verapamil has been researched along with Granulocytic Leukemia in 30 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thus the interpretation of results of clinical 'modulator' trials should consider the decreased bioavailability of MDR-reversing agents." | 1.29 | Decreased potency of MDR-modulators under serum conditions determined by a functional assay. ( Eisterer, W; Hilbe, W; Hofmann, J; Ludescher, C; Thaler, J, 1995) |
| "Verapamil treatment could not completely reverse ADR resistance." | 1.28 | Mechanisms involved in the development of adriamycin resistance in human leukemic cells. ( Ideguchi, H; Kato, S; Muta, K; Nawata, H; Nishimura, J, 1990) |
| "Etoposide was 10-fold more potent against K562 cells than against normal human bone marrow CFU-GM." | 1.27 | Effects of verapamil on etoposide, vincristine, and adriamycin activity in normal human bone marrow granulocyte-macrophage progenitors and in human K562 leukemia cells in vitro. ( Gross, M; Ross, WE; Yalowich, JC; Zucali, JR, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (20.00) | 18.7374 |
| 1990's | 17 (56.67) | 18.2507 |
| 2000's | 5 (16.67) | 29.6817 |
| 2010's | 1 (3.33) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Sagnou, M | 1 |
| Novikov, FN | 1 |
| Ivanova, ES | 1 |
| Alexiou, P | 1 |
| Stroylov, VS | 1 |
| Titov, IY | 1 |
| Tatarskiy, VV | 1 |
| Vagida, MS | 1 |
| Pelecanou, M | 1 |
| Shtil, AA | 1 |
| Chilov, GG | 1 |
| Ji, BS | 1 |
| He, L | 1 |
| Xu, HB | 1 |
| Li, L | 1 |
| Liu, GQ | 1 |
| Zhang, L | 1 |
| Yan, Y | 1 |
| Zhu, D | 1 |
| Yang, W | 1 |
| Wang, W | 1 |
| Hu, Y | 1 |
| Yang, B | 1 |
| He, Q | 1 |
| Pradhan, SG | 1 |
| Basrur, VS | 1 |
| Chitnis, MP | 1 |
| Adwani, SH | 1 |
| Yano, S | 1 |
| Sone, S | 1 |
| Nishioka, Y | 1 |
| Naito, M | 4 |
| Tsuruo, T | 6 |
| Ogura, T | 1 |
| Paietta, E | 1 |
| Andersen, J | 1 |
| Racevskis, J | 1 |
| Ashigbi, M | 1 |
| Cassileth, P | 1 |
| Wiernik, PH | 1 |
| Watanabe, T | 1 |
| Tsuge, H | 1 |
| Oh-Hara, T | 1 |
| Yung, BY | 1 |
| Bhalla, K | 1 |
| Huang, Y | 1 |
| Tang, C | 1 |
| Self, S | 1 |
| Ray, S | 1 |
| Mahoney, ME | 1 |
| Ponnathpur, V | 1 |
| Tourkina, E | 1 |
| Ibrado, AM | 1 |
| Bullock, G | 1 |
| Urasaki, Y | 1 |
| Ueda, T | 1 |
| Nakamura, T | 1 |
| Principe, P | 1 |
| Faussat-Suberville, AM | 1 |
| Coulomb, H | 1 |
| Marie, JP | 1 |
| Braquet, P | 1 |
| Maslak, P | 1 |
| Hegewisch-Becker, S | 1 |
| Godfrey, L | 1 |
| Andreeff, M | 1 |
| Boiron, JM | 1 |
| Belloc, F | 1 |
| Montastruc, M | 1 |
| Cony-Makhoul, P | 1 |
| Marit, G | 1 |
| Puntous, M | 1 |
| Dumain, P | 1 |
| Lacombe, F | 1 |
| Dubosc-Marchenay, N | 1 |
| Fabères, C | 1 |
| Tjandrawinata, RR | 1 |
| Hawel, L | 1 |
| Byus, CV | 1 |
| Ludescher, C | 1 |
| Eisterer, W | 1 |
| Hilbe, W | 1 |
| Hofmann, J | 1 |
| Thaler, J | 1 |
| Broxterman, HJ | 1 |
| Sonneveld, P | 1 |
| Feller, N | 1 |
| Ossenkoppele, GJ | 1 |
