Page last updated: 2024-10-24

verapamil and Death, Sudden, Cardiac

verapamil has been researched along with Death, Sudden, Cardiac in 28 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Death, Sudden, Cardiac: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)

Research Excerpts

ExcerptRelevanceReference
"The effect of verapamil on death and reinfarction after an acute myocardial infarction was studied in two double-blind, randomized, placebo-controlled multicenter trials, the Danish Verapamil Infarction Trials I and II (DAVIT I and II)."10.16Treatment with verapamil during and after an acute myocardial infarction: a review based on the Danish Verapamil Infarction Trials I and II. The Danish Study Group on Verapamil in Myocardial Infarction. ( Hansen, JF, 1991)
"The effect of verapamil on death and reinfarction after an acute myocardial infarction was studied in two double-blind, randomized, placebo-controlled multicenter trials, the Danish Verapamil Infarction Trials I and II (DAVIT I and II)."6.16Treatment with verapamil during and after an acute myocardial infarction: a review based on the Danish Verapamil Infarction Trials I and II. The Danish Study Group on Verapamil in Myocardial Infarction. ( Hansen, JF, 1991)
" A 59-year-old woman had a permanent pacemaker implanted after diagnosis of tachycardia-bradycardia syndrome, and her drug regimen of digoxin, verapamil, and warfarin was supplemented with flecainide to prevent paroxysmal atrial fibrillation."4.78Interference by antiarrhythmic agents with function of electrical cardiac devices. ( Bauman, JL; Ezri, M; Nazari, J; Tworek, DA, 1992)
"Mycophenolic acid was detected in all cats."2.61 ( Abrams, G; Adolfsson, E; Agarwal, PK; Akkan, AG; Al Alhareth, NS; Alves, VGL; Armentano, R; Bahroos, E; Baig, M; Baldridge, KK; Barman, S; Bartolucci, C; Basit, A; Bertoli, SV; Bian, L; Bigatti, G; Bobenko, AI; Boix, PP; Bokulic, T; Bolink, HJ; Borowiec, J; Bulski, W; Burciaga, J; Butt, NS; Cai, AL; Campos, AM; Cao, G; Cao, Y; Čapo, I; Caruso, ML; Chao, CT; Cheatum, CM; Chelminski, K; Chen, AJW; Chen, C; Chen, CH; Chen, D; Chen, G; Chen, H; Chen, LH; Chen, R; Chen, RX; Chen, X; Cherdtrakulkiat, R; Chirvony, VS; Cho, JG; Chu, K; Ciurlino, D; Coletta, S; Contaldo, G; Crispi, F; Cui, JF; D'Esposito, M; de Biase, S; Demir, B; Deng, W; Deng, Z; Di