verapamil has been researched along with Disease Exacerbation in 28 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study evaluates the clinical effectiveness of targeted arterial infusion of verapamil in interventional treatment of primary hepatocellular carcinoma." | 9.15 | Clinical evaluation of targeted arterial infusion of verapamil in the interventional chemotherapy of primary hepatocellular carcinoma. ( Duan, Q; Fan, P; Huang, J; Ji, C; Lin, X; Lv, Y; Qian, L; Yu, X, 2011) |
| "The purpose of this study is to evaluate whether metastatic breast cancer that has progressed on an anthracycline-containing drug regimen will subsequently respond to that identical regimen if dexverapamil, a modulator of P-glycoprotein-mediated drug resistance, is given concomitantly." | 9.08 | Phase II study of dexverapamil plus anthracycline in patients with metastatic breast cancer who have progressed on the same anthracycline regimen. ( Andrulis, I; Blackstein, M; Franssen, E; Fraser, RA; Goss, PE; Hedley, D; Hill, W; Kates, R; Knight, S; Myers, R; Oldfield, S; Pritchard, KI; Roche, K; Trudeau, M; Warner, E; Warr, D; Webster, S, 1998) |
| "To investigate the efficacy of verapamil eye drops for inhibition of diabetic cataract in rats." | 7.72 | Inhibition of experimental diabetic cataract by topical administration of RS-verapamil hydrochloride. ( Daxer, A; Ettl, A; Göttinger, W; Schmid, E, 2004) |
| "This study evaluates the clinical effectiveness of targeted arterial infusion of verapamil in interventional treatment of primary hepatocellular carcinoma." | 5.15 | Clinical evaluation of targeted arterial infusion of verapamil in the interventional chemotherapy of primary hepatocellular carcinoma. ( Duan, Q; Fan, P; Huang, J; Ji, C; Lin, X; Lv, Y; Qian, L; Yu, X, 2011) |
| "In subjects with type 2 diabetes and hypertension but with normoalbuminuria, the use of trandolapril plus verapamil and trandolapril alone decreased the incidence of microalbuminuria to a similar extent." | 5.11 | Preventing microalbuminuria in type 2 diabetes. ( Arnoldi, F; Bossi, A; Bruno, S; Brusegan, V; Dodesini, AR; Ene-Iordache, B; Fassi, A; Ganeva, M; Gaspari, F; Gherardi, G; Iliev, IP; Ilieva, AP; Perna, A; Remuzzi, G; Rubis, N; Ruggenenti, P; Trevisan, R, 2004) |
| "The purpose of this study is to evaluate whether metastatic breast cancer that has progressed on an anthracycline-containing drug regimen will subsequently respond to that identical regimen if dexverapamil, a modulator of P-glycoprotein-mediated drug resistance, is given concomitantly." | 5.08 | Phase II study of dexverapamil plus anthracycline in patients with metastatic breast cancer who have progressed on the same anthracycline regimen. ( Andrulis, I; Blackstein, M; Franssen, E; Fraser, RA; Goss, PE; Hedley, D; Hill, W; Kates, R; Knight, S; Myers, R; Oldfield, S; Pritchard, KI; Roche, K; Trudeau, M; Warner, E; Warr, D; Webster, S, 1998) |
| "To investigate the efficacy of verapamil eye drops for inhibition of diabetic cataract in rats." | 3.72 | Inhibition of experimental diabetic cataract by topical administration of RS-verapamil hydrochloride. ( Daxer, A; Ettl, A; Göttinger, W; Schmid, E, 2004) |
| "The present study evaluated the efficacy of chemotherapy combined with targeted arterial infusion of verapamil in patients with advanced gastric cancer." | 2.79 | Efficacy of chemotherapy combined with targeted arterial infusion of verapamil in patients with advanced gastric cancer. ( Chen, D; Duan, Q; Fan, G; Fan, P; Liu, A; Ning, Z; Zhang, T, 2014) |
