verapamil has been researched along with Intestinal Polyps in 2 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Intestinal Polyps: Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the current study, we have further substantiated the biological involvement of MDR1 in intestinal tumorigenesis based on the following evidence: (a) aberrant induction of the Mdr1a (Abcb1a) gene product, P-glycoprotein, associated with nuclear accumulation of the beta-catenin protein, was observed even in nascent microscopic adenomas of Min mice; (b) Mdr1-deficient Min (Apc(Min/+)Mdr1a/b(-/-)) mice developed significantly fewer intestinal polyps than did Apc(Min/+)Mdr1a/b(+/+) mice; and (c) Inhibitors of P-glycoprotein, verapamil, and cyclosporin A had a suppressive effect on the in vitro polypoid growth of IEC6 expressing stabilized (DeltaN89) beta-catenin protein." | 3.72 | Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice. ( Hayashi, R; Hirohashi, S; Ino, Y; Kondo, T; Mori, Y; Naishiro, Y; Takada, M; Yamada, T, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujimoto, K | 1 |
| Fujii, G | 1 |
| Mutoh, M | 1 |
| Yasunaga, M | 1 |
| Tanaka, H | 1 |
| Wada, M | 1 |
| Yamada, T | 1 |
| Mori, Y | 1 |
| Hayashi, R | 1 |
| Takada, M | 1 |
| Ino, Y | 1 |
| Naishiro, Y | 1 |
| Kondo, T | 1 |
| Hirohashi, S | 1 |
2 other studies available for verapamil and Intestinal Polyps
| Article | Year |
|---|---|
Suppression of intestinal polyp development in Apc(Min/+) mice through inhibition of P-glycoprotein using verapamil.
Topics: Adenomatous Polyposis Coli; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Diseas | 2013 |
Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; beta Catenin; Cell Division; Cyclo | 2003 |