verapamil has been researched along with Hemorrhage in 12 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Hemorrhage: Bleeding or escape of blood from a vessel.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pharmacokinetics and antithrombotic effects of the Factor Xa inhibitor rivaroxaban were studied in subjects with mild renal insufficiency concurrently taking the P-glycoprotein and moderate CYP3A inhibitor verapamil, a drug commonly administered to patients with hypertension, ischemic heart disease, or atrial fibrillation." | 9.27 | Impaired Rivaroxaban Clearance in Mild Renal Insufficiency With Verapamil Coadministration: Potential Implications for Bleeding Risk and Dose Selection. ( Chow, CR; Greenblatt, DJ; Harmatz, JS; Nicholson, WT; Patel, M; Rubino, CM, 2018) |
| "The VERDICT (Verapamil Versus Digoxin and Acute Versus Routine Serial Cardioversion Trial) is a prospective, randomized study to investigate whether: 1) acutely repeated serial electrical cardioversions (ECVs) after a relapse of atrial fibrillation (AF); and 2) prevention of intracellular calcium overload by verapamil, decrease intractability of AF." | 9.12 | Verapamil versus digoxin and acute versus routine serial cardioversion for the improvement of rhythm control for persistent atrial fibrillation. ( Bosker, HA; Crijns, HJ; Hemels, ME; Ranchor, AV; Van den Berg, MP; Van Gelder, IC; Van Noord, T; Van Veldhuisen, DJ; Veeger, NJ; Wiesfeld, AC, 2006) |
| "In the JADER analysis, hemorrhage was significantly associated with treatment with edoxaban and verapamil (reporting odds ratio = 1." | 8.31 | Association between hemorrhage and direct oral anticoagulants in combination with verapamil: Analysis of Japanese Adverse Drug Event Report database and electronic medical record data. ( Hosomi, K; Komatsu, Y; Takegami, M; Yodoshi, M; Yokoyama, S, 2023) |
| " Verapamil hydrochloride and diltiazem hydrochloride are combined P-glycoprotein (P-gp) and CYP3A4 inhibitors and may be associated with increases in the risk of bleeding with DOACs." | 7.96 | Association of Oral Anticoagulants and Verapamil or Diltiazem With Adverse Bleeding Events in Patients With Nonvalvular Atrial Fibrillation and Normal Kidney Function. ( Brown, JD; Lesko, L; Lip, GYH; Pham, P; Schmidt, S, 2020) |
| "To determine whether gallopamil (D600), a methoxy derivative of verapamil, administered immediately before coronary artery reperfusion reduces the extent of myocardial hemorrhage and necrosis, the left anterior descending coronary artery was occluded for 3 h and reperfused for 3 h in anesthetized, open-chest dogs." | 7.68 | Reduction in myocardial hemorrhage and the extent of necrosis by gallopamil (D600) in dogs with coronary artery reperfusion. ( Endo, T; Hayakawa, H; Maroko, PR; Sato, N, 1991) |
| "Verapamil treatment, which increased survival time and survival rate, significantly attenuated the changes in serum Mg2+ which normally followed hemorrhage." | 5.28 | Serum magnesium increases following severe hemorrhage in dogs blocked by verapamil treatment. ( Allison, EJ; Carroll, RG; Iams, SG; Pryor, WH, 1990) |
| "Pharmacokinetics and antithrombotic effects of the Factor Xa inhibitor rivaroxaban were studied in subjects with mild renal insufficiency concurrently taking the P-glycoprotein and moderate CYP3A inhibitor verapamil, a drug commonly administered to patients with hypertension, ischemic heart disease, or atrial fibrillation." | 5.27 | Impaired Rivaroxaban Clearance in Mild Renal Insufficiency With Verapamil Coadministration: Potential Implications for Bleeding Risk and Dose Selection. ( Chow, CR; Greenblatt, DJ; Harmatz, JS; Nicholson, WT; Patel, M; Rubino, CM, 2018) |
| " To quantify the impacts of concomitant verapamil administration and renal impairment on rivaroxaban pharmacokinetics, a minimal physiologically based pharmacokinetic model system was developed and used to evaluate potential increases in rivaroxaban exposure and the consequent increase in risk of major bleeding." | 5.27 | Minimal Physiologically Based Pharmacokinetic and Drug-Drug-Disease Interaction Model of Rivaroxaban and Verapamil in Healthy and Renally Impaired Subjects. ( Chow, CR; Ismail, M; Lee, VH; Rubino, CM, 2018) |
