verapamil and Hypotension studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.

Research Excerpts

Excerpt	Relevance	Reference
"A randomized blind cross-over study with placebo lead-in compared efficacy of calcium antagonists diltiazem and verapamil in 71 patients with stable angina concurrent with arterial hypotension (group 1) and 38 normotensive patients with ischemic heart disease (group 2)."	9.11	[Diltiazem and verapamil therapy in patients with angina pectoris associated with arterial hypotension]. ( Borovkova, NV; Chernov, VI; Idrisova, EM; Karpov, RS; Poponina, IuS; Stepacheva, TA; Vorob'eva, EV, 2004)
"Atrial fibrillation occurred in 15% of the patients receiving placebo and in 8% of the patients receiving verapamil (difference not significant)."	9.08	Verapamil as prophylactic treatment for atrial fibrillation after lung operations. ( Demedts, M; Demuynck, K; Deneffe, G; Lacquet, L; Tits, G; Tjandra-Maga, T; Van Mieghem, W, 1996)
"This study investigated the efficacy of oral administration of verapamil, started 24 hours after coronary artery bypass grafting (CABG), in reducing the incidence of postoperative supraventricular tachyarrhythmia (SVT)."	9.05	Prophylaxis of supraventricular tachyarrhythmia after coronary bypass surgery with oral verapamil: a randomized, double-blind trial. ( Davison, R; Feiereisel, P; Hartz, R; Kaplan, K; Michaelis, L; Parker, M, 1985)
"To review the available literature on the use of intravenous calcium salts for the prevention of hypotension associated with intravenous verapamil."	8.80	The use of calcium salts in the prevention and management of verapamil-induced hypotension. ( Moser, LR; Smythe, MA; Tisdale, JE, 2000)
"The present study evaluated the efficacy of intracoronary administration of verapamil to attenuate the no-reflow phenomenon following the primary percutaneous coronary intervention (PCI) in patients with the ST-segment elevation acute myocardial infarction (STEMI)."	7.79	Verapamil reverses myocardial no-reflow after primary percutaneous coronary intervention in patients with acute myocardial infarction. ( Fu, Q; Huang, YJ; Jiang, SZ; Lu, W; Wang, HB; Wang, LG; Wang, YJ; Wu, Q, 2013)
"Noncardiogenic pulmonary edema has not been (to our knowledge) previously reported associated with a verapamil overdose."	7.69	Noncardiogenic pulmonary edema complicating massive verapamil overdose. ( Frumin, H; Leesar, MA; Martyn, R; Talley, JD, 1994)
"A 65-years-old female patient in chronic use of verapamil who developed bradyarrhythmia and hypotension reverted by endovenous calcium gluconate."	7.69	[Sinus bradycardia with junctional rhythm escape reverted with calcium gluconate]. ( Besen, D; de Brito, FS; de Cleva, R; Gontow, N, 1994)
" Common factors were hyperkalemia and verapamil therapy."	7.68	Effect of hyperkalemia on experimental myocardial depression by verapamil. ( Jolly, SR; Keaton, N; Movahed, A; Reeves, WC; Rose, GC, 1991)
" Pretreatment of animals with verapamil did not affect the abnormality of glucose metabolism but abolished the associated acidosis."	7.68	Verapamil prevents cerebral acidosis during moderate hypoxia and hypotension. ( Lockwood, AH; Yap, EW, 1991)
"A case of life-threatening hypotension due to sinus arrest is described in a patient in whom exercise-induced hyperkalemia developed during a stable regimen that included verapamil, propranolol, and ibuprofen."	7.67	Hypotension and sinus arrest with exercise-induced hyperkalemia and combined verapamil/propranolol therapy. ( Antman, EM; Lee, TH; Rayment, CM; Salomon, DR, 1986)
"In 11 of 25 patients (44%) with sustained ventricular tachycardia (VT) who received intravenous verapamil (5 to 10 mg), acute severe hypotension or loss of consciousness developed, necessitating immediate cardioversion."	7.67	Hazards of intravenous verapamil for sustained ventricular tachycardia. ( Buxton, AE; Doherty, JU; Flores, B; Josephson, ME; Marchlinski, FE, 1987)
"Intravenous verapamil is effective in the acute termination of supraventricular tachycardia but is also used for broad-complex tachycardia when the diagnosis is uncertain."	7.67	Misuse of intravenous verapamil in patients with ventricular tachycardia. ( Cobbe, SM; Rae, AP; Rankin, AC, 1987)
"The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare."	7.67	Parenteral-verapamil-induced sustained hypotension. ( Serote, WF; Tucker, RA, 1984)
" A long-term, open clinical trial of verapamil therapy was conducted in ninety-three patients with coronary artery disease, selected on the basis of having stable angina pectoris and of being unsuitable for treatment with beta-adrenoceptor blocking drugs."	7.66	Verapamil in the long-term treatment of angina pectoris. ( Raftos, J, 1982)
"Verapamil (1."	5.29	Administration of intravenous calcium before verapamil to prevent hypotension in elderly patients with paroxysmal supraventricular tachycardia. ( Dohi, Y; Miyagawa, K; Ogihara, M; Sato, K, 1993)
"SVT complicated by hypotension has been considered a relative contraindication for the use of IV verapamil."	5.28	Supraventricular tachyarrhythmias and rate-related hypotension: cardiovascular effects and efficacy of intravenous verapamil. ( Haynes, BE; Haynes, KS; Niemann, JT, 1990)
"A randomized blind cross-over study with placebo lead-in compared efficacy of calcium antagonists diltiazem and verapamil in 71 patients with stable angina concurrent with arterial hypotension (group 1) and 38 normotensive patients with ischemic heart disease (group 2)."	5.11	[Diltiazem and verapamil therapy in patients with angina pectoris associated with arterial hypotension]. ( Borovkova, NV; Chernov, VI; Idrisova, EM; Karpov, RS; Poponina, IuS; Stepacheva, TA; Vorob'eva, EV, 2004)
"Toxicities included hypotension, asymptomatic bradycardia, and mild atrioventricular conduction delays, although one patient had dexverapamil discontinued for grade IV congestive heart failure."	5.08	Phase I/II trial of dexverapamil plus vinblastine for patients with advanced renal cell carcinoma. ( Cordon-Cardo, C; Fischer, P; Lianes, P; Lyn, P; Motzer, RJ; Ngo, RL; O'Brien, JP, 1995)
"Atrial fibrillation occurred in 15% of the patients receiving placebo and in 8% of the patients receiving verapamil (difference not significant)."	5.08	Verapamil as prophylactic treatment for atrial fibrillation after lung operations. ( Demedts, M; Demuynck, K; Deneffe, G; Lacquet, L; Tits, G; Tjandra-Maga, T; Van Mieghem, W, 1996)
