verapamil has been researched along with Experimental Leukemia in 46 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experiments were carried out in vitro on adriamycin (ADR) accumulation and cytotoxicity alone and in combination with calcium channel antagonist, verapamil (VRP), in ascites murine tumour models of Ehrlich carcinoma (EAC), sarcoma 180 (S180) and P388 lymphocytic leukaemia (P388)." | 7.67 | Modulation of in vitro response to adriamycin by verapamil in murine P388 leukaemia, Ehrlich ascites carcinoma and sarcoma 180. ( Basrur, VS; Chitnis, MP; Pradhan, SG; Tantri, SK, 1987) |
| "Experiments were carried out in vitro on adriamycin (ADR) accumulation and cytotoxicity alone and in combination with calcium channel antagonist, verapamil (VRP), in ascites murine tumour models of Ehrlich carcinoma (EAC), sarcoma 180 (S180) and P388 lymphocytic leukaemia (P388)." | 3.67 | Modulation of in vitro response to adriamycin by verapamil in murine P388 leukaemia, Ehrlich ascites carcinoma and sarcoma 180. ( Basrur, VS; Chitnis, MP; Pradhan, SG; Tantri, SK, 1987) |
| "Hexamethylene bisacetamide (HMBA) is a potent inducer of differentiation of murine erythroleukemia cells (MELC)." | 1.28 | Conversion of differentiation inducer resistance to differentiation inducer sensitivity in erythroleukemia cells. ( Chen, ZX; Lebedev, YB; Marks, PA; Michaeli, J; Richon, VM; Rifkind, RA, 1990) |
| " These effects of DMDP were greater than those of another calcium channel blocker, verapamil, and occurred at one-half the dosage levels." | 1.27 | The effects of verapamil and a tiapamil analogue, DMDP, on adriamycin-induced cytotoxicity in P388 adriamycin-resistant and -sensitive leukemia in vitro and in vivo. ( Bankusli, I; Mayhew, E; Radel, S; Rustum, YM, 1988) |
| "The verapamil-induced increase of drug accumulation in resistant cells is accounted for at least in part by the blockage or slowing of Rho-123 efflux from these cells." | 1.27 | Reversal of resistance to rhodamine 123 in adriamycin-resistant Friend leukemia cells. ( Krishan, A; Lampidis, TJ; Munck, JN; Tapiero, H, 1985) |
| " However, when the calcium channel blocker verapamil (75 mg/kg) was administered with VCR at 1." | 1.27 | Cure of mice bearing P388 leukemia by vincristine in combination with a calcium channel blocker. ( Iida, H; Sakurai, Y; Tsukagoshi, S; Tsuruo, T, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (65.22) | 18.7374 |
| 1990's | 14 (30.43) | 18.2507 |
| 2000's | 2 (4.35) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dhainaut, A | 1 |
| Regnier, G | 1 |
| Tizot, A | 1 |
| Pierre, A | 1 |
| Leonce, S | 1 |
| Guilbaud, N | 1 |
| Kraus-Berthier, L | 1 |
| Atassi, G | 1 |
| Li, J | 1 |
| Hu, XF | 1 |
| Loveland, BE | 1 |
| Xing, PX | 1 |
| Jankovicová, K | 1 |
| Krejsek, J | 1 |
| Kopecký, O | 1 |
| Tsuruo, T | 8 |
| Okabe-Kado, J | 1 |
| Hayashi, M | 1 |
| Honma, Y | 1 |
| Hozumi, M | 1 |
| Yanovich, S | 1 |
| Preston, L | 1 |
| Iida, H | 5 |
| Tsukagoshi, S | 5 |
| Sakurai, Y | 5 |
| Yamashiro, M | 1 |
| Adams, DJ | 1 |
| Knick, VC | 1 |
| Savaraj, N | 1 |
| Lampidis, TJ | 3 |
| Zhao, JY | 1 |
| Wu, CJ | 1 |
| Teeter, LD | 1 |
| Kuo, MT | 1 |
