Page last updated: 2024-10-24

verapamil and Drug Overdose

verapamil has been researched along with Drug Overdose in 106 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.

Research Excerpts

ExcerptRelevanceReference
"In an animal model of verapamil-induced shock, endogenous AVP levels increased nearly 40-fold compared with baseline levels."7.72Use of vasopressin in a canine model of severe verapamil poisoning: a preliminary descriptive study. ( Bond, GR; Johnson, SB; Sztajnkrycer, MD; Weaver, AL, 2004)
"Noncardiogenic pulmonary edema has not been (to our knowledge) previously reported associated with a verapamil overdose."7.69Noncardiogenic pulmonary edema complicating massive verapamil overdose. ( Frumin, H; Leesar, MA; Martyn, R; Talley, JD, 1994)
"To present three cases of slow-release verapamil poisoning that demonstrate the prolonged absorption of the drug and the role of polyethylene glycol and high-dose calcium in management."7.68Slow-release verapamil poisoning. Use of polyethylene glycol whole-bowel lavage and high-dose calcium. ( Buckley, N; Dawson, AH; Howarth, D; Whyte, IM, 1993)
"Verapamil intoxication is a life-threatening condition that often presents with severe hemodynamic instability and requires vasopressor support."6.50Acute respiratory distress syndrome after verapamil intoxication: case report and literature review. ( Altintas, ND; Izdes, S; Soykut, C, 2014)
" Case reports suggest that ILE may reverse hypotension caused by acute poisoning with lipophilic drugs such as verapamil, but the mechanism remains unclear."3.83In Vitro Studies Indicate Intravenous Lipid Emulsion Acts as Lipid Sink in Verapamil Poisoning. ( Dawling, S; Knollmann, BC; Kryshtal, DO; Seger, D, 2016)
"We report a case of a 61-year-old woman treated for a suspected verapamil overdose with continuous calcium chloride infusion, resulting in severe hypercalcemia of 32."3.74A fatal case of iatrogenic hypercalcemia after calcium channel blocker overdose. ( Sim, MT; Stevenson, FT, 2008)
"In an animal model of verapamil-induced shock, endogenous AVP levels increased nearly 40-fold compared with baseline levels."3.72Use of vasopressin in a canine model of severe verapamil poisoning: a preliminary descriptive study. ( Bond, GR; Johnson, SB; Sztajnkrycer, MD; Weaver, AL, 2004)
"Verapamil toxicity results in hypotension, myocardial depression and disturbances in cardiac conduction."3.69Overdose of sustained-release verapamil. ( Barrow, PM; Houston, PL; Wong, DT, 1994)
"Noncardiogenic pulmonary edema has not been (to our knowledge) previously reported associated with a verapamil overdose."3.69Noncardiogenic pulmonary edema complicating massive verapamil overdose. ( Frumin, H; Leesar, MA; Martyn, R; Talley, JD, 1994)
"We describe two cases of pulmonary edema, bradycardia, and hypotension associated with massive verapamil overdose."3.69Massive verapamil overdose complicated by noncardiogenic pulmonary edema. ( Brass, BJ; Lipper, BL; Winchester-Penny, S, 1996)
"For the evaluation of the hemodynamic interaction between the natural heart and an assist device, a reversible pharmacological model based on the channel blocker Verapamil under hyperkalemia, was developed for deterioration of left ventricular function."3.69Pharmacologically induced heart failure for the evaluation of circulatory assistance. ( Losert, U; Roschal, K; Schima, H; Schmidt, C; Schwendenwein, I; Wieselthaler, G; Wolner, E, 1996)
"Hypotension, sinus node suppression, and dysrhythmias often occur with calcium channel blocker overdoses, but atrioventricular nodal block occurs more often with verapamil (chi 2 test, P < ."3.68A one-year evaluation of calcium channel blocker overdoses: toxicity and treatment. ( Borys, D; Ramoska, EA; Spiller, HA; Winter, M, 1993)
"To present three cases of slow-release verapamil poisoning that demonstrate the prolonged absorption of the drug and the role of polyethylene glycol and high-dose calcium in management."3.68Slow-release verapamil poisoning. Use of polyethylene glycol whole-bowel lavage and high-dose calcium. ( Buckley, N; Dawson, AH; Howarth, D; Whyte, IM, 1993)
"Verapamil intoxication is a life-threatening condition that often presents with severe hemodynamic instability and requires vasopressor support."2.50Acute respiratory distress syndrome after verapamil intoxication: case report and literature review. ( Altintas, ND; Izdes, S; Soykut, C, 2014)
" In spite of the low dose ingested, the postmortem cardiac blood verapamil level was clearly toxic (6000 ng/mL, or 6 mg/L)."2.44Verapamil toxicity: an unusual case report and review of the literature. ( Batalis, NI; Harley, RA; Schandl, CA, 2007)
"Verapamil 99 is a commonly prescribed medicine for treatment of hypertension, angina, and migraine headache."2.39Massive overdose of sustained-release verapamil: a case report and review of literature. ( Ashraf, M; Chaudhary, K; Nelson, J; Thompson, W, 1995)
" Although specific recommendations for calcium dosing in the overdose situation have not been rigorously studied, maintenance of a normal serum ionized calcium concentration is suggested."2.38Verapamil overdose: case report and review of the literature. ( Crain, JL; Edwards, TD; Stiller, RA; Watling, SM, 1992)
"Verapamil intoxication was confirmed, and therapy was adjusted accordingly."1.43Severe verapamil intoxication despite correct use of low-dose verapamil. ( Bijlstra, PJ; Bollen, PD; Brands, E; Mandigers, L, 2016)
" IFE therapy is being recommended by US PCCs; protocols and dosing regimens are nearly uniform."1.39Lipid rescue 911: Are poison centers recommending intravenous fat emulsion therapy for severe poisoning? ( Christian, MR; Mycyk, MB; Pallasch, EM; Wahl, M, 2013)
" In patients with life-saving use in suicide attempts important role in addition to medication dosage plays an elapsed time of their consumption and speed of action taken to remove and prevent absorbtion the poison", as well as close supervision in the intensive care unit."1.38[Drugs acting on the heart-conductive system in suicide attempts]. ( Dabek, J; Jakubowski, D; Rychlik, W; Stachoń, K, 2012)
"Verapamil toxicity was achieved by a constant infusion of 15 mg/kg/hr."1.35Determining the optimal dose of intravenous fat emulsion for the treatment of severe verapamil toxicity in a rodent model. ( Bania, TC; Chu, J; Medlej, K; Perez, E, 2008)
" The decline in plasma verapamil and norverapamil concentrations followed first-order kinetics, and the half-life of verapamil was 7."1.30Pharmacokinetics of verapamil in overdose. ( Kivistö, KT; Neuvonen, PJ; Tarssanen, L, 1997)
"A patient with cardiac arrest after severe verapamil intoxication."1.30Successful resuscitation of a verapamil-intoxicated patient with percutaneous cardiopulmonary bypass. ( Behringer, W; Domanovits, H; Holzer, M; Schoerkhuber, W; Sterz, F; Stimpfl, T; Weinmar, D; Weinstabl, C, 1999)
"Amrinone and glucagon have been used separately and in combination with other agents in the treatment of calcium channel blocker overdose."1.29Use of amrinone and glucagon in a case of calcium channel blocker overdose. ( Otten, EJ; Spadafora, MP; Wolf, LR, 1993)
"Verapamil overdose, because of its frequency and severity, represents a significant problem for the emergency physician."1.29Cardiac dysrhythmias in severe verapamil overdose: characterization with a canine model. ( Koury, SI; Stone, CK; Thomas, SH, 1996)
" At severely toxic levels when arterial blood pressure fell by 50%, all three drugs decreased cardiac output."1.28Effects of calcium channel blocker overdose-induced toxicity in the conscious dog. ( Gambone, LM; Schoffstall, JM; Shaw, RP; Sit, SP; Spivey, WH, 1991)