"This study investigated the efficacy of oral administration of verapamil, started 24 hours after coronary artery bypass grafting (CABG), in reducing the incidence of postoperative supraventricular tachyarrhythmia (SVT)."	5.05	Prophylaxis of supraventricular tachyarrhythmia after coronary bypass surgery with oral verapamil: a randomized, double-blind trial. ( Davison, R; Feiereisel, P; Hartz, R; Kaplan, K; Michaelis, L; Parker, M, 1985)
"Moderate-quality evidence shows no differences in effects of adenosine and calcium channel antagonists for treatment of SVT on reverting to sinus rhythm, and low-quality evidence suggests no appreciable differences in the incidence of hypotension."	4.95	Adenosine versus intravenous calcium channel antagonists for supraventricular tachycardia. ( Alabed, S; Atallah, E; Chico, TJ; Providencia, R; Qintar, M; Sabouni, A, 2017)
"To review the available literature on the use of intravenous calcium salts for the prevention of hypotension associated with intravenous verapamil."	4.80	The use of calcium salts in the prevention and management of verapamil-induced hypotension. ( Moser, LR; Smythe, MA; Tisdale, JE, 2000)
"A 27-year-old female is admitted with an acute abdomen of 4 days after an event referred for a suicidal attempt due to an overdose of verapamil, operating surgically where there is a right transmural colon necrosis, performing a right hemicolectomy with terminal ileostomy."	3.91	Secondary colonic necrosis. Case report. ( Aburto-Fernández, MDC; Alvarado-González, A; Araujo-López, A; Arteaga-Villalba, LR; de Orendáin, AÁ; García-Godoy, IU; Gutiérrez-Samperio, JL; Herrera-Díaz, A; Jiménez-Ríos, CO; Lerma-Alvarado, RM; Ocio, MAR, 2019)
"BackgroundIn the clinical setting, verapamil is contraindicated in neonates and infants, because of the perceived risk of hypotension or bradyarrhythmia."	3.88	Postnatal developmental changes in the sensitivity of L-type Ca ( Ding, WG; Hoshino, S; Maruo, Y; Matsuura, H; Nakagawa, M; Omatsu-Kanbe, M; Sagawa, H; Yoshioka, K, 2018)
" Case reports suggest that ILE may reverse hypotension caused by acute poisoning with lipophilic drugs such as verapamil, but the mechanism remains unclear."	3.83	In Vitro Studies Indicate Intravenous Lipid Emulsion Acts as Lipid Sink in Verapamil Poisoning. ( Dawling, S; Knollmann, BC; Kryshtal, DO; Seger, D, 2016)
"The present study evaluated the efficacy of intracoronary administration of verapamil to attenuate the no-reflow phenomenon following the primary percutaneous coronary intervention (PCI) in patients with the ST-segment elevation acute myocardial infarction (STEMI)."	3.79	Verapamil reverses myocardial no-reflow after primary percutaneous coronary intervention in patients with acute myocardial infarction. ( Fu, Q; Huang, YJ; Jiang, SZ; Lu, W; Wang, HB; Wang, LG; Wang, YJ; Wu, Q, 2013)
"A 49-year-old man presented with verapamil toxicity complicated by hypotension and a junctional rhythm, in the context of deliberate self-poisoning with multiple drugs."	3.75	Early use of high-dose insulin euglycaemic therapy for verapamil toxicity. ( Little, M; Nickson, CP, 2009)
"To report a case of hypotension and bradyarrhythmia caused by verapamil toxicity in a patient prescribed telithromycin."	3.73	Verapamil toxicity resulting from a probable interaction with telithromycin. ( Heun, JM; Hicklin, GA; Reed, M; Shah, NP; Wall, GC, 2005)
" A second combination compound including verapamil 180 mg and trandolapril 2 mg daily was added 5 days prior to hospitalisation due to insufficient control of arterial hypertension."	3.72	[Lethal polypharmacy in a patient with arterial hypertension]. ( Diethelm, M; Joerger, M, 2004)
"Hypertonic sodium bicarbonate reversed the hypotension and cardiac output depression of severe verapamil toxicity in a swine model."	3.70	Hypertonic sodium bicarbonate is effective in the acute management of verapamil toxicity in a swine model. ( Curry, SC; Graeme, KA; Reagan, CG; Ruha, AM; Tanen, DA, 2000)
"A 65-years-old female patient in chronic use of verapamil who developed bradyarrhythmia and hypotension reverted by endovenous calcium gluconate."	3.69	[Sinus bradycardia with junctional rhythm escape reverted with calcium gluconate]. ( Besen, D; de Brito, FS; de Cleva, R; Gontow, N, 1994)
"Verapamil toxicity results in hypotension, myocardial depression and disturbances in cardiac conduction."	3.69	Overdose of sustained-release verapamil. ( Barrow, PM; Houston, PL; Wong, DT, 1994)
"Noncardiogenic pulmonary edema has not been (to our knowledge) previously reported associated with a verapamil overdose."	3.69	Noncardiogenic pulmonary edema complicating massive verapamil overdose. ( Frumin, H; Leesar, MA; Martyn, R; Talley, JD, 1994)
"Hypotension, sinus node suppression, and dysrhythmias often occur with calcium channel blocker overdoses, but atrioventricular nodal block occurs more often with verapamil (chi 2 test, P < ."	3.68	A one-year evaluation of calcium channel blocker overdoses: toxicity and treatment. ( Borys, D; Ramoska, EA; Spiller, HA; Winter, M, 1993)
" Pretreatment of animals with verapamil did not affect the abnormality of glucose metabolism but abolished the associated acidosis."	3.68	Verapamil prevents cerebral acidosis during moderate hypoxia and hypotension. ( Lockwood, AH; Yap, EW, 1991)
" Common factors were hyperkalemia and verapamil therapy."	3.68	Effect of hyperkalemia on experimental myocardial depression by verapamil. ( Jolly, SR; Keaton, N; Movahed, A; Reeves, WC; Rose, GC, 1991)
"We report the occurrence of supraventricular tachycardia and hypotension in a 54-year-old woman after maintenance therapy with fluoxetine."	3.68	Drug-induced supraventricular tachycardia: a case report of fluoxetine. ( Gardner, SF; Munger, MA; Panacek, EA; Rutherford, WF, 1991)
"The presenting symptoms, course, and treatment of 10 patients with severe theophylline toxicity (heart rate above 120, multifocal atrial tachycardia or premature ventricular contractions, hypotension, seizures) are described."	3.67	Severe theophylline toxicity. Role of conservative measures, antiarrhythmic agents, and charcoal hemoperfusion. ( Greenberg, A; Kroboth, PD; Piraino, BH; Weiss, J, 1984)
"The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare."	3.67	Parenteral-verapamil-induced sustained hypotension. ( Serote, WF; Tucker, RA, 1984)
"Intravenous verapamil is effective in the acute termination of supraventricular tachycardia but is also used for broad-complex tachycardia when the diagnosis is uncertain."	3.67	Misuse of intravenous verapamil in patients with ventricular tachycardia. ( Cobbe, SM; Rae, AP; Rankin, AC, 1987)