| Währer, DC | 1 |
| Eekman, CA | 1 |
| Schoester, M | 1 |
| Lankelma, J | 1 |
| Pinedo, HM | 1 |
| Löwenberg, B | 1 |
| Schuurhuis, GJ | 1 |
| Lin, JT | 1 |
| Sharma, R | 1 |
| Grady, JJ | 1 |
| Awasthi, S | 1 |
| Ferrao, P | 1 |
| Sincock, P | 1 |
| Cole, S | 1 |
| Ashman, L | 1 |
| Tsimberidou, AM | 1 |
| Paterakis, G | 1 |
| Androutsos, G | 1 |
| Anagnostopoulos, N | 1 |
| Galanopoulos, A | 1 |
| Kalmantis, T | 1 |
| Meletis, J | 1 |
| Rombos, Y | 1 |
| Sagriotis, A | 1 |
| Symeonidis, A | 1 |
| Tiniakou, M | 1 |
| Zoumbos, N | 1 |
| Yataganas, X | 1 |
| Laskin, DL | 1 |
| Sirak, AA | 1 |
| Robertson, FM | 1 |
| Laskin, JD | 1 |
| Boesch, D | 1 |
| Muller, K | 1 |
| Pourtier-Manzanedo, A | 1 |
| Loor, F | 1 |
| Kato, S | 1 |
| Ideguchi, H | 1 |
| Muta, K | 1 |
| Nishimura, J | 1 |
| Nawata, H | 1 |
| Bazill, GW | 1 |
| Dexter, TM | 1 |
| Hamada, H | 1 |
| Vasanthakumar, G | 1 |
| Ahmed, NK | 1 |
| Yalowich, JC | 1 |
| Zucali, JR | 1 |
| Gross, M | 1 |
| Ross, WE | 1 |
1 review available for verapamil and Granulocytic Leukemia
| Article | Year |
|---|---|
[Development of drugs to overcome drug resistance--basic approaches].
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporin | 1995 |
29 other studies available for verapamil and Granulocytic Leukemia
| Article | Year |
|---|---|
Novel curcumin derivatives as P-glycoprotein inhibitors: Molecular modeling, synthesis and sensitization of multidrug resistant cells to doxorubicin.
Topics: Amides; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Cell Surviv | 2020 |
CJX1, an amlodipine derivative, interacts with ATPase of human P-glycoprotein.
Topics: Adenosine Triphosphatases; Amlodipine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benz | 2009 |
Reversal of P-glycoprotein-mediated multidrug resistance by guggulsterone in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells.
Topics: Antibiotics, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Calcium Chann | 2009 |
Nutlin-1 strengthened anti-proliferation and differentiation-inducing activity of ATRA in ATRA-treated p-glycoprotein deregulated human myelocytic leukemia cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; ATP B | 2012 |
In vitro enhancement of adriamycin cytotoxicity in human myeloid leukemia cells exposed to verapamil.
Topics: Cell Survival; DNA Replication; Doxorubicin; Drug Synergism; Humans; Leukemia, Myeloid; Verapamil | 1984 |
Cyclosporin A enhances susceptibility of multi-drug resistant human cancer cells to anti-P-glycoprotein antibody-dependent cytotoxicity of monocytes, but not of lymphocytes.
Topics: Antibodies, Monoclonal; Antibody-Dependent Cell Cytotoxicity; Antineoplastic Agents; ATP Binding Cas | 1994 |
Modulation of multidrug resistance in de novo adult acute myeloid leukemia: variable efficacy of reverting agents in vitro. Eastern Cooperative Oncology Group.
