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verapamil and Hypotension, Orthostatic

verapamil has been researched along with Hypotension, Orthostatic in 10 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Hypotension, Orthostatic: A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.

Research Excerpts

ExcerptRelevanceReference
"The orthostatic changes in heart rate (HR) and blood pressure (BP) were recorded in ten patients with stable angina pectoris before and after simultaneous sublingual nitroglycerin administration."9.05Orthostatic response before and after nitroglycerin in metoprolol- and verapamil-treated angina pectoris. ( Hyldstrup, L; Mogensen, NB; Nielsen, PE, 1983)
"In three patients with orthostatic hypotension successfully treated by the peripheral dopaminergic antagonist domperidone 60 mg/day, the subsequent introduction of verapamil 240 mg/day did not modify the standing-induced decrease in systolic blood pressure: 46."5.27Hypertension with orthostatic hypotension: interest of verapamil. ( Chamontin, BF; Montastruc, JL; Salvador, MJ, 1987)
"The orthostatic changes in heart rate (HR) and blood pressure (BP) were recorded in ten patients with stable angina pectoris before and after simultaneous sublingual nitroglycerin administration."5.05Orthostatic response before and after nitroglycerin in metoprolol- and verapamil-treated angina pectoris. ( Hyldstrup, L; Mogensen, NB; Nielsen, PE, 1983)
" Our data suggest that the greater hypotensive activity of the combination results at least in part from a kinetic interaction that enhances the bioavailability of prazosin, but it is possible that a dynamic interaction at the level of vascular smooth muscle or compensatory cardiac activity also plays a role."1.27Combined alpha adrenoceptor antagonism and calcium channel blockade in normal subjects. ( Elliott, HL; McSharry, DR; Meredith, PA; Pasanisi, F; Reid, JL, 1984)
"In three patients with orthostatic hypotension successfully treated by the peripheral dopaminergic antagonist domperidone 60 mg/day, the subsequent introduction of verapamil 240 mg/day did not modify the standing-induced decrease in systolic blood pressure: 46."1.27Hypertension with orthostatic hypotension: interest of verapamil. ( Chamontin, BF; Montastruc, JL; Salvador, MJ, 1987)
"A case of orthostatic hypotension due to the combination of hypertrophic obstructive cardiomyopathy and autonomic failure is described."1.27Orthostatic hypotension due to hypertrophic cardiomyopathy and autonomic failure. ( Mader, SL; Wong, M, 1987)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19909 (90.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yu, W1
Horowitz, SH1
Hyldstrup, L1
Mogensen, NB1
Nielsen, PE1
Pasanisi, F1
Elliott, HL1
Meredith, PA1
McSharry, DR1
Reid, JL1
Kochar, MS1
Rosing, DR1
Condit, JR1
Maron, BJ1
Kent, KM1
Leon, MB1
Bonow, RO1
Lipson, LC1
Epstein, SE1
Bogoliubov, VM1
Anashkin, OD1
Trushinskiĭ, ZK1
Shashkov, VS1
Shatunina, TP1
Chamontin, BF1
Montastruc, JL2
Salvador, MJ1
Chamontin, B1
Villeneuve, A1
Berlan, M1
Salvador, M1
Karasawa, A1
Kubo, K1
Shuto, K1
Oka, T1
Nakamizo, N1
Mader, SL1
Wong, M1

Trials

1 trial available for verapamil and Hypotension, Orthostatic

ArticleYear
Orthostatic response before and after nitroglycerin in metoprolol- and verapamil-treated angina pectoris.
    Acta medica Scandinavica, 1983, Volume: 214, Issue:2

    Topics: Aged; Angina Pectoris; Blood Pressure; Heart Rate; Humans; Hypotension, Orthostatic; Metoprolol; Mid

1983

Other Studies

9 other studies available for verapamil and Hypotension, Orthostatic

ArticleYear
Treatment of sporadic hemiplegic migraine with calcium-channel blocker verapamil.
    Neurology, 2003, Jan-14, Volume: 60, Issue:1

    Topics: Acetazolamide; Adult; Calcium Channel Blockers; Female; Follow-Up Studies; Hemiplegia; Humans; Hypot

2003
Combined alpha adrenoceptor antagonism and calcium channel blockade in normal subjects.
    Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:6

    Topics: Administration, Oral; Adult; Biological Availability; Blood Pressure; Chromatography, High Pressure

1984
Simultaneous treatment of Raynaud's phenomenon and orthostatic hypotension.
    The American journal of medicine, 1983, Volume: 75, Issue:3

    Topics: Drug Therapy, Combination; Ephedrine; Female; Fludrocortisone; Follow-Up Studies; Humans; Hydralazin

1983
Verapamil therapy: a new approach to the pharmacologic treatment of hypertrophic cardiomyopathy: III. Effects of long-term administration.
    The American journal of cardiology, 1981, Volume: 48, Issue:3

    Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Cardiomyopathy, Hypertrophic; Echocardiography; Elect

1981
[Effect of isoptin in prevention of orthostatic hypotension after hypokinesia].
    Voenno-meditsinskii zhurnal, 1978, Issue:11

    Topics: Adult; Blood Pressure; Drug Evaluation; Humans; Hypotension, Orthostatic; Male; Movement Disorders;

1978
Hypertension with orthostatic hypotension: interest of verapamil.
    Journal of cardiovascular pharmacology, 1987, Volume: 10 Suppl 10

    Topics: Adult; Aged; Blood Pressure; Domperidone; Female; Follow-Up Studies; Heart Rate; Humans; Hypertensio

1987
[Arterial hypertension with orthostatic hypotension caused by dysregulation of the baroreflex. Correction with domperidone and verapamil].
    Presse medicale (Paris, France : 1983), 1986, Mar-22, Volume: 15, Issue:12

    Topics: Domperidone; Drug Therapy, Combination; Humans; Hypertension; Hypotension, Orthostatic; Male; Middle

1986
Effects of benidipine hydrochloride on atrioventricular conduction time and postural reflex in gallamine-immobilized cats.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:11A

    Topics: Animals; Antihypertensive Agents; Atrioventricular Node; Blood Pressure; Calcium Channel Blockers; C

1988
Orthostatic hypotension due to hypertrophic cardiomyopathy and autonomic failure.
    The American journal of medicine, 1987, Volume: 82, Issue:6

    Topics: Aged; Aged, 80 and over; Autonomic Nervous System Diseases; Cardiomyopathy, Hypertrophic; Echocardio

1987