| "Verapamil prevented the increase in fibrillatory frequency in PAF patients in relatively long-term observation." | 2.73 | Effect of oral L-type calcium channel blocker on repetitive paroxysmal atrial fibrillation: spectral analysis of fibrillation waves in the Holter monitoring. ( Fujiki, A; Fukaya, H; Hatakeyama, Y; Izumi, T; Niwano, S; Sasaki, T, 2007) |
| "Within the COPD GOLD II stage group, there appears to be no statistically significant difference in the number of exacerbations between the patients taking verapamil and digoxin (n = 24) and the patients taking BBs alone (n = 15), although, in patients taking BBs alone, there appears to be a trend towards a decrease in the exacerbations compared to the number of exacerbations in patients taking verapamil and digoxin (p = 0." | 1.51 | Beta-blocker Use in Moderate and Severe Chronic Obstructive Pulmonary Disease. ( Bedak, O; Begic, E; Bradaric, H; Custovic, F; Durak-Nalbantic, A; Hodzic, E; Mujakovic, A; Prnjavorac, B; Zvizdic, F, 2019) |
| " As a result of this, a significant decrease in the intestinal uptake and peroral bioavailability of the P-glycoprotein substrates (verapamil and atorvastatin) was observed along with the progression of diabetes as compared to normal animals." | 1.42 | Increased intestinal P-glycoprotein expression and activity with progression of diabetes and its modulation by epigallocatechin-3-gallate: Evidence from pharmacokinetic studies. ( Agarwal, M; Dash, RP; Ellendula, B; Nivsarkar, M, 2015) |
| "A couple of days after increasing the dosage of betaadrenergic- and adding calcium channel blockers due to an increased heart rate in atrial fibrillation, a 77 year old female was found in cardiogenic shock." | 1.38 | [The choked heart]. ( Furrer, F; Giambarba, C, 2012) |
| "We report a patient with a history of migraine without aura who developed cluster headache and HC simultaneously." | 1.36 | Coexisting trigeminal autonomic cephalalgias and hemicrania continua. ( Grosberg, BM; Lipton, RB; Robbins, MS, 2010) |
| "Human cytomegalovirus was used in a modified in vitro model for characterizing lathyrane compounds with antipromotion effect on human lung cancer cells." | 1.35 | [Perspectives of inhibition of multidrug resistance during cancer chemotherapy, in vitro and in vivo experiments]. ( Engi, H, 2009) |
| "18F-fluorodeoxyglucose (FDG) uptake in hepatocellular carcinoma (HCC) is associated with tumor differentiation and expression of P-glycoprotein (P-gp), a drug efflux pump that plays an important role in chemoresistance." | 1.35 | P-glycoprotein expression affects 18F-fluorodeoxyglucose accumulation in hepatocellular carcinoma in vivo and in vitro. ( Hatano, E; Higashi, T; Ikai, I; Iwaisako, K; Kitamura, K; Nakajima, A; Nakamoto, Y; Seo, S; Tada, M; Tamaki, N; Uemoto, S, 2009) |
| "Data regarding use of CCBs in human polycystic kidney disease (PKD) are limited and mixed." | 1.35 | Calcium, cyclic AMP, and MAP kinases: dysregulation in polycystic kidney disease. ( Cowley, BD, 2008) |
| "Verapamil treatment eliminated evidence of vasospasm and ameliorated histological and functional evidence of cardiomyopathic progression." | 1.32 | Secondary coronary artery vasospasm promotes cardiomyopathy progression. ( Collins, KA; Earley, JU; Hack, AA; Korcarz, CE; Lang, RM; Lapidos, KA; Lyons, MR; McNally, EM; Wheeler, MT; Zarnegar, S, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (17.86) | 18.2507 |
| 2000's | 13 (46.43) | 29.6817 |
| 2010's | 10 (35.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zvizdic, F | 1 |
| Begic, E | 1 |
| Mujakovic, A | 1 |
| Hodzic, E | 1 |
| Prnjavorac, B | 1 |
| Bedak, O | 1 |
| Custovic, F | 1 |
| Bradaric, H | 1 |
| Durak-Nalbantic, A | 1 |
| Kryczka, J | 1 |
| Boncela, J | 1 |
| Ning, Z | 1 |
| Chen, D | 1 |
| Liu, A | 1 |
| Fan, P | 2 |
| Duan, Q | 2 |