"We investigated the effect of sodium nitroprusside, verapamil, and hemorrhage on the resetting of the aortic baroreceptors of normotensive control rats to hypotension, and the reversal of resetting of baroreceptors of one-kidney, one clip hypertensive rats to normotension."	3.67	Extent of baroreceptor resetting in response to sodium nitroprusside and verapamil. ( Krieger, EM; Salgado, HC, 1988)
"In 11 of 25 patients (44%) with sustained ventricular tachycardia (VT) who received intravenous verapamil (5 to 10 mg), acute severe hypotension or loss of consciousness developed, necessitating immediate cardioversion."	3.67	Hazards of intravenous verapamil for sustained ventricular tachycardia. ( Buxton, AE; Doherty, JU; Flores, B; Josephson, ME; Marchlinski, FE, 1987)
"Intravenous verapamil hydrochloride was used alone in 63 episodes of atrial fibrillation and flutter and six episodes of supraventricular tachycardia (SVT) (group A)."	3.67	Treatment of atrial arrhythmias. Effectiveness of verapamil when preceded by calcium infusion. ( Habbab, MA; Haft, JI, 1986)
"A case of life-threatening hypotension due to sinus arrest is described in a patient in whom exercise-induced hyperkalemia developed during a stable regimen that included verapamil, propranolol, and ibuprofen."	3.67	Hypotension and sinus arrest with exercise-induced hyperkalemia and combined verapamil/propranolol therapy. ( Antman, EM; Lee, TH; Rayment, CM; Salomon, DR, 1986)
"Two infants with supraventricular tachycardia were given intravenous verapamil and subsequently suffered life threatening bradycardia and hypotension."	3.66	Side effects of verapamil in infants. ( Radford, D, 1983)
"Forty-nine consecutive patients (44 with atrial fibrillation and five with atrial flutter) received 10 mg of verapamil five to seven minutes before elective electroversion, to evaluate the feasibility of the latter while verapamil effects were present."	3.66	Electroversion after verapamil administration. ( Larrousse, E; Noguera, L; Permanyer-Miralda, G; Sagristá-Sauleda, J; Soler-Soler, J; Tornos, MP, 1983)
" A long-term, open clinical trial of verapamil therapy was conducted in ninety-three patients with coronary artery disease, selected on the basis of having stable angina pectoris and of being unsuitable for treatment with beta-adrenoceptor blocking drugs."	3.66	Verapamil in the long-term treatment of angina pectoris. ( Raftos, J, 1982)
"Three patients with ischaemic heart disease developed profound cardiac failure, hypotension and bradycardia during combined therapy with verapamil and beta-adrenergic blocking drugs."	3.66	Adverse interaction between beta-adrenergic blocking drugs and verapamil--report of three cases. ( Anderson, ST; Federman, J; Harper, RW; Laufer, E; Pitt, A; Wayne, VS, 1982)
" the effect of verapamil (Ca2+) inhibitor with antiarrhythmic action) on ritodrine does not modify the value of ritodrine in prolonging pregnancy, but clearly diminishes the incidence of maternal tachycardia and hypotension."	3.66	Verapamil to inhibit the cardiovascular side effects of ritodrine. ( Aranguren, G; Benito, JA; Rodriguez-Escudero, FJ, 1981)
" In anesthetized cats it produces varying degrees of hypotension with bradycardia, and antagonizes ST-T changes induced by ouabain."	3.64	IPROVERATRIL: EXPERIMENTAL DATA ON CORONARY DILATATION AND ANTIARRHYTHMIC ACTION. ( HUQ, S; MELVILLE, KI; SHISTER, HE, 1964)
" Both groups had similar 30-day major adverse cardiovascular events (3."	2.84	Efficacy and safety of intracoronary verapamil versus sodium nitroprusside for the prevention of microvascular obstruction during primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. ( Abdelaziz, HK; Elkilany, W; Khalid, S; Saad, M; Sabet, S, 2017)
"Dexverapamil was administered orally for 6 days and escalated over eight dose levels ranging from 240 to 1,200 mg/m2/d."	2.68	Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy. ( Balis, FM; Bates, SE; Bryant, G; Chabner, BA; Jamis-Dow, C; Klecker, RW; Kohler, DR; Steinberg, SM; Wilson, WH; Wittes, RE, 1995)
"Pretreatment of verapamil with intravenous calcium did not alter the disposition of intravenous verapamil."	2.67	Evaluation of the pharmacokinetics and electrocardiographic effects of intravenous verapamil with intravenous calcium chloride pretreatment in normal subjects. ( Bauman, JL; Beckman, KJ; Hariman, RJ; Hoon, TJ; Parker, RB; Schoen, MD, 1991)
"Verapamil was the first of a class of agents known as calcium entry blockers to be released for clinical use in the United States."	2.36	The clinical use of verapamil. ( Holmes, DR; McGoon, MD; Osborn, JE; Vlietstra, RE, 1982)
"Verapamil (2."	1.35	Levosimendan does not improve survival time in a rat model of verapamil toxicity. ( Abraham, MK; Barrueto, F; Meltzer, A; Scott, SB, 2009)
"The hypotension was also unchanged after autonomic ganglion or angiotensin-converting-enzyme blockade."	1.30	Hypotensive effect of the methanolic extract of Mimusops elengi in normotensive rats. ( Behbahanian, S; Dar, A; Jahan, N; Malik, A, 1999)
"Verapamil (1."	1.29	Administration of intravenous calcium before verapamil to prevent hypotension in elderly patients with paroxysmal supraventricular tachycardia. ( Dohi, Y; Miyagawa, K; Ogihara, M; Sato, K, 1993)
"Amrinone and glucagon have been used separately and in combination with other agents in the treatment of calcium channel blocker overdose."	1.29	Use of amrinone and glucagon in a case of calcium channel blocker overdose. ( Otten, EJ; Spadafora, MP; Wolf, LR, 1993)
"for 10 min)-induced hypotension, arrhythmias, and sudden death."	1.29	Reversal of acute theophylline toxicity by calcium channel blockers in dogs and rats. ( Alleva, FR; Balazs, T; Joseph, X; Vick, JA; Whitehurst, VE; Zhang, J, 1996)
"5 mm Hg per ng/ml when prazosin was combined with verapamil (p less than 0."	1.28	An additive or synergistic drug interaction: application of concentration-effect modeling. ( Elliott, HL; Meredith, PA, 1992)
" The mean nontoxic dose was 320 mg, whereas the mean toxic ingestion was 3."	1.28	Calcium channel blocker toxicity. ( Myers, A; Ramoska, EA; Spiller, HA, 1990)
"SVT complicated by hypotension has been considered a relative contraindication for the use of IV verapamil."	1.28	Supraventricular tachyarrhythmias and rate-related hypotension: cardiovascular effects and efficacy of intravenous verapamil. ( Haynes, BE; Haynes, KS; Niemann, JT, 1990)
"Seizures have not previously been described in association with verapamil therapy or poisoning."	1.27	Verapamil poisoning in an infant. ( Crespin, FH; Passal, DB, 1984)
"If practolol treatment failed, the patient was given 5 mg of verapamil half an hour later, and vice versa."	1.26	Comparison of verapamil and practolol in paroxysmal supraventricular tachycardia. ( Härtel, G; Hartikainen, M, 1976)