Research

Studies (106)

TimeframeStudies, this research(%)All Research%
pre-19901 (0.94)18.7374
1990's48 (45.28)18.2507
2000's24 (22.64)29.6817
2010's29 (27.36)24.3611
2020's4 (3.77)2.80

Authors

AuthorsStudies
Eijsink, JFH1
Grol, BJH1
Naber, HR1
van Egmond, PS1
Lodhi, FAK1
Shogren, SL1
Vedre, JG1
Haque, N1
Reriani, M1
Ali, R1
Gau, N1
Grossman, BJ1
Kohli, U1
Lam, S1
Eason, H1
Jani, P1
Olson, KR2
Levine, M4
Curry, SC2
Padilla-Jones, A2
Ruha, AM3
Christian, MR1
Pallasch, EM1
Wahl, M1
Mycyk, MB1
Pfeffer, AN2
Williams, SR2
Price, D1
Radke, J1
Albertson, T1
Chan, TB1
Chan, YC1
Lau, FL1
Curry, S1
Holger, JS1
Engebretsen, KM1
Stellpflug, SJ1
Cole, JB1
Kerns, W1
Kline, JA1
Izdes, S1
Altintas, ND1
Soykut, C1
Martin, C1
Gonzalez, H1
Ruiz, S1
Ribes, D1
Franchitto, N1
Minville, V1
Sampson, CS1
Bedy, SM1
Cibickova, L1
Caran, T1
Dobias, M1
Ondra, P1
Vorisek, V1
Cibicek, N1
Kryshtal, DO1
Dawling, S1
Seger, D1
Knollmann, BC1
Déniel, A1
Fedrizzi, S1
Lelong-Boulouard, V1
Coquerel, A1
Alexandre, J1
Mandigers, L1
Bollen, PD1
Bijlstra, PJ1
Brands, E1
Perez, E1
Bania, TC2
Medlej, K1
Chu, J1
Perbet, S1
Constantin, JM1
Guérin, R1
Faure, M1
Brugère, C1
Da Inès, D1
Joubert, J1
Bazin, JE1
Pillai, U1
Muzaffar, J1
Sen, S1
Yancey, A1
Varpula, T1
Rapola, J1
Sallisalmi, M1
Kurola, J1
Cohen, V1
Jellinek, SP1
Fancher, L1
Sangwan, G1
Wakslak, M1
Marquart, E1
Farahani, C1
Young, AC1
Velez, LI1
Kleinschmidt, KC1
Graudins, A1
George, M1
Senthilkumaran, S1
Balamurgan, N1
Sweni, S1
Thirumalaikolundusubramanian, P1
Doğan, M1
Basaranoglu, M1
Peker, E1
Akbayram, S1
Sahin, M1
Uner, A1
Caksen, H1
Mégarbane, B1
Karyo, S1
Abidi, K1
Delhotal-Landes, B1
Aout, M1
Sauder, P1
Baud, FJ1
Franxman, TJ1
Al-Nabhan, M1
Cavallazzi, RS1
Speak, AJ1
Sein Anand, J1
Barwina, M1
Wiśniewska, A1
French, D1
Armenian, P1
Ruan, W1
Wong, A1
Drasner, K1
Wu, AH1
Pichon, N1
Dugard, A1
Clavel, M1
Amiel, JB1
François, B1
Vignon, P1
Deters, M1
Bergmann, I1
Enden, G1
Kutz, S1
Liebetrau, G1
Plenert, B1
Prasa, D1
Hentschel, H1
Dabek, J1
Stachoń, K1
Jakubowski, D1
Rychlik, W1
Sami Karti, S1
Ulusoy, H1
Yandi, M1
Gündüz, A1
Koşucu, M1
Erol, K1
Ratip, S1
Gokel, Y1
Paydas, S1
Acikalin, A1
Bozkurt, A1
Kinoshita, H1
Taniguchi, T1
Nishiguchi, M1
Ouchi, H1
Minami, T1
Utsumi, T1
Motomura, H1
Tsuda, T1
Ohta, T1
Aoki, S1
Komeda, M1
Kamamoto, T1
Kubota, A1
Fuke, C1
Arao, T1
Miyazaki, T1
Hishida, S1
Kostrzewa, A1
Klimaszyk, D1
Sandroni, C1
Cavallaro, F1
Addario, C1
Ferro, G1
Gallizzi, F1
Antonelli, M1
Sztajnkrycer, MD1
Bond, GR1
Johnson, SB1
Weaver, AL1
Manov, I1
Motanis, H1
Frumin, I1
Iancu, TC1
Wilimowska, J1
Piekoszewski, W1
Krzyanowska-Kierepka, E1
Florek, E1
Pohler, HF1
Batalis, NI1
