Page last updated: 2024-10-24

verapamil and Intestinal Polyps

verapamil has been researched along with Intestinal Polyps in 2 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Intestinal Polyps: Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.

Research Excerpts

ExcerptRelevanceReference
" In the current study, we have further substantiated the biological involvement of MDR1 in intestinal tumorigenesis based on the following evidence: (a) aberrant induction of the Mdr1a (Abcb1a) gene product, P-glycoprotein, associated with nuclear accumulation of the beta-catenin protein, was observed even in nascent microscopic adenomas of Min mice; (b) Mdr1-deficient Min (Apc(Min/+)Mdr1a/b(-/-)) mice developed significantly fewer intestinal polyps than did Apc(Min/+)Mdr1a/b(+/+) mice; and (c) Inhibitors of P-glycoprotein, verapamil, and cyclosporin A had a suppressive effect on the in vitro polypoid growth of IEC6 expressing stabilized (DeltaN89) beta-catenin protein."3.72Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice. ( Hayashi, R; Hirohashi, S; Ino, Y; Kondo, T; Mori, Y; Naishiro, Y; Takada, M; Yamada, T, 2003)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fujimoto, K1
Fujii, G1
Mutoh, M1
Yasunaga, M1
Tanaka, H1
Wada, M1
Yamada, T1
Mori, Y1
Hayashi, R1
Takada, M1
Ino, Y1
Naishiro, Y1
Kondo, T1
Hirohashi, S1

Other Studies

2 other studies available for verapamil and Intestinal Polyps

ArticleYear
Suppression of intestinal polyp development in Apc(Min/+) mice through inhibition of P-glycoprotein using verapamil.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2013, Volume: 22, Issue:1

    Topics: Adenomatous Polyposis Coli; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Diseas

2013
Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice.
    Cancer research, 2003, Mar-01, Volume: 63, Issue:5

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; beta Catenin; Cell Division; Cyclo

2003