verapamil has been researched along with Drug-Related Side Effects and Adverse Reactions in 16 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was conducted to determine whether hypertonic sodium bicarbonate would improve the hypotension associated with severe verapamil toxicity compared with volume expansion." | 3.70 | Hypertonic sodium bicarbonate is effective in the acute management of verapamil toxicity in a swine model. ( Curry, SC; Graeme, KA; Reagan, CG; Ruha, AM; Tanen, DA, 2000) |
| "Oral prednisone was an effective short-term preventive therapy in our population of patients with episodic cluster headache." | 3.01 | Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial. ( Böger, A; Diener, HC; Freilinger, T; Gaul, C; Holle, D; Jansen, JP; Jürgens, TP; Katsarava, Z; Kaube, H; Kleinschnitz, C; Kraya, T; Nägel, S; Obermann, M; Ose, C; Scherag, A; Sonuc, N; Storch, P; Straube, A, 2021) |
| " Incidents of adverse cardiac drug reactions are more common in patients with preexisting heart disease than the general population." | 1.39 | Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. ( Bers, DM; Diecke, S; Gong, T; Knowles, JW; Lan, F; Lee, AS; Liang, P; Nguyen, PK; Robbins, RC; Sallam, K; Sanchez-Freire, V; Wang, PJ; Wang, Y; Wu, JC, 2013) |
| " Toxicity studies with Diclofenac, Paracetamol and Verapamil in both cell lines show dose-response characteristics and EC(50) values similar to hHeps." | 1.38 | Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism. ( Dooley, S; Ehnert, S; Hao, L; Lin, J; Liu, L; Mühl-Benninghaus, R; Neumann, J; Nussler, AK; Nussler, N; Schyschka, L; Stöckle, U, 2012) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| "Several side effects of drugs observed in an office of a general practitioner are described." | 1.28 | [The family physician and drug side-effects. Observations from general practice--conclusions for general practice]. ( Stahl, H, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Pedersen, JM | 1 |
| Matsson, P | 1 |
| Bergström, CA | 1 |
| Norinder, U | 1 |
| Hoogstraate, J | 1 |
| Artursson, P | 1 |
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Kim, J | 1 |
| Shanmugasundaram, A | 2 |
| Kim, DS | 2 |
| Jeong, YJ | 2 |
| Kanade, PP | 1 |
| Kim, ES | 2 |
| Lee, BK | 2 |
| Lee, DW | 3 |
| Choi, YW | 1 |
| Park, J | 1 |
| Oyunbaatar, NE | 1 |
| Choi, M | 1 |
| Obermann, M | 1 |
| Nägel, S | 1 |
| Ose, C | 1 |
| Sonuc, N | 1 |
| Scherag, A | 1 |
| Storch, P | 1 |
| Gaul, C | 1 |
| Böger, A | 1 |
| Kraya, T | 1 |
| Jansen, JP | 1 |
| Straube, A | 1 |
| Freilinger, T | 1 |
| Kaube, H | 1 |
| Jürgens, TP | 1 |
| Diener, HC | 1 |
| Katsarava, Z | 1 |
| Kleinschnitz, C | 1 |
| Holle, D | 1 |
| Liang, P | 1 |
| Lan, F | 1 |
| Lee, AS | 1 |
| Gong, T | 1 |
| Sanchez-Freire, V | 1 |
| Wang, Y | 1 |
| Diecke, S | 1 |
| Sallam, K | 1 |
| Knowles, JW | 1 |
| Wang, PJ | 1 |
| Nguyen, PK | 1 |
| Bers, DM | 1 |
| Robbins, RC | 1 |
| Wu, JC | 1 |
| Kim, JY | 1 |
| Choi, YS | 1 |
| Lewin, G | 1 |
| Hoymann, HG | 1 |
| Fuhst, R | 1 |
| Berger-Preiss, E | 1 |
| Pohlmann, G | 1 |
| Buschmann, J | 1 |
| Pernelle, K | 1 |
| Le Guevel, R | 1 |
| Glaise, D | 1 |
| Stasio, CG | 1 |
| Le Charpentier, T | 1 |
| Bouaita, B | 1 |
| Corlu, A | 1 |
| Guguen-Guillouzo, C | 1 |
| Lin, J | 1 |
| Schyschka, L | 1 |
| Mühl-Benninghaus, R | 1 |
| Neumann, J | 1 |
| Hao, L | 1 |
| Nussler, N | 1 |
| Dooley, S | 1 |
| Liu, L | 1 |
| Stöckle, U | 1 |
| Nussler, AK | 1 |
| Ehnert, S | 1 |
| Gueret, G | 1 |
| Pennec, JP | 1 |
| Arvieux, CC | 1 |
| Tanen, DA | 1 |
| Ruha, AM | 1 |
| Curry, SC | 1 |
| Graeme, KA | 1 |
| Reagan, CG | 1 |
| Stahl, H | 1 |
1 trial available for verapamil and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial.
Topics: Adult; Calcium Channel Blockers; Cluster Headache; Double-Blind Method; Drug Therapy, Combination; D | 2021 |
15 other studies available for verapamil and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Bi | 2008 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Quantitative assessment of cardiomyocyte mechanobiology through high-throughput cantilever-based functional well plate systems.
Topics: Cell Culture Techniques; Cells, Cultured; Drug Evaluation, Preclinical; Drug-Related Side Effects an | 2023 |
Highly durable crack sensor integrated with silicone rubber cantilever for measuring cardiac contractility.
Topics: Animals; Biosensing Techniques; Dimethylpolysiloxanes; Drug Evaluation, Preclinical; Drug-Related Si | 2020 |
Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity.
Topics: Action Potentials; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic, Familial; Cell Differentia | 2013 |
Surface-patterned SU-8 cantilever arrays for preliminary screening of cardiac toxicity.
Topics: Animals; Astemizole; Biosensing Techniques; Cardiotoxicity; Cells, Cultured; Drug-Related Side Effec | 2016 |
Assessment of pulmonary function and serum substance levels in newborn and juvenile rats.
Topics: Administration, Inhalation; Aging; Animals; Animals, Newborn; Drug Evaluation, Preclinical; Drug-Rel | 2010 |
Automated detection of hepatotoxic compounds in human hepatocytes using HepaRG cells and image-based analysis of mitochondrial dysfunction with JC-1 dye.
Topics: ATP Binding Cassette Transporter, Subfamily B; Benzimidazoles; Carbocyanines; Cell Differentiation; | 2011 |
Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism.
Topics: Acetaminophen; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Cytochrome P-450 Enzyme | 2012 |
Hemodynamic effects of intralipid after verapamil intoxication may be due to a direct effect of fatty acids on myocardial calcium channels.
Topics: Animals; Calcium Channels; Disease Models, Animal; Dogs; Drug-Related Side Effects and Adverse React | 2007 |
Hypertonic sodium bicarbonate is effective in the acute management of verapamil toxicity in a swine model.
Topics: Animals; Blood Pressure Determination; Disease Models, Animal; Drug-Related Side Effects and Adverse | 2000 |
[The family physician and drug side-effects. Observations from general practice--conclusions for general practice].
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Anaphylaxis; Anti-Inflammatory Agents, Non-Ste | 1989 |