Page last updated: 2024-10-24

verapamil and Diarrhea

verapamil has been researched along with Diarrhea in 24 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

Research Excerpts

ExcerptRelevanceReference
"The results of an open clinical trial carried out between 1985 and 1989, studying the effect of calcium antagonists, particularly verapamil, on chronic diarrhea of different etiologies, are presented."9.07[The therapeutic effects of the calcium blocker verapamil in chronic diarrhea. Preliminary communication]. ( Borsari, G, 1991)
"The initial use of verapamil for the symptomatic treatment of microscopic colitis is reported."7.71Use of verapamil for the symptomatic treatment of microscopic colitis. ( Meiselman, M; Scheidler, MD, 2001)
"The aim of this study was to investigate whether the blockade of L-type Ca2+ channels with verapamil suppresses giant migrating contractions (GMCs) and therefore diarrhea during small intestinal inflammation."7.69Ca2+ channel blockade by verapamil inhibits GMCs and diarrhea during small intestinal inflammation. ( Casper, MA; Lee, CW; Sarna, SK; Singaram, C, 1997)
"The results of an open clinical trial carried out between 1985 and 1989, studying the effect of calcium antagonists, particularly verapamil, on chronic diarrhea of different etiologies, are presented."5.07[The therapeutic effects of the calcium blocker verapamil in chronic diarrhea. Preliminary communication]. ( Borsari, G, 1991)
"The initial use of verapamil for the symptomatic treatment of microscopic colitis is reported."3.71Use of verapamil for the symptomatic treatment of microscopic colitis. ( Meiselman, M; Scheidler, MD, 2001)
"The aim of this study was to investigate whether the blockade of L-type Ca2+ channels with verapamil suppresses giant migrating contractions (GMCs) and therefore diarrhea during small intestinal inflammation."3.69Ca2+ channel blockade by verapamil inhibits GMCs and diarrhea during small intestinal inflammation. ( Casper, MA; Lee, CW; Sarna, SK; Singaram, C, 1997)
"webbiana for treating diarrhea and asthma."1.91Ethnopharmacological basis and pharmacodynamics prospectives for folkloric claims of Rosa webbiana wall. Ex. Royle in diarrhea and asthma via In vitro, In vivo and In silico techniques. ( Ali, A; Saqib, F, 2023)
"Lercanidipine 10 mg daily was prescribed as an alternative antihypertensive drug."1.43Adverse event potentially due to an interaction between ibrutinib and verapamil: a case report. ( Bilbault, P; Gourieux, B; Lambert Kuhn, E; Levêque, D; Lioure, B, 2016)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19906 (25.00)18.7374
1990's5 (20.83)18.2507
2000's2 (8.33)29.6817
2010's9 (37.50)24.3611
2020's2 (8.33)2.80

Authors

AuthorsStudies
Ali, A1
Saqib, F1
Rehman, NU2
Ansari, MN1
Samad, A1
Palla, AH1
Khan, NA1
Bashir, S1
Ur-Rehman, N1
Iqbal, J2
Gilani, AH7
Ali, N1
Alam, H1
Khan, A3
Ahmed, G1
Shah, WA1
Nabi, M1
Junaid, M1
Shareef, H1
Rizwani, GH1
Mandukhail, SR1
Watanabe, N1
Nazneen, M1
El Gamal, AA1
Fawzy, GA1
Al-Ati, HY1
Abdel-kader, MS1
Lambert Kuhn, E1
Levêque, D1
Lioure, B1
Gourieux, B1
Bilbault, P1
Mandukhail, SU1
Yasinzai, M1
Aziz, N2
Shah, AJ1
Bhulani, NN1
Khan, SH1
Ur Rehman, N1
Mehmood, MH1
Ghayur, MN1
Khan, M1
Khan, AU1
Gullikson, GW1
Dajani, EZ1
Bianchi, RG1
Kanwar, RK1
Ganguly, NK4
Kumar, L1
Rakesh, J1
Panigrahi, D2
Walia, BN4
Lee, CW1
Sarna, SK1
Singaram, C1
Casper, MA1
Floch, MH1
Scheidler, MD1
Meiselman, M1
Borsari, G1
Khurana, S1
Khullar, M1
Tabibian, N1
Cox, E1
Cools, V1
Houvenaghel, A1
Goyal, J2
Mahajan, RC2
Garg, UC2
Baeyens, JM1
Esposito, E1
Ossowska, G1
Samanin, R1
Ahlman, H1
Nilsson, O1
Grönstad, KO1
Skolnik, G1
Tisell, LE1
Dahlström, A1