Harley, RA1
Schandl, CA1
Fiszer, M1
Kołaciński, Z1
Rechciński, T1
Boyer, EW1
Pozner, CN1
Geib, AJ1
Thomsen, T1
Mick, N1
Thomas, SH4
Johansen, KK1
Belhage, B1
Winchester, DE1
Holstege, C1
Sim, MT1
Stevenson, FT1
Ashraf, M1
Chaudhary, K1
Nelson, J1
Thompson, W1
Buckley, CD1
Aronson, JK1
Lip, GY2
Ferner, RE1
Huelmos, A1
Alegría, E1
Vázquez, C1
Stone, CK4
May, WA1
Carroll, R1
Roberge, RJ1
Martin, TG1
Hodgman, M1
Benitez, JG1
Brunswick, JE1
Barrow, PM1
Houston, PL1
Wong, DT1
Rodríguez Blanco, VM2
Rodríguez Suárez, ML1
Möller Bustinza, I1
Castellanos Martínez, E1
Puebla Rojo, V1
Barriales Alvarez, V2
Cortina Llosa, A1
Zimmers, T2
Hofer, CA1
Smith, JK1
Tenholder, MF1
Leesar, MA1
Martyn, R1
Talley, JD1
Frumin, H1
Cleary, JD1
Hayman, J1
Sherwood, J1
Lasala, GP1
Piazza-Hepp, T1
Chia-Lin, Y1
Ramoska, EA1
Spiller, HA2
Winter, M1
Borys, D1
Buckley, N1
Dawson, AH1
Howarth, D1
Whyte, IM1
Bonechi, F1
Brandinelli Geri, A1
Maioli, M1
Ieri, A1
Doyon, S1
Roberts, JR1
Wolf, LR1
Spadafora, MP1
Otten, EJ1
Honan, MP1
Stankevicute, N1
van Wanroy, JL1
de Weerdt, O1
Joore, JC1
van der Hoven, B1
van de Wiel, A1
Gutierrez, H1
Jorgensen, M1
Brass, BJ1
Winchester-Penny, S1
Lipper, BL1
Smilkstein, MJ1
Koury, SI3
Low, RB1
Schmidt, C1
Schwendenwein, I1
Wieselthaler, G1
Roschal, K1
Schima, H1
Losert, U1
Wolner, E1
Li Saw Hee, FL1
Kivistö, KT1
Neuvonen, PJ1
Tarssanen, L1
Liao, WB1
Bullard, MJ1
Kuo, CT1
Hsiao, CT1
Chu, PH1
Chiang, CW1
Manoach, SM1
Hamilton, RJ1
Barriales Villa, R1
Batalla Celorio, A1
Kalman, S1
Berg, S1
Lisander, B1
Oe, H1
Taniura, T1
Ohgitani, N1
Holzer, M1
Sterz, F1
Schoerkhuber, W1
Behringer, W1
Domanovits, H1
Weinmar, D1
Weinstabl, C1
Stimpfl, T1
Ori, Y1
Korzets, A1
Caneti, M1
Weinstein, T1
Chagnac, A1
Salman, H1
Malachi, T1
Gafter, U1
Kuhlmann, U1
Schoenemann, H1
Müller, TF1
Keuchel, M1
Lange, H1
Blaufeux, B1
Hughes, S1
Almond, GL1
Homel, P1
Vadlamudi, L1
Wijdicks, EF1
Ramo, MP1
Grupp, I1
Pesola, MK1
Heikkila, J1
Luomanmaki, K1
Schroder, T1
Grupp, G1
Shah, AR1
Passalacqua, BR1
Watling, SM1
Crain, JL1
Edwards, TD1
Stiller, RA1
MacDonald, D1
Alguire, PC1
Kuo, MJ1
Tseng, YZ1
Chen, TF1
Fong, DE1
Frierson, J1
Bailly, D1
Shultz, T1
Sund, S1
Dimas, A1
Watson, NA1
FitzGerald, CP1
Schoffstall, JM1
Spivey, WH1
Gambone, LM1
Shaw, RP1
Sit, SP1
Meyers, A1
Ziemba, T1
Riley, M1
Spurlock, BW1
Virani, NA1
Henry, CA1
Minella, RA1
Schulman, DS1
Rankin, RJ1
Edwards, IR1
Horowitz, BZ1
Rhee, KJ1

Reviews

14 reviews available for verapamil and Drug Overdose

ArticleYear
Hypocalcaemia after an occult calcium channel blocker overdose: a case report and literature review.
    Basic & clinical pharmacology & toxicology, 2014, Volume: 114, Issue:2