Research

Studies (110)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Change in Number of Absence Seizures From Week 8 (Baseline) to Week 12

Timeframe	Studies, this research(%)	All Research%
pre-1990	51 (46.36)	18.7374
1990's	40 (36.36)	18.2507
2000's	11 (10.00)	29.6817
2010's	7 (6.36)	24.3611
2020's	1 (0.91)	2.80

Authors	Studies
Bannister, BE	1
Parry, DR	1
Pouliot, JD	1
Aburto-Fernández, MDC	1
Araujo-López, A	1
García-Godoy, IU	1
Alvarado-González, A	1
Gutiérrez-Samperio, JL	1
de Orendáin, AÁ	1
Ocio, MAR	1
Arteaga-Villalba, LR	1
Herrera-Díaz, A	1
Jiménez-Ríos, CO	1
Lerma-Alvarado, RM	1
Alabed, S	1
Sabouni, A	1
Providencia, R	1
Atallah, E	1
Qintar, M	1
Chico, TJ	1
Sagawa, H	1
Hoshino, S	1
Yoshioka, K	1
Ding, WG	1
Omatsu-Kanbe, M	1
Nakagawa, M	1
Maruo, Y	1
Matsuura, H	1
Lawson, BD	1
Khan, MZ	1
Cooke, RH	1
Exaire, JE	1
Guzman, LA	1
Gertz, ZM	1
Fu, Q	1
Lu, W	1
Huang, YJ	1
Wu, Q	1
Wang, LG	1
Wang, HB	1
Jiang, SZ	1
Wang, YJ	1
Kryshtal, DO	1
Dawling, S	1
Seger, D	1
Knollmann, BC	1
Abdelaziz, HK	1
Elkilany, W	1
Khalid, S	1
Sabet, S	1
Saad, M	1
Abraham, MK	1
Scott, SB	1
Meltzer, A	1
Barrueto, F	1
Tuka, V	1
Ricarova, B	1
Janota, T	1
Malik, J	1
Kotrlikova, E	1
Nickson, CP	1
Little, M	1
MELVILLE, KI	1
SHISTER, HE	1
HUQ, S	1
Idrisova, EM	1
Stepacheva, TA	1
Borovkova, NV	1
Chernov, VI	1
Karpov, RS	1
Vorob'eva, EV	1
Poponina, IuS	1
Joerger, M	1
Diethelm, M	1
Reed, M	1
Wall, GC	1
Shah, NP	1
Heun, JM	1
Hicklin, GA	1
Tanel, RE	1
Leaver, SK	1
Ho, TB	1
Fiszer, M	1
Kołaciński, Z	1
Rechciński, T	1
Rodriguez-Escudero, FJ	1
Aranguren, G	1
Benito, JA	1
Iaina, A	1
Eliahou, HE	1
Crump, BJ	1
Holt, DW	1
Vale, JA	1
Wayne, VS	1
Harper, RW	1
Laufer, E	1
Federman, J	1
Anderson, ST	1
Pitt, A	1
Orr, GM	1
Bodansky, HJ	1
Dymond, DS	1
Taylor, M	1
Covinsky, JO	1
Hamburger, SC	1
Enyeart, JJ	1
Price, WA	1
Hoffman, DA	1
Woods, L	1
Proctor, HJ	1
Palladino, GW	1
Fillipo, D	1
Sanders, R	1
Morris, DL	1
Goldschlager, N	1
Tucker, RA	1
Serote, WF	1
Passal, DB	1
Crespin, FH	1
Greenberg, A	1
Piraino, BH	1
Kroboth, PD	1
Weiss, J	1
Sapire, DW	1
O'Riordan, AC	1
Black, IF	1
Raftos, J	1
Soler-Soler, J	1
Permanyer-Miralda, G	1
Sagristá-Sauleda, J	1
Noguera, L	1
Larrousse, E	1
Tornos, MP	1
Radford, D	1
McGoon, MD	1
Vlietstra, RE	1
Holmes, DR	1
Osborn, JE	1
Lipman, J	1
Jardine, I	1
Roos, C	1
Dreosti, L	1
Resnekov, L	1
Karlsberg, RP	1
Aronow, WS	1
Anshelevich, IuV	1
Dumesh, SZ	1
Slaĭdyn', AK	1
Sporan, VG	1
Epstein, SE	1
Rosing, DR	1
Immonen, P	1
Linkola, A	1
Waris, E	1
Arstall, MA	1
Stewart, S	1
Haste, MA	1
Horowitz, JD	1
Motzer, RJ	1
Lyn, P	1
Fischer, P	1
Lianes, P	1
Ngo, RL	1
Cordon-Cardo, C	1
O'Brien, JP	1
Wilson, WH	1
Jamis-Dow, C	1
Bryant, G	1
Balis, FM	1
Klecker, RW	1
Bates, SE	1
Chabner, BA	1
Steinberg, SM	1
Kohler, DR	1
Wittes, RE	1
Miyagawa, K	1
Dohi, Y	1
Ogihara, M	1
Sato, K	1
Mager, A	1
Strasberg, B	1
Rechavia, E	1
Birnbaum, Y	1
Mazur, A	1
Yativ, N	1
Sclarovsky, S	1
de Cleva, R	1
Gontow, N	1
de Brito, FS	1
Besen, D	1
Patel, R	1
Lipper, B	1
Schwartzbard, A	1
Nelson, C	1
O'Connor, MA	1
Frishman, W	1
Barrow, PM	1
Houston, PL	1
Wong, DT	1
Peitz, TJ	1
Leesar, MA	1
Martyn, R	1
Talley, JD	1
Frumin, H	1
Svensson, P	1
Rosenberg, J	1
Ostergren, J	1
Karlson-Stiber, C	1
Ramoska, EA	2
Spiller, HA	3
Winter, M	1
Borys, D	1
Doyon, S	1
Roberts, JR	1
Wolf, LR	1
Spadafora, MP	1
Otten, EJ	1
Sugimoto, N	1
Haque, A	1
Horiguchi, Y	1
Matsuda, M	1
Van Mieghem, W	1
Tits, G	1
Demuynck, K	1
Lacquet, L	1
Deneffe, G	1
Tjandra-Maga, T	1
Demedts, M	1
Whitehurst, VE	1
Joseph, X	1
Vick, JA	1
Alleva, FR	1
Zhang, J	1
Balazs, T	1
Balakumaran, A	1
Campbell, GA	1
Moslen, MT	1
Tuncok, Y	2
Apaydin, S	2
Kalkan, S	1
Ates, M	2
Guven, H	2
Gelal, A	1
Kaeser, YA	1
Brunner, F	1
Drewe, J	1
Haefeli, WE	1
Holland, HL	1
Gu, JX	1
Orallo, F	1
Camiña, M	1
Fabeiro, P	1
Willetts, AJ	1
Yörükoğlu, D	1
Göktug, A	1
Alanoğlu, Z	1
Tulunay, M	1
Moser, LR	1
Smythe, MA	1
Tisdale, JE	1
Tanen, DA	1
Ruha, AM	1
Curry, SC	1
Graeme, KA	1
Reagan, CG	1
Dar, A	1
Behbahanian, S	1
Malik, A	1
Jahan, N	1
Härtel, G	1
Hartikainen, M	1
Jameson, SJ	1
Hargarten, SW	1
Kuo, MJ	1
Tseng, YZ	1
Chen, TF	1
Fong, DE	1
Meredith, PA	1
Elliott, HL	1
Kuhn, M	2
Schriger, DL	2
Lockwood, AH	1
Yap, EW	1
Traube, C	1
Marush, A	1
Plawes, S	1
Jolly, SR	1
Keaton, N	1
Movahed, A	1
Rose, GC	1
Reeves, WC	1
Schoen, MD	1
Parker, RB	1
Hoon, TJ	1
Hariman, RJ	1
Bauman, JL	1
Beckman, KJ	1
Gardner, SF	1
Rutherford, WF	1
Munger, MA	1
Panacek, EA	1
Meyers, A	1
Ziemba, T	1
Riley, M	1
Torres, C	1
Altus, P	1
Dolan, DL	1
Diamant, S	1
Kaplan, NA	1
Buckley, BJ	1
Peterson, BJ	1
Camacho, J	1
Weinhouse, E	1
Gootman, N	1
Myers, A	1
Haynes, BE	1
Niemann, JT	1
Haynes, KS	1
Hendren, WG	1
Schieber, RS	1
Garrettson, LK	1
Kovách, AG	1
Nguyen, LT	1
Pék, L	1
Dezsi, L	1
Lohinai, ZS	1
Rankin, AC	1
Rae, AP	1
Cobbe, SM	1
Maisel, AS	1
Motulsky, HJ	1
Insel, PA	1
Li, CH	1
Ying, SD	1
Liu, GM	1
Niu, SY	1
Zatuchni, J	2
Reines, E	1
Johnsen, A	1
Husum, D	1
Jensen, G	1
Salgado, HC	1
Krieger, EM	1
Hill, AC	1
Schecter, WP	1
Mori, H	1
Stevens, MB	1
Husseni, W	1
Lim, RC	1
Hoffman, JI	1
Kirk, CR	1
Gibbs, JL	1
Thomas, R	1
Radley-Smith, R	1
Qureshi, SA	1
Borowitz, JL	1
Stebbins, G	1
Isom, GE	1
Johnson, GE	1
Buxton, AE	1
Marchlinski, FE	1
Doherty, JU	1
Flores, B	1
Josephson, ME	1
Lewis, GB	1
Oszko, MA	1
Klutman, NE	1
Haft, JI	1
Habbab, MA	1
Lee, TH	1
Salomon, DR	1
Rayment, CM	1
Antman, EM	1
Davison, R	1
Hartz, R	1
Kaplan, K	1
Parker, M	1
Feiereisel, P	1
Michaelis, L	1
Ellrodt, AG	1
Ault, MJ	1
Krikler, D	1
Ljungström, A	1
Aberg, H	1
Vaughan-Neil, EF	1
Snell, NJ	1
Bevan, G	1
Yokoyama, H	1
Osugi, S	1
Bass, O	1
Friedemann, M	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Simulation of Adenosine Push Methods for Treatment of SVT Using Agitated Saline Visualized by Ultrasound[NCT04051541]		20 participants (Actual)	Interventional	2019-05-06	Completed
Treatment of Supraventricular Tachycardia in Patients With Non-cardiac Surgery by Dexmedetomidine During the Perioperative Period[NCT04284150]		60 participants (Anticipated)	Interventional	2020-02-26	Not yet recruiting
Verapamil as Adjunctive Seizure Therapy for Children and Young Adults With Dravet Syndrome[NCT01607073]	Phase 2	2 participants (Actual)	Interventional	2012-04-30	Completed
Calcium Administration to Prevent Hypotension Caused by Diltiazem Administration in the Treatment of Atrial Fibrillation With Rapid Ventricular Response[NCT05691959]	Phase 2	378 participants (Anticipated)	Interventional	2023-01-26	Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The secondary outcome measure is the change in number of absence seizures from Week 8 (Baseline) to Week 12 (NCT01607073)
Timeframe: Week 8 to Week 12

