verapamil has been researched along with Glial Cell Tumors in 37 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " As a novel type of nano-radiosensitizer, silver nanoparticles (AgNPs) have shown promising radiosensitizing properties in the radiotherapy of glioma, but their ability to efficiently enter and accumulate in tumor cells needs to be improved." | 8.02 | Increasing the accumulation of aptamer AS1411 and verapamil conjugated silver nanoparticles in tumor cells to enhance the radiosensitivity of glioma. ( Cao, Y; Chen, W; Li, D; Liu, P; Ma, J; Yang, H; Zhao, J, 2021) |
| "The effects of chronic treatment with antidepressants, verapamil, or lithium on serotonin (5-HT)-induced Ca2+ increase were investigated in single C6BU-1 glioma cells with digital imaging microscopy." | 7.69 | Chronic treatment with antidepressants, verapamil, or lithium inhibits the serotonin-induced intracellular calcium response in individual C6 rat glioma cells. ( Kagaya, A; Uchitomi, Y; Yamaji, T; Yamawaki, S; Yokota, N, 1997) |
| "The action of verapamil, /+/-D600 and nisoldipine on the inward calcium current (ICa) was studied in mouse neuroblastoma x rat glioma hybrid cells of the line 108CC5 under voltage clamp conditions by means of a suction pipette method." | 7.67 | Inhibition of calcium channels in neuroblastoma x glioma hybrid cells by verapamil, D600, diltiazem and nisoldipine. ( Bodewei, R; Hering, S; Schubert, B; Wollenberger, A, 1987) |
| " As a novel type of nano-radiosensitizer, silver nanoparticles (AgNPs) have shown promising radiosensitizing properties in the radiotherapy of glioma, but their ability to efficiently enter and accumulate in tumor cells needs to be improved." | 4.02 | Increasing the accumulation of aptamer AS1411 and verapamil conjugated silver nanoparticles in tumor cells to enhance the radiosensitivity of glioma. ( Cao, Y; Chen, W; Li, D; Liu, P; Ma, J; Yang, H; Zhao, J, 2021) |
| "The effects of chronic treatment with antidepressants, verapamil, or lithium on serotonin (5-HT)-induced Ca2+ increase were investigated in single C6BU-1 glioma cells with digital imaging microscopy." | 3.69 | Chronic treatment with antidepressants, verapamil, or lithium inhibits the serotonin-induced intracellular calcium response in individual C6 rat glioma cells. ( Kagaya, A; Uchitomi, Y; Yamaji, T; Yamawaki, S; Yokota, N, 1997) |
| "The action of verapamil, /+/-D600 and nisoldipine on the inward calcium current (ICa) was studied in mouse neuroblastoma x rat glioma hybrid cells of the line 108CC5 under voltage clamp conditions by means of a suction pipette method." | 3.67 | Inhibition of calcium channels in neuroblastoma x glioma hybrid cells by verapamil, D600, diltiazem and nisoldipine. ( Bodewei, R; Hering, S; Schubert, B; Wollenberger, A, 1987) |
| "The effects of 2 specific calcium channel blockers, verapamil and nimodipine, on the proliferation of human glioma tumour cells were investigated in vitro." | 3.67 | Inhibitory effect of calcium channel blockers on proliferation of human glioma cells in vitro. ( Kunert-Radek, J; Lyson, K; Pawlikowski, M; Radek, A; Stepien, H, 1989) |
| "Membrane-modifying agents such as reserpine, calcium antagonists (nicardipine, verapamil) and calmodulin inhibitor (trifluoperazine) were found to enhance the cytotoxicity of ACNU in vitro and in vivo in ACNU-resistant C 6 (C 6/ACNU) glioma." | 3.67 | [Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma]. ( Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1986) |
