Page last updated: 2024-10-24

verapamil and Left Ventricular Dysfunction

verapamil has been researched along with Left Ventricular Dysfunction in 30 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Research Excerpts

ExcerptRelevanceReference
"To review the safety and efficacy of verapamil and diltiazem with respect to ventricular response in atrial fibrillation (AF) in the setting of left ventricular (LV) systolic dysfunction."3.69Calcium channel blockers for heart rate control in atrial fibrillation complicated by congestive heart failure. ( Heywood, JT, 1995)
"Patients with heart failure are particularly susceptible to the negative effects of calcium channel blockers because the failing heart demonstrates a defect in the delivery of calcium to the contractile proteins, and an attenuation of the normal sympathetic reflexes."2.40[Calcium channel blockers in heart failure]. ( Dickstein, K; Gundersen, T; Hole, T; Kjekshus, J; Myhre, ES; Rønnevik, PK; Westheim, AS, 1997)
" In this case sustained ventricular tachycardia was developed suddenly a year later after ablation, despite the treatment with low dosage verapamil (80 mg/tid)."1.35A case report. A patient with idiopathic ventricular tachycardia. ( Avaliani, I; Kacharava, G; Rahmat, B; Venkata, KI, 2008)
"Idiopathic left ventricular tachycardia (ILVT) is a rare but well-recognized clinical entity."1.35Idiopathic left ventricular tachycardia in children. ( Jariyapongpaiboon, Y; Khongphatthanayothin, A; Promphan, W; Sirisopikun, T; Sitthisook, S; Suesaowalak, M; Sunsaneewttayakul, B, 2008)
"Idiopathic verapamil-sensitive left ventricular tachycardia (ILVT) is the most common form of idiopathic left ventricular tachycardia (VT)."1.32Comparison of presystolic purkinje and late diastolic potentials for selection of ablation site in idiopathic verapamil sensitive left ventricular tachycardia. ( Arya, A; Dehghani, MR; Emkanjoo, Z; Fazelifar, AF; Haghjoo, M; Heydari, A; Sadr-Ameli, MA, 2004)
"Idiopathic verapamil-responsive left ventricular tachycardia is an uncommon arrhythmia in childhood."1.30[Idiopathic left ventricular tachycardia in infancy: long-term control with verapamil]. ( Bartolomé, FB; Sánchez Fernández-Bernal, C, 1998)
"Verapamil-sensitive idiopathic left ventricular tachycardia (VT) is due to reentry with an excitable gap."1.30Significance of late diastolic potential preceding Purkinje potential in verapamil-sensitive idiopathic left ventricular tachycardia. ( Honda, T; Iwasa, A; Okumura, K; Tabuchi, T; Tsuchiya, T; Yasue, H, 1999)
"We report a case of an almost permanent ventricular tachycardia that occurred in a 39-year-old man a few weeks before admission to the hospital."1.29Chronic irregular idiopathic ventricular tachycardia with myocardial dysfunction suppressed by verapamil in an adult. ( Cachin, JC; Castaigne, A; Lellouche, D; Nghiem, DK; Perez, Y, 1994)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (40.00)18.2507
2000's14 (46.67)29.6817
2010's4 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Paraskevaidis, S1
Theofilogiannakos, EK1
Konstantinou, DM1
Mantziari, L1
Kefalidis, C1
Megarisiotou, A1
Sarafidou, A1
Styliadis, I1
Politi, L1
Monopoli, DE1
Sgura, FA1
Rossi, R1
Bursi, F1
Modena, MG1
Venkata, KI1
Rahmat, B1
Kacharava, G1
Avaliani, I1
Suesaowalak, M1
Khongphatthanayothin, A1
Sunsaneewttayakul, B1
Sirisopikun, T1
Promphan, W1
Jariyapongpaiboon, Y1
Sitthisook, S1
Sugishita, K1
Asakawa, M1
Usui, S1
Takahashi, T1
Kajimoto, K1
Imai, T1
Minami, Y1
Kasanuki, H1
Oghlakian, GO1
Sipahi, I1
Fang, JC1
Iskenderov, BG1
Sisina, ON1
Burmistrova, LF1
Arya, A1
Haghjoo, M1
Emkanjoo, Z1
Fazelifar, AF1
Dehghani, MR1
Heydari, A1
Sadr-Ameli, MA1
Mark, B1
Scheidt, T1
Zeymer, U1
Hsu, JT1
Lin, KH1
Luqman, N1
Sung, RJ1
Kuo, CT1
Nagai, T1
Suyama, K2
Shimizu, W2
Noda, T1
Satomi, K1
Kurita, T2
Aihara, N2
Kamakura, S2
Abu-Fanne, R1
Rott, D1
Klein, M1
Leitersdorf, E1
Pollak, A1
Yao, SY1
Chu, JM1
Fang, PH1
Zhang, KJ1
Ma, J1
Zhang, S1
Heywood, JT1
Perez, Y1
Lellouche, D1
Nghiem, DK1
Cachin, JC1
Castaigne, A1
Fan, J1
Zhang, Y1
Zhang, M1
Hansen, JF1
Tingsted, L1
Rasmussen, V1
Madsen, JK1
Jespersen, CM1
Fischer-Hansen, J1
Hole, T1
Dickstein, K1
Gundersen, T1
Kjekshus, J1
Myhre, ES1
Rønnevik, PK1
Westheim, AS1
Suzuki, M1
Cheng, CP1
Ohte, N1
Little, WC1
White, CM1
Kappos, KG1
Sideris, AM1
Kranidis, AJ1
Tsilias, KP1
Anthopoulos, LP1
Bartolomé, FB1
Sánchez Fernández-Bernal, C1
Tsuchiya, T2
Okumura, K2
Honda, T2
Iwasa, A1
Yasue, H1
Tabuchi, T1
Hung, MJ1
Cherng, WJ1
Wang, CH1
Kuo, LT1
Aiba, T1
Taguchi, A1
Feldman, J1
Laxer, I1
Yaretzky, A1
Maruyama, M1
Tadera, T1
Miyamoto, S1
Ino, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of Renal Sodium Excretion After Salt Loading in Heart Failure With Preserved Ejection Fraction[NCT03837470]Early Phase 114 participants (Actual)Interventional2019-05-06Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for verapamil and Left Ventricular Dysfunction

