verapamil has been researched along with Intermittent Claudication in 6 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Intermittent Claudication: A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Since the balance between the positive and the negative effects of vasodilation may be delicate in ischemic diseases a dose-response study (dose range, 120 to 480 mg) was established to determine optimal, individual dosages of slow-release verapamil in 44 patients with stable intermittent claudication (Fontaine classification stage II) with respect to walking capacity." | 9.08 | Effect of verapamil in intermittent claudication A randomized, double-blind, placebo-controlled, cross-over study after individual dose-response assessment. ( Bagger, JP; Helligsoe, P; Jensen, BS; Kimose, HH; Randsbaek, F, 1997) |
| "The clinical effect of verapamil was tested in 24 patients with intermittent claudication in a randomized, placebo-controlled, double-blind, crossover study." | 9.06 | Placebo-controlled, double-blind study of the effect of verapamil in intermittent claudication. ( Aagaard, MT; Bagger, JP; Kimose, HH; Paulsen, PK, 1990) |
| "Hypertension is a risk factor for PAD." | 2.45 | Treatment of hypertension in peripheral arterial disease. ( Lane, DA; Lip, GY, 2009) |
| "Therefore, treatment for hypertension must be compatible with the symptoms of PAD." | 2.42 | Treatment of hypertension in peripheral arterial disease. ( Lip, GY; Makin, AJ, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lane, DA | 1 |
| Lip, GY | 2 |
| Makin, AJ | 1 |
| Bagger, JP | 3 |
| Helligsoe, P | 1 |
| Randsbaek, F | 1 |
| Kimose, HH | 2 |
| Jensen, BS | 1 |
| Switzer, DS | 1 |
| Aagaard, MT | 1 |
| Paulsen, PK | 2 |
| Mathar, R | 1 |
| Gormsen, J | 1 |
| Olsen, KH | 1 |
2 reviews available for verapamil and Intermittent Claudication
| Article | Year |
|---|---|
Treatment of hypertension in peripheral arterial disease.
Topics: Antihypertensive Agents; Humans; Hypertension; Intermittent Claudication; Perindopril; Peripheral Va | 2009 |
Treatment of hypertension in peripheral arterial disease.
Topics: Antihypertensive Agents; Humans; Hypertension; Intermittent Claudication; Perindopril; Peripheral Va | 2003 |
2 trials available for verapamil and Intermittent Claudication
| Article | Year |
|---|---|
Effect of verapamil in intermittent claudication A randomized, double-blind, placebo-controlled, cross-over study after individual dose-response assessment.
Topics: Aged; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Intermitten | 1997 |
Placebo-controlled, double-blind study of the effect of verapamil in intermittent claudication.
Topics: Adult; Aged; Double-Blind Method; Drug Evaluation; Female; Humans; Intermittent Claudication; Locomo | 1990 |
2 other studies available for verapamil and Intermittent Claudication
| Article | Year |
|---|---|
Effect of verapamil in intermittent claudication.
Topics: Aged; Delayed-Action Preparations; Humans; Intermittent Claudication; Middle Aged; Pain; Randomized | 1997 |
Verapamil induced increment of oxygen extraction in the arteriosclerotic limb.
Topics: Aged; Blood Pressure; Female; Humans; Intermittent Claudication; Ischemia; Leg; Male; Middle Aged; O | 1985 |