| "Pretreatment with verapamil, a voltage-dependent Ca2+ channel inhibitor, also blocks both the sustained [Ca2+]i elevation and arachidonate liberation without altering peak intracellular Ca2+ release." | 1.28 | Receptor-stimulated phospholipase A2 activation is coupled to influx of external calcium and not to mobilization of intracellular calcium in C62B glioma cells. ( Brooks, RC; Lapetina, EG; McCarthy, KD; Morell, P, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (35.14) | 18.7374 |
| 1990's | 18 (48.65) | 18.2507 |
| 2000's | 3 (8.11) | 29.6817 |
| 2010's | 2 (5.41) | 24.3611 |
| 2020's | 1 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, J | 1 |
| Li, D | 1 |
| Ma, J | 1 |
| Yang, H | 1 |
| Chen, W | 1 |
| Cao, Y | 1 |
| Liu, P | 1 |
| Ham, SW | 1 |
| Jeon, HY | 1 |
| Kim, H | 1 |
| Fong, D | 1 |
| Yeh, A | 1 |
| Naftalovich, R | 1 |
| Choi, TH | 1 |
| Chan, MM | 1 |
| Arbab, AS | 1 |
| Ueki, J | 1 |
| Koizumi, K | 1 |
| Araki, T | 1 |
| Bähr, O | 1 |
| Rieger, J | 1 |
| Duffner, F | 1 |
| Meyermann, R | 1 |
| Weller, M | 1 |
| Wick, W | 1 |
| Atlas, D | 1 |
| Adler, M | 1 |
| Abe, T | 1 |
| Koike, K | 1 |
| Ohga, T | 1 |
| Kubo, T | 1 |
| Wada, M | 1 |
| Kohno, K | 1 |
| Mori, T | 1 |
| Hidaka, K | 1 |
| Kuwano, M | 1 |
| Ichida, S | 1 |
| Wada, T | 1 |
| Nakazaki, S | 1 |
| Matsuda, N | 1 |
| Kishino, H | 1 |
| Akimoto, T | 1 |
| Chueh, SH | 1 |
| Kao, LS | 1 |
| Yamaji, T | 3 |
| Kagaya, A | 3 |
| Okamoto, Y | 2 |
| Hayashi, T | 2 |
| Nagaoka, I | 1 |
| Motohashi, N | 2 |
| Yamawaki, S | 3 |
| Lo, TM | 1 |
| Thayer, SA | 1 |
| Matsukado, K | 1 |
| Ikezaki, K | 1 |
| Nomura, T | 1 |
| Fukui, M | 1 |
| Kowtha, VC | 1 |
| Bryant, HJ | 1 |
| Krauthamer, V | 1 |
| Iwasa, KH | 1 |
| Stenger, DA | 1 |
| Ducharme, J | 1 |
| Abdullah, S | 1 |
| Wainer, IW | 1 |
| Uchitomi, Y | 1 |
| Yokota, N | 1 |
| Hu, Q | 1 |
| Huang, F | 1 |
| Shi, Y | 1 |
| Gérard, V | 1 |
| Rouzaire-Dubois, B | 1 |
| Dilda, P | 1 |
| Dubois, JM | 1 |
| Joshi, PG | 1 |
| Mishra, S | 1 |
| Saqr, HE | 1 |
| Guan, Z | 1 |
| Yates, AJ | 1 |
| Stokes, BT | 1 |
| Andersson, U | 1 |
| Grankvist, K | 1 |
| Bergenheim, AT | 1 |
| Behnam-Motlagh, P | 1 |
| Hedman, H | 1 |
| Henriksson, R | 1 |
| Huet, S | 2 |
| Schott, B | 1 |
| Robert, J | 2 |
| Henderson, GB | 1 |
| Strauss, BP | 1 |
| George, TP | 1 |
| Cook, HW | 1 |
| Byers, DM | 1 |
| Palmer, FB | 1 |
| Spence, MW | 1 |
| Bowles, AP | 1 |
| Pantazis, CG | 1 |
| Wansley, W | 1 |
| Creba, JA | 1 |
| Karobath, M | 1 |
| Bodewei, R | 1 |
| Hering, S | 1 |
| Schubert, B | 1 |
| Wollenberger, A | 1 |
| Brooks, RC | 1 |
| McCarthy, KD | 1 |
| Lapetina, EG | 1 |
| Morell, P | 1 |
| Kunert-Radek, J | 1 |
| Stepien, H | 1 |
| Radek, A | 1 |
| Lyson, K | 1 |
| Pawlikowski, M | 1 |
| Huber, KR | 2 |
| Schmidt, WF | 2 |
| al-Assaad, B | 1 |
| Neuberg, RW | 2 |
| Ettinger, RS | 2 |
| Miwa, N | 1 |
| Sugino, H | 1 |
| Ueno, R | 1 |
| Hayaishi, O | 1 |
| Yoshida, T | 2 |
| Shimizu, K | 2 |
| Ushio, Y | 2 |
| Hayakawa, T | 1 |
| Kato, A | 1 |
| Mogami, H | 2 |
| Sakamoto, Y | 2 |
| Merry, S | 1 |
| Fetherston, CA | 1 |
| Kaye, SB | 1 |
| Freshney, RI | 1 |
| Plumb, JA | 1 |
| Kaba, K | 1 |
| Tani, E | 1 |
| Morimura, T | 1 |
| Matsumoto, T | 1 |
1 trial available for verapamil and Glial Cell Tumors
| Article | Year |
|---|---|
Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity.