Pinto, F; Domenech-Ximenos, B; Dong, G; Drácz, L; Du, XJ; Duan, LJ; Duan, Y; Ekendahl, D; Fan, W; Fang, L; Feng, C; Followill, DS; Foreman, SC; Fortunato, G; Frew, R; Fu, M; Gaál, V; Ganzevoort, W; Gao, DM; Gao, X; Gao, ZW; Garcia-Alvarez, A; Garza, MS; Gauthier, L; Gazzaz, ZJ; Ge, RS; Geng, Y; Genovesi, S; Geoffroy, V; Georg, D; Gigli, GL; Gong, J; Gong, Q; Groeneveld, J; Guerra, V; Guo, Q; Guo, X; Güttinger, R; Guyo, U; Haldar, J; Han, DS; Han, S; Hao, W; Hayman, A; He, D; Heidari, A; Heller, S; Ho, CT; Ho, SL; Hong, SN; Hou, YJ; Hu, D; Hu, X; Hu, ZY; Huang, JW; Huang, KC; Huang, Q; Huang, T; Hwang, JK; Izewska, J; Jablonski, CL; Jameel, T; Jeong, HK; Ji, J; Jia, Z; Jiang, W; Jiang, Y; Kalumpha, M; Kang, JH; Kazantsev, P; Kazemier, BM; Kebede, B; Khan, SA; Kiss, J; Kohen, A; Kolbenheyer, E; Konai, MM; Koniarova, I; Kornblith, E; Krawetz, RJ; Kreouzis, T; Kry, SF; Laepple, T; Lalošević, D; Lan, Y; Lawung, R; Lechner, W; Lee, KH; Lee, YH; Leonard, C; Li, C; Li, CF; Li, CM; Li, F; Li, J; Li, L; Li, S; Li, X; Li, Y; Li, YB; Li, Z; Liang, C; Lin, J; Lin, XH; Ling, M; Link, TM; Liu, HH; Liu, J; Liu, M; Liu, W; Liu, YP; Lou, H; Lu, G; Lu, M; Lun, SM; Ma, Z; Mackensen, A; Majumdar, S; Martineau, C; Martínez-Pastor, JP; McQuaid, JR; Mehrabian, H; Meng, Y; Miao, T; Miljković, D; Mo, J; Mohamed, HSH; Mohtadi, M; Mol, BWJ; Moosavi, L; Mosdósi, B; Nabu, S; Nava, E; Ni, L; Novakovic-Agopian, T; Nyamunda, BC; Nyul, Z; Önal, B; Özen, D; Özyazgan, S; Pajkrt, E; Palazon, F; Park, HW; Patai, Á; Patai, ÁV; Patzke, GR; Payette, G; Pedoia, V; Peelen, MJCS; Pellitteri, G; Peng, J; Perea, RJ; Pérez-Del-Rey, D; Popović, DJ; Popović, JK; Popović, KJ; Posecion, L; Povall, J; Prachayasittikul, S; Prachayasittikul, V; Prat-González, S; Qi, B; Qu, B; Rakshit, S; Ravelli, ACJ; Ren, ZG; Rivera, SM; Salo, P; Samaddar, S; Samper, JLA; Samy El Gendy, NM; Schmitt, N; Sekerbayev, KS; Sepúlveda-Martínez, Á; Sessolo, M; Severi, S; Sha, Y; Shen, FF; Shen, X; Shen, Y; Singh, P; Sinthupoom, N; Siri, S; Sitges, M; Slovak, JE; Solymosi, N; Song, H; Song, J; Song, M; Spingler, B; Stewart, I; Su, BL; Su, JF; Suming, L; Sun, JX; Tantimavanich, S; Tashkandi, JM; Taurbayev, TI; Tedgren, AC; Tenhunen, M; Thwaites, DI; Tibrewala, R; Tomsejm, M; Triana, CA; Vakira, FM; Valdez, M; Valente, M; Valentini, AM; Van de Winckel, A; van der Lee, R; Varga, F; Varga, M; Villarino, NF; Villemur, R; Vinatha, SP; Vincenti, A; Voskamp, BJ; Wang, B; Wang, C; Wang, H; Wang, HT; Wang, J; Wang, M; Wang, N; Wang, NC; Wang, Q; Wang, S; Wang, X; Wang, Y; Wang, Z; Wen, N; Wesolowska, P; Willis, M; Wu, C; Wu, D; Wu, L; Wu, X; Wu, Z; Xia, JM; Xia, X; Xia, Y; Xiao, J; Xiao, Y; Xie, CL; Xie, LM; Xie, S; Xing, Z; Xu, C; Xu, J; Yan, D; Yan, K; Yang, S; Yang, X; Yang, XW; Ye, M; Yin, Z; Yoon, N; Yoon, Y; Yu, H; Yu, K; Yu, ZY; Zhang, B; Zhang, GY; Zhang, H; Zhang, J; Zhang, M; Zhang, Q; Zhang, S; Zhang, W; Zhang, X; Zhang, Y; Zhang, YW; Zhang, Z; Zhao, D; Zhao, F; Zhao, P; Zhao, W; Zhao, Z; Zheng, C; Zhi, D; Zhou, C; Zhou, FY; Zhu, D; Zhu, J; Zhu, Q; Zinyama, NP; Zou, M; Zou, Z, 2019)
"Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmogenic disease that can cause sudden cardiac death due to ventricular fibrillation (VF)."2.47Successful treatment of catecholaminergic polymorphic ventricular tachycardia with flecainide: a case report and review of the current literature. ( Bittner, A; Dechering, DG; Eckardt, L; Köbe, J; Kotthoff, S; Mönnig, G; Muszynski, A; Pott, C; Reinke, F; Schulze-Bahr, E; Wasmer, K; Zellerhoff, S, 2011)
"Because sudden cardiac death is the most serious complication of HCM, particularly in young and asymptomatic patients, it follows that correct diagnosis, followed by risk stratification of patients with regard to the need for prophylactic implantation of an implantable cardiac defibrillator (ICD), can be of life-saving importance."2.47The diagnosis and treatment of hypertrophic cardiomyopathy. ( Faber, L; Farr, M; Hering, D; Horstkotte, D; Prinz, C, 2011)
"Drug treatment of hypertrophic cardiomyopathy is the first-line treatment, at the onset of clinical signs and symptoms."1.35[Drug treatment for hypertrophic cardiomyopathy]. ( Gibelin, P, 2009)
"Short-coupled variant of torsade de pointes have a high incidence of sudden death, so it is very important for physicians to identify and treat it promptly."1.32[Short coupled variant of torsade de pointes: our experience and review of the literature]. ( Abdessalem, S; Barakett, N; Fehri, W; Haouala, H; Mhenni, H; Rahal, N; Smiri, Z, 2004)
" These results confirm the absorption of sildenafil, verapamil and trimetazidine before the death and hair analysis indicates the chronic use of sildenafil."1.31Last performance with VIAGRA: post-mortem identification of sildenafil and its metabolites in biological specimens including hair sample. ( Belooussoff, T; Cirimele, V; Dumestre-Toulet, V; Gromb, S; Kintz, P; Lavault, D; Ludes, B, 2002)
"Ventricular tachycardia is a dangerous dysrhythmia most commonly encountered in adult patients with heart disease."1.29Child with idiopathic ventricular tachycardia of prolonged duration. ( Feit, LR; Linakis, JG; Simon, HK; Suner, S, 1995)
"The short-coupled variant of torsade de pointes should be identified because of their ECG pattern and the risk of sudden death in young adults with no structural heart disease."1.29Short-coupled variant of torsade de pointes. A new electrocardiographic entity in the spectrum of idiopathic ventricular tachyarrhythmias. ( Burguera, M; Coumel, P; Glaser, E; Leenhardt, A; Maison-Blanche, P; Nürnberg, M, 1994)