| Gruber, A | 1 |
| Larsson, R | 1 |
| Nygren, P | 1 |
| Björkholm, M | 1 |
| Peterson, C | 1 |
| Abderrabi, M | 1 |
| Marchal, S | 1 |
| Merlin, JL | 1 |
| Lahmy, S | 1 |
| Salmon, JM | 1 |
| Vigo, J | 1 |
| Viallet, P | 1 |
| Boesch, D | 1 |
| Muller, K | 1 |
| Pourtier-Manzanedo, A | 1 |
| Loor, F | 1 |
| Jaffrézou, JP | 1 |
| Herbert, JM | 1 |
| Levade, T | 1 |
| Gau, MN | 1 |
| Chatelain, P | 1 |
| Laurent, G | 1 |
| Michaeli, J | 1 |
| Lebedev, YB | 1 |
| Richon, VM | 1 |
| Chen, ZX | 1 |
| Marks, PA | 1 |
| Rifkind, RA | 1 |
| Slapak, CA | 1 |
| Daniel, JC | 1 |
| Levy, SB | 1 |
| Donenko, FV | 4 |
| Chikvashvili, BSh | 1 |
| Borovkova, NB | 4 |
| Devichenskiĭ, VM | 1 |
| Kabieva, AO | 2 |
| Korneva, EN | 1 |
| Telegin, LIu | 1 |
| Shcherbakov, VM | 1 |
| Letiagin, VP | 1 |
| Moroz, LV | 4 |
| Adwankar, MK | 1 |
| Chitnis, MP | 2 |
| Sitdikova, SM | 3 |
| Mircheva, JJ | 1 |
| Ramu, A | 1 |
| Yagen, B | 1 |
| Ramu, N | 1 |
| Ahmed, NK | 1 |
| Vasanthakumar, G | 1 |
| Bose, R | 1 |
| Lam, HY | 1 |
| Radel, S | 1 |
| Bankusli, I | 1 |
| Mayhew, E | 1 |
| Rustum, YM | 1 |
| Sehested, M | 1 |
| Skovsgaard, T | 1 |
| van Deurs, B | 1 |
| Winther-Nielsen, H | 1 |
| McGown, A | 1 |
| Poppitt, DG | 1 |
| Fox, BW | 1 |
| Slater, LM | 1 |
| Murray, SL | 1 |
| Wetzel, MW | 1 |
| Sweet, P | 1 |
| Stupecky, M | 1 |
| Streeter, DG | 2 |
| Johl, JS | 1 |
| Gordon, GR | 1 |
| Peters, JH | 2 |
| Yamaguchi, T | 1 |
| Nakagawa, M | 1 |
| Shiraishi, N | 1 |
| Yoshida, T | 1 |
| Kiyosue, T | 1 |
| Arita, M | 1 |
| Akiyama, S | 1 |
| Kuwano, M | 1 |
| Krishan, A | 3 |
| Tapiero, H | 2 |
| Fourcade, A | 1 |
| Munck, JN | 2 |
| Zwingelstein, G | 1 |
| Baguley, BC | 1 |
| Ferguson, LR | 1 |
| Pradhan, SG | 1 |
| Basrur, VS | 1 |
| Tantri, SK | 1 |
| Tirosh, R | 1 |
| Berke, G | 1 |
| Capranico, G | 1 |
| Dasdia, T | 1 |
| Zunino, F | 1 |
| Sauerteig, A | 1 |
| Gordon, K | 1 |
| Swinkin, C | 1 |
| Taylor, DL | 1 |
| Acton, EM | 1 |
| Kawabata, H | 1 |
| Nagumo, N | 1 |
| Kitatani, Y | 1 |
| Borowitz, JL | 1 |
| Hadley, R | 1 |
| Stebbins, G | 1 |
| Sasaki, K | 1 |
| Nagaoka, S | 1 |
| Murakami, T | 1 |
| Kawasaki, S | 1 |
| Takahashi, M | 1 |
46 other studies available for verapamil and Experimental Leukemia
| Article | Year |
|---|---|
New purines and purine analogs as modulators of multidrug resistance.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Cha | 1996 |
Pim-1 expression and monoclonal antibody targeting in human leukemia cell lines.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Antineoplastic Agents; Apoptosis; ATP Binding | 2009 |
[Multidrug resistance of leukemia cells to cytostatics--the functional fluorescent dye efflux assay evaluated by flow cytometry].
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Drug Resistance, Multiple; Drug | 2001 |
[Reversal of acquired resistance to vinca alkaloids and anthracycline antibiotics by calcium channel blockers and calmodulin inhibitors].
Topics: Animals; Antibiotics, Antineoplastic; Calcium Channel Blockers; Calmodulin; Drug Resistance; Drug Sy | 1984 |
Effects of inducers of erythroid differentiation of human leukemia K562 cells on vincristine-resistant K562/VCR cells.
