verapamil has been researched along with Hypertension, Portal in 17 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Hypertension, Portal: Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Seven patients with alcoholic cirrhosis received verapamil, 10 mg i." | 7.67 | Combination of ketanserin and verapamil or propranolol in patients with alcoholic cirrhosis: search for an additive effect. ( Cerini, R; Hadengue, A; Koshy, A; Lebrec, D; Lee, SS; Moreau, R, 1989) |
| "This study aimed to assess the effects of verapamil, a calcium-channel blocker, on porto-hepatic pressure gradient and on hepatic function as measured by the intrinsic hepatic clearance of indocyanine green (ICG) in patients with biopsy proven alcoholic cirrhosis." | 3.67 | Verapamil has no effect on porto-hepatic pressure gradient, hepatic blood flow and elimination function of the liver in patients with liver cirrhosis. ( Cales, P; Caucanas, JP; Combis, JM; Pascal, JP; Vinel, JP; Voigt, JJ, 1989) |
| " Seven patients with alcoholic cirrhosis received verapamil, 10 mg i." | 3.67 | Combination of ketanserin and verapamil or propranolol in patients with alcoholic cirrhosis: search for an additive effect. ( Cerini, R; Hadengue, A; Koshy, A; Lebrec, D; Lee, SS; Moreau, R, 1989) |
| "Verapamil (CAS 52-53-9) is a calcium channel blocker with a vasodilatatory effect." | 2.68 | Pharmacokinetic parameters of verapamil and its active metabolite norverapamil in patients with hepatopathy. ( Brátová, M; Fendrich, Z; Hůlek, P; Macek, K; Vlcek, J, 1995) |
| " Long term administration of isosorbide dinitrate also had a significant effect (p less than 0." | 2.66 | Effect of isosorbide dinitrate, verapamil, and labetalol on portal pressure in cirrhosis. ( Barton, JR; Freeman, JG; Record, CO, 1985) |
| "Portal hypertension was induced by partial portal vein ligation in Sprague-Dawley rats." | 1.30 | Portal hypotensive effects of tetrandrine and verapamil in portal hypertensive rats. ( Hong, CY; Huang, YT; Lin, HC; Liu, TB; Sun, CM, 1997) |
| " With the portal vein isolated, the parathyroid hormone shifted the dose-response curves of KCl and acetylcholine to the right." | 1.28 | Responsiveness to synthetic parathyroid hormone in the portal vein of portal hypertensive rats. ( Chao, TW; Kuo, JS; Pang, PK; Yang, MC; Yu, PC, 1992) |
| " Acute and chronic use of verapamil significantly reduced the hepatic venous pressure gradient for about an average of 20% at 1 hr after drug administration (p less than 0." | 1.27 | Effects of verapamil on estimated hepatic blood flow in patients with HBsAg-positive cirrhosis. ( Chen, KY; Chiang, BN; Kong, CW; Lay, CS; Lee, FY; Lee, SD; Lo, KJ; Tsai, YT, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (41.18) | 18.7374 |
| 1990's | 9 (52.94) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lay, CS | 3 |
| May, CM | 1 |
| Lee, FY | 2 |
| Tsai, YT | 3 |
| Lee, SD | 2 |
| Chien, S | 2 |
| Sinchon, S | 1 |
| Whalen, GF | 1 |
| Hackel, DB | 1 |
| Mikat, E | 1 |
| Vlcek, J | 1 |
| Macek, K | 1 |
| Hůlek, P | 1 |
| Brátová, M | 1 |
| Fendrich, Z | 1 |
| Hanisch, E | 1 |
| Strasse, R | 1 |
| Wenzel, M | 1 |
| Lorey, T | 1 |
| Li, D | 2 |
| Lu, H | 1 |
| Li, X | 2 |
| Quan, Q | 1 |
| Lu, W | 1 |
| Yang, MC | 2 |
| Wu, SL | 1 |
| Wu, KL | 1 |
| Liu, TB | 1 |
| Lin, HC | 1 |
| Huang, YT | 1 |
| Sun, CM | 1 |
| Hong, CY | 1 |
| Chao, TW | 1 |
| Yu, PC | 1 |
| Kuo, JS | 1 |
| Pang, PK | 1 |
| Combis, JM | 2 |
| Vinel, JP | 2 |
| Altmann, O | 1 |
| Caucanas, JP | 1 |
| Cales, P | 1 |
| Voigt, JJ | 1 |
| Pascal, JP | 1 |
| Hadengue, A | 1 |
| Moreau, R | 1 |
| Cerini, R | 1 |
| Koshy, A | 1 |
| Lee, SS | 1 |
| Lebrec, D | 1 |
| Merkel, C | 1 |
| Gatta, A | 1 |
| Bolognesi, M | 1 |
| Padrini, R | 1 |
| Finucci, GF | 1 |
| Angeli, P | 1 |
| Ruol, A | 1 |
| Kong, CW | 1 |
| Chen, KY | 1 |
| Chiang, BN | 1 |
| Lo, KJ | 1 |
| Reichen, J | 1 |
| Hirlinger, A | 1 |
| Ha, HR | 1 |
| Sägesser, S | 1 |
| Freeman, JG | 1 |
| Barton, JR | 1 |
| Record, CO | 1 |
1 review available for verapamil and Hypertension, Portal
| Article | Year |
|---|---|
[Vasodilator agents in portal hypertension].