Topics: Adult; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Brain Neoplasms; Chromatogr | 1996 |
36 other studies available for verapamil and Glial Cell Tumors
| Article | Year |
|---|---|
Increasing the accumulation of aptamer AS1411 and verapamil conjugated silver nanoparticles in tumor cells to enhance the radiosensitivity of glioma.
Topics: Aptamers, Nucleotide; Brain Neoplasms; Cell Line, Tumor; Glioma; Humans; Metal Nanoparticles; Oligod | 2021 |
Verapamil augments carmustine- and irradiation-induced senescence in glioma cells by reducing intracellular reactive oxygen species and calcium ion levels.
Topics: Antineoplastic Combined Chemotherapy Protocols; Calcium; Calcium Channels, L-Type; Carmustine; Cell | 2017 |
Curcumin inhibits the side population (SP) phenotype of the rat C6 glioma cell line: towards targeting of cancer stem cells with phytochemicals.
Topics: Animals; Antineoplastic Agents, Phytogenic; Benzimidazoles; Cell Differentiation; Cell Growth Proces | 2010 |
Effects of extracellular Na+ and Ca2+ ions and Ca2+ channel modulators on the cell-associated activity of 99mTc-MIBI and 99mTc-tetrofosmin in tumour cells.
Topics: Amiloride; Animals; Antineoplastic Agents; Calcium; Calcium Channels; Carcinoma, Lewis Lung; Cell Su | 2003 |
P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Tra | 2003 |
alpha-adrenergic antagonists as possible calcium channel inhibitors.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Calcium; Cell Line; Cell Membran | 1981 |
Chemosensitisation of spontaneous multidrug resistance by a 1,4-dihydropyridine analogue and verapamil in human glioma cell lines overexpressing MRP or MDR1.
Topics: Alkaloids; Antigens, Neoplasm; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, | 1995 |
Specific bindings of [3H](+)PN200-110 and [125I]omega-conotoxin to crude membranes from differentiated NG108-15 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Extracellular ATP stimulates calcium influx in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Bradykinin; Calcium; Calcium Channel Blo | 1993 |
Intracellular calcium concentration in C6BU-1 rat glioma cells: a single cell study using fluorescence microscopy/video imaging system.
Topics: Animals; Antidepressive Agents; Calcium; Cell Line; Clomipramine; Glioma; Microscopy, Fluorescence; | 1993 |
Refilling the inositol 1,4,5-trisphosphate-sensitive Ca2+ store in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: Animals; Bradykinin; Calcium; Calcium-Transporting ATPases; Dose-Response Relationship, Drug; Flunar | 1993 |
Effect of calcium antagonists on regional cerebral blood flow in transplanted rat brain tumors.
Topics: Analysis of Variance; Animals; Brain; Brain Neoplasms; Calcium Channel Blockers; Cerebrovascular Cir | 1996 |
Spontaneous firing of NG108-15 cells induced by transient exposure to ammonium chloride.
Topics: Amiloride; Ammonium Chloride; Animals; Cell Differentiation; Cell Membrane; Glioma; Hybrid Cells; Hy | 1996 |
Effects of clomipramine and verapamil on 5-HT-induced intracellular calcium changes in individual C6 rat glioma cells.
Topics: Animals; Calcium; Clomipramine; Dose-Response Relationship, Drug; Glioma; Rats; Serotonin; Time Fact | 1996 |
Chronic treatment with antidepressants, verapamil, or lithium inhibits the serotonin-induced intracellular calcium response in individual C6 rat glioma cells.
Topics: Animals; Antidepressive Agents; Calcium; Calcium Channel Blockers; Citalopram; Clomipramine; Drug In | 1997 |
Inhibition of Toosendanin on the delayed rectifier potassium current in neuroblastoma x glioma NG108-15 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Alterations of ionic membrane permeabilities in multidrug-resistant neuroblastoma x glioma hybrid cells.
Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cell Membrane Permeability; Cell Size; Chlorid | 1998 |
A novel type of Ca2+ channel in U-87 MG cells activated by anti-galactocerebroside.
Topics: Calcium; Calcium Channel Blockers; Calcium Channels; Cations, Divalent; Galactosylceramides; Glioma; | 1998 |
Mechanisms through which PDGF alters intracellular calcium levels in U-1242 MG human glioma cells.
Topics: Becaplermin; Brain Neoplasms; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium | 1999 |
Rapid induction of long-lasting drug efflux activity in brain vascular endothelial cells but not malignant glioma following irradiation.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2002 |
P-glycoprotein overexpression cannot explain the complete doxorubicin-resistance phenotype in rat glioblastoma cell lines.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Divisio | 1992 |
Evidence for cAMP and cholate extrusion in C6 rat glioma cells by a common anion efflux pump.
Topics: Animals; Antimycin A; Biological Transport, Active; Cholic Acids; Cyclic AMP; Glioma; Isoproterenol; | 1991 |
Inhibition of phosphatidylcholine and phosphatidylethanolamine biosynthesis by cytochalasin B in cultured glioma cells: potential regulation of biosynthesis by Ca(2+)-dependent mechanisms.
Topics: Animals; Biological Transport, Active; Calcium; Carbon Radioisotopes; Cell Line; Choline; Cytochalas | 1991 |
Use of verapamil to enhance the antiproliferative activity of BCNU in human glioma cells: an in vitro and in vivo study.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Division; Drug Screening Assays, Antitumor; Fluorescent D | 1990 |
The effect of dihydropyridine calcium agonists and antagonists on neuronal voltage sensitive calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |
The reversal of doxorubicin resistance by verapamil is not due to an effect on calcium channels.
Topics: Animals; Barium; Calcium; Cell Line; Doxorubicin; Drug Resistance; Glioma; Ion Channels; Manganese; | 1988 |
Inhibition of calcium channels in neuroblastoma x glioma hybrid cells by verapamil, D600, diltiazem and nisoldipine.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Gallopamil; Glioma; Ion Channels; Neuroblasto | 1987 |
Receptor-stimulated phospholipase A2 activation is coupled to influx of external calcium and not to mobilization of intracellular calcium in C62B glioma cells.
Topics: Acetylcholine; Animals; Benzofurans; Calcium; Cell Line; Enzyme Activation; Fluorescent Dyes; Fura-2 | 1989 |
Inhibitory effect of calcium channel blockers on proliferation of human glioma cells in vitro.
Topics: Calcium; Calcium Channel Blockers; Cell Division; Glioma; Humans; Nimodipine; Thymidine; Tumor Cells | 1989 |
Human tumor cells resistant to verapamil.
Topics: Cell Cycle; Cell Division; Cell Line; Cerebellar Neoplasms; Doxorubicin; Drug Resistance; Glioma; Hu | 1989 |
Prostaglandin induces Ca2+ influx and cyclic GMP formation in mouse neuroblastoma X rat glioma hybrid NG108-15 cells in culture.
Topics: Aminoquinolines; Animals; Calcium; Cyclic GMP; Diltiazem; Dinoprost; Dinoprostone; Fluorescent Dyes; | 1988 |
Antiproliferative effect of verapamil alone on brain tumor cells in vitro.
Topics: Calcium; Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Glioma; Humans; In Vitro Techn | 1988 |
[Mechanism and overcoming of resistance in ACNU-resistant sublines of rat brain tumors].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Membrane Permeability; Drug Resistance; Glioma | 1986 |
[Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Cells, Cultured; Drug Resistance; Drug T | 1986 |
Resistance of human glioma to adriamycin in vitro: the role of membrane transport and its circumvention with verapamil.
Topics: Biological Transport; Cell Line; Cell Survival; Doxorubicin; Drug Resistance; Drug Synergism; Glioma | 1986 |
Potentiation of vincristine effect in human and murine gliomas by calcium channel blockers or calmodulin inhibitors.
Topics: Animals; Brain Neoplasms; Calcium Channel Blockers; Calmodulin; Drug Synergism; Glioma; Humans; In V | 1985 |