    Topics: Adult; Calcium; Calcium Channel Blockers; Critical Illness; Drug Overdose; Female; Humans; Hypocalce

2014
Acute respiratory distress syndrome after verapamil intoxication: case report and literature review.
    Acta clinica Belgica, 2014, Volume: 69, Issue:2

    Topics: Adult; Drug Overdose; Female; Humans; Male; Respiratory Distress Syndrome; Verapamil; Young Adult

2014
Tarka® (trandolapril/verapamil hydrochloride extended-release) overdose.
    The Journal of emergency medicine, 2011, Volume: 40, Issue:3

    Topics: Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Co

2011
Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects.
    Acta pharmacologica Sinica, 2006, Volume: 27, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Ster

2006
A little goes a long way: Clinical management of calcium channel blocker overdose.
    Journal of emergency nursing, 2006, Volume: 32, Issue:4

    Topics: Adult; Calcium Channel Blockers; Calcium Chloride; Drug Overdose; Enterosorption; Female; Glucose; H

2006
Verapamil toxicity: an unusual case report and review of the literature.
    The American journal of forensic medicine and pathology, 2007, Volume: 28, Issue:2

    Topics: Accidents; Antihypertensive Agents; Calcium Channel Blockers; Drug Combinations; Drug Overdose; Fema

2007
Massive overdose of sustained-release verapamil: a case report and review of literature.
    The American journal of the medical sciences, 1995, Volume: 310, Issue:6

    Topics: Calcium Gluconate; Combined Modality Therapy; Delayed-Action Preparations; Drug Overdose; Female; Gl

1995
Poisoning with anti-hypertensive drugs: calcium antagonists.
    Journal of human hypertension, 1995, Volume: 9, Issue:3

    Topics: Age Factors; Antihypertensive Agents; Calcium; Diltiazem; Drug Overdose; Humans; Hypertension; Nifed

1995
[The toxicity of slow-release verapamil and chronic kidney disease].
    Revista espanola de cardiologia, 1994, Volume: 47, Issue:11

    Topics: Aged; Delayed-Action Preparations; Drug Overdose; Female; Humans; Hypertension; Kidney Failure, Chro

1994
[A suicide attempt with oral verapamil: a case report].
    Revista espanola de cardiologia, 1993, Volume: 46, Issue:12

    Topics: Administration, Oral; Adult; Drug Overdose; Electrocardiography; Heart Block; Humans; Male; Suicide,

1993
Verapamil intoxication: a literature review of overdoses and discussion of therapeutic options.
    The American journal of medicine, 1993, Volume: 95, Issue:4

    Topics: Adult; Drug Overdose; Fatal Outcome; Humans; Male; Treatment Outcome; Verapamil

1993
[The massive ingestion of verapamil with suicidal intent].
    Anales de medicina interna (Madrid, Spain : 1984), 1997, Volume: 14, Issue:10

    Topics: Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Drug Overdose; Humans; Male; Suicide, Attem

1997
Verapamil overdose: case report and review of the literature.
    The Annals of pharmacotherapy, 1992, Volume: 26, Issue:11

    Topics: Adolescent; Cardiac Pacing, Artificial; Charcoal; Drug Overdose; Fluid Therapy; Gastric Lavage; Hear

1992
Massive verapamil ingestion: a report of two cases and a review of the literature.
    The American journal of emergency medicine, 1989, Volume: 7, Issue:6

    Topics: Adrenergic alpha-Agonists; Adult; Calcium; Cardiovascular Agents; Drug Overdose; Female; Glucagon; H

1989

Other Studies

92 other studies available for verapamil and Drug Overdose

ArticleYear
Comparison of two treatments for verapamil overdose.
    Clinical toxicology (Philadelphia, Pa.), 2023, Volume: 61, Issue:4

    Topics: Calcium Channel Blockers; Drug Overdose; Humans; Verapamil

2023
Calcium Channel Blocker Toxicity Causing Acute Respiratory Distress Syndrome: A Commonly Used Drug Triggering a Life-Threatening Condition.
    WMJ : official publication of the State Medical Society of Wisconsin, 2020, Volume: 119, Issue:1

    Topics: Adult; Anticonvulsants; Calcium Channel Blockers; Clonazepam; Drug Overdose; Female; Humans; Respira

2020
Therapeutic plasma exchange for iatrogenic hypertrigylceridemia.
    Transfusion, 2020, Volume: 60, Issue:12

    Topics: Aged; Drug Overdose; Fat Emulsions, Intravenous; Female; Glucose; Humans; Hypertriglyceridemia; Iatr

2020
Heart Rhythm Abnormalities Following Acute Verapamil Overdose.
    Indian journal of pediatrics, 2021, Volume: 88, Issue:3

    Topics: Drug Overdose; Heart Rate; Humans; Verapamil

2021
What is the best treatment for acute calcium channel blocker overdose?
    Annals of emergency medicine, 2013, Volume: 62, Issue:3

    Topics: Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Female; Humans; Male; Vasoconstri

2013
Critical care management of verapamil and diltiazem overdose with a focus on vasopressors: a 25-year experience at a single center.
    Annals of emergency medicine, 2013, Volume: 62, Issue:3

    Topics: Adolescent; Adult; Aged; Arizona; Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose;

2013
Lipid rescue 911: Are poison centers recommending intravenous fat emulsion therapy for severe poisoning?
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2013, Volume: 9, Issue:3

    Topics: Acute Disease; Adult; Amitriptyline; Bupivacaine; Drug Overdose; Fat Emulsions, Intravenous; Guideli

