verapamil has been researched along with Experimental Neoplasms in 32 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multidrug resistant H22 (H22/FAP) hepatocellular carcinoma cells were produced in vitro by continuous exposure to increasing doses of doxorubicin, cisplatin and 5-fluorouracil (FAP regimen)." | 7.79 | Association between reversal of multidrug resistance by methyl jasmonate and P-glycoprotein ATPase activity in hepatocellular carcinoma. ( Huang, FZ; Jiang, XZ; Liu, XY; Nie, WP; Wang, CF; Wang, YQ, 2013) |
| "Multidrug resistant H22 (H22/FAP) hepatocellular carcinoma cells were produced in vitro by continuous exposure to increasing doses of doxorubicin, cisplatin and 5-fluorouracil (FAP regimen)." | 3.79 | Association between reversal of multidrug resistance by methyl jasmonate and P-glycoprotein ATPase activity in hepatocellular carcinoma. ( Huang, FZ; Jiang, XZ; Liu, XY; Nie, WP; Wang, CF; Wang, YQ, 2013) |
| "A variant, MS23, of murine thymoma W7 cells, previously selected for its resistance to low concentrations of dexamethasone, is cross-resistant to unrelated drugs such as puromycin and colchicine." | 3.68 | Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis. ( Bourgeois, S; Gruol, DJ; Newby, RF; Rajah, FM, 1993) |
| "Effects of maitotoxin, the most potent marine toxin, were studied using a rat pheochromocytoma cell line, PC12h." | 3.66 | Maitotoxin, a Ca2+ channel activator candidate. ( Ohizumi, Y; Takahashi, M; Yasumoto, T, 1982) |
| "Verapamil is an agent which inhibits the transmembrane flux of calcium ions and is used clinically in the management of cardiac arrhythmias." | 2.37 | The calcium channel blocker verapamil and cancer chemotherapy. ( Simpson, WG, 1985) |
| " Pharmacokinetic experiments show oral bioavailability through gastric absorption." | 1.48 | Pharmacology and in vivo efficacy of pyridine-pyrimidine amides that inhibit microtubule polymerization. ( Cescon, DW; Hansen, MD; Hoj, JP; Siddiqui-Jain, A, 2018) |
| "Treatment with verapamil (VRP) reduced the resistance to tallimustine, but not to MEN 10710, in MCF7/DX cells." | 1.30 | Cytotoxic and antitumor activity of MEN 10710, a novel alkylating derivative of distamycin. ( Animati, F; Bigioni, M; Lombardi, P; Manzini, S; Palma, C; Pratesi, G; Salvatore, C; Supino, R; Zunino, F, 1997) |
| " However, the chronic administration of ADR and DAU alone or in combination with VRP prior to the peak of TPA-induced DNA synthesis 16 h after each promotion treatment with TPA fails to alter the promotion of skin papillomas in the two-stage protocol of mouse skin carcinogenesis." | 1.28 | Modulation by adriamycin, daunomycin, verapamil, and trifluoperazine of the biochemical processes linked to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. ( Perchellet, JP; Satyamoorthy, K, 1989) |
| "Verapamil may enhance the cytotoxicity of EGF-PE by blocking lysosomal degradation of EGF-PE." | 1.27 | [The effect of calcium antagonists on intracellular transport of epidermal growth factor and the conjugate of epidermal growth factor with pseudomonas exotoxin]. ( Akiyama, S, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (46.88) | 18.7374 |
| 1990's | 8 (25.00) | 18.2507 |
| 2000's | 3 (9.38) | 29.6817 |
| 2010's | 6 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ai, Y | 1 |
| Zhu, B | 1 |
| Ren, C | 1 |
| Kang, F | 1 |
| Li, J | 1 |
| Huang, Z | 1 |
| Lai, Y | 1 |
| Peng, S | 1 |
| Ding, K | 1 |
| Tian, J | 2 |
| Zhang, Y | 1 |
| Siddiqui-Jain, A | 1 |
| Hoj, JP | 1 |
| Cescon, DW | 1 |
| Hansen, MD | 1 |
| Vesci, L | 1 |
| Milazzo, FM | 1 |
| Stasi, MA | 1 |
| Pace, S | 1 |
| Manera, F | 1 |
| Tallarico, C | 1 |
| Cini, E | 1 |
