verapamil has been researched along with Ewing Sarcoma in 4 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Etoposide was given daily (150 mg m-2 day-1) for three doses (each over 1 h); the first dose was given 12 h into the verapamil infusion." | 2.68 | Continuous-infusion verapamil with etoposide in relapsed or resistant paediatric cancers. ( Cowie, FJ; Dick, G; Flanagan, RJ; Judson, I; McCarthy, PT; Phillips, M; Pinkerton, CR, 1995) |
| "We have isolated a subpopulation of Ewing's sarcoma cells, from both human cell lines and human xenografts grown in immune deficient mice, which express high aldehyde dehydrogenase (ALDH(high)) activity and are enriched for clonogenicity, sphere-formation, and tumor initiation." | 1.36 | High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition. ( Awad, O; Brown, ML; Gul, N; Katuri, V; Kong, Y; Loeb, DM; O'Neill, A; Shah, P; Toretsky, JA; Yustein, JT, 2010) |
| "Recent evidence has supported the cancer stem cell theory that cancer contains a small number of cancer stem cells (CSC) as a reservoir of cancer cells." | 1.34 | Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines. ( Hayashi, Y; Kaneko, M; Kaneko, S; Komuro, H; Saihara, R; Shinya, M; Takita, J, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Awad, O | 1 |
| Yustein, JT | 1 |
| Shah, P | 1 |
| Gul, N | 1 |
| Katuri, V | 1 |
| O'Neill, A | 1 |
| Kong, Y | 1 |
| Brown, ML | 1 |
| Toretsky, JA | 1 |
| Loeb, DM | 1 |
| Okada, T | 1 |
| Tanaka, K | 1 |
| Nakatani, F | 1 |
| Sakimura, R | 1 |
| Matsunobu, T | 1 |
| Li, X | 1 |
| Hanada, M | 1 |
| Nakamura, T | 1 |
| Oda, Y | 1 |
| Tsuneyoshi, M | 1 |
| Iwamoto, Y | 1 |
| Komuro, H | 1 |
| Saihara, R | 1 |
| Shinya, M | 1 |
| Takita, J | 1 |
| Kaneko, S | 1 |
| Kaneko, M | 1 |
| Hayashi, Y | 1 |
| Cowie, FJ | 1 |
| Pinkerton, CR | 1 |
| Phillips, M | 1 |
| Dick, G | 1 |
| Judson, I | 1 |
| McCarthy, PT | 1 |
| Flanagan, RJ | 1 |
1 trial available for verapamil and Ewing Sarcoma
| Article | Year |
|---|---|
Continuous-infusion verapamil with etoposide in relapsed or resistant paediatric cancers.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Drug Resis | 1995 |
3 other studies available for verapamil and Ewing Sarcoma
| Article | Year |
|---|---|
High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition.
Topics: Aldehyde Dehydrogenase; Animals; Antineoplastic Agents; Calcium Channel Blockers; Cell Line, Tumor; | 2010 |
Involvement of P-glycoprotein and MRP1 in resistance to cyclic tetrapeptide subfamily of histone deacetylase inhibitors in the drug-resistant osteosarcoma and Ewing's sarcoma cells.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Neoplasms | 2006 |
Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines.
Topics: Cell Division; Cell Line, Tumor; Cell Separation; Child; Child, Preschool; Drug Resistance, Neoplasm | 2007 |