verapamil has been researched along with Hypercholesterolemia in 15 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Angiotensin II (Ang II) is able to induce free radical generation in neutrophils, which is more elevated in neutrophils of patients with hypercholesterolemia (HC)." | 7.73 | The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome. ( Balogh, Z; Fóris, G; Fülöp, P; Kassai, A; Kosztáczky, B; Paragh, G; Seres, I; Varga, Z, 2006) |
| "The regeneratory reactions of cardiomyocytes in the heart under conditions of cytopathic exposure to hypercholesterolemia and during verapamil treatment were studied by immunohistochemical detection of proliferation marker Ki-67 and evaluation of cardiomyocyte count." | 3.81 | Stimulation of Cardiomyocyte Regeneratory Reactions under Conditions of Cytopathic Hypercholesterolemia. ( Klinnikova, MG; Lushnikova, EL; Nepomnyashchikh, LM; Yuzhik, EI, 2015) |
| "Angiotensin II (Ang II) is able to induce free radical generation in neutrophils, which is more elevated in neutrophils of patients with hypercholesterolemia (HC)." | 3.73 | The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome. ( Balogh, Z; Fóris, G; Fülöp, P; Kassai, A; Kosztáczky, B; Paragh, G; Seres, I; Varga, Z, 2006) |
| " In spite of the low dose ingested, the postmortem cardiac blood verapamil level was clearly toxic (6000 ng/mL, or 6 mg/L)." | 2.44 | Verapamil toxicity: an unusual case report and review of the literature. ( Batalis, NI; Harley, RA; Schandl, CA, 2007) |
| "Verapamil-treated segments distal to the matrices also showed significantly lower neointimal smooth muscle cell density and increased lumen size." | 1.30 | Controlled periadventitial administration of verapamil inhibits neointimal smooth muscle cell proliferation and ameliorates vasomotor abnormalities in experimental vein bypass grafts. ( Bhuta, S; Brauner, R; Chaudhuri, G; Drake, T; Drinkwater, DC; Fishbein, I; Golomb, G; Laks, H; Mishaly, D; Shvarts, O, 1997) |
| " Long-term administration of the slow calcium channel blockers produces another decrease in the content of the bound form of arachidonic acid." | 1.28 | [Changes in the relative levels of fatty acids in blood and myocardium in the Prague breed of rats with hereditary hypercholesteremia after administration of slow calcium channel blockers]. ( Bukovská, A; Edelsteinová, S; Kuzelová, M; Svec, P; Vozár, I, 1992) |
| "Hypercholesterolemia was induced in rabbits by feeding pellet food containing 1% cholesterol for 3 months." | 1.27 | [The release of thromboxane A2 and prostacyclin due to vasoactive agents in hypercholesterolemic rabbits]. ( Takahashi, K, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Klinnikova, MG | 2 |
| Yuzhik, EI | 2 |
| Pichigin, VI | 1 |
| Lushnikova, EL | 2 |
| Nepomnyashchikh, LM | 1 |
| Muñoz Díaz, AB | 1 |
| Aguilar, P | 1 |
| Cooper-Dehoff, R | 1 |
| Cohen, JD | 1 |
| Bakris, GL | 1 |
| Messerli, FH | 1 |
| Erdine, S | 1 |
| Hewkin, AC | 1 |
| Kupfer, S | 1 |
| Pepine, CJ | 1 |
| Batalis, NI | 1 |
| Harley, RA | 1 |
| Schandl, CA | 1 |
| Seres, I | 1 |
| Fóris, G | 1 |
| Varga, Z | 1 |
| Kosztáczky, B | 1 |
| Kassai, A | 1 |
| Balogh, Z | 1 |
| Fülöp, P | 1 |
| Paragh, G | 1 |
| Iskenderov, BG | 1 |
| Burmistrova, LF | 1 |
| Berenshteĭn, NV | 1 |
| Lokhina, TV | 1 |
| Ragazzi, E | 1 |
| Chinellato, A | 1 |
| Pandolfo, L | 1 |
| Froldi, G | 1 |
| Caparrotta, L | 1 |
| Fassina, G | 1 |
| Brauner, R | 1 |
| Laks, H | 1 |
| Drinkwater, DC | 1 |
| Chaudhuri, G | 1 |
| Shvarts, O | 1 |
| Drake, T | 1 |
| Bhuta, S | 1 |
| Mishaly, D | 1 |
| Fishbein, I | 1 |
| Golomb, G | 1 |
| Martínez-Castelao, A | 1 |
| Hueso, M | 1 |
| Sanz, V | 1 |
| Rejas, J | 1 |
| Alsina, J | 1 |
