verapamil has been researched along with Experimental Mammary Neoplasms in 24 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The influence of the calcium channel blocker verapamil on the sensitivity of mouse fibrosarcoma cells of the line EMT-6 to treatment with Photofrin II (PII) or tetra(4-sulfonatophenyl)porphine (TPPS4) and light has been assessed." | 3.70 | Verapamil enhances the uptake and the photocytotoxic effect of PII, but not that of tetra(4-sulfonatophenyl)porphine. ( Berg, K; Geze, M; Maziere, JC; Santus, R, 1998) |
| "Multiorgan metastasis of drug-resistant 4T1 breast tumors was totally resistant to doxorubicin treatment." | 1.37 | Increased expression of P-glycoprotein is associated with doxorubicin chemoresistance in the metastatic 4T1 breast cancer model. ( Bao, L; Dash, S; Haque, A; Hazari, S; Jackson, K; Jetly, R; Moroz, K, 2011) |
| "Verapamil treatment of these cells also resulted in significant depletion of cellular GSH." | 1.28 | Glutathione depletion in human and in rat multi-drug resistant breast cancer cell lines. ( Batist, G; Greene, D; Lehnert, S; Schecter, R; Woo, A, 1991) |
| "Treatment with verapamil or CaCl2 following PEP treatment also effectively enhanced the cytotoxic effect of PEP, suggesting an interaction with PEP-induced damage." | 1.27 | Modulation of the cytotoxicity of the antitumor antibiotic peplomycin by membrane-interacting drugs and by increased levels of calcium ions. ( Ishida, A; Mizuno, S; Nanjo, T; Uehara, Y, 1983) |
| "Verapamil was administered as an i." | 1.26 | Effect of verapamil on malignant tissue blood flow in SMT-2A tumor-bearing rats. ( Jirtle, RL; Kaelin, WG; Shand, DG; Shrivastav, S, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (20.83) | 18.7374 |
| 1990's | 9 (37.50) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 5 (20.83) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Gurrapu, S | 1 |
| Jonnalagadda, SK | 1 |
| Alam, MA | 1 |
| Ronayne, CT | 1 |
| Nelson, GL | 1 |
| Solano, LN | 1 |
| Lueth, EA | 1 |
| Drewes, LR | 1 |
| Mereddy, VR | 1 |
| Lee, S | 1 |
| Kwon, NH | 1 |
| Seo, B | 1 |
| Lee, JY | 1 |
| Cho, HY | 1 |
| Kim, K | 1 |
| Kim, HS | 1 |
| Jung, K | 1 |
| Jeon, YH | 1 |
| Kim, S | 1 |
| Suh, YG | 1 |
| McCarthy, M | 1 |
| Auda, G | 1 |
| Agrawal, S | 1 |
| Taylor, A | 1 |
| Backstrom, Z | 1 |
| Mondal, D | 1 |
| Moroz, K | 2 |
| Dash, S | 2 |
| Kam, Y | 1 |
| Das, T | 1 |
| Tian, H | 1 |
| Foroutan, P | 1 |
| Ruiz, E | 1 |
| Martinez, G | 1 |
| Minton, S | 1 |
| Gillies, RJ | 1 |
| Gatenby, RA | 1 |
| Guo, DQ | 1 |
| Zhang, H | 1 |
| Tan, SJ | 1 |
| Gu, YC | 1 |
| Bao, L | 1 |
| Haque, A | 1 |
| Jackson, K | 1 |
| Hazari, S | 1 |
| Jetly, R | 1 |
| Zheng, G | 1 |
| Lyons, JG | 1 |
| Liu, Z | 1 |
| Ballinger, JR | 2 |
| Rauth, AM | 1 |
| Bendayan, R | 1 |
| Wu, XY | 1 |
| Mizuno, S | 1 |
| Ishida, A | 1 |
| Uehara, Y | 1 |
| Nanjo, T | 1 |
| Kaelin, WG | 1 |
| Shrivastav, S | 1 |
| Shand, DG | 1 |
| Jirtle, RL | 1 |
| Kondo, T | 1 |
| Habara, Y | 1 |
| Kanno, T | 1 |
| Kano, E | 1 |
| Coley, HM | 2 |
| Amos, WB | 1 |
| Twentyman, PR | 3 |
| Workman, P | 2 |
| Wright, KA | 1 |
| Etiévant, C | 1 |
| Pauwels, O | 1 |
| Kiss, R | 1 |
| Alaoui-Jamali, MA | 1 |
| Schecter, RL | 1 |
| Rustum, YM | 1 |
| Centurioni, MG | 1 |
| Lehnert, S | 2 |
| Batist, G | 2 |
| Berg, K | 1 |
| Maziere, JC | 1 |
| Geze, M | 1 |
| Santus, R | 1 |
| Soybir, G | 1 |
| Köksoy, F | 1 |
| Koyuncu, H | 1 |
| Yalçin, O | 1 |
| Köse, H | 1 |
| Topuzlu, C | 1 |
| Tunggal, JK | 1 |
| Melo, T | 1 |
| Tannock, IF | 1 |
| Kang, CD | 1 |
| Ahn, BK | 1 |
| Jeong, CS | 1 |
| Kim, KW | 1 |
| Lee, HJ | 1 |
| Yoo, SD | 1 |
| Chung, BS | 1 |
| Kim, SH | 1 |
| Schecter, R | 1 |
| Woo, A | 1 |
| Greene, D | 1 |
| Jähde, E | 1 |
| Glüsenkamp, KH | 1 |
| Rajewsky, MF | 1 |
| Takagi, E | 1 |
| Kawatsu, H | 1 |
| Shimokata, K | 1 |
| Nishiyama, Y | 1 |
| Kojima, K | 1 |
| Yoshida, S | 1 |
| Biaglow, JE | 1 |
| Varnes, ME | 1 |
| Jacobson, B | 1 |
| Suit, HD | 1 |
24 other studies available for verapamil and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Coumarin carboxylic acids as monocarboxylate transporter 1 inhibitors: In vitro and in vivo studies as potential anticancer agents.