Topics: Animals; Butyrates; Butyric Acid; Cell Differentiation; Cells, Cultured; Cytarabine; Dactinomycin; D | 1983 |
Effects of verapamil on daunomycin cellular retention and cytotoxicity in P388 leukemic cells.
Topics: Animals; Biological Transport; Cell Survival; Daunorubicin; Drug Resistance; Kinetics; Leukemia P388 | 1984 |
Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.
Topics: Animals; Calcium Channel Blockers; Calcium-Binding Proteins; Calmodulin; Clomipramine; Doxorubicin; | 1982 |
Enhancement of vincristine- and adriamycin-induced cytotoxicity by verapamil in P388 leukemia and its sublines resistant to vincristine and adriamycin.
Topics: Animals; Doxorubicin; Drug Resistance; Leukemia P388; Leukemia, Experimental; Mice; Verapamil; Vincr | 1982 |
Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.
Topics: Animals; Biological Transport; Drug Resistance; Drug Therapy, Combination; Female; Leukemia, Experim | 1981 |
P-glycoprotein mediated resistance to 5'-nor-anhydro-vinblastine (Navelbine).
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 1995 |
Two multidrug-resistant Friend leukemic cell lines selected with different drugs exhibit overproduction of different P-glycoproteins.
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Pr | 1994 |
A non-P-glycoprotein-mediated mechanism of vincristine transport which is affected by resistance modifiers and present in chemosensitive cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Prot | 1994 |
Comparative in vitro evaluation of dithiane analogs of tiapamil, Ro 11-2933, Ro 44-5911 and Ro 44-5912 as multidrug resistance modulators.
Topics: Adenocarcinoma; Breast Neoplasms; Calcium Channel Blockers; Daunorubicin; Drug Resistance, Multiple; | 1996 |
Identification of multi-drug resistant cells in sensitive Friend leukemia cells by quantitative videomicrofluorimetry.
Topics: Benzimidazoles; Drug Resistance; Fluorescent Dyes; Friend murine leukemia virus; Image Processing, C | 1992 |
Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative.
Topics: Amiodarone; Animals; Cyclosporins; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; | 1991 |
Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labeling of P-glycoprotein.
Topics: Animals; Calcium Channel Blockers; Drug Resistance; Indolizines; Leukemia, Experimental; Mice; Phene | 1991 |
Conversion of differentiation inducer resistance to differentiation inducer sensitivity in erythroleukemia cells.
Topics: Acetamides; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Differentiation; | 1990 |
Sequential emergence of distinct resistance phenotypes in murine erythroleukemia cells under adriamycin selection: decreased anthracycline uptake precedes increased P-glycoprotein expression.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; C | 1990 |
[The effect of finoptin on the metabolism and pharmacological action of cyclophosphane in vivo and in vitro].
Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Interactions; Drug Screening Assay | 1991 |
Modulation of in vitro chemosensitivity by extracellular Ca++ in adriamycin sensitive and resistant P388 leukemic cells.
Topics: Animals; Calcium; DNA, Neoplasm; Doxorubicin; Drug Resistance; Leukemia P388; Leukemia, Experimental | 1990 |
Verapamil effect on the accumulation of doxorubicin in the leukemia P388 cells with induced antibiotic resistance.
Topics: Animals; Doxorubicin; Drug Resistance, Microbial; Leukemia P388; Leukemia, Experimental; Male; Mice; | 1990 |
[The effect of finoptin on doxorubicin accumulation in leukemia P-388 cells with induced resistance to the combination of finoptin and doxorubicin].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Interactions; Drug Resist | 1990 |
[The effect of finoptin on the accumulation of doxorubicin in leukemia P388 cells with induced resistance to the antibiotic].
Topics: Animals; Doxorubicin; Drug Interactions; Drug Resistance, Microbial; Drug Screening Assays, Antitumo | 1989 |
Effect of calcium influx blocker verapamil on adriamycin-induced cytotoxicity in leukemia cells in vitro.
Topics: Animals; Cell Division; Cell Survival; Doxorubicin; Leukemia, Experimental; Tumor Cells, Cultured; V | 1989 |
The cytotoxicity of T-2 toxin and related 12,13-epoxytrichothecenes to Adriamycin-sensitive and -resistant P388 leukemia cells.
Topics: Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Doxorubicin; Drug Resi | 1989 |
Characterization of daunorubicin resistance in K562 leukemia cells lacking daunorubicin reductase activity.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Cell Line; Cell Survival; Daunoru | 1987 |
Membrane transport changes in an adriamycin-resistant murine leukemia cell line and in its sensitive parental cell line.