Change in Number of General Tonic-clonic Seizures From Week 8 (Baseline) Visit to Week 12 Visit

Intervention	Abscence seizures (Number)
Week 8 Baseline	165
Week 12 Verapamil 4mg/kg/Day	101

The primary study endpoint is the change in number of seizures from baseline. Since we only had one participant finish the study, the endpoint was changed to Week 12 visit. Participants were on verapamil for 4 weeks at Week 12. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

Change in Number of Myoclonic Seizures From Week 8 (Baseline) to Week 12

Intervention	General tonic-clonic seizures (Number)
Week 8 Baseline	39
Week 12 Verapamil 4mg/kg/Day	14

The secondary outcome is the change in number of myoclonic seizures between baseline Week 8 visit and Week 12 visit. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

Article	Year
Adenosine versus intravenous calcium channel antagonists for supraventricular tachycardia. The Cochrane database of systematic reviews, 2017, 10-12, Volume: 10 Topics: Adenosine; Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Emergency Service, Hospital; Hum	2017
Adenosine versus intravenous calcium channel antagonists for supraventricular tachycardia. The Cochrane database of systematic reviews, 2017, 10-12, Volume: 10 Topics: Adenosine; Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Emergency Service, Hospital; Hum	2017
Adenosine versus intravenous calcium channel antagonists for supraventricular tachycardia. The Cochrane database of systematic reviews, 2017, 10-12, Volume: 10 Topics: Adenosine; Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Emergency Service, Hospital; Hum	2017
Adenosine versus intravenous calcium channel antagonists for supraventricular tachycardia. The Cochrane database of systematic reviews, 2017, 10-12, Volume: 10 Topics: Adenosine; Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Emergency Service, Hospital; Hum	2017
From beta blockers to Ca2+ blockers in hypertension: a review. Israel journal of medical sciences, 1982, Volume: 18, Issue:7 Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Coronary Circulation; Drug Therapy, Combinati	1982
Slow channel blockers. Southern medical journal, 1983, Volume: 76, Issue:1 Topics: Angina Pectoris; Arrhythmias, Cardiac; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Cons	1983
The clinical use of verapamil. Mayo Clinic proceedings, 1982, Volume: 57, Issue:8 Topics: Administration, Oral; Adult; Animals; Arrhythmias, Cardiac; Biological Availability; Calcium; Cardio	1982
The use of calcium salts in the prevention and management of verapamil-induced hypotension. The Annals of pharmacotherapy, 2000, Volume: 34, Issue:5 Topics: Calcium Channel Blockers; Calcium Gluconate; Clinical Trials as Topic; Humans; Hypotension; Infusion	2000
Extracorporeal bypass for the treatment of verapamil poisoning. Annals of emergency medicine, 1989, Volume: 18, Issue:9 Topics: Cardiopulmonary Bypass; Child, Preschool; Combined Modality Therapy; Delayed-Action Preparations; Hu	1989
[Verapamil poisoning. A case with fatal course and literature review]. Ugeskrift for laeger, 1987, Nov-09, Volume: 149, Issue:46 Topics: Central Nervous System Diseases; Heart Block; Humans; Hypotension; Male; Metabolic Diseases; Middle	1987

Article	Year
Efficacy and safety of intracoronary verapamil versus sodium nitroprusside for the prevention of microvascular obstruction during primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Coronary artery disease, 2017, Volume: 28, Issue:1 Topics: Coronary Angiography; Coronary Circulation; Coronary Vessels; Echocardiography; Electrocardiography;	2017
[Diltiazem and verapamil therapy in patients with angina pectoris associated with arterial hypotension]. Klinicheskaia meditsina, 2004, Volume: 82, Issue:2 Topics: Angina Pectoris; Calcium Channel Blockers; Cross-Over Studies; Diltiazem; Humans; Hypotension; Male;	2004
Phase I/II trial of dexverapamil plus vinblastine for patients with advanced renal cell carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:8 Topics: Adult; Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bradycardia; Carcinoma, Renal	1995
Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:8 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cross-Over Studies; Cyclophosphamide; D	1995
Verapamil as prophylactic treatment for atrial fibrillation after lung operations. The Annals of thoracic surgery, 1996, Volume: 61, Issue:4 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Humans; Hypotension; Incidence	1996
Comparison of intravenous metoprolol, verapamil and diltiazem on the attenuation of haemodynamic changes associated with tracheal extubation. European journal of anaesthesiology, 1999, Volume: 16, Issue:7 Topics: Adult; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Pressure; Bradycardia; Diastole; Dilti	1999
Evaluation of the pharmacokinetics and electrocardiographic effects of intravenous verapamil with intravenous calcium chloride pretreatment in normal subjects. The American journal of cardiology, 1991, Feb-01, Volume: 67, Issue:4 Topics: Adolescent; Adult; Analysis of Variance; Blood Pressure; Calcium Chloride; Double-Blind Method; Elec	1991
Prophylaxis of supraventricular tachyarrhythmia after coronary bypass surgery with oral verapamil: a randomized, double-blind trial. The Annals of thoracic surgery, 1985, Volume: 39, Issue:4 Topics: Administration, Oral; Arrhythmias, Cardiac; Clinical Trials as Topic; Coronary Artery Bypass; Double	1985

