verapamil has been researched along with Hyperglycemia in 14 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Hyperglycemia: Abnormally high BLOOD GLUCOSE level.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present work, we investigated whether verapamil, an established TXNIP inhibitor, may provide protection against hyperglycemic stroke and tPA-induced blood-brain barrier (BBB) disruption." | 8.02 | Verapamil as an Adjunct Therapy to Reduce tPA Toxicity in Hyperglycemic Stroke: Implication of TXNIP/NLRP3 Inflammasome. ( Ahmed, HA; Ishrat, T; Ismael, S; Mirzahosseini, G; Nasoohi, S; Yoo, A, 2021) |
| " In the present study we investigated effect of hyperglycemia on cytotoxic efficacy of carboplatin and 5-fluorouracil in MCF-7 cells." | 7.77 | Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells. ( Bhat, MK; Chaube, B; Pandey, V, 2011) |
| "Effects of calcium channel blockers from structurally different classes and hydralazine on epinephrine-induced hyperglycemia were studied in vivo." | 7.67 | Effects of calcium channel blockers and hydralazine on epinephrine-induced hyperglycemia in vivo. ( Ogihara, M, 1989) |
| " In the present work, we investigated whether verapamil, an established TXNIP inhibitor, may provide protection against hyperglycemic stroke and tPA-induced blood-brain barrier (BBB) disruption." | 4.02 | Verapamil as an Adjunct Therapy to Reduce tPA Toxicity in Hyperglycemic Stroke: Implication of TXNIP/NLRP3 Inflammasome. ( Ahmed, HA; Ishrat, T; Ismael, S; Mirzahosseini, G; Nasoohi, S; Yoo, A, 2021) |
| " In the present study we investigated effect of hyperglycemia on cytotoxic efficacy of carboplatin and 5-fluorouracil in MCF-7 cells." | 3.77 | Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells. ( Bhat, MK; Chaube, B; Pandey, V, 2011) |
| "Endothelium-dependent vasodilation was assessed through brachial artery infusion of methacholine chloride both before and during 6 hours of local hyperglycemia (300 mg/dL) achieved by intra-arterial infusion of 50% dextrose." | 3.70 | Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. ( Creager, MA; Goldfine, AB; Roddy, MA; Simonson, DC; Timimi, FK; Ting, HH; Williams, SB, 1998) |
| "Verapamil poisoning is known to produce hyperglycemia and metabolic acidosis in humans." | 3.69 | The diabetogenic effects of acute verapamil poisoning. ( Kline, JA; Raymond, RM; Schroeder, JD; Watts, JA, 1997) |
| "Effects of calcium channel blockers from structurally different classes and hydralazine on epinephrine-induced hyperglycemia were studied in vivo." | 3.67 | Effects of calcium channel blockers and hydralazine on epinephrine-induced hyperglycemia in vivo. ( Ogihara, M, 1989) |
| " Islets from both genetic models showed a left-shifted glucose dose-response curve for insulin release (concentrations for half-maximal release, 5 to 6 mmol/L v 12 to 13 mmol/L in LA/N lean littermates and 3 mmol/L v 10 mmol/L in lean SHR/N)." | 1.28 | Genetically obese rats with (SHR/N-cp) and without diabetes (LA/N-cp) share abnormal islet responses to glucose. ( Recant, L; Timmers, KI; Voyles, NR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (21.43) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Ismael, S | 1 |
| Nasoohi, S | 1 |
| Yoo, A | 1 |
| Mirzahosseini, G | 1 |
| Ahmed, HA | 1 |
| Ishrat, T | 1 |
| Louters, LL | 1 |
| Stehouwer, N | 1 |
| Rekman, J | 1 |
| Tidball, A | 1 |
| Cok, A | 1 |
| Holstege, CP | 1 |
| Pandey, V | 1 |
| Chaube, B | 1 |
| Bhat, MK | 1 |
| Butakova, SS | 1 |
| Nozdrachev, AD | 1 |
| Levine, M | 1 |
| Boyer, EW | 1 |
| Pozner, CN | 1 |
| Geib, AJ | 1 |
| Thomsen, T | 1 |
| Mick, N | 1 |
| Thomas, SH | 2 |
| Winchester, DE | 1 |
| Holstege, C | 1 |
| Enyeart, JJ | 1 |
| Price, WA | 1 |
| Hoffman, DA | 1 |
| Woods, L | 1 |
| Stone, CK | 1 |
| May, WA | 1 |
| Kline, JA | 1 |
| Raymond, RM | 1 |
| Schroeder, JD | 1 |
| Watts, JA | 1 |
| Williams, SB | 1 |
| Goldfine, AB | 2 |
| Timimi, FK | 1 |
| Ting, HH | 1 |
| Roddy, MA | 1 |
| Simonson, DC | 1 |
| Creager, MA | 2 |
| Beckman, JA | 1 |
| Gordon, MB | 1 |
| Timmers, KI | 1 |
| Voyles, NR | 1 |
| Recant, L | 1 |
| Ogihara, M | 1 |
| Roth, A | 1 |
| Miller, HI | 1 |
| Belhassen, B | 1 |
| Laniado, S | 1 |
1 trial available for verapamil and Hyperglycemia
| Article | Year |
|---|---|
Ascorbate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans.
