verapamil has been researched along with Ischemic Attack, Transient in 24 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Ischemic Attack, Transient: Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "(S)-Emopamil has a less potent calcium antagonistic effect (EC50 = 270 nmol/l) on the aorta than verapamil and gallopamil (EC50 = 35 and 14 nmol/l, respectively)." | 5.28 | (S)-emopamil, a novel calcium and serotonin antagonist for the treatment of cerebrovascular disorders. 1st communication: pharmacological profile. ( Hofmann, HP; Raschack, M; Unger, L, 1989) |
| "Various potential molecules with putative positive role in stroke pathology have failed to confer neuro-protection in animal models due to their insufficient bioavailability in brain." | 1.39 | Verapamil augments the neuroprotectant action of berberine in rat model of transient global cerebral ischemia. ( Chopra, K; Singh, DP, 2013) |
| "(S)-Emopamil is a calcium channel blocker of the phenylalkylamine class, having potent serotonin S2 antagonistic properties and high blood-brain barrier penetrability." | 1.28 | Postischemic (S)-emopamil therapy ameliorates focal ischemic brain injury in rats. ( Busto, R; Dietrich, WD; Duncan, RC; Ginsberg, MD; Morikawa, E, 1991) |
| "(S)-Emopamil has a less potent calcium antagonistic effect (EC50 = 270 nmol/l) on the aorta than verapamil and gallopamil (EC50 = 35 and 14 nmol/l, respectively)." | 1.28 | (S)-emopamil, a novel calcium and serotonin antagonist for the treatment of cerebrovascular disorders. 1st communication: pharmacological profile. ( Hofmann, HP; Raschack, M; Unger, L, 1989) |
| "Pretreatment with flunarizine significantly prevented the damage to Na+,K+-ATPase while the effect of verapamil was marginal." | 1.27 | Protective action of calcium channel blockers on Na+,K+-ATPase in gerbil cerebral cortex following ischemia. ( Christie-Pope, BC; Palmer, GC; Palmer, SJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (37.50) | 18.7374 |
| 1990's | 12 (50.00) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Jangholi, E | 1 |
| Sharifi, ZN | 1 |
| Hoseinian, M | 1 |
| Zarrindast, MR | 1 |
| Rahimi, HR | 1 |
| Mowla, A | 1 |
| Aryan, H | 1 |
| Javidi, MA | 1 |
| Parsa, Y | 1 |
| Ghaffarpasand, F | 1 |
| Yadollah-Damavandi, S | 1 |
| Arani, HZ | 1 |
| Shahi, F | 1 |
| Movassaghi, S | 1 |
| Singh, DP | 1 |
| Chopra, K | 1 |
| Cooper-Dehoff, R | 1 |
| Cohen, JD | 1 |
| Bakris, GL | 1 |
| Messerli, FH | 1 |
| Erdine, S | 1 |
| Hewkin, AC | 1 |
| Kupfer, S | 1 |
| Pepine, CJ | 1 |
| Ellrodt, AG | 1 |
| Singh, BN | 1 |
| Kamiya, K | 2 |
| Takagi, T | 1 |
| Fukuoka, H | 1 |
| Nagai, H | 1 |
| Hotta, K | 1 |
| Leblanc, R | 1 |
| Feindel, W | 1 |
| Yamamoto, L | 1 |
| Milton, JG | 1 |
| Frojmovic, MM | 1 |
| Reves, JG | 1 |
| Kissin, I | 1 |
| Lell, WA | 1 |
| Tosone, S | 1 |
| Heim, C | 3 |
| Sieklucka, M | 1 |
| Sontag, KH | 3 |
| Bentué-Ferrer, D | 1 |
| Decombe, R | 1 |
| Saïag, B | 1 |
| Allain, H | 1 |
| Van den Driessche, J | 1 |
| He, GQ | 1 |
| Zhang, A | 1 |
| Altura, BT | 1 |
| Altura, BM | 1 |
| Elger, B | 2 |
| Seega, J | 2 |
| Raschack, M | 2 |
| Block, F | 2 |
| Szabo, L | 1 |
| Jaspers, RM | 2 |
| Yamamoto, YL | 2 |
| Ueda, T | 1 |
| Shimauchi, M | 1 |
| Diksic, M | 2 |
| Hosaka, T | 1 |
| Morikawa, E | 1 |
| Ginsberg, MD | 1 |
| Dietrich, WD | 1 |
| Duncan, RC | 1 |
| Busto, R | 1 |
| Handa, J | 1 |
| Shiino, A | 1 |
| Kidooka, M | 1 |
| Lantos, J | 1 |
| Sárosi, I | 1 |
| Temes, G | 1 |
| Török, B | 1 |
| Hofmann, HP | 1 |
| Unger, L | 1 |
| Palmer, GC | 2 |
| Palmer, SJ | 1 |
| Christie-Pope, BC | 2 |
| Weber, J | 1 |
| Krieglstein, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| INternational VErapamil SR Trandolapril STudy[NCT00133692] | Phase 4 | 22,000 participants | Interventional | 1997-09-30 | Completed | ||
| A Randomised, Double-blind, Placebo Controlled, Parallel Group, Multi-centre Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of Verapamil SR on Preservation of Beta-cell Function (Ver-A-T1D)[NCT04545151] | Phase 2 | 138 participants (Anticipated) | Interventional | 2021-02-08 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for verapamil and Ischemic Attack, Transient
| Article | Year |
|---|---|
Clinical applications of slow channel blocking compounds.
Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Blood Platelets; Blood Vessels; Calcium | 1983 |
Calcium entry blockers: uses and implications for anesthesiologists.
Topics: Anesthesia, General; Animals; Arrhythmias, Cardiac; Biotransformation; Calcium Channel Blockers; Cor | 1982 |
[Ca antagonists in neurosurgical practice].
Topics: Animals; Anticonvulsants; Brain; Calcium Channel Blockers; Cerebral Infarction; Disease Models, Anim | 1990 |
1 trial available for verapamil and Ischemic Attack, Transient
20 other studies available for verapamil and Ischemic Attack, Transient
| Article | Year |
|---|---|
Verapamil Inhibits Mitochondria-Induced Reactive Oxygen Species and Dependent Apoptosis Pathways in Cerebral Transient Global Ischemia/Reperfusion.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Brain; Caspase 3; Cell Survival; Cytochrom | 2020 |
Verapamil augments the neuroprotectant action of berberine in rat model of transient global cerebral ischemia.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Berberine; Brain; Disease Models, Animal; Glutathio | 2013 |
[Effect of Ca2+ antagonists on experimental cerebral vasospasm (author's transl)].
Topics: Animals; Blood Pressure; Calcium; Cinnarizine; Dogs; Dose-Response Relationship, Drug; Intracranial | 1980 |
[Effect of diltiazem on experimental cerebral vasospasm incomparison with effects of cinnarizine, verapamil and nifedipine].
Topics: Animals; Benzazepines; Blood Pressure; Cinnarizine; Diltiazem; Dogs; Dose-Response Relationship, Dru | 1983 |
Reversal of acute experimental cerebral vasospasm by calcium antagonism with verapamil.
Topics: Acute Disease; Adenosine Diphosphate; Animals; Calcium Channel Blockers; Cats; Female; Ischemic Atta | 1984 |
Levemopamil injection after cerebral oligemia reduces spatial memory deficits in rats.
Topics: Acetylcholine; Animals; Brain Chemistry; Calcium Channel Blockers; Carotid Arteries; gamma-Aminobuty | 1994 |
L-type voltage-dependent calcium channels do not modulate aminergic neurotransmitter release induced by transient global cerebral ischaemia: an in vivo microdialysis study in rat.
Topics: Animals; Biogenic Monoamines; Biological Availability; Calcium Channels; Corpus Striatum; Dialysis; | 1993 |
Cocaine-induced cerebrovasospasm and its possible mechanism of action.
Topics: Animals; Biological Transport; Brain; Calcium; Cells, Cultured; Cocaine; Cyclooxygenase Inhibitors; | 1994 |
Oedema reduction by levemopamil in focal cerebral ischaemia of spontaneously hypertensive rats studied by magnetic resonance imaging.
Topics: Animals; Body Temperature; Brain Edema; Calcium Channel Blockers; Cerebral Infarction; Dose-Response | 1994 |
Levemopamil reduces spatial learning deficit following transient occlusion of common carotid arteries in normotensive rats.
Topics: Animals; Arterial Occlusive Diseases; Brain; Carotid Arteries; Cerebrovascular Circulation; Ischemic | 1993 |
Diffusion- and T2-weighted imaging: evaluation of oedema reduction in focal cerebral ischaemia by the calcium and serotonin antagonist levemopamil.
Topics: Animals; Brain; Brain Edema; Calcium Channel Blockers; Ischemic Attack, Transient; Magnetic Resonanc | 1993 |
Efficacy of bypass between extracerebral artery and cerebral vein with retrograde verapamil infusion into focal cerebral ischemic tissue in rats.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Cerebral Infarction; Cerebral Revascularization; Cereb | 1991 |
Efficacy of retrograde perfusion of the cerebral vein with verapamil after focal ischemia in rat brain.
Topics: Animals; Brain; Cerebrovascular Circulation; Ischemic Attack, Transient; Male; Perfusion; Rats; Rats | 1991 |
Postischemic (S)-emopamil therapy ameliorates focal ischemic brain injury in rats.
Topics: Animals; Blood Pressure; Brain; Cerebral Arteries; Cerebral Infarction; Ischemic Attack, Transient; | 1991 |
S-emopamil ameliorates ischemic brain damage in rats: histological and behavioural approaches.
Topics: Animals; Behavior, Animal; Brain; Cerebral Cortex; Hippocampus; Ischemic Attack, Transient; Learning | 1990 |
Influence of protective drugs on the EEG during short-term transient ischaemia.
Topics: Animals; Dogs; Electroencephalography; Ischemic Attack, Transient; Lidocaine; Phenytoin; Piracetam; | 1990 |
(S)-emopamil, a novel calcium and serotonin antagonist for the treatment of cerebrovascular disorders. 1st communication: pharmacological profile.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Cerebrovascular Disorders; Female; Guinea P | 1989 |
Protective action of calcium channel blockers on Na+,K+-ATPase in gerbil cerebral cortex following ischemia.
Topics: Animals; Calcium Channel Blockers; Cerebral Cortex; Female; Flunarizine; Gerbillinae; In Vitro Techn | 1988 |
Modulation of ischemic-induced damage to cerebral adenylate cyclase in gerbils by calcium channel blockers.
Topics: Adenylyl Cyclases; Animals; Calcium Channel Blockers; Disease Models, Animal; Female; Flunarizine; G | 1986 |
Effect of gallopamil on energy metabolism of the isolated perfused rat brain in the postischemic period.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Brain; Electroencephalography; Energy Meta | 1985 |