Article	Year
Clinically Significant Bradycardia and Hypotension Following Consumption of Betel Leaf in a Patient Treated for Chronic Atrial Fibrillation. Journal of pharmacy practice, 2023, Volume: 36, Issue:2 Topics: Aged; Atrial Fibrillation; Bradycardia; Diabetes Mellitus, Type 2; Female; Humans; Hypotension; Meto	2023
Secondary colonic necrosis. Case report. Cirugia y cirujanos, 2019, Volume: 87, Issue:S1 Topics: Abdomen, Acute; Abdominal Abscess; Adult; Colectomy; Colon; Drainage; Female; Humans; Hypotension; I	2019
Postnatal developmental changes in the sensitivity of L-type Ca Pediatric research, 2018, Volume: 83, Issue:6 Topics: Animals; Bradycardia; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Disease Models,	2018
Safety of Calcium-Channel Blockers During Radial Cardiac Catheterization in Patients With Acute Myocardial Infarction or Systolic Heart Failure. The Journal of invasive cardiology, 2019, Volume: 31, Issue:4 Topics: Aged; Calcium Channel Blockers; Cardiac Catheterization; Catheterization, Peripheral; Drug Monitorin	2019
Verapamil reverses myocardial no-reflow after primary percutaneous coronary intervention in patients with acute myocardial infarction. Cell biochemistry and biophysics, 2013, Volume: 67, Issue:3 Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Atropine; Bradycardia; Coronary Angiography; Female;	2013
In Vitro Studies Indicate Intravenous Lipid Emulsion Acts as Lipid Sink in Verapamil Poisoning. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2016, Volume: 12, Issue:2 Topics: Absorption, Physicochemical; Animals; Calcium Channel Blockers; Calcium Signaling; Cardiotoxicity; C	2016
Levosimendan does not improve survival time in a rat model of verapamil toxicity. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2009, Volume: 5, Issue:1 Topics: Animals; Antidotes; Body Temperature; Bradycardia; Calcium Channel Blockers; Drug Interactions; Elec	2009
Surprisingly delayed escalation of severe verapamil poisoning. European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2009, Volume: 16, Issue:2 Topics: Aged; Blood Pressure Determination; Calcium Channel Blockers; Coma; Delayed-Action Preparations; Hum	2009
Early use of high-dose insulin euglycaemic therapy for verapamil toxicity. The Medical journal of Australia, 2009, Sep-21, Volume: 191, Issue:6 Topics: Calcium Channel Blockers; Dose-Response Relationship, Drug; Humans; Hypotension; Infusions, Intraven	2009
IPROVERATRIL: EXPERIMENTAL DATA ON CORONARY DILATATION AND ANTIARRHYTHMIC ACTION. Canadian Medical Association journal, 1964, Mar-28, Volume: 90 Topics: Animals; Anti-Arrhythmia Agents; Anura; Blood Pressure; Bradycardia; Cats; Chloroform; Coronary Vess	1964
[Lethal polypharmacy in a patient with arterial hypertension]. Deutsche medizinische Wochenschrift (1946), 2004, Dec-10, Volume: 129, Issue:50 Topics: Aged; Aged, 80 and over; Amiloride; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agent	2004
Verapamil toxicity resulting from a probable interaction with telithromycin. The Annals of pharmacotherapy, 2005, Volume: 39, Issue:2 Topics: Aged; Bradycardia; Drug Interactions; Female; Humans; Hypotension; Ketolides; Verapamil	2005
ECGs in the ED. Pediatric emergency care, 2005, Volume: 21, Issue:10 Topics: Adolescent; Bradycardia; Calcium Channel Blockers; Electrocardiography; Female; Humans; Hypotension;	2005
Inadvertent toxic drug reaction in the management of atrial fibrillation. Journal of the Royal Society of Medicine, 2006, Volume: 99, Issue:3 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Digoxin; Drug Interactions; Electrocardiog	2006
[The application of 4-aminopyridine in calcium channel inhibitors acute poisoning]. Przeglad lekarski, 2007, Volume: 64, Issue:4-5 Topics: 4-Aminopyridine; Acute Disease; Adrenergic beta-Antagonists; Adult; Antidotes; Antihypertensive Agen	2007
Verapamil to inhibit the cardiovascular side effects of ritodrine. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1981, Volume: 19, Issue:4 Topics: Drug Evaluation; Female; Humans; Hypotension; Obstetric Labor, Premature; Pregnancy; Propanolamines;	1981
Lack of response to intravenous calcium in severe verapamil poisoning. Lancet (London, England), 1982, Oct-23, Volume: 2, Issue:8304 Topics: Adult; Bradycardia; Calcium Gluconate; Female; Gluconates; Humans; Hypotension; Infusions, Parentera	1982
Adverse interaction between beta-adrenergic blocking drugs and verapamil--report of three cases. Australian and New Zealand journal of medicine, 1982, Volume: 12, Issue:4 Topics: Adrenergic beta-Antagonists; Aged; Bradycardia; Coronary Disease; Drug Interactions; Drug Therapy, C	1982
Fatal verapamil overdose. Lancet (London, England), 1982, Nov-27, Volume: 2, Issue:8309 Topics: Adolescent; Female; Heart Arrest; Humans; Hypotension; Verapamil	1982
Verapamil for arrhythmias. The Medical letter on drugs and therapeutics, 1981, Mar-20, Volume: 23, Issue:6 Topics: Arrhythmias, Cardiac; Humans; Hypotension; Ion Channels; Muscle, Smooth, Vascular; Tachycardia; Vera	1981
Profound hyperglycemia and metabolic acidosis after verapamil overdose. Journal of the American College of Cardiology, 1983, Volume: 2, Issue:6 Topics: Acidosis; Adult; Dopamine; Electrocardiography; Female; Gastric Lavage; Humans; Hyperglycemia; Hypot	1983
Cerebral high energy phosphates after hypoxic-hypotension: effect of verapamil and nifedipine. Circulatory shock, 1984, Volume: 14, Issue:2 Topics: Adenosine Triphosphate; Animals; Brain; Cerebrovascular Circulation; Hypotension; Hypoxia, Brain; Ma	1984
Calcium infusion for reversal of adverse effects of intravenous verapamil. JAMA, 1983, Jun-17, Volume: 249, Issue:23 Topics: Bradycardia; Calcium Chloride; Cardiomyopathy, Hypertrophic; Drug Synergism; Female; Humans; Hypoten	1983
Parenteral-verapamil-induced sustained hypotension. Drug intelligence & clinical pharmacy, 1984, Volume: 18, Issue:3 Topics: Dopamine; Drug Interactions; Humans; Hypotension; Injections, Intravenous; Male; Middle Aged; Propra	1984
Verapamil poisoning in an infant. Pediatrics, 1984, Volume: 73, Issue:4 Topics: Bradycardia; Calcium Chloride; Coma; Female; Humans; Hypotension; Infant; Respiratory Insufficiency;	1984
Severe theophylline toxicity. Role of conservative measures, antiarrhythmic agents, and charcoal hemoperfusion. The American journal of medicine, 1984, Volume: 76, Issue:5 Topics: Aged; Heart Rate; Hemoperfusion; Humans; Hypotension; Kinetics; Male; Middle Aged; Propranolol; Seiz	1984
Safety and efficacy of short- and long-term verapamil therapy in children with tachycardia. The American journal of cardiology, 1981, Volume: 48, Issue:6 Topics: Administration, Oral; Atrial Fibrillation; Child; Child, Preschool; Dose-Response Relationship, Drug	1981
Verapamil in the long-term treatment of angina pectoris. Clinical and experimental pharmacology & physiology. Supplement, 1982, Volume: 6 Topics: Angina Pectoris; Bradycardia; Calcium Channel Blockers; Constipation; Coronary Disease; Dose-Respons	1982
Electroversion after verapamil administration. Chest, 1983, Volume: 83, Issue:2 Topics: Adolescent; Adult; Aged; Atrial Fibrillation; Atrial Flutter; Electric Countershock; Female; Humans;	1983
Side effects of verapamil in infants. Archives of disease in childhood, 1983, Volume: 58, Issue:6 Topics: Bradycardia; Female; Humans; Hypotension; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male;	1983
Intravenous Calcium chloride as an antidote to verapamil-induced hypotension. Intensive care medicine, 1982, Volume: 8, Issue:1 Topics: Aged; Atrial Fibrillation; Binding, Competitive; Calcium Chloride; Humans; Hypotension; Male; Verapa	1982
Calcium ion blocking drugs. Comprehensive therapy, 1982, Volume: 8, Issue:7 Topics: Administration, Oral; Bradycardia; Calcium Channel Blockers; Diltiazem; Dizziness; Headache; Heart D	1982
