verapamil has been researched along with Hepatic Insufficiency in 2 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Hepatic Insufficiency: Conditions in which the LIVER functions fall below the normal ranges. Severe hepatic insufficiency may cause LIVER FAILURE or DEATH. Treatment may include LIVER TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pharmacokinetic and pharmacodynamic changes depend on the nature and degree of hepatic impairment and on the characteristics of the dosed drug." | 2.49 | [Effect of liver cirrhosis on pharmacokinetics and pharmacodynamics of drugs]. ( Perlík, F, 2013) |
| " The validated lesinurad plasma quantification method was successfully applied for the pharmacokinetic evaluations to support the clinical studies in renal impaired patients." | 1.51 | The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS. ( Nguyen, M; Sun, L; Wilson, DM; Yeh, LT; Zhou, D, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, D | 1 |
| Sun, L | 1 |
| Nguyen, M | 1 |
| Yeh, LT | 1 |
| Wilson, DM | 1 |
| Perlík, F | 1 |
1 review available for verapamil and Hepatic Insufficiency
| Article | Year |
|---|---|
[Effect of liver cirrhosis on pharmacokinetics and pharmacodynamics of drugs].
Topics: Analgesics; Anesthetics, Local; Anti-Arrhythmia Agents; Antihypertensive Agents; Hepatic Insufficien | 2013 |
1 other study available for verapamil and Hepatic Insufficiency
| Article | Year |
|---|---|
The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS.
Topics: Allopurinol; Calibration; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Hepatic In | 2019 |