verapamil has been researched along with Invasiveness, Neoplasm in 7 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of this early phase II trial was to evaluate the effects of dexverapamil on epirubicin toxicity, activity and pharmacokinetics in patients with metastatic breast cancer." | 9.08 | Phase II trial of dexverapamil and epirubicin in patients with non-responsive metastatic breast cancer. ( Kroeger, N; Kupper, H; Lehnert, M; Mross, K; Schueller, J; Thuerlimann, B, 1998) |
| " The purpose of this early phase II trial was to evaluate the effects of dexverapamil on epirubicin toxicity, activity and pharmacokinetics in patients with metastatic breast cancer." | 5.08 | Phase II trial of dexverapamil and epirubicin in patients with non-responsive metastatic breast cancer. ( Kroeger, N; Kupper, H; Lehnert, M; Mross, K; Schueller, J; Thuerlimann, B, 1998) |
| "Verapamil, a calcium channel antagonist, inhibits murine B16 melanoma and colon adenocarcinoma C26 tumor metastasis by altering platelet aggregation [Tsuruo, T." | 3.68 | Inhibition of tumor cell invasion by verapamil. ( Clothier, JL; Geary, RJ; Hendrix, MJ; Montague, SL; Welch, DR; Winters, AL; Yohem, KH, 1991) |
| "The invasion and metastasis process involves degradation of the extracellular matrix mediated by tumor- and host-produced proteolytic enzymes." | 1.30 | Verapamil inhibits tumor protease production, local invasion and metastasis development in murine carcinoma cells. ( Aguirre Ghiso, JA; Bal de Kier Joffé, E; Farías, EF; Ladeda, V, 1998) |
| "We have previously observed that breast cancer cell lines could exhibit either epithelial or fibroblastic phenotypes as reflected by their morphologies and intermediate filament protein expression (C." | 1.28 | Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines. ( Byers, SW; Gelmann, EP; Heckford, SE; Skerker, JM; Sommers, CL; Thompson, EW; Torri, JA; Worland, P, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sabnis, DH | 1 |
| Storer, LCD | 1 |
| Liu, JF | 1 |
| Jackson, HK | 1 |
| Kilday, JP | 1 |
| Grundy, RG | 1 |
| Kerr, ID | 1 |
| Coyle, B | 1 |
| Zheng, G | 1 |
| Lyons, JG | 1 |
| Hofmann-Wellenhof, R | 1 |
| Fink-Puches, R | 1 |
| Smolle, J | 1 |
| Helige, C | 1 |
| Tritthart, HA | 1 |
| Kerl, H | 1 |
| Lehnert, M | 1 |
| Mross, K | 1 |
| Schueller, J | 1 |
| Thuerlimann, B | 1 |
| Kroeger, N | 1 |
| Kupper, H | 1 |
| Farías, EF | 1 |
| Aguirre Ghiso, JA | 1 |
| Ladeda, V | 1 |
| Bal de Kier Joffé, E | 1 |
| Sommers, CL | 1 |
| Heckford, SE | 1 |
| Skerker, JM | 1 |
| Worland, P | 1 |
| Torri, JA | 1 |
| Thompson, EW | 1 |
| Byers, SW | 1 |
| Gelmann, EP | 1 |
| Yohem, KH | 1 |
| Clothier, JL | 1 |
| Montague, SL | 1 |
| Geary, RJ | 1 |
| Winters, AL | 1 |
| Hendrix, MJ | 1 |
| Welch, DR | 1 |
1 trial available for verapamil and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Phase II trial of dexverapamil and epirubicin in patients with non-responsive metastatic breast cancer.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Blood Pressure; Breast Neoplasms; Calcium Channel Blockers | 1998 |
6 other studies available for verapamil and Invasiveness, Neoplasm
| Article | Year |
|---|---|
A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma.
Topics: ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Movement; Cell Proliferation; | 2019 |
Cyclosporin A improves the selection of cells transfected with the puromycin acetyltransferase gene.
Topics: Acetyltransferases; Antineoplastic Agents; Cell Survival; Cyclosporine; Drug Resistance, Neoplasm; F | 2002 |
Correlation of melanoma cell motility and invasion in vitro.
Topics: Animals; Calcium Channel Blockers; Cell Movement; Cells, Cultured; Chick Embryo; Cytochalasins; Dequ | 1995 |
Verapamil inhibits tumor protease production, local invasion and metastasis development in murine carcinoma cells.
Topics: Animals; Calcium Channel Blockers; Cell Division; Dose-Response Relationship, Drug; Endopeptidases; | 1998 |
Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines.
Topics: Antibodies; Biomarkers, Tumor; Breast Neoplasms; Cell Adhesion Molecules; Cytoskeletal Proteins; Des | 1992 |
Inhibition of tumor cell invasion by verapamil.
Topics: Animals; Cytoskeletal Proteins; Female; Humans; Lung Neoplasms; Matrix Metalloproteinase 9; Melanoma | 1991 |