Trials

1 trial available for verapamil and Diarrhea

ArticleYear
[The therapeutic effects of the calcium blocker verapamil in chronic diarrhea. Preliminary communication].
    Schweizerische medizinische Wochenschrift, 1991, Aug-31, Volume: 121, Issue:35

    Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Colitis; Diarrhea; Diverticulum, Colon; Dose-Respon

1991

Other Studies

23 other studies available for verapamil and Diarrhea

ArticleYear
Ethnopharmacological basis and pharmacodynamics prospectives for folkloric claims of Rosa webbiana wall. Ex. Royle in diarrhea and asthma via In vitro, In vivo and In silico techniques.
    Journal of ethnopharmacology, 2023, Dec-05, Volume: 317

    Topics: Animals; Antidiarrheals; Asthma; Bronchodilator Agents; Calcium; Calcium Channels; Diarrhea; Gastroi

2023
In Silico, Ex Vivo and In Vivo Studies of Roflumilast as a Potential Antidiarrheal and Antispasmodic agent: Inhibition of the PDE-4 Enzyme and Voltage-gated Ca++ ion Channels.
    Molecules (Basel, Switzerland), 2020, Feb-24, Volume: 25, Issue:4

    Topics: Aminopyridines; Animals; Antidiarrheals; Benzamides; Binding Sites; Calcium Channel Blockers; Carbac

2020
Pharmacological basis for the medicinal use of Linum usitatissimum (Flaxseed) in infectious and non-infectious diarrhea.
    Journal of ethnopharmacology, 2015, Feb-03, Volume: 160

    Topics: Animals; Antidiarrheals; Calcium; Castor Oil; Diarrhea; Dose-Response Relationship, Drug; Flax; Gast

2015
Antispasmodic and antidiarrhoeal activity of the fruit of Rosa moschata (J).
    BMC complementary and alternative medicine, 2014, Dec-13, Volume: 14

    Topics: Animals; Antidiarrheals; Calcium; Calcium Channel Blockers; Diarrhea; Female; Fruit; Gastrointestina

2014
Studies on antidiarrhoeal, antispasmodic and bronchodilator activities of Operculina turpethum Linn.
    BMC complementary and alternative medicine, 2014, Dec-12, Volume: 14

    Topics: Animals; Antidiarrheals; Asthma; Bronchodilator Agents; Calcium; Calcium Channel Blockers; Carbachol

2014
Antidiarrheal and Antispasmodic Activities of Buddleja polystachya are Mediated Through Dual Inhibition of Ca(++) Influx and Phosphodiesterase Enzyme.
    Phytotherapy research : PTR, 2015, Volume: 29, Issue:8

    Topics: Animals; Antidiarrheals; Buddleja; Calcium; Castor Oil; Diarrhea; Female; Guinea Pigs; Ileum; In Vit

2015
Adverse event potentially due to an interaction between ibrutinib and verapamil: a case report.
    Journal of clinical pharmacy and therapeutics, 2016, Volume: 41, Issue:1

    Topics: Adenine; Aged; Antihypertensive Agents; Antineoplastic Agents; Cytochrome P-450 CYP3A Inhibitors; Di

2016
Antispasmodic and vasodilator activities of Morinda citrifolia root extract are mediated through blockade of voltage dependent calcium channels.
    BMC complementary and alternative medicine, 2010, Jan-13, Volume: 10

    Topics: Animals; Aorta, Thoracic; Calcium; Calcium Channels; Diarrhea; Dose-Response Relationship, Drug; Gui

2010
Calcium channel blocking activity of Mentha longifolia L. explains its medicinal use in diarrhoea and gut spasm.
    Phytotherapy research : PTR, 2010, Volume: 24, Issue:9

    Topics: Animals; Antidiarrheals; Calcium; Calcium Channel Blockers; Castor Oil; Cations; Diarrhea; Jejunum;