Topics: Adrenergic alpha-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; He | 1991 |
3 trials available for verapamil and Hypertension, Portal
| Article | Year |
|---|---|
Pharmacokinetic parameters of verapamil and its active metabolite norverapamil in patients with hepatopathy.
Topics: Adult; Aged; Antipyrine; Breath Tests; Female; Half-Life; Humans; Hypertension, Portal; Liver Diseas | 1995 |
Calcium channel blockers in cirrhotic patients with portal hypertension.
Topics: Adolescent; Adult; Aged; Alkaloids; Animals; Benzylisoquinolines; Calcium Channel Blockers; Cinnariz | 1995 |
Effect of isosorbide dinitrate, verapamil, and labetalol on portal pressure in cirrhosis.
Topics: Humans; Hypertension, Portal; Isosorbide Dinitrate; Labetalol; Liver Cirrhosis; Venous Pressure; Ver | 1985 |
13 other studies available for verapamil and Hypertension, Portal
| Article | Year |
|---|---|
Effect of verapamil on nitric oxide synthase in a portal vein-ligated rat model: role of prostaglandin.
Topics: Animals; Epoprostenol; Hemodynamics; Hypertension, Portal; Indomethacin; Male; Nitric Oxide Synthase | 2006 |
Prevention of portal hypertension and small bowel hemorrhage in dogs treated with verapamil during hemorrhagic shock.
Topics: Animals; Blood Pressure; Dogs; Gastrointestinal Hemorrhage; Hypertension, Portal; Intestine, Small; | 1980 |
[In vitro contractility behavior of portal veins in normal rats and in rats with liver cirrhosis--effect of calcium antagonists and octreotide].
Topics: Animals; Blood Pressure; Culture Techniques; Dose-Response Relationship, Drug; Hypertension, Portal; | 1993 |
Effect of verapamil on renal haemodynamics in a portal hypertensive rat model.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Hemodynamics; Hypertension, Portal; Male; | 1996 |
Portal hypotensive effects of tetrandrine and verapamil in portal hypertensive rats.
Topics: Alkaloids; Animals; Antihypertensive Agents; Benzylisoquinolines; Calcium Channel Blockers; Dose-Res | 1997 |
Responsiveness to synthetic parathyroid hormone in the portal vein of portal hypertensive rats.
Topics: Animals; Blood Pressure; Colforsin; Hypertension, Portal; In Vitro Techniques; Male; Parathyroid Hor | 1992 |
[Pharmacological lowering of portal pressure in normal rats and in experimental liver cirrhosis].
Topics: Acute Disease; Animals; Blood Pressure; Canrenoic Acid; Heart Rate; Hypertension, Portal; Liver Cirr | 1991 |
[Use of calcium-channel blockers in cirrhotic patients with portal hypertension].
Topics: Adolescent; Adult; Aged; Alkaloids; Animals; Benzylisoquinolines; Calcium Channel Blockers; Cinnariz | 1990 |
Verapamil has no effect on porto-hepatic pressure gradient, hepatic blood flow and elimination function of the liver in patients with liver cirrhosis.
Topics: Adult; Aged; Blood Pressure; Female; Hepatic Veins; Humans; Hypertension, Portal; Indocyanine Green; | 1989 |
Combination of ketanserin and verapamil or propranolol in patients with alcoholic cirrhosis: search for an additive effect.
Topics: Drug Synergism; Drug Therapy, Combination; Hemodynamics; Humans; Hypertension, Portal; Ketanserin; L | 1989 |
The calcium-channel blocker, verapamil, does not improve portal pressure in patients with alcoholic cirrhosis.
Topics: Adult; Blood Pressure; Humans; Hypertension, Portal; Liver Circulation; Liver Cirrhosis, Alcoholic; | 1988 |
Effects of verapamil on estimated hepatic blood flow in patients with HBsAg-positive cirrhosis.
Topics: Hepatitis B Surface Antigens; Humans; Hypertension, Portal; Liver Circulation; Liver Cirrhosis; Male | 1988 |
Chronic verapamil administration lowers portal pressure and improves hepatic function in rats with liver cirrhosis.
Topics: Animals; Blood Pressure; Hypertension, Portal; Liver; Liver Cirrhosis, Experimental; Liver Function | 1986 |