verapamil has been researched along with Fibrosarcoma in 7 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Verapamil had previously been shown to increase cellular melphalan uptake and cytotoxicity in fibrosarcomas, and increased the area under the blood concentration versus time curve (AUC) for melphalan in CBA mice." | 7.67 | Effects of verapamil and alcohol on blood flow, melphalan uptake and cytotoxicity, in murine fibrosarcomas and human melanoma xenografts. ( Clutterbuck, RD; McElwain, TJ; Millar, JL; Robinson, BA, 1986) |
| "Growth delay by melphalan of two fibrosarcomas in CBA mice was prolonged by intraperitoneal (i." | 7.67 | Verapamil potentiation of melphalan cytotoxicity and cellular uptake in murine fibrosarcoma and bone marrow. ( Clutterbuck, RD; McElwain, TJ; Millar, JL; Robinson, BA, 1985) |
| "The influence of the calcium channel blocker verapamil on the sensitivity of mouse fibrosarcoma cells of the line EMT-6 to treatment with Photofrin II (PII) or tetra(4-sulfonatophenyl)porphine (TPPS4) and light has been assessed." | 3.70 | Verapamil enhances the uptake and the photocytotoxic effect of PII, but not that of tetra(4-sulfonatophenyl)porphine. ( Berg, K; Geze, M; Maziere, JC; Santus, R, 1998) |
| "Verapamil had previously been shown to increase cellular melphalan uptake and cytotoxicity in fibrosarcomas, and increased the area under the blood concentration versus time curve (AUC) for melphalan in CBA mice." | 3.67 | Effects of verapamil and alcohol on blood flow, melphalan uptake and cytotoxicity, in murine fibrosarcomas and human melanoma xenografts. ( Clutterbuck, RD; McElwain, TJ; Millar, JL; Robinson, BA, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nejime, N | 1 |
| Kagota, S | 1 |
| Tada, Y | 1 |
| Nakamura, K | 1 |
| Hashimoto, M | 1 |
| Kunitomo, M | 1 |
| Shinozuka, K | 1 |
| Baskin, R | 1 |
| Sayeski, PP | 1 |
| Berg, K | 1 |
| Maziere, JC | 1 |
| Geze, M | 1 |
| Santus, R | 1 |
| Gossner, L | 1 |
| Wittke, H | 1 |
| Warzecha, A | 1 |
| Sroka, R | 1 |
| Ernst, H | 1 |
| Meier, M | 1 |
| Ell, C | 1 |
| Robinson, BA | 2 |
| Clutterbuck, RD | 2 |
| Millar, JL | 2 |
| McElwain, TJ | 2 |
| Biaglow, JE | 1 |
| Varnes, ME | 1 |
| Jacobson, B | 1 |
| Suit, HD | 1 |
7 other studies available for verapamil and Fibrosarcoma
| Article | Year |
|---|---|
Possible participation of chloride ion channels in ATP release from cancer cells in suspension.
Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transpor | 2009 |
Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1.
Topics: Angiotensin II; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line, Tumor; Cell | 2012 |
Verapamil enhances the uptake and the photocytotoxic effect of PII, but not that of tetra(4-sulfonatophenyl)porphine.
Topics: Animals; Cell Survival; Dihematoporphyrin Ether; Drug Synergism; Fibrosarcoma; Humans; Mammary Neopl | 1998 |
Verapamil and hematoporphyrin derivative for tumour destruction by photodynamic therapy.
Topics: Animals; Antineoplastic Agents; Cell Line; Female; Fibrosarcoma; Hematoporphyrin Derivative; Hematop | 1991 |
Effects of verapamil and alcohol on blood flow, melphalan uptake and cytotoxicity, in murine fibrosarcomas and human melanoma xenografts.
Topics: Animals; Cinnarizine; Drug Synergism; Ethanol; Female; Fibrosarcoma; Flunarizine; Humans; Male; Mela | 1986 |
Effect of calcium channel blocking drugs on tumor cell oxygen utilization.
Topics: Animals; Calcium Channel Blockers; Cell Line; Diltiazem; Fibrosarcoma; Glucose; Kinetics; Mammary Ne | 1986 |
Verapamil potentiation of melphalan cytotoxicity and cellular uptake in murine fibrosarcoma and bone marrow.
Topics: Animals; Bone Marrow; Cell Survival; Colony-Forming Units Assay; Drug Synergism; Female; Fibrosarcom | 1985 |