2013
Annals of Emergency Medicine Journal Club. Treatment of calcium channel blocker poisoning: should we re-prioritize our potpourri of treatment options?
    Annals of emergency medicine, 2013, Volume: 62, Issue:3

    Topics: Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Female; Humans; Male; Vasoconstri

2013
Ischemia complications after calcium channel blocker poisoning.
    Annals of emergency medicine, 2014, Volume: 63, Issue:1

    Topics: Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Female; Humans; Male; Vasoconstri

2014
In reply.
    Annals of emergency medicine, 2014, Volume: 63, Issue:1

    Topics: Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Female; Humans; Male; Vasoconstri

2014
Critical care management of verapamil and diltiazem overdose with a focus on vasopressors: a 25-year experience at a single center.
    Annals of emergency medicine, 2014, Volume: 63, Issue:1

    Topics: Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Female; Humans; Male; Vasoconstri

2014
Insulin for calcium channel toxicity.
    Annals of emergency medicine, 2014, Volume: 63, Issue:1

    Topics: Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Female; Humans; Male; Vasoconstri

2014
In reply.
    Annals of emergency medicine, 2014, Volume: 63, Issue:1

    Topics: Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Female; Humans; Male; Vasoconstri

2014
Annals of Emergency Medicine Journal Club. Treatment of calcium channel blocker poisoning: should we reprioritize our potpourri of treatment options?: answers to the September 2013 Journal Club questions.
    Annals of emergency medicine, 2014, Volume: 63, Issue:2

    Topics: Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Female; Humans; Male; Vasoconstri

2014
Acute respiratory distress syndrome following verapamil overdose treated with intravenous lipid emulsion: a rare life-threatening complication.
    Annales francaises d'anesthesie et de reanimation, 2014, Volume: 33, Issue:6

    Topics: Calcium Channel Blockers; Drug Overdose; Extracorporeal Membrane Oxygenation; Fat Emulsions, Intrave

2014
Lipid emulsion therapy given intraosseously in massive verapamil overdose.
    The American journal of emergency medicine, 2015, Volume: 33, Issue:12

    Topics: Anti-Arrhythmia Agents; Drug Overdose; Fat Emulsions, Intravenous; Fatal Outcome; Female; Humans; In

2015
Multi-drug intoxication fatality involving atorvastatin: A case report.
    Forensic science international, 2015, Volume: 257

    Topics: Acute Kidney Injury; Aged; Alcoholics; Anthraquinones; Anti-Inflammatory Agents; Antihypertensive Ag

2015
In Vitro Studies Indicate Intravenous Lipid Emulsion Acts as Lipid Sink in Verapamil Poisoning.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2016, Volume: 12, Issue:2

    Topics: Absorption, Physicochemical; Animals; Calcium Channel Blockers; Calcium Signaling; Cardiotoxicity; C

2016
Fatal Cardiac Arrest Associated with Concomitant Bisoprolol and Verapamil Overdose.
    Journal of the American Geriatrics Society, 2016, Volume: 64, Issue:2

    Topics: Aged, 80 and over; Antihypertensive Agents; Bisoprolol; Calcium Channel Blockers; Drug Overdose; Ech

2016
Severe verapamil intoxication despite correct use of low-dose verapamil.
    Drug metabolism and personalized therapy, 2016, Volume: 31, Issue:1

    Topics: Bradycardia; Calcium Channel Blockers; Cytochrome P-450 Enzyme System; Dose-Response Relationship, D

2016
Determining the optimal dose of intravenous fat emulsion for the treatment of severe verapamil toxicity in a rodent model.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2008, Volume: 15, Issue:12

    Topics: Acid-Base Equilibrium; Animals; Blood Pressure; Calcium Channel Blockers; Disease Models, Animal; Do

2008
Non-occlusive colonic ischemia induced by verapamil ER overdose.
    Intensive care medicine, 2009, Volume: 35, Issue:5

    Topics: Colon; Drug Overdose; Humans; Ischemia; Male; Middle Aged; Suicide, Attempted; Vasodilator Agents; V

2009
Grapefruit juice and verapamil: a toxic cocktail.
    Southern medical journal, 2009, Volume: 102, Issue:3

    Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Citrus par

2009
Treatment of serious calcium channel blocker overdose with levosimendan, a calcium sensitizer.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:3

    Topics: Acidosis, Lactic; Amlodipine; Calcium Channel Blockers; Cardiotonic Agents; Coma; Drug Overdose; Ech

2009
Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose.
    Resuscitation, 2009, Volume: 80, Issue:5

    Topics: Adult; Bradycardia; Calcium Channel Blockers; Delayed-Action Preparations; Drug Overdose; Electrocar

2009
Letter regarding levosimendan in a rat model of severe verapamil poisoning.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2009, Volume: 5, Issue:3

    Topics: Animals; Antidotes; Cardiotonic Agents; Cardiovascular Agents; Disease Models, Animal; Drug Overdose

2009
Severe lactic acidosis in a patient after calcium channel blocker toxicity.
    Pediatric emergency care, 2010, Volume: 26, Issue:1

    Topics: Acidosis, Lactic; Adolescent; Calcium Channel Blockers; Diagnosis, Differential; Drug Overdose; Huma

2010
Acute episode of reversible blindness after an overdose of beta blockers and calcium channel antagonist.
    The American journal of emergency medicine, 2011, Volume: 29, Issue:4

    Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Blindness; Calcium Channel Blockers; Drug Overdose; F

2011
Tarka® overdose in a young child.
    Human & experimental toxicology, 2011, Volume: 30, Issue:9

    Topics: Child, Preschool; Drug Combinations; Drug Overdose; Electrocardiography; Female; Humans; Indoles; Pa

2011
Predictors of mortality in verapamil overdose: usefulness of serum verapamil concentrations.
    Basic & clinical pharmacology & toxicology, 2011, Volume: 108, Issue:6