Calcium channel blockers: indications and limitations 1. Clinical pharmacology and use as antiarrhythmic agents. Postgraduate medicine, 1982, Volume: 72, Issue:5 Topics: Anti-Arrhythmia Agents; Biological Availability; Calcium; Calcium Channel Blockers; Cardiovascular D	1982
[Complications after intravenous administration of anti-arrhythmia agents]. Kardiologiia, 1982, Volume: 22, Issue:11 Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Ad	1982
Verapamil: its potential for causing serious complications in patients with hypertrophic cardiomyopathy. Circulation, 1981, Volume: 64, Issue:3 Topics: Arrhythmias, Cardiac; Blood Pressure; Cardiomyopathy, Hypertrophic; Death, Sudden; Depression, Chemi	1981
Three cases of severe verapamil poisoning. International journal of cardiology, 1981, Volume: 1, Issue:1 Topics: Adult; Aged; Arrhythmias, Cardiac; Dopamine; Female; Humans; Hypotension; Male; Medazepam; Metaprote	1981
Streptokinase-induced transient aggravation of myocardial injury. International journal of cardiology, 1995, Jun-30, Volume: 50, Issue:2 Topics: Adult; Aged; Anti-Arrhythmia Agents; Blood Pressure; Coronary Circulation; Drug Therapy, Combination	1995
Administration of intravenous calcium before verapamil to prevent hypotension in elderly patients with paroxysmal supraventricular tachycardia. Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:2 Topics: Aged; Aged, 80 and over; Blood Pressure; Calcium; Electrocardiography; Heart Rate; Humans; Hypotensi	1993
Clinical significance and predisposing factors to symptomatic bradycardia and hypotension after percutaneous transluminal coronary angioplasty. The American journal of cardiology, 1994, Dec-01, Volume: 74, Issue:11 Topics: Adrenergic beta-Antagonists; Adult; Aged; Angioplasty, Balloon, Coronary; Bradycardia; Coronary Dise	1994
[Sinus bradycardia with junctional rhythm escape reverted with calcium gluconate]. Arquivos brasileiros de cardiologia, 1994, Volume: 62, Issue:5 Topics: Aged; Bradycardia; Calcium Gluconate; Female; Humans; Hypotension; Infusions, Intravenous; Verapamil	1994
Toxic effects of diltiazem in a patient with chronic renal failure. Journal of clinical pharmacology, 1994, Volume: 34, Issue:3 Topics: Acidosis; Adult; Diltiazem; Heart Failure; Humans; Hyperkalemia; Hypotension; Kidney Failure, Chroni	1994
Overdose of sustained-release verapamil. British journal of anaesthesia, 1994, Volume: 72, Issue:3 Topics: Adult; Delayed-Action Preparations; Drug Overdose; Female; Heart Block; Humans; Hypotension; Time Fa	1994
Intravenous diltiazem hydrochloride rather than verapamil for resistant paroxysmal supraventricular tachycardia. The Western journal of medicine, 1993, Volume: 159, Issue:5 Topics: Diltiazem; Drug Tolerance; Humans; Hypotension; Injections, Intravenous; Tachycardia, Paroxysmal; Ta	1993
Noncardiogenic pulmonary edema complicating massive verapamil overdose. Chest, 1994, Volume: 105, Issue:2 Topics: Adult; Drug Overdose; Dyspnea; Female; Humans; Hypotension; Hypoxia; Pulmonary Edema; Verapamil	1994
[Do ACE inhibitors potentiate snake venom? Severe and prolonged hypotension caused by adder bite]. Lakartidningen, 1993, Aug-11, Volume: 90, Issue:32-33 Topics: Angiotensin-Converting Enzyme Inhibitors; Antivenins; Drug Synergism; Enalapril; Humans; Hypotension	1993
A one-year evaluation of calcium channel blocker overdoses: toxicity and treatment. Annals of emergency medicine, 1993, Volume: 22, Issue:2 Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Atropine; Calcium; Calcium Channel Blockers; Child; C	1993
The use of glucagon in a case of calcium channel blocker overdose. Annals of emergency medicine, 1993, Volume: 22, Issue:7 Topics: Acute Disease; Aged; Bradycardia; Dobutamine; Dopamine; Drug Overdose; Drug Therapy, Combination; Fe	1993
Use of amrinone and glucagon in a case of calcium channel blocker overdose. Annals of emergency medicine, 1993, Volume: 22, Issue:7 Topics: Adult; Amrinone; Drug Overdose; Drug Therapy, Combination; Female; Glucagon; Humans; Hypotension; Ve	1993
Coronary vasoconstriction is the most probable cause of death of rats intoxicated with botulinolysin, a hemolysin produced by Clostridium botulinum. Toxicon : official journal of the International Society on Toxinology, 1995, Volume: 33, Issue:9 Topics: Animals; Aspirin; Blood Pressure; Botulinum Toxins; Botulism; Clostridium botulinum; Electrocardiogr	1995
Reversal of acute theophylline toxicity by calcium channel blockers in dogs and rats. Toxicology, 1996, Jun-17, Volume: 110, Issue:1-3 Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bronchodilator Agents; Calcium; Calcium Channel Block	1996
Calcium channel blockers induce thymic apoptosis in vivo in rats. Toxicology and applied pharmacology, 1996, Volume: 139, Issue:1 Topics: Animals; Apoptosis; Calcium Channel Blockers; Chlorpromazine; Diltiazem; Dopamine Antagonists; Dose-	1996
The effects of amrinone and glucagon on verapamil-induced cardiovascular toxicity in anaesthetized rats. International journal of experimental pathology, 1996, Volume: 77, Issue:5 Topics: Amrinone; Animals; Blood Pressure; Bradycardia; Calcium Channel Blockers; Cardiovascular Diseases; D	1996
The effects of 4-aminopyridine and Bay K 8644 on verapamil-induced cardiovascular toxicity in anesthetized rats. Journal of toxicology. Clinical toxicology, 1998, Volume: 36, Issue:4 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e	1998
Severe hypotension and bradycardia associated with verapamil and clarithromycin. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1998, Nov-15, Volume: 55, Issue:22 Topics: Anti-Arrhythmia Agents; Anti-Bacterial Agents; Bradycardia; Clarithromycin; Drug Interactions; Femal	1998
Enantioselective synthesis and pharmacological evaluation of a new type of verapamil analog with hypotensive and calcium antagonist activities. Pharmaceutical research, 1999, Volume: 16, Issue:2 Topics: Animals; Aorta; Atrial Function; Biotransformation; Calcium Channel Blockers; Dose-Response Relation	1999
Hypertonic sodium bicarbonate is effective in the acute management of verapamil toxicity in a swine model. Annals of emergency medicine, 2000, Volume: 36, Issue:6 Topics: Animals; Blood Pressure Determination; Disease Models, Animal; Drug-Related Side Effects and Adverse	2000
Hypotensive effect of the methanolic extract of Mimusops elengi in normotensive rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 1999, Volume: 6, Issue:5 Topics: Acute Disease; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Drug Syne	1999
Comparison of verapamil and practolol in paroxysmal supraventricular tachycardia. European journal of cardiology, 1976, Volume: 4, Issue:1 Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hum	1976
Calcium pretreatment to prevent verapamil-induced hypotension in patients with SVT. Annals of emergency medicine, 1992, Volume: 21, Issue:1 Topics: Calcium; Humans; Hypotension; Premedication; Tachycardia, Supraventricular; Verapamil	1992
Verapamil overdose and severe hypocalcemia. Journal of toxicology. Clinical toxicology, 1992, Volume: 30, Issue:2 Topics: Adult; Arrhythmias, Cardiac; Blood Pressure; Calcium Gluconate; Drug Overdose; Humans; Hypocalcemia;	1992
An additive or synergistic drug interaction: application of concentration-effect modeling. Clinical pharmacology and therapeutics, 1992, Volume: 51, Issue:6 Topics: Adult; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Drug The	1992
Low-dose calcium pretreatment to prevent verapamil-induced hypotension. American heart journal, 1992, Volume: 124, Issue:1 Topics: Blood Pressure; Calcium; Humans; Hypotension; Incidence; Middle Aged; Premedication; Retrospective S	1992
Verapamil prevents cerebral acidosis during moderate hypoxia and hypotension. Metabolic brain disease, 1991, Volume: 6, Issue:1 Topics: Acidosis; Animals; Brain; Glucose; Hypotension; Hypoxia; Male; Rats; Rats, Inbred Strains; Verapamil	1991
