16) in both sensitive and resistant cancer cells.
Topics: Animals; Carcinoma, Transitional Cell; Culture Media; Drug Resistance; Etoposide; Glucose; Humans; K | 1991 |
[Reversal of multidrug resistance with (R)-verapamil in vitro and in vivo].
Topics: Animals; Antineoplastic Agents; Cytarabine; Doxorubicin; Drug Resistance; Female; Leukemia L1210; Mi | 1991 |
The issues of transport multiplicity and energetics pertaining to methotrexate efflux in L1210 cells addressed by an analysis of cis and trans effects of inhibitors.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Energy Metabolism; Leukemia L1210; Methotrexa | 1991 |
Activity of various amphiphilic agents in reversing multidrug resistance of L 1210 cells.
Topics: Animals; Drug Resistance; Ethylamines; Hycanthone; Leukemia L1210; Phenotype; Piperidines; Quinidine | 1990 |
Changes in calcium channel activity in membranes from cis-diammine-dichloroplatinum(II)-resistant and -sensitive L1210 cells.
Topics: Animals; Calcium; Cell Line; Cell Membrane; Cell-Free System; Cisplatin; Drug Resistance; Ion Channe | 1987 |
Reduced formation of lesions in the DNA of a multidrug-resistant L1210 subline selected for teniposide resistance.
Topics: Animals; DNA; DNA Damage; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Leukemia L1210; | 1989 |
Verapamil potentiation of VP-16-213 in acute lymphatic leukemia and reversal of pleiotropic drug resistance.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Daunorubicin; Dose-Response Relation | 1986 |
Approaches to overcome in vivo anti-cancer drug resistance.
Topics: 3-Deazauridine; Animals; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Cell Line; Cy | 1986 |
Expressions of resistance and cross-resistance in teniposide-resistant L1210 cells.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line; Cyanides; Drug Resistance; Leukemia L1210; Li | 1987 |
Effects of 5,8-dideazaisopteroylglutamate (IAHQ) on L1210 leukemia in mice when given alone and in combination with methotrexate, probenecid, or verapamil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Folic Acid Antagonists; Leukemia L1210; Mal | 1986 |
Verapamil-induced augmentation of etoposide accumulation in L1210 cells in vitro.
Topics: Animals; Cells, Cultured; DNA Repair; Drug Synergism; Etoposide; Leukemia L1210; Mice; Podophyllotox | 1985 |