verapamil has been researched along with Experimental Hepatoma in 25 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human and murine hepatoma cells were treated with berberine (0." | 1.30 | Up-regulation of multidrug resistance transporter expression by berberine in human and murine hepatoma cells. ( Chi, CW; Lin, HL; Liu, TY; Lui, WY, 1999) |
| "Verapamil was given to rabbits by intravenous or IAH administration, and its effects on heart rates were compared." | 1.29 | Verapamil-reversing concentrations induce blood flow changes that could counteract in vivo the MDR-1-modulating effects. ( Ardouin, P; Bognel, C; Gouyette, A; Munck, JN; Ramirez, LH; Ricard, M; Rougier, P; Zhao, Z, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.00) | 18.7374 |
| 1990's | 20 (80.00) | 18.2507 |
| 2000's | 1 (4.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, J | 1 |
| Wang, R | 1 |
| Lou, L | 1 |
| Li, W | 1 |
| Tang, G | 1 |
| Bu, X | 1 |
| Yin, S | 1 |
| Chen, D | 1 |
| Soh, CK | 1 |
| Goh, WH | 1 |
| Wang, H | 1 |
| Ramirez, LH | 1 |
| Munck, JN | 1 |
| Zhao, Z | 1 |
| Bognel, C | 1 |
| Ricard, M | 1 |
| Ardouin, P | 1 |
| Rougier, P | 1 |
| Gouyette, A | 1 |
| Venetianer, A | 2 |
| Pirity, M | 2 |
| Hever-Szabo, A | 2 |
| Lecureur, V | 1 |
| Fardel, O | 2 |
| Guillouzo, A | 2 |
| Uehara, H | 1 |
| Nakaizumi, A | 1 |
| Baba, M | 1 |
| Iishi, H | 1 |
| Tatsuta, M | 1 |
| Brambilla, G | 1 |
| Hawel, L | 1 |
| Tjandrawinata, RR | 1 |
| Byus, CV | 1 |
| Arizono, K | 1 |
| Peterson, KL | 1 |
| Brady, FO | 1 |
| Topliss, DJ | 1 |
| Scholz, GH | 1 |
| Kolliniatis, E | 1 |
| Barlow, JW | 1 |
| Stockigt, JR | 1 |
| Ribeiro, RC | 3 |
| Cavalieri, RR | 3 |
| Lomri, N | 3 |
| Rahmaoui, CM | 1 |
| Baxter, JD | 3 |
| Scharschmidt, BF | 3 |
| Takahashi, N | 1 |
| Asakura, T | 1 |
| Ohkawa, K | 1 |
| Fukuda, K | 1 |
| Aoki, T | 1 |
| Leveille-Webster, CR | 1 |
| Arias, IA | 1 |
| Payen, L | 1 |
| Courtois, A | 1 |
| Vernhet, L | 1 |
| Lin, HL | 1 |
| Liu, TY | 1 |
| Lui, WY | 1 |
| Chi, CW | 1 |
| Gujaeva, EL | 1 |
| Kobliakov, VA | 1 |
| Zabotina, TN | 1 |
| Rybalkina, EJ | 1 |
| Stravrovskaya, AA | 1 |
| Simeoni, LA | 2 |
| Park, SW | 1 |
| Neves, FA | 1 |
| Gardner, DG | 1 |
| Ellis, AL | 1 |
| Munger, CE | 1 |
| Bunch, RT | 1 |
| Woods, KE | 1 |
| Randolph, JK | 1 |
| Boise, L | 1 |
| Swerdlow, PS | 1 |
| Zwelling, LA | 1 |
| Hinds, M | 1 |
| Yanovich, S | 1 |
| Hall, KS | 1 |
| Endresen, L | 1 |
| Rugstad, HE | 1 |
| Shimoda, T | 1 |
| Miyazaki, M | 1 |
| Utagawa, I | 1 |
| Koshikawa, H | 1 |
| Ito, H | 1 |
| Suzuki, H | 1 |
| Okui, K | 1 |
| Chan, SO | 1 |
| Wong, SS | 1 |
| Yeung, DC | 1 |
| Sweet, P | 1 |
| Chan, PK | 1 |
| Slater, LM | 1 |
| Vayuvegula, B | 1 |
| Slater, L | 1 |
| Meador, J | 1 |
| Gupta, S | 1 |
25 other studies available for verapamil and Experimental Hepatoma
| Article | Year |
|---|---|
Jatrophane Diterpenoids as Modulators of P-Glycoprotein-Dependent Multidrug Resistance (MDR): Advances of Structure-Activity Relationships and Discovery of Promising MDR Reversal Agents.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Cell Prol | 2016 |
Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Screening Assays, Antitumor; Heterografts | 2018 |
Verapamil-reversing concentrations induce blood flow changes that could counteract in vivo the MDR-1-modulating effects.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Doxorubicin; Dru | 1994 |
The function of heat-shock proteins in stress tolerance.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, N | 1994 |
The antiprogestatin drug RU 486 potentiates doxorubicin cytotoxicity in multidrug resistant cells through inhibition of P-glycoprotein function.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Doxorubicin; Drug | 1994 |
Inhibition by verapamil of hepatocarcinogenesis induced by N-nitrosomorpholine in Sprague-Dawley rats.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Body Weight; Carcinogens; gamma-Glutamyltransfe | 1993 |
Verapamil: what is the mechanism of its anticarcinogenic activity?