An approach to the diagnosis of wide QRS tachycardias. Hospital practice (Office ed.), 1991, Mar-30, Volume: 26, Issue:3A Topics: Diagnosis, Differential; Electrocardiography; Heart Rate; Hemodynamics; Humans; Hypotension; Tachyca	1991
Verapamil administration to patients with contraindications: is it associated with adverse outcomes? Annals of emergency medicine, 1991, Volume: 20, Issue:10 Topics: Adult; Contraindications; Emergencies; Humans; Hypotension; Male; Middle Aged; Retrospective Studies	1991
Effect of hyperkalemia on experimental myocardial depression by verapamil. American heart journal, 1991, Volume: 121, Issue:2 Pt 1 Topics: Acute Disease; Animals; Bradycardia; Calcium; Depression, Chemical; Disease Models, Animal; Dogs; Dr	1991
Drug-induced supraventricular tachycardia: a case report of fluoxetine. Annals of emergency medicine, 1991, Volume: 20, Issue:2 Topics: Electrocardiography; Female; Fluoxetine; Humans; Hypotension; Middle Aged; Tachycardia, Supraventric	1991
Delayed onset of cardiac arrhythmias from sustained-release verapamil. Annals of emergency medicine, 1991, Volume: 20, Issue:2 Topics: Adult; Delayed-Action Preparations; Drug Overdose; Heart Block; Humans; Hypotension; Male; Verapamil	1991
Shock in a woman with chronic pain. Hospital practice (Office ed.), 1991, Apr-15, Volume: 26, Issue:4 Topics: Adult; Bradycardia; Calcium; Female; Humans; Hypotension; Migraine Disorders; Pain, Postoperative; V	1991
Intravenous calcium before verapamil to prevent hypotension. Annals of emergency medicine, 1991, Volume: 20, Issue:5 Topics: Calcium; Humans; Hypotension; Infusions, Intravenous; Tachycardia, Supraventricular; Verapamil	1991
Increasing extracellular calcium concentration does not prevent hypotensive effects of verapamil in neonatal swine. Developmental pharmacology and therapeutics, 1990, Volume: 15, Issue:1 Topics: Animals; Calcium Chloride; Electrocardiography; Hemodynamics; Hypotension; Infusions, Intravenous; M	1990
Calcium channel blocker toxicity. Annals of emergency medicine, 1990, Volume: 19, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Child; Child, Preschool; Delaware;	1990
Supraventricular tachyarrhythmias and rate-related hypotension: cardiovascular effects and efficacy of intravenous verapamil. Annals of emergency medicine, 1990, Volume: 19, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Injections,	1990
The effect of calcium entry blocker S-emopamil on cerebrocortical metabolism and blood flow changes evoked by graded hypotension. Advances in experimental medicine and biology, 1989, Volume: 248 Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cats; Cerebral Cortex; Cerebrovascular Circulatio	1989
Misuse of intravenous verapamil in patients with ventricular tachycardia. Lancet (London, England), 1987, Aug-29, Volume: 2, Issue:8557 Topics: Adult; Aged; Aged, 80 and over; Diagnostic Errors; Drug Evaluation; Female; Humans; Hypotension; Inf	1987
Hypotension after quinidine plus verapamil. Possible additive competition at alpha-adrenergic receptors. The New England journal of medicine, 1985, Jan-17, Volume: 312, Issue:3 Topics: Aged; Animals; Arrhythmias, Cardiac; Binding, Competitive; Drug Synergism; Drug Therapy, Combination	1985
Hemodynamic effects of hypotension induced by verapamil or labetalol in dogs. Chinese medical journal, 1988, Volume: 101, Issue:2 Topics: Animals; Dogs; Hemodynamics; Hypotension; Labetalol; Verapamil	1988
Cardiovascular collapse after verapamil in supraventricular tachycardia. Archives of disease in childhood, 1988, Volume: 63, Issue:9 Topics: Digoxin; Drug Interactions; Humans; Hypotension; Propranolol; Tachycardia, Supraventricular; Verapam	1988
Extent of baroreceptor resetting in response to sodium nitroprusside and verapamil. Hypertension (Dallas, Tex. : 1979), 1988, Volume: 11, Issue:2 Pt 2 Topics: Animals; Blood Pressure; Ferricyanides; Hypertension, Renovascular; Hypotension; Nitroprusside; Pres	1988
The effect of verapamil on cerebral cortical and spinal cord blood flow during proximal descending thoracic aortic occlusion. The Journal of trauma, 1988, Volume: 28, Issue:8 Topics: Animals; Aorta, Thoracic; Cerebral Cortex; Constriction; Dogs; Hypertension; Hypotension; Ischemia;	1988
Cardiovascular collapse after verapamil in supraventricular tachycardia. Archives of disease in childhood, 1987, Volume: 62, Issue:12 Topics: Female; Humans; Hypotension; Infant, Newborn; Male; Tachycardia, Supraventricular; Verapamil	1987
Studies of the hypotensive effect of calcium injected into lateral brain ventricles. Research communications in chemical pathology and pharmacology, 1987, Volume: 55, Issue:1 Topics: Animals; Blood Pressure; Calcium Chloride; Cerebral Ventricles; Hypotension; Injections, Intraventri	1987
Hazards of intravenous verapamil for sustained ventricular tachycardia. The American journal of cardiology, 1987, May-01, Volume: 59, Issue:12 Topics: Adult; Aged; Electric Countershock; Humans; Hypotension; Injections, Intravenous; Middle Aged; Risk;	1987
Haemodynamic disturbances during anaesthesia in a patient receiving verapamil. British journal of anaesthesia, 1987, Volume: 59, Issue:10 Topics: Aged; Anesthesia, General; Atrial Fibrillation; Cataract Extraction; Humans; Hypotension; Intraopera	1987
Use of calcium salts during cardiopulmonary resuscitation for reversing verapamil-associated hypotension. Clinical pharmacy, 1987, Volume: 6, Issue:6 Topics: Calcium; Humans; Hypotension; Resuscitation; Verapamil	1987
Treatment of atrial arrhythmias. Effectiveness of verapamil when preceded by calcium infusion. Archives of internal medicine, 1986, Volume: 146, Issue:6 Topics: Adolescent; Adult; Aged; Atrial Fibrillation; Atrial Flutter; Calcium Chloride; Digoxin; Drug Evalua	1986
Hypotension and sinus arrest with exercise-induced hyperkalemia and combined verapamil/propranolol therapy. The American journal of medicine, 1986, Volume: 80, Issue:6 Topics: Drug Interactions; Heart Arrest; Humans; Hypotension; Ibuprofen; Male; Middle Aged; Physical Exertio	1986
Bradycardia and hypotension after propranolol HCl and verapamil. Heart & lung : the journal of critical care, 1985, Volume: 14, Issue:1 Topics: Bradycardia; Drug Interactions; Female; Humans; Hypotension; Middle Aged; Propranolol; Tachycardia,	1985
Calcium-channel blockers in acute hypertension. The American journal of emergency medicine, 1985, Volume: 3, Issue:6 Suppl Topics: Acute Disease; Blood Pressure; Calcium Channel Blockers; Costs and Cost Analysis; Emergencies; Heart	1985
Verapamil in cardiology. European journal of cardiology, 1974, Volume: 2, Issue:1 Topics: Administration, Oral; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Anura; Arrhythmi	1974
[Interaction between beta receptor blockaders and verapamil]. Lakartidningen, 1973, Oct-10, Volume: 70, Issue:41 Topics: Bradycardia; Drug Interactions; Graves Disease; Humans; Hypotension; Male; Middle Aged; Propranolol;	1973
Hypotension after verapamil. British medical journal, 1972, May-27, Volume: 2, Issue:5812 Topics: Atrial Fibrillation; Humans; Hypotension; Male; Middle Aged; Verapamil	1972
[Clinical physiopathological studies on myocardial oxygen metabolism. 3. Myocardial oxygen metabolism during administration of coronary dilators]. Japanese circulation journal, 1971, Volume: 35, Issue:1 Topics: Adolescent; Adult; Aged; Benzoates; Benzofurans; Coronary Disease; Coumarins; Dipyridamole; Female;	1971
[Clinical pathophysiological studies on coronary circulation. 3. The effects of so-called coronary vasodilator agents on coronary circulation in various diseases]. Japanese circulation journal, 1971, Volume: 35, Issue:2 Topics: Adolescent; Adult; Aged; Benzoates; Benzofurans; Blood Flow Velocity; Blood Pressure; Coronary Disea	1971
[The antiarrhythmic action mechanism of verapamil (Isoptin)]. Schweizerische medizinische Wochenschrift, 1971, May-29, Volume: 101, Issue:21 Topics: Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Atropine; Blood Pressure; Drug Antagonism	1971

verapamil and Hypotension