| Zhang, T | 1 |
| Fan, G | 1 |
| Dash, RP | 1 |
| Ellendula, B | 1 |
| Agarwal, M | 1 |
| Nivsarkar, M | 1 |
| Engi, H | 1 |
| Seo, S | 1 |
| Hatano, E | 1 |
| Higashi, T | 1 |
| Nakajima, A | 1 |
| Nakamoto, Y | 1 |
| Tada, M | 1 |
| Tamaki, N | 1 |
| Iwaisako, K | 1 |
| Kitamura, K | 1 |
| Ikai, I | 1 |
| Uemoto, S | 1 |
| Robbins, MS | 1 |
| Grosberg, BM | 1 |
| Lipton, RB | 1 |
| Nagao, S | 2 |
| Morita, M | 1 |
| Kugita, M | 1 |
| Yoshihara, D | 2 |
| Yamaguchi, T | 2 |
| Kurahashi, H | 2 |
| Calvet, JP | 2 |
| Wallace, DP | 2 |
| Huang, J | 1 |
| Ji, C | 1 |
| Lv, Y | 1 |
| Lin, X | 1 |
| Qian, L | 1 |
| Yu, X | 1 |
| Levine, LA | 2 |
| Furrer, F | 1 |
| Giambarba, C | 1 |
| Paulis, G | 1 |
| Brancato, T | 1 |
| D'Ascenzo, R | 1 |
| De Giorgio, G | 1 |
| Nupieri, P | 1 |
| Orsolini, G | 1 |
| Alvaro, R | 1 |
| Estrada, CR | 1 |
| Ettl, A | 1 |
| Daxer, A | 1 |
| Göttinger, W | 1 |
| Schmid, E | 1 |
| Wheeler, MT | 1 |
| Korcarz, CE | 1 |
| Collins, KA | 1 |
| Lapidos, KA | 1 |
| Hack, AA | 1 |
| Lyons, MR | 1 |
| Zarnegar, S | 1 |
| Earley, JU | 1 |
| Lang, RM | 1 |
| McNally, EM | 1 |
| Catalano, A | 1 |
| Rodilossi, S | 1 |
| Rippo, MR | 1 |
| Caprari, P | 1 |
| Procopio, A | 1 |
| Ruggenenti, P | 1 |
| Fassi, A | 1 |
| Ilieva, AP | 1 |
| Bruno, S | 1 |
| Iliev, IP | 1 |
| Brusegan, V | 1 |
| Rubis, N | 1 |
| Gherardi, G | 1 |
| Arnoldi, F | 1 |
| Ganeva, M | 1 |
| Ene-Iordache, B | 1 |
| Gaspari, F | 1 |
| Perna, A | 1 |
| Bossi, A | 1 |
| Trevisan, R | 1 |
| Dodesini, AR | 1 |
| Remuzzi, G | 1 |
| Nitschmann, S | 1 |
| Bennett, NE | 1 |
| Guhring, P | 1 |
| Mulhall, JP | 1 |
| Niwano, S | 1 |
| Fukaya, H | 1 |
| Sasaki, T | 1 |
| Hatakeyama, Y | 1 |
| Fujiki, A | 1 |
| Izumi, T | 1 |
| Nishii, K | 1 |
| Nagaoka, K | 1 |
| Yamashita, T | 1 |
| Takahashi, H | 1 |
| Cowley, BD | 1 |
| Kametaka, S | 1 |
| Kasahara, T | 1 |
| Ueo, M | 1 |
| Takenaka, M | 1 |
| Saito, M | 1 |
| Sakamoto, K | 1 |
| Nakahara, T | 1 |
| Ishii, K | 1 |
| Ferrés-Sánchez, P | 1 |
| Subirana-Domènech, M | 1 |
| Torner-Soler, M | 1 |
| Ciaudo, M | 1 |
| Chauvenet, L | 1 |
| Audouin, J | 1 |
| Rossert, J | 1 |
| Favier, R | 1 |
| Horellou, MH | 1 |
| Bernadou, A | 1 |
| Samama, M | 1 |
| Chen, SA | 1 |
| Chiang, CE | 1 |
| Tai, CT | 1 |
| Lee, SH | 1 |
| Chiou, CW | 1 |
| Ueng, KC | 1 |
| Wen, ZC | 1 |
| Cheng, CC | 1 |
| Chang, MS | 1 |
| Münter, K | 1 |
| Hergenröder, S | 1 |
| Jochims, K | 1 |
| Kirchengast, M | 1 |
| Warner, E | 1 |
| Hedley, D | 1 |
| Andrulis, I | 1 |
| Myers, R | 1 |
| Trudeau, M | 1 |
| Warr, D | 1 |
| Pritchard, KI | 1 |
| Blackstein, M | 1 |
| Goss, PE | 1 |
| Franssen, E | 1 |
| Roche, K | 1 |
| Knight, S | 1 |
| Webster, S | 1 |
| Fraser, RA | 1 |
| Oldfield, S | 1 |
| Hill, W | 1 |
| Kates, R | 1 |
2 reviews available for verapamil and Disease Exacerbation
| Article | Year |
|---|---|
Cell Migration Related to MDR-Another Impediment to Effective Chemotherapy?
Topics: Antibodies, Monoclonal; Antineoplastic Agents; ATP-Binding Cassette Transporters; Cancer-Associated | 2018 |
Intralesional verapamil for the treatment of Peyronie's disease: a review.
Topics: Calcium Channel Blockers; Disease Progression; Humans; Injections, Intralesional; Male; Penile Indur | 2002 |
7 trials available for verapamil and Disease Exacerbation
| Article | Year |
|---|---|
Efficacy of chemotherapy combined with targeted arterial infusion of verapamil in patients with advanced gastric cancer.
Topics: Adult; Aged; Antineoplastic Agents; Disease Progression; Drug Therapy, Combination; Female; Humans; | 2014 |
Clinical evaluation of targeted arterial infusion of verapamil in the interventional chemotherapy of primary hepatocellular carcinoma.