Topics: Animals; Antineoplastic Agents; Carboxylic Acids; Cell Line, Tumor; Cell Proliferation; Coumarins; D | 2016 |
Discovery of novel potent migrastatic Thiazolo[5,4-b]pyridines targeting Lysyl-tRNA synthetase (KRS) for treatment of Cancer metastasis.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response R | 2021 |
In vivo anticancer synergy mechanism of doxorubicin and verapamil combination treatment is impaired in BALB/c mice with metastatic breast cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily | 2014 |
Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges".
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cell Proliferation; C | 2015 |
Nifedipine promotes the proliferation and migration of breast cancer cells.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Gene Express | 2014 |
Increased expression of P-glycoprotein is associated with doxorubicin chemoresistance in the metastatic 4T1 breast cancer model.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line, T | 2011 |
Cyclosporin A improves the selection of cells transfected with the puromycin acetyltransferase gene.
Topics: Acetyltransferases; Antineoplastic Agents; Cell Survival; Cyclosporine; Drug Resistance, Neoplasm; F | 2002 |
Delivery of an anticancer drug and a chemosensitizer to murine breast sarcoma by intratumoral injection of sulfopropyl dextran microspheres.
Topics: Animals; Cell Line, Tumor; Delayed-Action Preparations; Dextrans; Doxorubicin; Drug Resistance, Neop | 2003 |
Modulation of the cytotoxicity of the antitumor antibiotic peplomycin by membrane-interacting drugs and by increased levels of calcium ions.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Calcium; Cell Membrane; Cell Membrane Permeability; | 1983 |
Effect of verapamil on malignant tissue blood flow in SMT-2A tumor-bearing rats.
Topics: Adenocarcinoma; Animals; Blood Pressure; Cardiac Output; Female; Heart Rate; Mammary Neoplasms, Expe | 1982 |
Thermosensitization and modification of cytosolic calcium concentration by verapamil and diltiazem in mouse mammary carcinoma cells.
Topics: Animals; Calcium; Cytosol; Diltiazem; Hot Temperature; Mammary Neoplasms, Experimental; Mice; Tumor | 1994 |
Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carci | 1993 |
Derivation and characterisation of a mouse tumour cell line with acquired resistance to cyclosporin A.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinosarcoma; Carrier Proteins; | 1993 |
Digital cell image analysis of verapamil-induced effects in chemosensitive and chemoresistant neoplastic cell lines.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Aziridines; Cell Division; Diamines; Dose-Resp | 1993 |
In vivo reversal of doxorubicin resistance by a new tiapamil analog Ro11-2933.
Topics: Animals; Calcium Channel Blockers; Cell Division; DNA Damage; Doxorubicin; Drug Resistance; Female; | 1993 |
Verapamil enhances the uptake and the photocytotoxic effect of PII, but not that of tetra(4-sulfonatophenyl)porphine.
Topics: Animals; Cell Survival; Dihematoporphyrin Ether; Drug Synergism; Fibrosarcoma; Humans; Mammary Neopl | 1998 |
Chemoprevention of DMBA-induced mammary gland carcinogenesis--preventive effects of free oxygen radical scavengers.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Calcium Channel Blockers; Carcin | 1998 |
The influence of expression of P-glycoprotein on the penetration of anticancer drugs through multicellular layers.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neop | 2000 |
Downregulation of JNK/SAPK activity is associated with the cross-resistance to P-glycoprotein-unrelated drugs in multidrug-resistant FM3A/M cells overexpressing P-glycoprotein.
Topics: Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 2000 |
Glutathione depletion in human and in rat multi-drug resistant breast cancer cell lines.
Topics: Animals; Breast Neoplasms; Buthionine Sulfoximine; Doxorubicin; Drug Resistance; Female; Glutathione | 1991 |
Protection of cultured malignant cells from mitoxantrone cytotoxicity by low extracellular pH: a possible mechanism for chemoresistance in vivo.
Topics: Animals; Cell Survival; Drug Resistance; Extracellular Space; Hydrogen-Ion Concentration; Mammary Ne | 1990 |
Identification of anthracyclines and related agents that retain preferential activity over adriamycin in multidrug-resistant cell lines, and further resistance modification by verapamil and cyclosporin A.
Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Small Cell; Cell Line; Coloring Agents; Cyclosporin | 1989 |
Establishment and characterization of resistant cells to etoposide (VP16) from a mouse breast cancer cell line, FM3A.
Topics: Animals; Cell Survival; DNA Topoisomerases, Type II; Drug Resistance; Etoposide; Mammary Neoplasms, | 1988 |
Effect of calcium channel blocking drugs on tumor cell oxygen utilization.
Topics: Animals; Calcium Channel Blockers; Cell Line; Diltiazem; Fibrosarcoma; Glucose; Kinetics; Mammary Ne | 1986 |