" The rats were observed for toxic signs and survival over a period of 15 days."1.29Reversal of acute theophylline toxicity by calcium channel blockers in dogs and rats. ( Alleva, FR; Balazs, T; Joseph, X; Vick, JA; Whitehurst, VE; Zhang, J, 1996)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's14 (50.00)18.2507
2000's11 (39.29)29.6817
2010's3 (10.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bobenko, AI1
Heller, S1
Schmitt, N1
Cherdtrakulkiat, R1
Lawung, R1
Nabu, S1
Tantimavanich, S1
Sinthupoom, N1
Prachayasittikul, S1
Prachayasittikul, V1
Zhang, B1
Wu, C1
Zhang, Z2
Yan, K1
Li, C2
Li, Y4
Li, L3
Zheng, C1
Xiao, Y1
He, D1
Zhao, F1
Su, JF1
Lun, SM1
Hou, YJ1
Duan, LJ1
Wang, NC1
Shen, FF1
Zhang, YW1
Gao, ZW1
Li, J5
Du, XJ1
Zhou, FY1
Yin, Z1
Zhu, J2
Yan, D1
Lou, H1
Yu, H1
Feng, C1
Wang, Z1
Wang, Y4
Hu, X1
Li, Z2
Shen, Y1
Hu, D1
Chen, H1
Wu, X1
Duan, Y1
Zhi, D1
Zou, M2
Zhao, Z1
Zhang, X2
Yang, X2
Zhang, J3
Wang, H1
Popović, KJ1
Popović, DJ1
Miljković, D1
Lalošević, D1
Čapo, I1
Popović, JK1
Liu, M1
Song, H2
Xing, Z1
Lu, G1
Chen, D1
Valentini, AM1
Di Pinto, F1
Coletta, S1
Guerra, V1
Armentano, R1
Caruso, ML1
Gong, J1
Wang, N1
Bian, L1
Wang, M1
Ye, M1
Wen, N1
Fu, M1
Fan, W2
Meng, Y1
Dong, G1
Lin, XH1
Liu, HH1
Gao, DM1
Cui, JF1
Ren, ZG1
Chen, RX1
Önal, B1
Özen, D1
Demir, B1
Akkan, AG1
Özyazgan, S1
Payette, G1
Geoffroy, V1
Martineau, C1
Villemur, R1
Jameel, T1
Baig, M1
Gazzaz, ZJ1
Tashkandi, JM1
Al Alhareth, NS1
Khan, SA1
Butt, NS1
Wang, J2
Geng, Y1
Zhang, Y3
Wang, X2
Liu, J2
Basit, A1
Miao, T1
Liu, W1
Jiang, W1
Yu, ZY1
Wu, L2
Qu, B1
Sun, JX1
Cai, AL1
Xie, LM1
Groeneveld, J1
Ho, SL1
Mackensen, A1
Mohtadi, M1
Laepple, T1
Genovesi, S1
Nava, E1
Bartolucci, C1
Severi, S1
Vincenti, A1
Contaldo, G1
Bigatti, G1
Ciurlino, D1
Bertoli, SV1
Slovak, JE1
Hwang, JK1
Rivera, SM1
Villarino, NF1
Li, S1
Cao, G1
Ling, M1
Ji, J1
Zhao, D1
Sha, Y1
Gao, X1
Liang, C2
Guo, Q1
Zhou, C1
Ma, Z1
Xu, J1
Wang, C1
Zhao, W1
Xia, X1
Jiang, Y1
Peng, J1
Jia, Z1
Li, F1
Chen, X2
Mo, J1
Zhang, S2
Li, X1
Huang, T1
Zhu, Q1
Wang, S1
Ge, RS1
Fortunato, G1
Lin, J2
Agarwal, PK1
Kohen, A1
Singh, P1
Cheatum, CM1
Zhu, D1
Hayman, A1
Kebede, B1
Stewart, I1
Chen, G1
Frew, R1
Guo, X1
Gong, Q1
Borowiec, J1
Han, S1
Zhang, M1
Willis, M1
Kreouzis, T1
Yu, K1
Chirvony, VS1
Sekerbayev, KS1
Pérez-Del-Rey, D1
Martínez-Pastor, JP1
Palazon, F1
Boix, PP1
Taurbayev, TI1
Sessolo, M1
Bolink, HJ1
Lu, M1
Lan, Y1
Xiao, J1
Song, M1
Chen, C1
Huang, Q1
Cao, Y1
Ho, CT1
Qi, B1
Wang, Q1
Zhang, W1
Fang, L1
Xie, CL1
Chen, R1
Yang, S1
Xia, JM1
Zhang, GY1
Chen, CH1
Yang, XW1
Domenech-Ximenos, B1
Garza, MS1
Prat-González, S1
Sepúlveda-Martínez, Á1
Crispi, F1
Perea, RJ1
Garcia-Alvarez, A1
Sitges, M1
Kalumpha, M1
Guyo, U1
Zinyama, NP1