Topics: Antineoplastic Agents; Body Weight; Carcinoma, Hepatocellular; Disease Progression; Drug Resistance, | 2011 |
Efficacy of vitamin E in the conservative treatment of Peyronie's disease: legend or reality? A controlled study of 70 cases.
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Blueberry Plants; Cal | 2013 |
Preventing microalbuminuria in type 2 diabetes.
Topics: Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium | 2004 |
Intralesional verapamil prevents the progression of Peyronie's disease.
Topics: Adult; Disease Progression; Follow-Up Studies; Humans; Injections, Intralesional; Male; Middle Aged; | 2007 |
Effect of oral L-type calcium channel blocker on repetitive paroxysmal atrial fibrillation: spectral analysis of fibrillation waves in the Holter monitoring.
Topics: Adult; Aged; Atrial Fibrillation; Calcium Channel Blockers; Disease Progression; Electrocardiography | 2007 |
Phase II study of dexverapamil plus anthracycline in patients with metastatic breast cancer who have progressed on the same anthracycline regimen.
Topics: Adult; Aged; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; B | 1998 |
19 other studies available for verapamil and Disease Exacerbation
| Article | Year |
|---|---|
Beta-blocker Use in Moderate and Severe Chronic Obstructive Pulmonary Disease.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bisoprolol; Case-Control | 2019 |
Increased intestinal P-glycoprotein expression and activity with progression of diabetes and its modulation by epigallocatechin-3-gallate: Evidence from pharmacokinetic studies.
Topics: Animals; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availabil | 2015 |
[Perspectives of inhibition of multidrug resistance during cancer chemotherapy, in vitro and in vivo experiments].
Topics: Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 2009 |
P-glycoprotein expression affects 18F-fluorodeoxyglucose accumulation in hepatocellular carcinoma in vivo and in vitro.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Carcinoma, Hepato | 2009 |
Coexisting trigeminal autonomic cephalalgias and hemicrania continua.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Brain; Calcium Channel Blockers; Cl | 2010 |
Polycystic kidney disease in Han:SPRD Cy rats is associated with elevated expression and mislocalization of SamCystin.
Topics: Animals; Blotting, Western; Calcium Channel Blockers; Cell Proliferation; Disease Progression; DNA M | 2010 |
Current approach to the man with acute phase Peyronie's disease--case presentation and discussion.
Topics: Adult; Arginine; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy, Combination; H | 2011 |
[The choked heart].
Topics: Adrenergic beta-Antagonists; Aged; Atrial Fibrillation; Bisoprolol; Calcium Channel Blockers; Cardia | 2012 |
Inhibition of experimental diabetic cataract by topical administration of RS-verapamil hydrochloride.
Topics: Animals; Calcium Channel Blockers; Cataract; Diabetes Mellitus, Experimental; Disease Progression; I | 2004 |
Secondary coronary artery vasospasm promotes cardiomyopathy progression.
Topics: Animals; Calcium Channel Blockers; Cardiomyopathies; Coronary Vasospasm; Cytoskeletal Proteins; Dise | 2004 |
Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Separation; Culture Media, Conditioned; Cytokines; Disease Progres | 2004 |
[Prevention of microalbuminuria in type 2 diabetes. BENEDICT study].
Topics: Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium | 2006 |
Calcium channel inhibition accelerates polycystic kidney disease progression in the Cy/+ rat.
Topics: Animals; Apoptosis; Blood Urea Nitrogen; Calcium; Calcium Channel Blockers; Cell Proliferation; Cycl | 2008 |
Calcium, cyclic AMP, and MAP kinases: dysregulation in polycystic kidney disease.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Proliferation; Contraindications; Cyclic AMP; Disea | 2008 |
Effect of nifedipine on severe experimental cataract in diabetic rats.
Topics: Animals; Blood Glucose; Blood Pressure; Body Weight; Calcium Channel Blockers; Cataract; Diabetes Me | 2008 |
Chest pain during exercise as first manifestation of Friedreich's ataxia.
Topics: Adolescent; Chest Pain; Disease Progression; Echocardiography; Electrocardiography; Exercise; Friedr | 1995 |
Peripheral-T-cell lymphoma with hemophagocytic histiocytosis localised to the bone marrow associated with inappropriate secretion of antidiuretic hormone.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Diseases; Cisplatin; Cy | 1995 |
Longitudinal clinical and electrophysiological assessment of patients with symptomatic Wolff-Parkinson-White syndrome and atrioventricular node reentrant tachycardia.
Topics: Adolescent; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrioventricular N | 1996 |
Individual and combined effects of verapamil or trandolapril on attenuating hypertensive glomerulopathic changes in the stroke-prone rat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Calcium | 1996 |