verapamil has been researched along with Di Guglielmo Disease in 16 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Verapamil was able to completely restore doxorubicin accumulation in the resistant cells to the level obtained in sensitive cells, but only partially reversed doxorubicin resistance." | 1.29 | Differential effects of verapamil and quinine on the reversal of doxorubicin resistance in a human leukemia cell line. ( Bennis, S; Ichas, F; Robert, J, 1995) |
| "[14C]putrescine was converted into [14C]spermidine following between 15 min and 32 h of culture, and into [14C]-spermine after 16 h of culture, in both the cell types; however, the levels of interconverted radioactive polyamines were always lower in MDR cells as compared with wild type cells." | 1.29 | Transport and metabolism of polyamines in wild and multidrug resistant human leukemia (K 562) cells. ( Fardel, O; Fauchet, R; Havouis, R; Khan, NA; Moulinoux, JP, 1994) |
| "Verapamil did not enhance drug accumulation but inhibited drug efflux in K562r cells." | 1.29 | [Intracellular accumulation, retention, and distribution of anthracyclines in a multidrug-resistant variant K562r]. ( Chen, WY; Hu, X, 1994) |
| "Hexamethylene bisacetamide (HMBA) is a potent inducer of differentiation of murine erythroleukemia cells (MELC)." | 1.28 | Conversion of differentiation inducer resistance to differentiation inducer sensitivity in erythroleukemia cells. ( Chen, ZX; Lebedev, YB; Marks, PA; Michaeli, J; Richon, VM; Rifkind, RA, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 12 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Ravel, MR | 1 |
| Alameh, G | 1 |
| Melikian, M | 1 |
| Mahiout, Z | 1 |
| Emptoz-Bonneton, A | 1 |
| Matera, EL | 1 |
| Lomberget, T | 1 |
| Barret, R | 1 |
| Rocheblave, L | 1 |
| Walchshofer, N | 1 |
| Beltran, S | 1 |
| El Jawad, L | 1 |
| Mappus, E | 1 |
| Grenot, C | 1 |
| Pugeat, M | 1 |
| Dumontet, C | 1 |
| Le Borgne, M | 1 |
| Cuilleron, CY | 1 |
| Song, YN | 1 |
| Guo, XL | 1 |
| Zheng, BB | 1 |
| Liu, XY | 1 |
| Dong, X | 1 |
| Yu, LG | 1 |
| Cheng, YN | 1 |
| Klimecki, WT | 1 |
| Taylor, CW | 1 |
| Dalton, WS | 1 |
| Bennis, S | 2 |
| Ichas, F | 1 |
| Robert, J | 2 |
| Van Acker, KL | 1 |
| Van Hove, LM | 1 |
| Boogaerts, MA | 1 |
| Khan, NA | 1 |
| Fardel, O | 1 |
| Havouis, R | 1 |
| Fauchet, R | 1 |
| Moulinoux, JP | 1 |
| Hu, X | 1 |
| Chen, WY | 1 |
| Canitrot, Y | 1 |
| Lautier, D | 1 |
| Viallet, P | 1 |
| Salmon, JM | 1 |
| Reymann, A | 1 |
| Looft, G | 1 |
| Woermann, C | 1 |
| Dietel, M | 1 |
| Erttmann, R | 1 |
| Homolya, L | 1 |
| Holló, M | 1 |
| Müller, M | 1 |
| Mechetner, EB | 1 |
| Sarkadi, B | 1 |
| Maynadié, M | 1 |
| Matutes, E | 1 |
| Catovsky, D | 1 |
| Carpentier, Y | 1 |
| Gorisse, MC | 1 |
| Desoize, B | 1 |
| Michaeli, J | 1 |
| Lebedev, YB | 1 |
| Richon, VM | 1 |
| Chen, ZX | 1 |
| Marks, PA | 1 |
| Rifkind, RA | 1 |
| Yanovich, S | 1 |
| Hall, RE | 1 |
| Gewirtz, DA | 1 |
| Supino, R | 1 |
| Gibelli, N | 1 |
| Galatulas, I | 1 |
| Zunino, F | 1 |
16 other studies available for verapamil and Di Guglielmo Disease
| Article | Year |
|---|---|
Synthesis of new steroidal inhibitors of P-glycoprotein-mediated multidrug resistance and biological evaluation on K562/R7 erythroleukemia cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Crystallography, X-Ray; Drug | 2015 |
Ligustrazine derivate DLJ14 reduces multidrug resistance of K562/A02 cells by modulating GSTπ activity.
Topics: Antibiotics, Antineoplastic; Blotting, Western; Cell Proliferation; Down-Regulation; Doxorubicin; Dr | 2011 |
Inhibition of cell-mediated cytolysis and P-glycoprotein function in natural killer cells by verapamil isomers and cyclosporine A analogs.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Cytotoxicity, Immuno | 1995 |
Differential effects of verapamil and quinine on the reversal of doxorubicin resistance in a human leukemia cell line.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; | 1995 |
[Difference between the effects of S9788, verapamil and quinine on the reversion of multidrug resistance in two human tumor cell lines].
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Death; Doxorubicin; Drug Resistance, Multiple; Humans; | 1994 |
Evaluation of flow cytometry for multidrug resistance detection in low resistance K562 cells using daunorubicin and monoclonal antibodies.
Topics: Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; C | 1993 |
Transport and metabolism of polyamines in wild and multidrug resistant human leukemia (K 562) cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Cel | 1994 |
[Intracellular accumulation, retention, and distribution of anthracyclines in a multidrug-resistant variant K562r].
Topics: Antibiotics, Antineoplastic; Cell Nucleus; Chromatography, High Pressure Liquid; Cytoplasm; Daunorub | 1994 |
Modulation of rhodamine 123 uptake by nigericin in sensitive and multidrug resistant leukemic cells.
Topics: Animals; Antimetabolites, Antineoplastic; Doxorubicin; Drug Interactions; Drug Resistance; Drug Scre | 1994 |
Reversal of multidrug resistance in Friend leukemia cells by dexniguldipine-HCl.
Topics: Animals; Cell Division; Daunorubicin; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resis | 1993 |
A new method for a quantitative assessment of P-glycoprotein-related multidrug resistance in tumour cells.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Tr | 1996 |
Quantification of P-glycoprotein in chronic lymphocytic leukemia by flow cytometry.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antibodies, Monoclonal; ATP Binding Cas | 1997 |
Evaluation of a method for detection of cells with reduced drug retention in solid tumours.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Breast Neopl | 1992 |
Conversion of differentiation inducer resistance to differentiation inducer sensitivity in erythroleukemia cells.
Topics: Acetamides; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Differentiation; | 1990 |
Characterization of a K562 multidrug-resistant cell line.
Topics: Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell | 1989 |
Influence of calcium and calcium-modulating agents on differentiation of murine erythroleukaemia cells.
Topics: 4-Aminopyridine; Aminopyridines; Amrinone; Animals; Calcimycin; Calcium; Calcium Channel Blockers; C | 1985 |