Topics: Animals; Anticarcinogenic Agents; Liver Neoplasms, Experimental; Rats; Rats, Sprague-Dawley; Verapam | 1994 |
Selective putrescine export is regulated by insulin and ornithine in Reuber H35 hepatoma cells.
Topics: Animals; Biological Transport; Culture Media; Insulin; Liver Neoplasms, Experimental; Ornithine; Put | 1994 |
Inhibitors of Ca2+ channels, calmodulin and protein kinases prevent A23187 and other inductions of metallothionein mRNA in EC3 rat hepatoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Chloroadenosine; Animals; Calcimycin; Calcium; Calc | 1993 |
Influence of calmodulin antagonists and calcium channel blockers on triiodothyronine uptake by rat hepatoma and myoblast cell lines.
Topics: Analysis of Variance; Animals; Cadmium; Calcium; Calcium Channel Blockers; Calmodulin; Cell Line; Di | 1993 |
Thyroid hormone export regulates cellular hormone content and response.
Topics: Animals; Animals, Newborn; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; C | 1996 |
Overexpression of P-glycoprotein in heat- and/or drug-resistant hepatoma variants.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clone Cells | 1996 |
[Intracellular distribution of bovine serum albumin-conjugated doxorubicin and multidrug resistance].
Topics: Animals; Cattle; Cell Nucleus; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; En | 1997 |
Establishment and serial quantification of intrahepatic xenografts of human hepatocellular carcinoma in severe combined immunodeficiency mice, and development of therapeutic strategies to overcome multidrug resistance.
Topics: Animals; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cisplatin; | 1996 |
The multidrug resistance-associated protein (MRP) is over-expressed and functional in rat hepatoma cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; | 1999 |
Up-regulation of multidrug resistance transporter expression by berberine in human and murine hepatoma cells.
Topics: Animals; Antineoplastic Agents, Hormonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; B | 1999 |
Coordinated regulation of P-glycoprotein activity and cytochrome P-4501A induction in sublines of rat hepatoma McA RH7777 cells with different levels of colchicine resistance.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzopyrenes; Colchicine; Cytochro | 1998 |
Thyroid hormone export in rat FRTL-5 thyroid cells and mouse NIH-3T3 cells is carrier-mediated, verapamil-sensitive, and stereospecific.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Tr | 1999 |
Thyroid hormone export varies among primary cells and appears to differ from hormone uptake.
Topics: Animals; Calcium Channel Blockers; Chorion; Decidua; Female; Heart Ventricles; Humans; Indicators an | 2002 |
Components of intrinsic drug resistance in the rat hepatoma.
Topics: Animals; Antineoplastic Agents; Binding Sites; Blotting, Northern; Blotting, Western; Cell Division; | 1992 |
Verapamil potentiates 4'-epidoxorubicin cytotoxicity in a rat hepatoma cell line and in a substrain resistant to 4'-epidoxorubicin.
Topics: Animals; Carcinoma, Hepatocellular; Cell Survival; Drug Resistance; Drug Synergism; Epirubicin; Live | 1990 |
[Enhancement of anti-tumor effect of adriamycin by verapamil in a hepatic arterial infusion in the rats: preliminary report].
Topics: Animals; Doxorubicin; Drug Synergism; Hepatic Artery; Infusions, Intra-Arterial; Liver Neoplasms, Ex | 1991 |
Regulation of Ki-ras expression in Reuber H35 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Calcimycin; Calcium; Cell Line; | 1990 |
Cyclosporin A and verapamil enhancement of daunorubicin-produced nucleolar protein B23 translocation in daunorubicin-resistant and -sensitive human and murine tumor cells.
Topics: Animals; Cell Line; Cyclosporins; Daunorubicin; Drug Resistance; Humans; Liver Neoplasms, Experiment | 1989 |
Correction of altered plasma membrane potentials. A possible mechanism of cyclosporin A and verapamil reversal of pleiotropic drug resistance in neoplasia.
Topics: Animals; Antineoplastic Agents; Calcium; Cell Line; Cell Membrane; Cyclosporins; Drug Resistance; Le | 1988 |