verapamil has been researched along with Leukemia, T-Cell in 8 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Leukemia, T-Cell: A malignant disease of the T-LYMPHOCYTES in the bone marrow, thymus, and/or blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This fact permits the use of high Drol Z dosage in order to achieve a relevant modulating effect in vivo and to use this drug in combination with a further modulator so as to reach maximum efficacy with tolerable side effects." | 1.30 | In vitro efficacy of known P-glycoprotein modulators compared to droloxifene E and Z: studies on a human T-cell leukemia cell line and their resistant variants. ( Gieseler, F; Gullis, E; Hasmann, M; Löser, R; Nüssler, V; Pelka-Fleisc, R; Stötzer, O; Wilmanns, W; Zwierzina, H, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (87.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tajima, Y | 1 |
| Nakagawa, H | 1 |
| Tamura, A | 1 |
| Kadioglu, O | 1 |
| Satake, K | 1 |
| Mitani, Y | 1 |
| Murase, H | 1 |
| Regasini, LO | 1 |
| Bolzani, Vda S | 1 |
| Ishikawa, T | 1 |
| Fricker, G | 1 |
| Efferth, T | 1 |
| Soudon, J | 1 |
| Berlion, M | 1 |
| Lucas, C | 1 |
| Haddad, P | 1 |
| Bizzari, JP | 1 |
| Calvo, F | 1 |
| Principe, P | 1 |
| Faussat-Suberville, AM | 1 |
| Coulomb, H | 1 |
| Marie, JP | 1 |
| Braquet, P | 1 |
| Hill, BT | 1 |
| Hosking, LK | 1 |
| Didier, A | 1 |
| Wenger, J | 1 |
| Loor, F | 1 |
| Davey, MW | 1 |
| Hargrave, RM | 1 |
| Davey, RA | 1 |
| Kantharidis, P | 1 |
| El-Osta, A | 1 |
| deSilva, M | 1 |
| Wall, DM | 1 |
| Hu, XF | 1 |
| Slater, A | 1 |
| Nadalin, G | 1 |
| Parkin, JD | 1 |
| Zalcberg, JR | 1 |
| Nüssler, V | 1 |
| Pelka-Fleisc, R | 1 |
| Gieseler, F | 1 |
| Hasmann, M | 1 |
| Löser, R | 1 |
| Gullis, E | 1 |
| Stötzer, O | 1 |
| Zwierzina, H | 1 |
| Wilmanns, W | 1 |
1 trial available for verapamil and Leukemia, T-Cell
| Article | Year |
|---|---|
In vitro activity of S 9788 on a multidrug-resistant leukemic cell line and on normal hematopoietic cells-reversal of multidrug resistance by sera from phase I-treated patients.
Topics: Antineoplastic Agents; Bone Marrow Cells; Cell Division; Cell Line; Cell Survival; Culture Media; Do | 1995 |
7 other studies available for verapamil and Leukemia, T-Cell
| Article | Year |
|---|---|
Nitensidine A, a guanidine alkaloid from Pterogyne nitens, is a novel substrate for human ABC transporter ABCB1.
Topics: Adenosine Triphosphatases; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subf | 2014 |
Flow cytometric monitoring of anthracycline accumulation after anti-neoplastic ether phospholipid treatment.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunor | 1994 |
Differential effectiveness of a range of novel drug-resistance modulators, relative to verapamil, in influencing vinblastine or teniposide cytotoxicity in human lymphoblastoid CCRF-CEM sublines expressing classic or atypical multidrug resistance.
Topics: Cyclosporine; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance; Drug Screening As | 1994 |
Decreased uptake of cyclosporin A by P-glycoprotein (Pgp) expressing CEM leukemic cells and restoration of normal retention by Pgp blockers.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporin | 1995 |
Comparison of drug accumulation in P-glycoprotein-expressing and MRP-expressing human leukaemia cells.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subf | 1996 |
Altered methylation of the human MDR1 promoter is associated with acquired multidrug resistance.
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azacitidin | 1997 |
In vitro efficacy of known P-glycoprotein modulators compared to droloxifene E and Z: studies on a human T-cell leukemia cell line and their resistant variants.
Topics: Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassett | 1998 |