verapamil has been researched along with Granulocytic Leukemia, Chronic in 13 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have previously generated chronic myeloid leukemia (CML) cell lines resistant to the tyrosine kinase inhibitor imatinib mesylate (STI571), and one line (LAMA84-r) showed overexpression not only of the Bcr-Abl protein but also of Pgp." | 7.72 | MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. ( Belloc, F; Chollet, C; Goldman, JM; Lagarde, V; Mahon, FX; Melo, JV; Moreau-Gaudry, F; Reiffers, J, 2003) |
| " We have previously generated chronic myeloid leukemia (CML) cell lines resistant to the tyrosine kinase inhibitor imatinib mesylate (STI571), and one line (LAMA84-r) showed overexpression not only of the Bcr-Abl protein but also of Pgp." | 3.72 | MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. ( Belloc, F; Chollet, C; Goldman, JM; Lagarde, V; Mahon, FX; Melo, JV; Moreau-Gaudry, F; Reiffers, J, 2003) |
| "Dipyridamole strongly inhibited spontaneous in vitro proliferation of peripheral blood mononuclear cells from patients with acute myelogenous leukaemia (n = 9), chronic myelogenous leukaemia in first chronic phase (n = 4) and blast phase (n = 1)." | 3.68 | Effect of dipyridamole, theophyllamine and verapamil on spontaneous in vitro proliferation of myelogenous leukaemia cells. ( Bruserud, O, 1992) |
| "Curcumin (1) is a secondary metabolite isolated from the turmeric of Curcuma longa L." | 1.46 | A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells. ( Correia-da-Silva, M; Lima, RT; Lopes-Rodrigues, V; Oliveira, A; Pinto, M; Sousa, E; Vasconcelos, MH, 2017) |
| "The idarubicin treated subline, K/IDA, was only resistant to taxol but was 12-fold sensitized to etoposide, suggesting that idarubicin had affected topoisomerase II in this subline." | 1.29 | Development of drug resistance is reduced with idarubicin relative to other anthracyclines. ( Davey, MW; Davey, RA; Hargrave, RM; Kidman, AD, 1995) |
| "Pgp was positive in 75% of acute nonlymphoblastic leukemia (ANLL) and 50% of acute lymphoblastic leukemia (ALL)." | 1.28 | P-glycoprotein expression in refractory hematological neoplasms and circumvention of resistance with verapamil or cyclosporine A containing protocols. ( Akan, H; Beksaç, M; Ertürk, S; Güneyli, A; Ikizünal, Y; Ilhan, O; Koç, H; Sardaş, OS, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 8 (61.54) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lopes-Rodrigues, V | 1 |
| Oliveira, A | 1 |
| Correia-da-Silva, M | 1 |
| Pinto, M | 1 |
| Lima, RT | 1 |
| Sousa, E | 1 |
| Vasconcelos, MH | 1 |
| Mahon, FX | 1 |
| Belloc, F | 1 |
| Lagarde, V | 1 |
| Chollet, C | 1 |
| Moreau-Gaudry, F | 1 |
| Reiffers, J | 1 |
| Goldman, JM | 1 |
| Melo, JV | 1 |
| Ohtani, H | 2 |
| Ikegawa, T | 2 |
| Honda, Y | 1 |
| Kohyama, N | 1 |
| Morimoto, S | 2 |
| Shoyama, Y | 2 |
| Juichi, M | 1 |
| Naito, M | 3 |
| Tsuruo, T | 3 |
| Sawada, Y | 2 |
| Hargrave, RM | 1 |
| Davey, MW | 2 |
| Davey, RA | 2 |
| Kidman, AD | 2 |
| Maslak, P | 1 |
| Hegewisch-Becker, S | 1 |
| Godfrey, L | 1 |
| Andreeff, M | 1 |
| Marks, DC | 1 |
| Maynadié, M | 1 |
| Matutes, E | 1 |
| Catovsky, D | 1 |
| Ushigome, F | 1 |
| Koyabu, N | 1 |
| Beksaç, M | 1 |
| Akan, H | 1 |
| Koç, H | 1 |
| Ilhan, O | 1 |
| Ertürk, S | 1 |
| Güneyli, A | 1 |
| Ikizünal, Y | 1 |
| Sardaş, OS | 1 |
| Takemura, Y | 1 |
| Koide, Y | 1 |
| Miyachi, H | 1 |
| Shibata, T | 1 |
| Sekiguchi, S | 1 |
| Tukemura, Y | 1 |
| Bruserud, O | 1 |
| Satyamoorthy, K | 1 |
| Chitnis, MP | 1 |
| Pradhan, SG | 1 |
| Advani, SH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Retrospective Study to Validate Pharmacogenetics Model for Imatinib Metabolism in Patients With Chronic Myeloid Leukemia[NCT01437202] | 100 participants (Actual) | Observational | 2011-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 other studies available for verapamil and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycl | 2017 |
MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamides; Cell Death; Cell Div | 2003 |
Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Su | 2007 |
Development of drug resistance is reduced with idarubicin relative to other anthracyclines.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, West | 1995 |
Flow cytometric determination of the multidrug-resistant phenotype in acute leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemoth | 1994 |
Differentiation and multidrug resistance in response to drug treatment in the K562 human leukaemia cell line.
Topics: Antigens, Neoplasm; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Carr | 1993 |
Quantification of P-glycoprotein in chronic lymphocytic leukemia by flow cytometry.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antibodies, Monoclonal; ATP Binding Cas | 1997 |
Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells.
Topics: Acetates; ATP Binding Cassette Transporter, Subfamily B; Beverages; Blotting, Western; Citrus; Cyclo | 2000 |
Functionally active homodimer of P-glycoprotein in multidrug-resistant tumor cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transpor | 1992 |
P-glycoprotein expression in refractory hematological neoplasms and circumvention of resistance with verapamil or cyclosporine A containing protocols.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, | 1992 |
Effect of verapamil on the class I major histocompatibility complex antigen expression in K562 chronic myelogenous leukemia cells treated with recombinant human interferon-gamma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Blotting, Northern; Calcimyci | 1992 |
Effect of dipyridamole, theophyllamine and verapamil on spontaneous in vitro proliferation of myelogenous leukaemia cells.
Topics: Aminophylline; Blast Crisis; Cell Division; Dipyridamole; Dose-Response Relationship, Drug; Drug Scr | 1992 |
Modulation of mitoxantrone cytotoxicity by verapamil in human chronic myeloid leukemia cells.
Topics: DNA; Drug Synergism; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mitoxantrone; Tumor C | 1989 |