| Petricci, E | 1 |
| Manetti, F | 1 |
| De Santis, R | 1 |
| Giannini, G | 1 |
| Ren, Q | 1 |
| Yang, G | 1 |
| Guo, M | 1 |
| Guo, J | 1 |
| Li, Y | 2 |
| Lu, J | 1 |
| Yang, Q | 1 |
| Tang, H | 1 |
| Fang, X | 1 |
| Sun, Y | 1 |
| Qi, JG | 2 |
| Wang, H | 1 |
| Wang, X | 1 |
| Ren, QW | 1 |
| Liu, XX | 1 |
| Yang, YT | 1 |
| Wang, BH | 1 |
| Zhai, R | 1 |
| Tian, JW | 1 |
| Wang, HB | 1 |
| Bi, Y | 1 |
| Wang, CF | 1 |
| Wang, YQ | 1 |
| Huang, FZ | 1 |
| Nie, WP | 1 |
| Liu, XY | 1 |
| Jiang, XZ | 1 |
| He, L | 1 |
| Zhao, C | 1 |
| Yan, M | 1 |
| Zhang, LY | 1 |
| Xia, YZ | 1 |
| Degasperi, GR | 1 |
| Zecchin, KG | 1 |
| Borecký, J | 1 |
| Cruz-Höfling, MA | 1 |
| Castilho, RF | 1 |
| Velloso, LA | 1 |
| Guimarães, F | 1 |
| Vercesi, AE | 1 |
| Shen, F | 1 |
| Chu, S | 1 |
| Bence, AK | 1 |
| Bailey, B | 1 |
| Xue, X | 1 |
| Erickson, PA | 1 |
| Montrose, MH | 1 |
| Beck, WT | 1 |
| Erickson, LC | 1 |
| Takahashi, M | 1 |
| Ohizumi, Y | 1 |
| Yasumoto, T | 1 |
| Hiserodt, JC | 1 |
| Britvan, LJ | 1 |
| Targan, SR | 1 |
| Tsuruo, T | 2 |
| Geras, E | 1 |
| Rebecchi, MJ | 1 |
| Gershengorn, MC | 1 |
| Iida, H | 1 |
| Naganuma, K | 1 |
| Tsukagoshi, S | 1 |
| Sakurai, Y | 1 |
| Gottesman, MM | 2 |
| Mickisch, GH | 1 |
| Pastan, I | 2 |
| Schott, B | 1 |
| Londos-Gagliardi, D | 1 |
| Ries, C | 1 |
| Huet, S | 1 |
| Robert, J | 1 |
| Bourgeois, S | 1 |
| Gruol, DJ | 1 |
| Newby, RF | 1 |
| Rajah, FM | 1 |
| Pérez, V | 1 |
| Pierré, A | 1 |
| Léonce, S | 1 |
| Anstett, M | 1 |
| Prost, JF | 1 |
| Atassi, G | 1 |
| Homolya, L | 1 |
| Holló, M | 1 |
| Müller, M | 1 |
| Mechetner, EB | 1 |
| Sarkadi, B | 1 |
| Starling, JJ | 1 |
| Shepard, RL | 1 |
| Cao, J | 1 |
| Law, KL | 1 |
| Norman, BH | 1 |
| Kroin, JS | 1 |
| Ehlhardt, WJ | 1 |
| Baughman, TM | 1 |
| Winter, MA | 1 |
| Bell, MG | 1 |
| Shih, C | 1 |
| Gruber, J | 1 |
| Elmquist, WF | 1 |
| Dantzig, AH | 1 |
| Bigioni, M | 1 |
| Salvatore, C | 1 |
| Palma, C | 1 |
| Manzini, S | 1 |
| Animati, F | 1 |
| Lombardi, P | 1 |
| Pratesi, G | 1 |
| Supino, R | 1 |
| Zunino, F | 1 |
| Galper, JB | 1 |
| Catterall, WA | 1 |
| Goldstein, LJ | 1 |
| Satyamoorthy, K | 1 |
| Perchellet, JP | 1 |
| Wood, PJ | 2 |
| Hirst, DG | 2 |
| Adams, GE | 1 |
| Stratford, IJ | 1 |
| Godden, J | 1 |
| Howells, N | 1 |
| Vayuvegula, B | 1 |
| Slater, L | 1 |
| Meador, J | 1 |
| Gupta, S | 1 |
| Formelli, F | 1 |
| Cleris, L | 1 |
| Carsana, R | 1 |
| Simpson, WG | 1 |
| Akiyama, S | 1 |
| Cesano, L | 1 |
| Vietti Ramus, G | 1 |
| Barbalonga, A | 1 |
3 reviews available for verapamil and Experimental Neoplasms
| Article | Year |
|---|---|
In vivo models of P-glycoprotein-mediated multidrug resistance.
Topics: Animals; Animals, Genetically Modified; Antineoplastic Agents; ATP Binding Cassette Transporter, Sub | 1994 |
Multidrug resistance in human cancer.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Pro | 1992 |
The calcium channel blocker verapamil and cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Drug Syne | 1985 |
29 other studies available for verapamil and Experimental Neoplasms
| Article | Year |
|---|---|
Discovery of New Monocarbonyl Ligustrazine-Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Curcumin; Dose-Response Relati | 2016 |
Pharmacology and in vivo efficacy of pyridine-pyrimidine amides that inhibit microtubule polymerization.
Topics: Amides; Animals; Cell Line, Tumor; Cell Proliferation; Dogs; Dose-Response Relationship, Drug; Human | 2018 |
Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dos | 2018 |
Design, synthesis, and discovery of ocotillol-type amide derivatives as orally available modulators of P-glycoprotein-mediated multidrug resistance.