| "The VERDICT (Verapamil Versus Digoxin and Acute Versus Routine Serial Cardioversion Trial) is a prospective, randomized study to investigate whether: 1) acutely repeated serial electrical cardioversions (ECVs) after a relapse of atrial fibrillation (AF); and 2) prevention of intracellular calcium overload by verapamil, decrease intractability of AF." | 5.12 | Verapamil versus digoxin and acute versus routine serial cardioversion for the improvement of rhythm control for persistent atrial fibrillation. ( Bosker, HA; Crijns, HJ; Hemels, ME; Ranchor, AV; Van den Berg, MP; Van Gelder, IC; Van Noord, T; Van Veldhuisen, DJ; Veeger, NJ; Wiesfeld, AC, 2006) |
| "In the JADER analysis, hemorrhage was significantly associated with treatment with edoxaban and verapamil (reporting odds ratio = 1." | 4.31 | Association between hemorrhage and direct oral anticoagulants in combination with verapamil: Analysis of Japanese Adverse Drug Event Report database and electronic medical record data. ( Hosomi, K; Komatsu, Y; Takegami, M; Yodoshi, M; Yokoyama, S, 2023) |
| " Verapamil hydrochloride and diltiazem hydrochloride are combined P-glycoprotein (P-gp) and CYP3A4 inhibitors and may be associated with increases in the risk of bleeding with DOACs." | 3.96 | Association of Oral Anticoagulants and Verapamil or Diltiazem With Adverse Bleeding Events in Patients With Nonvalvular Atrial Fibrillation and Normal Kidney Function. ( Brown, JD; Lesko, L; Lip, GYH; Pham, P; Schmidt, S, 2020) |
| "Systemic hemodynamics and hepatic macro- and microcirculation (ultrasonic technique, biomicroscopy) were studied in intact rats and rats with acute massive hemorrhage after intravenous administration of the calcium antagonists verapamil and nifedipine." | 3.68 | [The effect of verapamil and nifedipine on the systemic hemodynamics and liver macro- and microcirculations in rats with acute massive blood loss]. ( Kovalenko, NIa; Matsievskiĭ, DD, 1993) |
| "To determine whether gallopamil (D600), a methoxy derivative of verapamil, administered immediately before coronary artery reperfusion reduces the extent of myocardial hemorrhage and necrosis, the left anterior descending coronary artery was occluded for 3 h and reperfused for 3 h in anesthetized, open-chest dogs." | 3.68 | Reduction in myocardial hemorrhage and the extent of necrosis by gallopamil (D600) in dogs with coronary artery reperfusion. ( Endo, T; Hayakawa, H; Maroko, PR; Sato, N, 1991) |
| "Verapamil treatment, which increased survival time and survival rate, significantly attenuated the changes in serum Mg2+ which normally followed hemorrhage." | 1.28 | Serum magnesium increases following severe hemorrhage in dogs blocked by verapamil treatment. ( Allison, EJ; Carroll, RG; Iams, SG; Pryor, WH, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Komatsu, Y | 1 |
| Yodoshi, M | 1 |
| Takegami, M | 1 |
| Yokoyama, S | 1 |
| Hosomi, K | 1 |
| Pham, P | 1 |
| Schmidt, S | 1 |
| Lesko, L | 1 |
| Lip, GYH | 1 |
| Brown, JD | 1 |
| Greenblatt, DJ | 1 |
| Patel, M | 1 |
| Harmatz, JS | 1 |
| Nicholson, WT | 1 |
| Rubino, CM | 2 |
| Chow, CR | 2 |
| Ismail, M | 1 |
| Lee, VH | 1 |
| Utkin, MM | 1 |
| Batyrov, FA | 1 |
| Hemels, ME | 1 |
| Van Noord, T | 1 |
| Crijns, HJ | 1 |
| Van Veldhuisen, DJ | 1 |
| Veeger, NJ | 1 |
| Bosker, HA | 1 |
| Wiesfeld, AC | 1 |
| Van den Berg, MP | 1 |
| Ranchor, AV | 1 |
| Van Gelder, IC | 1 |
| Gutiérrez, JM | 1 |
| Ownby, CL | 1 |
| Odell, GV | 1 |
| Kovalenko, NIa | 1 |
| Matsievskiĭ, DD | 1 |
| Pickford, MA | 1 |
| Manek, S | 1 |
| Price, AB | 1 |
| Green, CJ | 1 |
| Carroll, RG | 1 |
| Iams, SG | 1 |
| Pryor, WH | 1 |
| Allison, EJ | 1 |
| Endo, T | 1 |
| Sato, N | 1 |
| Hayakawa, H | 1 |
| Maroko, PR | 1 |
| Mosler, KH | 1 |
| Linka, F | 1 |
| Dornhöfer, W | 1 |
| Ehrhart, J | 1 |
1 review available for verapamil and Hemorrhage
| Article | Year |
|---|---|
Tocolytic therapy in obstetrics.