| Grinyó, JM | 1 |
| Elliott, WJ | 1 |
| Edelsteinová, S | 1 |
| Bukovská, A | 1 |
| Svec, P | 1 |
| Vozár, I | 1 |
| Kuzelová, M | 1 |
| Rossitch, E | 1 |
| Alexander, E | 1 |
| Black, PM | 1 |
| Cooke, JP | 1 |
| Takahashi, K | 2 |
| Kawaguchi, H | 1 |
| Yasuda, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| INternational VErapamil SR Trandolapril STudy[NCT00133692] | Phase 4 | 22,000 participants | Interventional | 1997-09-30 | Completed | ||
| A Randomised, Double-blind, Placebo Controlled, Parallel Group, Multi-centre Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of Verapamil SR on Preservation of Beta-cell Function (Ver-A-T1D)[NCT04545151] | Phase 2 | 138 participants (Anticipated) | Interventional | 2021-02-08 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for verapamil and Hypercholesterolemia
| Article | Year |
|---|---|
Verapamil toxicity: an unusual case report and review of the literature.
Topics: Accidents; Antihypertensive Agents; Calcium Channel Blockers; Drug Combinations; Drug Overdose; Fema | 2007 |
3 trials available for verapamil and Hypercholesterolemia
11 other studies available for verapamil and Hypercholesterolemia
| Article | Year |
|---|---|
Remodeling of myocardium in rat with chronic dyslipidemia and under conditions of verapamil treatment.
Topics: Animals; Atherosclerosis; Calcium Channel Blockers; Cardiotonic Agents; Drug Evaluation, Preclinical | 2014 |
Stimulation of Cardiomyocyte Regeneratory Reactions under Conditions of Cytopathic Hypercholesterolemia.
Topics: Animals; Cell Proliferation; Chronic Disease; Hypercholesterolemia; Male; Myocardium; Myocytes, Card | 2015 |
[Idiopathic membranous nephropathy associated with anti-calcineurin toxicity. Prognosis and other immunosuppressive treatments].
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcineurin Inhibitors; Ca | 2004 |
The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome.
Topics: Adult; Angiotensin I; Angiotensin II; Anticholesteremic Agents; Cholesterol; Diabetes Mellitus, Type | 2006 |
Effect of calcium antagonists on isolated aorta from hypercholesterolemic Yoshida rats of different ages.
Topics: Aging; Animals; Aorta, Thoracic; Dinoprostone; Hypercholesterolemia; In Vitro Techniques; Male; Musc | 1994 |
Controlled periadventitial administration of verapamil inhibits neointimal smooth muscle cell proliferation and ameliorates vasomotor abnormalities in experimental vein bypass grafts.
Topics: Animals; Calcium Channel Blockers; Cell Division; Coronary Artery Bypass; Dose-Response Relationship | 1997 |
Timing treatment to the rhythm of disease. A short course in chronotherapeutics.
Topics: Antineoplastic Agents; Asthma; Cardiovascular Diseases; Chronotherapy; Circadian Rhythm; Humans; Hyd | 2001 |
[Changes in the relative levels of fatty acids in blood and myocardium in the Prague breed of rats with hereditary hypercholesteremia after administration of slow calcium channel blockers].
Topics: Animals; Diltiazem; Fatty Acids; Hypercholesterolemia; Myocardium; Rats; Rats, Inbred Strains; Verap | 1992 |
L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits.
Topics: Acetylcholine; Animals; Arginine; Endothelium, Vascular; Hypercholesterolemia; Nitric Oxide; Potassi | 1991 |
The hypertensive response to vasopressor agents stimulates the release of thromboxane A2 in hypercholesterolaemic rabbits.
Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin II; Animals; Blood Pressure; Dose-Response Relationship, D | 1989 |
[The release of thromboxane A2 and prostacyclin due to vasoactive agents in hypercholesterolemic rabbits].
Topics: Angiotensin II; Animals; Blood Pressure; Epoprostenol; Ergonovine; Hypercholesterolemia; Nitroglycer | 1986 |