2010
Pharmacological basis for the medicinal use of psyllium husk (Ispaghula) in constipation and diarrhea.
    Digestive diseases and sciences, 2011, Volume: 56, Issue:5

    Topics: Animals; Arginine Vasopressin; Constipation; Diarrhea; Female; Guinea Pigs; Jejunum; Male; Mice; Mic

2011
Pharmacological explanation for the medicinal use of Juniperus excelsa in hyperactive gastrointestinal and respiratory disorders.
    Journal of natural medicines, 2012, Volume: 66, Issue:2

    Topics: Animals; Bronchodilator Agents; Calcium Channel Blockers; Diarrhea; Gastrointestinal Diseases; Guine

2012
Inhibition of intestinal secretion in the dog: a new approach for the management of diarrheal states.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 219, Issue:3

    Topics: Animals; Antidiarrheals; Body Water; Chlorpromazine; Deoxycholic Acid; Diarrhea; Dogs; Electrolytes;

1981
Calcium and protein kinase C play an important role in Campylobacter jejuni-induced changes in Na+ and Cl- transport in rat ileum in vitro.
    Biochimica et biophysica acta, 1995, Apr-24, Volume: 1270, Issue:2-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Calmodulin; Campylobact

1995
Ca2+ channel blockade by verapamil inhibits GMCs and diarrhea during small intestinal inflammation.
    The American journal of physiology, 1997, Volume: 273, Issue:4

    Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Diarrhea; Dogs; Infla

1997
Use of verapamil in the treatment of diarrhea due to microscopic colitis.
    Journal of clinical gastroenterology, 2001, Volume: 32, Issue:4

    Topics: Calcium Channel Blockers; Colitis; Diarrhea; Humans; Verapamil

2001
Use of verapamil for the symptomatic treatment of microscopic colitis.
    Journal of clinical gastroenterology, 2001, Volume: 32, Issue:4

    Topics: Aged; Aged, 80 and over; Calcium Channel Blockers; Colitis; Diarrhea; Female; Humans; Male; Middle A

2001
Studies on the mechanism of Salmonella typhimurium enterotoxin-induced diarrhoea.
    Biochimica et biophysica acta, 1991, Oct-21, Volume: 1097, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Calcimycin; Calcium; Chlor

1991
Successful treatment of refractory post-vagotomy syndrome with verapamil (Calan SR)
    The American journal of gastroenterology, 1990, Volume: 85, Issue:3

    Topics: Adult; Aged; Diarrhea; Dumping Syndrome; Female; Humans; Male; Middle Aged; Vagotomy; Verapamil

1990
Effect of antisecretory drugs on experimentally induced weanling diarrhoea in piglets.
    Veterinary research communications, 1989, Volume: 13, Issue:2

    Topics: Animals; Animals, Newborn; Chlorpromazine; Clonidine; Diarrhea; Disease Models, Animal; Escherichia

1989
Studies on the mechanism of Escherichia coli heat-stable enterotoxin-induced diarrhoea in mice.
    Biochimica et biophysica acta, 1987, Sep-11, Volume: 925, Issue:3

    Topics: Animals; Bacterial Toxins; Calcimycin; Calcium; Calmodulin; Chlorides; Diarrhea; Enterotoxins; Esche

1987
Role of Ca2+/calmodulin in the regulation of sugar uptake in Escherichia coli heat-stable enterotoxin induced diarrhoea in mice.
    Biochemistry international, 1987, Volume: 15, Issue:4

    Topics: 3-O-Methylglucose; Animals; Bacterial Toxins; Calcimycin; Calcium; Calmodulin; Carbohydrate Metaboli

1987
Effects of peripheral and central administration of calcium channel blockers in the naloxone-precipitated abstinence syndrome in morphine-dependent rats.
    European journal of pharmacology, 1987, May-07, Volume: 137, Issue:1

    Topics: Animals; Body Weight; Brain; Calcium Channel Blockers; Clonidine; Diarrhea; Flunarizine; Injections,

1987
Verapamil and diarrhoea in the carcinoid syndrome--clinical and experimental observations on serotonin release.
    British journal of cancer, 1986, Volume: 54, Issue:2

    Topics: Aged; Animals; Diarrhea; Humans; Isoproterenol; Male; Malignant Carcinoid Syndrome; Pentagastrin; Ra

1986