Page last updated: 2024-10-24

verapamil and Depression

verapamil has been researched along with Depression in 8 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"When antihypertensive treatment options are clinically equivalent, prescribers may first consider using a verapamil SR-based strategy, especially in patients with CAD who have no history of depression."5.12Depressive symptoms in coronary artery disease patients after hypertension treatment. ( Lopez, LM; Pepine, CJ; Ried, LD; Sauer, BC; Taylor, MD; Tueth, MJ, 2006)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19903 (37.50)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's1 (12.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Salgin-Goksen, U1
Telli, G1
Erikci, A1
Dedecengiz, E1
Tel, BC1
Kaynak, FB1
Yelekci, K1
Ucar, G1
Gokhan-Kelekci, N1
Yu, H1
Li, M1
Shen, X1
Lv, D1
Sun, X1
Wang, J1
Gu, X1
Hu, J1
Wang, C1
Capasso, R1
Borrelli, F1
Capasso, F1
Mascolo, N1
Izzo, AA1
Ried, LD1
Tueth, MJ1
Taylor, MD1
Sauer, BC1
Lopez, LM1
Pepine, CJ1
Srivastava, SK1
Nath, C1
Price, WA1
Shalley, JE1
Geoffroy, M1
Mogilnicka, E1
Nielsen, M1
Rafaelsen, OJ1
Fogelman, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
INternational VErapamil SR Trandolapril STudy[NCT00133692]Phase 422,000 participants Interventional1997-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for verapamil and Depression

ArticleYear
Depressive symptoms in coronary artery disease patients after hypertension treatment.
    The Annals of pharmacotherapy, 2006, Volume: 40, Issue:4

    Topics: Aged; Antihypertensive Agents; Atenolol; Coronary Artery Disease; Depression; Female; Humans; Male;

2006

Other Studies

7 other studies available for verapamil and Depression

ArticleYear
New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors.
    Journal of medicinal chemistry, 2021, 02-25, Volume: 64, Issue:4

    Topics: Animals; Antidepressive Agents; Depression; Hep G2 Cells; Humans; Hydrazones; Mice; Molecular Dockin

2021
The Requirement of L-Type Voltage-Dependent Calcium Channel (L-VDCC) in the Rapid-Acting Antidepressant-Like Effects of Scopolamine in Mice.
    The international journal of neuropsychopharmacology, 2018, 02-01, Volume: 21, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Calcium Channel

2018
Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.
    Urology, 2004, Volume: 64, Issue:1

    Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anthracenes; Antidepressive Agents; Atropine; Bridge

2004
The differential effects of calcium channel blockers in the behavioural despair test in mice.
    Pharmacological research, 2000, Volume: 42, Issue:4

    Topics: Animals; Antidepressive Agents; Calcium Channel Blockers; Clomipramine; Clonidine; Cyproheptadine; D

2000
Lithium-verapamil toxicity in the elderly.
    Journal of the American Geriatrics Society, 1987, Volume: 35, Issue:2

    Topics: Aged; Depression; Drug Interactions; Female; Humans; Lithium; Lithium Carbonate; Verapamil

1987
Effect of nifedipine on the shuttlebox escape deficit induced by inescapable shock in the rat.
    European journal of pharmacology, 1988, Sep-23, Volume: 154, Issue:3

    Topics: Animals; Binding Sites; Brain; Depression; Electroshock; Escape Reaction; Imipramine; Kinetics; Male

1988
Verapamil may cause depression, confusion, and impotence.
    Texas medicine, 1987, Volume: 83, Issue:11

    Topics: Cognition Disorders; Confusion; Depression; Erectile Dysfunction; Humans; Male; Middle Aged; Verapam

1987