Topics: Administration, Oral; Amides; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subf | 2019 |
Synthesis and biological evaluation of novel H6 analogues as drug resistance reversal agents.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistanc | 2019 |
Association between reversal of multidrug resistance by methyl jasmonate and P-glycoprotein ATPase activity in hepatocellular carcinoma.
Topics: Acetates; Adenosine Triphosphate; Animals; Antineoplastic Agents; Antineoplastic Combined Chemothera | 2013 |
Inhibition of P-glycoprotein function by procyanidine on blood-brain barrier.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biflavo | 2009 |
Verapamil-sensitive Ca2+ channel regulation of Th1-type proliferation of splenic lymphocytes induced by Walker 256 tumor development in rats.
Topics: Animals; Blotting, Western; Calcium Channel Blockers; Calcium Channels; CD4-Positive T-Lymphocytes; | 2006 |
Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cas | 2008 |
Maitotoxin, a Ca2+ channel activator candidate.
Topics: Adrenal Gland Neoplasms; Animals; Calcium; Cell Line; Ion Channels; Kinetics; Manganese; Marine Toxi | 1982 |
Differential effects of various pharmacological agents on the cytolytic reaction mechanism of the human natural killer lymphocyte: further resolution of programming for lysis and KCIL into discrete stages.
Topics: Calcium; Cyclic AMP; Cysteine; Cytotoxicity, Immunologic; Dimethyl Sulfoxide; Dinoprostone; Dithioth | 1982 |
[Reversal of acquired resistance to vinca alkaloids and anthracycline antibiotics by calcium channel blockers and calmodulin inhibitors].
Topics: Animals; Antibiotics, Antineoplastic; Calcium Channel Blockers; Calmodulin; Drug Resistance; Drug Sy | 1984 |
Evidence that stimulation of thyrotropin and prolactin secretion by thyrotropin-releasing hormone occur via different calcium-mediated mechanisms: studies with verapamil.
Topics: Animals; Biological Transport, Active; Calcium; Kinetics; Mice; Neoplasms, Experimental; Pituitary N | 1982 |
Promotion by verapamil of vincristine responsiveness in tumor cell lines inherently resistant to the drug.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Synergism; | 1983 |
Pharmacological and molecular characterization of intrinsic and acquired doxorubicin resistance in murine tumor cell lines.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Carrier Protein | 1993 |
Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Southern; Car | 1993 |
[In vitro characterization of S9788, a new modulator of multidrug resistance].
Topics: Animals; Antineoplastic Agents; Cell Cycle; Drug Resistance; Drug Screening Assays, Antitumor; Human | 1993 |
A new method for a quantitative assessment of P-glycoprotein-related multidrug resistance in tumour cells.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Tr | 1996 |
Pharmacological characterization of LY335979: a potent cyclopropyldibenzosuberane modulator of P-glycoprotein.
Topics: Acridines; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 1997 |
Cytotoxic and antitumor activity of MEN 10710, a novel alkylating derivative of distamycin.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Calcium Channel Blockers; Cell Su | 1997 |
Inhibition of sodium channels by D600.
Topics: Binding, Competitive; Calcium; Cells, Cultured; Gallopamil; Ion Channels; Myocardium; Neoplasms, Exp | 1979 |
Modulation by adriamycin, daunomycin, verapamil, and trifluoperazine of the biochemical processes linked to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Daunorubicin; DNA; Doxorubicin; | 1989 |
Modification of tumour response by calcium antagonists in the SCVII/St tumour implanted at two different sites.
Topics: Animals; Back; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Dose-Response | 1989 |
Enhancement of the anti-tumor effect of melphalan in experimental mice by some vaso-active agents.
Topics: Animals; Drug Synergism; Drug Therapy, Combination; Hydralazine; Melphalan; Mice; Neoplasms, Experim | 1989 |
Calcium antagonists as radiation modifiers: site specificity in relation to tumor response.
Topics: Animals; Calcium Channel Blockers; Combined Modality Therapy; Female; Flunarizine; Mice; Mice, Inbre | 1989 |
Correction of altered plasma membrane potentials. A possible mechanism of cyclosporin A and verapamil reversal of pleiotropic drug resistance in neoplasia.
Topics: Animals; Antineoplastic Agents; Calcium; Cell Line; Cell Membrane; Cyclosporins; Drug Resistance; Le | 1988 |
Effect of verapamil on doxorubicin activity and pharmacokinetics in mice bearing resistant and sensitive solid tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line; Doxorubicin; Drug | 1988 |
[The effect of calcium antagonists on intracellular transport of epidermal growth factor and the conjugate of epidermal growth factor with pseudomonas exotoxin].
Topics: Biological Transport; Calcium Channel Blockers; Cathepsin B; Cathepsins; Cell Line; Cell Survival; C | 1985 |
[Verapamil inhibits DNA synthesis in vitro. II. Study of the MCF7 and Jurkat neoplastic cell lines].
Topics: Breast Neoplasms; Calcium; Cell Line; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Female | 1985 |