    Topics: Adult; Calcium Channel Blockers; Critical Care; Delayed-Action Preparations; Drug Overdose; Female;

2011
Lipid emulsion therapy for verapamil overdose.
    Annals of internal medicine, 2011, Feb-15, Volume: 154, Issue:4

    Topics: Adult; Calcium Gluconate; Charcoal; Combined Modality Therapy; Drug Overdose; Fat Emulsions, Intrave

2011
[The lower legs amputation--rare side effects of acute poisoning].
    Przeglad lekarski, 2010, Volume: 67, Issue:8

    Topics: Amputation, Surgical; Drug Combinations; Drug Overdose; Ethanol; Humans; Indoles; Ischemia; Leg; Mal

2010
Serum verapamil concentrations before and after Intralipid® therapy during treatment of an overdose.
    Clinical toxicology (Philadelphia, Pa.), 2011, Volume: 49, Issue:4

    Topics: Calcium Channel Blockers; Drug Overdose; Emulsions; Fat Emulsions, Intravenous; Humans; Male; Middle

2011
Extracorporeal albumin dialysis in three cases of acute calcium channel blocker poisoning with life-threatening refractory cardiogenic shock.
    Annals of emergency medicine, 2012, Volume: 59, Issue:6

    Topics: Adolescent; Albumins; Calcium Channel Blockers; Delayed-Action Preparations; Diltiazem; Drug Overdos

2012
Calcium channel antagonist exposures reported to the Poisons Information Center Erfurt.
    European journal of internal medicine, 2011, Volume: 22, Issue:6

    Topics: Adolescent; Adult; Age Distribution; Aged; Calcium Channel Blockers; Child; Dihydropyridines; Diltia

2011
[Drugs acting on the heart-conductive system in suicide attempts].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2012, Volume: 33, Issue:194

    Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Calcium Channel Blockers; Causality; Comorbidity; Dru

2012
Non-cardiogenic pulmonary oedema in the course of verapamil intoxication.
    Emergency medicine journal : EMJ, 2002, Volume: 19, Issue:5

    Topics: Adult; Drug Overdose; Female; Humans; Poisoning; Pulmonary Edema; Respiration, Artificial; Suicide,

2002
High-dose verapamil + trandolapril-induced thrombotic microangiopathy.
    Haematologia, 2002, Volume: 32, Issue:3

    Topics: Adult; Anemia, Hemolytic; Blood Cell Count; Drug Overdose; Female; Hematocrit; Hemoglobins; Humans;

2002
An autopsy case of combined drug intoxication involving verapamil, metoprolol and digoxin.
    Forensic science international, 2003, Apr-23, Volume: 133, Issue:1-2

    Topics: Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Digoxin; Drug

2003
[ECG disturbances as a consequence of cardiac drugs overdose].
    Przeglad lekarski, 2003, Volume: 60, Issue:4

    Topics: Adult; Aged; Bradycardia; Cardiotonic Agents; Drug Overdose; Electrocardiography; Female; Humans; Ma

2003
Successful treatment with enoximone for severe poisoning with atenolol and verapamil: a case report.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:6

    Topics: Adrenergic Agonists; Anti-Arrhythmia Agents; Atenolol; Blood Pressure; Cardiac Output; Cardiotonic A

2004
Use of vasopressin in a canine model of severe verapamil poisoning: a preliminary descriptive study.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2004, Volume: 11, Issue:12

    Topics: Animals; Arginine Vasopressin; Blood Pressure; Calcium Channel Blockers; Disease Models, Animal; Dog

2004
Monitoring of verapamil enantiomers concentration in overdose.
    Clinical toxicology (Philadelphia, Pa.), 2006, Volume: 44, Issue:2

    Topics: Blood Pressure; Calcium Channel Blockers; Drug Overdose; Female; Humans; Metabolic Clearance Rate; M

2006
[The application of 4-aminopyridine in calcium channel inhibitors acute poisoning].
    Przeglad lekarski, 2007, Volume: 64, Issue:4-5

    Topics: 4-Aminopyridine; Acute Disease; Adrenergic beta-Antagonists; Adult; Antidotes; Antihypertensive Agen

2007
Assessment of hyperglycemia after calcium channel blocker overdoses involving diltiazem or verapamil.
    Critical care medicine, 2007, Volume: 35, Issue:9

    Topics: Adult; Aged; Blood Glucose; Calcium Channel Blockers; Diltiazem; Drug Overdose; Humans; Hyperglycemi

2007
[A 48-year-old woman's survival from a massive verapamil overdose].
    Ugeskrift for laeger, 2007, Nov-19, Volume: 169, Issue:47

    Topics: Calcium Channel Blockers; Drug Overdose; Female; Humans; Middle Aged; Poisoning; Suicide, Attempted;

2007
Inclusion of patients who overdose with dihydropyridine calcium channel blockers would potentially increase clinical utility of hyperglycemia.
    Critical care medicine, 2008, Volume: 36, Issue:2

    Topics: Calcium Channel Blockers; Dihydropyridines; Diltiazem; Drug Overdose; Heart Rate; Humans; Hyperglyce

2008
A fatal case of iatrogenic hypercalcemia after calcium channel blocker overdose.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2008, Volume: 4, Issue:1

    Topics: Calcium Channel Blockers; Drug Overdose; Fatal Outcome; Female; Humans; Hypercalcemia; Middle Aged;

2008
Prolonged half-life of verapamil in a case of overdose: implications for therapy.
    British journal of clinical pharmacology, 1995, Volume: 39, Issue:6

    Topics: Drug Overdose; Half-Life; Humans; Male; Middle Aged; Verapamil

1995
Treatment of verapamil overdose with glucagon in dogs.
    Annals of emergency medicine, 1995, Volume: 25, Issue:3

    Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Drug Overdose; Glucagon; Heart Rate; Random Allocatio