Topics: Acute Disease; Antigens, CD; Antigens, CD34; ATP Binding Cassette Transporter, Subfamily B, Member 1 | 1995 |
Comparative study on reversal efficacy of SDZ PSC 833, cyclosporin A and verapamil on multidrug resistance in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cyclosporine; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; | 1995 |
Sphinganine potentiation of cellular differentiation induced by various anti-leukemia drugs in human leukemia cell line HL-60.
Topics: Antineoplastic Agents; Calcium; Cell Differentiation; Cell Line; Egtazic Acid; Etoposide; Humans; Le | 1994 |
Characterization of a human myeloid leukemia cell line highly resistant to taxol.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Division; | 1994 |
Circumvention of daunorubicin resistance by a new tamoxifen derivative, toremifene, in multidrug-resistant cell line.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Chemical Phenomena; Chemi | 1994 |
Flow cytometric monitoring of anthracycline accumulation after anti-neoplastic ether phospholipid treatment.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunor | 1994 |
Flow cytometric determination of the multidrug-resistant phenotype in acute leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemoth | 1994 |
Daunorubicin (DNR) accumulation in fresh leukemic cells: correlation with clinical and biological features.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Bone Marrow; Bo | 1994 |
Regulation of putrescine export in lipopolysaccharide or IFN-gamma-activated murine monocytic-leukemic RAW 264 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; DNA; Dose-Response Relationship, Drug; Eflornithine | 1994 |
Decreased potency of MDR-modulators under serum conditions determined by a functional assay.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transpor | 1995 |
Quality control of multidrug resistance assays in adult acute leukemia: correlation between assays for P-glycoprotein expression and activity.
Topics: Acute Disease; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; | 1996 |
A flow cell assay for evaluation of whole cell drug efflux kinetics: analysis of paclitaxel efflux in CCRF-CEM leukemia cells overexpressing P-glycoprotein.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biologic | 2001 |
Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia.
Topics: Acute Disease; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 2001 |
Evaluation of the clinical relevance of the expression and function of P-glycoprotein, multidrug resistance protein and lung resistance protein in patients with primary acute myelogenous leukemia.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; | 2002 |
Distinct patterns of chemotactic peptide-induced calcium mobilization in differentiated myeloid leukemia cells and peripheral blood neutrophils.
Topics: Biological Transport, Active; Bucladesine; Calcium; Chemotactic Factors; Dose-Response Relationship, | 1991 |
Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative.
Topics: Amiodarone; Animals; Cyclosporins; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; | 1991 |
Mechanisms involved in the development of adriamycin resistance in human leukemic cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Division; Cell Line | 1990 |
Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Survival; Chloroquine; Diltiazem; Drug Synergism; End | 1990 |
Competitive inhibition by verapamil of ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug-resistant K562 cells without calcium ion involvement.
Topics: Adenosine Triphosphate; Binding, Competitive; Calcium; Cell Membrane; Doxorubicin; Drug Resistance; | 1989 |
ATP/Mg2+-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 cells.
Topics: Adenosine Triphosphate; Binding Sites; Biological Transport; Camptothecin; Cell Membrane; Dactinomyc | 1988 |
Acquired vs innate multidrug resistance and the effect of calcium channel blockers.
Topics: Animals; Antineoplastic Agents; Calcium Channel Blockers; Cell Line; Doxorubicin; Drug Resistance; D | 1986 |
Contribution of drug transport and reductases to daunorubicin resistance in human myelocytic cells.
Topics: Adult; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Biological Transport; Cell | 1986 |
Effects of verapamil on etoposide, vincristine, and adriamycin activity in normal human bone marrow granulocyte-macrophage progenitors and in human K562 leukemia cells in vitro.
Topics: Bone Marrow; Cell Survival; Cells, Cultured; Doxorubicin; Drug Synergism; Etoposide; Granulocytes; H | 1985 |