Topics: Adrenergic beta-Agonists; Cyclic AMP; Ethanol; Female; Hemorrhage; Humans; Monitoring, Physiologic; | 1974 |
3 trials available for verapamil and Hemorrhage
| Article | Year |
|---|---|
Impaired Rivaroxaban Clearance in Mild Renal Insufficiency With Verapamil Coadministration: Potential Implications for Bleeding Risk and Dose Selection.
Topics: Adult; Aged; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Factor Xa Inhibitors; Female; Hem | 2018 |
Minimal Physiologically Based Pharmacokinetic and Drug-Drug-Disease Interaction Model of Rivaroxaban and Verapamil in Healthy and Renally Impaired Subjects.
Topics: Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Factor Xa Inhibitors; Hemorrhage; Humans; Midd | 2018 |
Verapamil versus digoxin and acute versus routine serial cardioversion for the improvement of rhythm control for persistent atrial fibrillation.
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Calcium; Digoxin; Electric Countershock; Female; | 2006 |
8 other studies available for verapamil and Hemorrhage
| Article | Year |
|---|---|
Association between hemorrhage and direct oral anticoagulants in combination with verapamil: Analysis of Japanese Adverse Drug Event Report database and electronic medical record data.
Topics: Administration, Oral; Adverse Drug Reaction Reporting Systems; Anticoagulants; Atrial Fibrillation; | 2023 |
Association of Oral Anticoagulants and Verapamil or Diltiazem With Adverse Bleeding Events in Patients With Nonvalvular Atrial Fibrillation and Normal Kidney Function.
Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Comorbidity; Databases, Factua | 2020 |
[Intensive pharmacotherapy for massive recurrent pulmonary hemorrhages].
Topics: Adult; Drug Therapy, Combination; Female; Hemodynamics; Hemorrhage; Humans; Isosorbide Dinitrate; Lu | 2005 |
Isolation of a myotoxin from Bothrops asper venom: partial characterization and action on skeletal muscle.
Topics: Animals; Calcium; Crotalid Venoms; Hemolysis; Hemorrhage; Hydrolysis; Immunodiffusion; Mice; Molecul | 1984 |
[The effect of verapamil and nifedipine on the systemic hemodynamics and liver macro- and microcirculations in rats with acute massive blood loss].
Topics: Acute Disease; Animals; Cardiovascular Physiological Phenomena; Cardiovascular System; Drug Evaluati | 1993 |
The pathology of rat lung isografts following 48 or 72-hour cold storage and subsequent reperfusion in vivo for up to 1 month.
Topics: Animals; Cryopreservation; Epoprostenol; Hemorrhage; Lung; Lung Transplantation; Male; Organ Preserv | 1992 |
Serum magnesium increases following severe hemorrhage in dogs blocked by verapamil treatment.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood Glucose; Dogs; Hemorrhage; Hydroxy | 1990 |
Reduction in myocardial hemorrhage and the extent of necrosis by gallopamil (D600) in dogs with coronary artery reperfusion.
Topics: Animals; Autoradiography; Blood Pressure; Coronary Vessels; Dogs; Female; Gallopamil; Heart Diseases | 1991 |