1995
Supraventricular tachyarrhythmia associated with baclofen overdose.
    Journal of toxicology. Clinical toxicology, 1994, Volume: 32, Issue:3

    Topics: Adenosine; Adult; Baclofen; Drug Overdose; Electrocardiography; Humans; Intubation, Intratracheal; M

1994
Overdose of sustained-release verapamil.
    British journal of anaesthesia, 1994, Volume: 72, Issue:3

    Topics: Adult; Delayed-Action Preparations; Drug Overdose; Female; Heart Block; Humans; Hypotension; Time Fa

1994
Cases in electrocardiography.
    The American journal of emergency medicine, 1994, Volume: 12, Issue:3

    Topics: Bradycardia; Drug Overdose; Electrocardiography; Female; Humans; Male; Middle Aged; Nicotine; Verapa

1994
Noncardiogenic pulmonary edema complicating massive verapamil overdose.
    Chest, 1994, Volume: 105, Issue:2

    Topics: Adult; Drug Overdose; Dyspnea; Female; Humans; Hypotension; Hypoxia; Pulmonary Edema; Verapamil

1994
Amphotericin B overdose in pediatric patients with associated cardiac arrest.
    The Annals of pharmacotherapy, 1993, Volume: 27, Issue:6

    Topics: Amphotericin B; Arrhythmias, Cardiac; Candidiasis; Child; Child, Preschool; Drug Overdose; Female; H

1993
Cases in electrocardiography.
    The American journal of emergency medicine, 1993, Volume: 11, Issue:5

    Topics: Adult; Drug Overdose; Electrocardiography; Emergency Service, Hospital; Female; Heart Block; Humans;

1993
A one-year evaluation of calcium channel blocker overdoses: toxicity and treatment.
    Annals of emergency medicine, 1993, Volume: 22, Issue:2

    Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Atropine; Calcium; Calcium Channel Blockers; Child; C

1993
Slow-release verapamil poisoning. Use of polyethylene glycol whole-bowel lavage and high-dose calcium.
    The Medical journal of Australia, 1993, Feb-01, Volume: 158, Issue:3

    Topics: Adolescent; Adult; Calcium; Charcoal; Delayed-Action Preparations; Drug Overdose; Female; Gastric La

1993
[Verapamil poisoning for suicidal purposes. A case report].
    Giornale italiano di cardiologia, 1993, Volume: 23, Issue:1

    Topics: Aged; Aged, 80 and over; Drug Overdose; Female; Humans; Suicide, Attempted; Verapamil

1993
The use of glucagon in a case of calcium channel blocker overdose.
    Annals of emergency medicine, 1993, Volume: 22, Issue:7

    Topics: Acute Disease; Aged; Bradycardia; Dobutamine; Dopamine; Drug Overdose; Drug Therapy, Combination; Fe

1993
Use of amrinone and glucagon in a case of calcium channel blocker overdose.
    Annals of emergency medicine, 1993, Volume: 22, Issue:7

    Topics: Adult; Amrinone; Drug Overdose; Drug Therapy, Combination; Female; Glucagon; Humans; Hypotension; Ve

1993
A case of calcium channel blocker overdose.
    Hospital practice (1995), 1995, Nov-15, Volume: 30, Issue:11

    Topics: Adult; Calcium Channel Blockers; Drug Overdose; Female; Heart Block; Humans; Suicide, Attempted; Ver

1995
[Overdose of a drug with delayed action].
    Nederlands tijdschrift voor geneeskunde, 1996, Jan-06, Volume: 140, Issue:1

    Topics: Adult; Calcium Channel Blockers; Critical Care; Delayed-Action Preparations; Drug Overdose; Fatal Ou

1996
Colonic ischemia after verapamil overdose.
    Annals of internal medicine, 1996, Mar-01, Volume: 124, Issue:5

    Topics: Colon; Drug Overdose; Female; Humans; Ischemia; Middle Aged; Suicide, Attempted; Verapamil

1996
Massive verapamil overdose complicated by noncardiogenic pulmonary edema.
    The American journal of emergency medicine, 1996, Volume: 14, Issue:5

    Topics: Adult; Bradycardia; Calcium Channel Blockers; Combined Modality Therapy; Critical Care; Drug Overdos

1996
Perfusion salad: making sense of verapamil overdose.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 1996, Volume: 3, Issue:2

    Topics: Animals; Calcium Channel Blockers; Clinical Trials as Topic; Drug Overdose; Humans; Receptors, Adren

1996
Glucagon and phenylephrine combination vs glucagon alone in experimental verapamil overdose.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 1996, Volume: 3, Issue:2

    Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Antidotes; Calcium Channel Blockers; Dogs;

1996
Pharmacologically induced heart failure for the evaluation of circulatory assistance.
    Artificial organs, 1996, Volume: 20, Issue:6

    Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Cattle;

1996
Amrinone as an antidote in experimental verapamil overdose.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 1996, Volume: 3, Issue:8

    Topics: Amrinone; Animals; Antidotes; Dogs; Drug Overdose; Hemodynamics; Verapamil

1996
Case report: fatal verapamil overdosage despite intensive therapy and use of high dose intravenous calcium.
    Journal of human hypertension, 1996, Volume: 10, Issue:7

    Topics: Calcium; Dose-Response Relationship, Drug; Drug Overdose; Fatal Outcome; Female; Humans; Injections,

1996
Cardiac dysrhythmias in severe verapamil overdose: characterization with a canine model.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 1996, Volume: 3, Issue:1

    Topics: Animals; Calcium Channel Blockers; Disease Models, Animal; Dogs; Drug Overdose; Electrocardiography;