Topics: Animals; Biological Transport; Cell Membrane; Doxorubicin; Drug Resistance; Leukemia P388; Leukemia, | 1988 |
The effects of verapamil and a tiapamil analogue, DMDP, on adriamycin-induced cytotoxicity in P388 adriamycin-resistant and -sensitive leukemia in vitro and in vivo.
Topics: Animals; Calcium Channel Blockers; Doxorubicin; Drug Resistance; Drug Synergism; Female; Glycoprotei | 1988 |
Increased plasma membrane traffic in daunorubicin resistant P388 leukaemic cells. Effect of daunorubicin and verapamil.
Topics: Animals; Cell Membrane; Daunorubicin; Drug Resistance; Endocytosis; Exocytosis; Female; Leukemia P38 | 1987 |
Comparison of daunorubicin and anthrapyrazolone sensitivity and transport in resistant cell lines.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Daunorubicin; Dose-Response Relationship, Drug; Drug | 1987 |
Verapamil potentiation of VP-16-213 in acute lymphatic leukemia and reversal of pleiotropic drug resistance.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Daunorubicin; Dose-Response Relation | 1986 |
Uptake and retention of morpholinyl anthracyclines by adriamycin-sensitive and -resistant P388 cells.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line; Doxorubicin; Drug Resistance; Leukemia P388; Leukem | 1986 |
Overcoming drug resistance in cancer cells with synthetic isoprenoids.
Topics: Animals; Antineoplastic Agents; Calcium; Doxorubicin; Drug Resistance; Ethylenediamines; Lethal Dose | 1986 |
Flow cytometric monitoring of anthracycline transport in tumor cells.
Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Chlorpromazine; Daunorubicin; Flow Cytom | 1986 |
Cellular pharmacology of anthracycline resistance and its circumvention.
Topics: Animals; Antibiotics, Antineoplastic; Biological Transport, Active; Cells, Cultured; Drug Resistance | 1986 |
Verapamil modulates mutagenicity of antitumour acridines in bacteria and yeast.
Topics: Acridines; Amsacrine; Animals; Cell Line; Doxorubicin; Drug Resistance; Leukemia, Experimental; Mice | 1986 |
Modulation of in vitro response to adriamycin by verapamil in murine P388 leukaemia, Ehrlich ascites carcinoma and sarcoma 180.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Cell Survival; Depression, Chemical; DNA, Neoplasm; Do | 1987 |
T-Lymphocyte-mediated cytolysis as an excitatory process of the target. I. Evidence that the target cell may be the site of Ca2+ action.
Topics: Aminoquinolines; Animals; Calcimycin; Calcium; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immuno | 1985 |
Comparison of doxorubicin-induced DNA damage in doxorubicin-sensitive and -resistant P388 murine leukemia cells.
Topics: Animals; Cell Line; DNA; Doxorubicin; Drug Resistance; Leukemia P388; Leukemia, Experimental; Mathem | 1986 |
Flow cytometric monitoring of cellular anthracycline accumulation in murine leukemic cells.
Topics: Animals; Biological Transport; Cell Line; Chlorpromazine; Daunorubicin; Doxorubicin; Flow Cytometry; | 1986 |
Comparative cytotoxicities of various morpholinyl anthracyclines.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Doxorubicin; Drug Resistance; Drug Synergi | 1985 |
Reversal of resistance to rhodamine 123 in adriamycin-resistant Friend leukemia cells.
Topics: Animals; Doxorubicin; Drug Resistance; Friend murine leukemia virus; Leukemia, Experimental; Rhodami | 1985 |
Cure of mice bearing P388 leukemia by vincristine in combination with a calcium channel blocker.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Leukemia P388; Leukemia, Experimental; Mice | 1985 |
Potentiation of antitumor agents by calcium channel blockers with special reference to cross-resistance patterns.
Topics: Animals; Antineoplastic Agents; Calcium Channel Blockers; Cell Line; Doxorubicin; Drug Resistance; D | 1985 |
Effects of calcium and verapamil on normal and tumor murine leukocytes.
Topics: Animals; Calcium; Chlorpromazine; Ethanol; Leukemia P388; Leukemia, Experimental; Leukocytes; Mice; | 1985 |
[Effects of calcium influx blocker on the cellular transport of Adriamycin].
Topics: Animals; Biological Transport; Calcium Channel Blockers; Cell Line; Culture Media; Doxorubicin; Flow | 1985 |