Topics: Acute Disease; Adult; Ascorbic Acid; Blood Flow Velocity; Blood Glucose; Dose-Response Relationship, | 2001 |
13 other studies available for verapamil and Hyperglycemia
| Article | Year |
|---|---|
Verapamil as an Adjunct Therapy to Reduce tPA Toxicity in Hyperglycemic Stroke: Implication of TXNIP/NLRP3 Inflammasome.
Topics: Animals; Carrier Proteins; Drug Therapy, Combination; Fibrinolytic Agents; Hyperglycemia; Male; Mice | 2021 |
Verapamil inhibits the glucose transport activity of GLUT1.
Topics: Animals; Antimetabolites; Calcium Channel Blockers; Calcium Chloride; Chelating Agents; Deoxyglucose | 2010 |
Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells.
Topics: Acetylcysteine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carboplat | 2011 |
Calcium channel blockers inhibit the hyperglycemic effect of calcitonin.
Topics: Animals; Bone Density Conservation Agents; Calcitonin; Calcium; Calcium Channel Blockers; Glucose; G | 2012 |
Assessment of hyperglycemia after calcium channel blocker overdoses involving diltiazem or verapamil.
Topics: Adult; Aged; Blood Glucose; Calcium Channel Blockers; Diltiazem; Drug Overdose; Humans; Hyperglycemi | 2007 |
Inclusion of patients who overdose with dihydropyridine calcium channel blockers would potentially increase clinical utility of hyperglycemia.
Topics: Calcium Channel Blockers; Dihydropyridines; Diltiazem; Drug Overdose; Heart Rate; Humans; Hyperglyce | 2008 |
Profound hyperglycemia and metabolic acidosis after verapamil overdose.
Topics: Acidosis; Adult; Dopamine; Electrocardiography; Female; Gastric Lavage; Humans; Hyperglycemia; Hypot | 1983 |
Exacerbation of verapamil-induced hyperglycemia with glucagon.
Topics: Animals; Dogs; Glucagon; Hyperglycemia; Verapamil | 1995 |
The diabetogenic effects of acute verapamil poisoning.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Female; Glucagon; Glucose; Hyperglycemia; Infusions, | 1997 |
Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo.
Topics: Acute Disease; Adult; Diabetes Mellitus; Endothelium, Vascular; Female; Humans; Hyperglycemia; Male; | 1998 |
Genetically obese rats with (SHR/N-cp) and without diabetes (LA/N-cp) share abnormal islet responses to glucose.
Topics: Animals; Blood Glucose; Blotting, Western; Cell Separation; Cells, Cultured; Diabetes Mellitus, Expe | 1992 |
Effects of calcium channel blockers and hydralazine on epinephrine-induced hyperglycemia in vivo.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Epinephrine; Food Deprivation; Glucose Tolerance Test; | 1989 |
Slow-release verapamil and hyperglycemic metabolic acidosis.
Topics: Acidosis; Aged; Delayed-Action Preparations; Female; Humans; Hyperglycemia; Verapamil | 1989 |