1996
Pharmacokinetics of verapamil in overdose.
    Human & experimental toxicology, 1997, Volume: 16, Issue:1

    Topics: Adult; Calcium Channel Blockers; Drug Overdose; Female; Half-Life; Humans; Male; Middle Aged; Poison

1997
Anticholinergic overdose induced torsade de pointes successfully treated with verapamil.
    Japanese heart journal, 1996, Volume: 37, Issue:6

    Topics: Adolescent; Antidepressive Agents; Antipsychotic Agents; Cholinergic Antagonists; Drug Overdose; Fem

1996
Amrinone and verapamil overdose study design.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 1997, Volume: 4, Issue:8

    Topics: Amrinone; Animals; Antidotes; Dogs; Drug Overdose; Research Design; Verapamil

1997
Combined overdose with verapamil and atenolol: treatment with high doses of adrenergic agonists.
    Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:3

    Topics: Adrenergic Agonists; Adrenergic beta-Antagonists; Atenolol; Calcium Channel Blockers; Drug Overdose;

1998
A case of severe verapamil overdose.
    Japanese circulation journal, 1998, Volume: 62, Issue:1

    Topics: Aged; Calcium Channel Blockers; Drug Overdose; Female; Humans; Japan; Suicide, Attempted; Verapamil

1998
Successful resuscitation of a verapamil-intoxicated patient with percutaneous cardiopulmonary bypass.
    Critical care medicine, 1999, Volume: 27, Issue:12

    Topics: Adult; Calcium Channel Blockers; Cardiopulmonary Bypass; Drug Overdose; Electrocardiography; Emergen

1999
Lymphocytic intracellular calcium in a patient with complicated verapamil overdose.
    The American journal of the medical sciences, 2000, Volume: 319, Issue:1

    Topics: Calcium; Calcium Channel Blockers; Drug Overdose; Female; Humans; Lymphocytes; Middle Aged; Suicide,

2000
Plasmapheresis in fatal overdose with verapamil.
    Intensive care medicine, 1999, Volume: 25, Issue:12

    Topics: Anti-Arrhythmia Agents; Critical Care; Drug Overdose; Fatal Outcome; Humans; Plasmapheresis; Suicide

1999
Calcium and digoxin vs. calcium alone for severe verapamil toxicity.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2000, Volume: 7, Issue:10

    Topics: Animals; Calcium; Calcium Channel Blockers; Chi-Square Distribution; Digoxin; Disease Models, Animal

2000
Multifocal myoclonus due to verapamil overdose.
    Neurology, 2002, Mar-26, Volume: 58, Issue:6

    Topics: Calcium Channel Blockers; Drug Overdose; Female; Humans; Middle Aged; Myoclonus; Verapamil

2002
Cardiac glycosides in the treatment of experimental overdose with calcium-blocking agents.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1992, Volume: 192, Issue:5

    Topics: Animals; Atropine; Calcium; Calcium Channel Blockers; Calcium Gluconate; Depression, Chemical; Digox

1992
Case report: sustained-release verapamil overdose causing stroke: an unusual complication.
    The American journal of the medical sciences, 1992, Volume: 304, Issue:6

    Topics: Cerebrovascular Disorders; Delayed-Action Preparations; Drug Overdose; Female; Humans; Middle Aged;

1992
Case report: fatal overdose with sustained-release verapamil.
    The American journal of the medical sciences, 1992, Volume: 303, Issue:2

    Topics: 4-Aminopyridine; Adult; Delayed-Action Preparations; Drug Overdose; Female; Humans; Male; Verapamil

1992
Verapamil overdose and severe hypocalcemia.
    Journal of toxicology. Clinical toxicology, 1992, Volume: 30, Issue:2

    Topics: Adult; Arrhythmias, Cardiac; Blood Pressure; Calcium Gluconate; Drug Overdose; Humans; Hypocalcemia;

1992
Refractory cardiogenic shock and complete heart block after unsuspected verapamil-SR and atenolol overdose.
    Clinical cardiology, 1991, Volume: 14, Issue:11

    Topics: Atenolol; Delayed-Action Preparations; Drug Overdose; Electrocardiography; Emergency Service, Hospit

1991
Management of massive verapamil overdose.
    The Medical journal of Australia, 1991, Jul-15, Volume: 155, Issue:2

    Topics: Cardiac Pacing, Artificial; Combined Modality Therapy; Drug Overdose; Gastric Lavage; Humans; Male;

1991
Effects of calcium channel blocker overdose-induced toxicity in the conscious dog.
    Annals of emergency medicine, 1991, Volume: 20, Issue:10

    Topics: Animals; Coronary Circulation; Diltiazem; Dogs; Drug Overdose; Female; Hemodynamics; Infusions, Intr

1991
Delayed onset of cardiac arrhythmias from sustained-release verapamil.
    Annals of emergency medicine, 1991, Volume: 20, Issue:2

    Topics: Adult; Delayed-Action Preparations; Drug Overdose; Heart Block; Humans; Hypotension; Male; Verapamil

1991
Verapamil overdose.
    The Western journal of medicine, 1991, Volume: 154, Issue:2

    Topics: Adult; Drug Overdose; Female; Humans; Verapamil

1991
Fatal verapamil toxicity and hypokalemia.
    American heart journal, 1991, Volume: 121, Issue:6 Pt 1

    Topics: Adult; Drug Overdose; Hemodynamics; Humans; Hypokalemia; Male; Suicide; Verapamil

1991
Overdose of sustained release verapamil.
    The New Zealand medical journal, 1990, Apr-11, Volume: 103, Issue:887

    Topics: Delayed-Action Preparations; Drug Overdose; Heart Arrest; Humans; Male; Middle Aged; Verapamil

1990