ArticleYear
Treatment of heart failure with preserved ejection fraction: have we been pursuing the wrong paradigm?
    Mayo Clinic proceedings, 2011, Volume: 86, Issue:6

    Topics: Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme

2011
[Calcium channel blockers in heart failure].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1997, Jun-20, Volume: 117, Issue:16

    Topics: Calcium Channel Blockers; Dihydropyridines; Diltiazem; Heart Failure; Humans; Ventricular Dysfunctio

1997
Calcium channel blockers in left ventricular dysfunction or congestive heart failure.
    Connecticut medicine, 1997, Volume: 61, Issue:10

    Topics: Amlodipine; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Felodipine; Heart Failure

1997
Idiopathic left ventricular tachycardia: clinical features, mechanisms and management.
    Cardiac electrophysiology review, 2002, Volume: 6, Issue:1-2

    Topics: Catheter Ablation; Heart Conduction System; Humans; Tachycardia, Ventricular; Ventricular Dysfunctio

2002

Trials

3 trials available for verapamil and Left Ventricular Dysfunction

ArticleYear
The morphology changes in limb leads after ablation of verapamil-sensitive idiopathic left ventricular tachycardia and their correlation with recurrence.
    Journal of cardiovascular electrophysiology, 2008, Volume: 19, Issue:3

    Topics: Adolescent; Adult; Catheter Ablation; Child; Electrocardiography; Female; Humans; Male; Middle Aged;

2008
The unnecessary controversy or lack of knowledge?
    European heart journal, 1997, Volume: 18, Issue:1

    Topics: Calcium Channel Blockers; Cause of Death; Diltiazem; Humans; Risk Factors; Survival Rate; Ventricula

1997
Effects of verapamil in normal elderly individuals with left ventricular diastolic dysfunction.
    Echocardiography (Mount Kisco, N.Y.), 2001, Volume: 18, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Calcium Channel Blockers; Cross-Over Studies; Diastole; Drug Adminis

2001

Other Studies

23 other studies available for verapamil and Left Ventricular Dysfunction

ArticleYear
Narrow QRS complex in idiopathic (fascicular) left ventricular tachycardia.
    Herz, 2015, Volume: 40, Issue:1

    Topics: Adult; Bundle-Branch Block; Calcium Channel Blockers; Diagnosis, Differential; Electrocardiography;

2015
Images in cardiovascular medicine. Spontaneous echocardiographic wall motion abnormalities in variant angina.
    Circulation, 2008, Jul-01, Volume: 118, Issue:1

    Topics: Angina Pectoris, Variant; Coronary Vasospasm; Echocardiography; Electrocardiography; Humans; Isosorb

2008
A case report. A patient with idiopathic ventricular tachycardia.
    Georgian medical news, 2008, Issue:164

    Topics: Adult; Anti-Arrhythmia Agents; Humans; Male; Tachycardia, Ventricular; Treatment Outcome; Ventricula

2008
Idiopathic left ventricular tachycardia in children.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2008, Volume: 91, Issue:11

    Topics: Adolescent; Anti-Arrhythmia Agents; Catheter Ablation; Child; Child, Preschool; Female; Heart Ventri

2008
A case of iron overload cardiomyopathy: beneficial effects of iron chelating agent and calcium channel blocker on left ventricular dysfunction.
    International heart journal, 2009, Volume: 50, Issue:6

    Topics: Aged, 80 and over; Calcium Channel Blockers; Cardiomyopathies; Deferoxamine; Ferritins; Humans; Iron

2009
Comparison of acute reduction in left ventricular outflow tract pressure gradient in obstructive hypertrophic cardiomyopathy by disopyramide versus pilsicainide versus cibenzoline.
    The American journal of cardiology, 2010, Nov-01, Volume: 106, Issue:9

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiomyopathy, Hypertrophic; Disopyramide; Echocardiography, D

2010
[Selection of rational combinations of indapamide with various of calcium antagonists in patients with arterial hypertension].
    Kardiologiia, 2011, Volume: 51, Issue:4

    Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulat

2011
Comparison of presystolic purkinje and late diastolic potentials for selection of ablation site in idiopathic verapamil sensitive left ventricular tachycardia.
    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2004, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Catheter Ablation; Child; Diastole; Electrocardiography;

2004
Large myocardial infarction and a severe spasm of the left coronary artery.
    Zeitschrift fur Kardiologie, 2004, Volume: 93, Issue:12

    Topics: Adult; Contrast Media; Coronary Angiography; Coronary Vasospasm; Diagnosis, Differential; Female; Fo

2004
Unusual features of an idiopathic ventricular tachycardia arising from the left ventricular outflow tract.
    Pacing and clinical electrophysiology : PACE, 2005, Volume: 28, Issue:2

    Topics: Adult; Anti-Arrhythmia Agents; Bundle-Branch Block; Cardiac Pacing, Artificial; Catheter Ablation; D

2005
Pilsicainide-induced verapamil sensitive idiopathic left ventricular tachycardia.
    Pacing and clinical electrophysiology : PACE, 2006, Volume: 29, Issue:5

    Topics: Adult; Anti-Arrhythmia Agents; Drug Combinations; Electrocardiography; Humans; Lidocaine; Male; Tach

2006
Recurrent apical ballooning despite treatment with verapamil.
    Cardiology, 2007, Volume: 108, Issue:3

    Topics: Aged; Calcium Channel Blockers; Cardiomyopathies; Coronary Angiography; Diagnosis, Differential; Ele

2007
Calcium channel blockers for heart rate control in atrial fibrillation complicated by congestive heart failure.
    The Canadian journal of cardiology, 1995, Volume: 11, Issue:9

    Topics: Atrial Fibrillation; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Female; Heart Fa

1995
Chronic irregular idiopathic ventricular tachycardia with myocardial dysfunction suppressed by verapamil in an adult.
    European heart journal, 1994, Volume: 15, Issue:10

    Topics: Adult; Cardiac Pacing, Artificial; Chronic Disease; Echocardiography; Electrocardiography; Electroca

1994
[Effects of verapamil on left ventricular diastolic dysfunction].
    Zhonghua nei ke za zhi, 1995, Volume: 34, Issue:6

    Topics: Adolescent; Adult; Aged; Calcium Channel Blockers; Cardiac Catheterization; Cardiomyopathy, Hypertro

1995
Verapamil and angiotensin-converting enzyme inhibitors in patients with coronary artery disease and reduced left ventricular ejection fraction.
    The American journal of cardiology, 1996, Jun-20, Volume: 77, Issue:16

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Coronary Disease; Drug Eva

1996
Left ventricular spherical dilation and regional contractile dysfunction in dogs with heart failure.
    The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 2

    Topics: Animals; Cardiac Pacing, Artificial; Dextrans; Dogs; Heart Failure; Heart Rate; Hemodynamics; Myocar

1997
Idiopathic left ventricular tachycardia due to reentry mechanism, cured during catheter manipulation.
    International journal of cardiology, 1997, Dec-19, Volume: 62, Issue:3

    Topics: Adolescent; Bundle-Branch Block; Cardiac Catheterization; Electrocardiography; Female; Heart Septum;

1997
[Idiopathic left ventricular tachycardia in infancy: long-term control with verapamil].
    Revista espanola de cardiologia, 1998, Volume: 51, Issue:3

    Topics: Anti-Arrhythmia Agents; Child, Preschool; Humans; Male; Tachycardia, Ventricular; Ventricular Dysfun

1998
Significance of late diastolic potential preceding Purkinje potential in verapamil-sensitive idiopathic left ventricular tachycardia.
    Circulation, 1999, May-11, Volume: 99, Issue:18

    Topics: Action Potentials; Adolescent; Adult; Bundle-Branch Block; Calcium Channel Blockers; Catheter Ablati

1999
The role of Purkinje and pre-Purkinje potentials in the reentrant circuit of verapamil-sensitive idiopathic LV tachycardia.
    Pacing and clinical electrophysiology : PACE, 2001, Volume: 24, Issue:3

    Topics: Adolescent; Adult; Bundle-Branch Block; Calcium Channel Blockers; Catheter Ablation; Electrocardiogr

2001
[Left ventricular outflow tract obstruction without left ventricular hypertrophy treated with ACE inhibitors].
    Harefuah, 1999, Nov-01, Volume: 137, Issue:9

    Topics: Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Echocardiography; Female; Heart F

1999
Demonstration of the reentrant circuit of verapamil-sensitive idiopathic left ventricular tachycardia: direct evidence for macroreentry as the underlying mechanism.
    Journal of cardiovascular electrophysiology, 2001, Volume: 12, Issue:8

    Topics: Adult; Anti-Arrhythmia Agents; Electrophysiologic Techniques, Cardiac; Heart Conduction System; Huma

2001