Vakira, FM1
Nyamunda, BC1
Varga, M1
Drácz, L1
Kolbenheyer, E1
Varga, F1
Patai, ÁV1
Solymosi, N1
Patai, Á1
Kiss, J1
Gaál, V1
Nyul, Z1
Mosdósi, B1
Valdez, M1
Moosavi, L1
Heidari, A1
Novakovic-Agopian, T1
Kornblith, E1
Abrams, G1
McQuaid, JR1
Posecion, L1
Burciaga, J1
D'Esposito, M1
Chen, AJW1
Samy El Gendy, NM1
Wesolowska, P1
Georg, D1
Lechner, W1
Kazantsev, P1
Bokulic, T1
Tedgren, AC1
Adolfsson, E1
Campos, AM1
Alves, VGL1
Suming, L1
Hao, W1
Ekendahl, D1
Koniarova, I1
Bulski, W1
Chelminski, K1
Samper, JLA1
Vinatha, SP1
Rakshit, S1
Siri, S1
Tomsejm, M1
Tenhunen, M1
Povall, J1
Kry, SF1
Followill, DS1
Thwaites, DI1
Izewska, J1
Kang, JH1
Yoon, Y1
Song, J1
Van de Winckel, A1
Gauthier, L1
Chao, CT1
Lee, YH1
Li, CM1
Han, DS1
Huang, JW1
Huang, KC1
Ni, L1
Güttinger, R1
Triana, CA1
Spingler, B1
Baldridge, KK1
Patzke, GR1
Shen, X1
Wang, B1
Xie, S1
Deng, W1
Wu, D1
Zhang, Q1
Voskamp, BJ1
Peelen, MJCS1
Ravelli, ACJ1
van der Lee, R1
Mol, BWJ1
Pajkrt, E1
Ganzevoort, W1
Kazemier, BM1
Tibrewala, R1
Bahroos, E1
Mehrabian, H1
Foreman, SC1
Link, TM1
Pedoia, V1
Majumdar, S1
Jablonski, CL1
Leonard, C1
Salo, P1
Krawetz, RJ1
Yoon, N1
Hong, SN1
Cho, JG1
Jeong, HK1
Lee, KH1
Park, HW1
Barman, S1
Konai, MM1
Samaddar, S1
Haldar, J1
Mohamed, HSH1
Li, CF1
Hu, ZY1
Deng, Z1
Chen, LH1
Su, BL1
Chu, K1
Liu, YP1
Li, YB1
Zhang, H1
Xu, C1
Zou, Z1
Wu, Z1
Xia, Y1
Zhao, P1
Wang, HT1
de Biase, S1
Pellitteri, G1
Gigli, GL1
Valente, M1
Gibelin, P1
Pott, C1
Dechering, DG1
Reinke, F1
Muszynski, A1
Zellerhoff, S1
Bittner, A1
Köbe, J1
Wasmer, K1
Schulze-Bahr, E1
Mönnig, G1
Kotthoff, S1
Eckardt, L1
Prinz, C1
Farr, M1
Hering, D1
Horstkotte, D1
Faber, L1
Sumitomo, N1
Harada, K1
Nagashima, M1
Yasuda, T1
Nakamura, Y1
Aragaki, Y1
Saito, A1
Kurosaki, K1
Jouo, K1
Koujiro, M1
Konishi, S1
Matsuoka, S1
Oono, T1
Hayakawa, S1
Miura, M1
Ushinohama, H1
Shibata, T1
Niimura, I1
Favale, S1
Pappone, C1
Nacci, F1
Fino, F1
Resta, F1
Dicandia, CD1
Maron, BJ3
McKenna, WJ2
Danielson, GK1
Kappenberger, LJ1
Kuhn, HJ1
Seidman, CE2
Shah, PM1
Spencer, WH1
Spirito, P2
Ten Cate, FJ1
Wigle, ED1
Ray, WA1
Murray, KT1
Meredith, S1
Narasimhulu, SS1
Hall, K1
Stein, CM1
Fehri, W1
Abdessalem, S1
Smiri, Z1
Mhenni, H1
Barakett, N1
Rahal, N1
Haouala, H1
Hjemdahl, P2
Eriksson, SV1
Held, C2
Forslund, L2
Näsman, P1
Rehnqvist, N2
Melacini, P1
Bobbo, F1
Basso, C1
Tokajuk, B1
Zucchetto, M1
Thiene, G2
Iliceto, S1
Hansen, JF3
Suner, S1
Simon, HK1
Feit, LR1
Linakis, JG1
Leenhardt, A1
Glaser, E1
Burguera, M1
Nürnberg, M1
Maison-Blanche, P1
Coumel, P1
Andersen, L1
Sigurd, B1
Hansen, J1
Whitehurst, VE1
Joseph, X1
Vick, JA1
Alleva, FR1
Balazs, T1
Timour, Q1
Freysz, M1
Aupetit, JF1
Loufoua, J1
Frassati, D1
Faucon, G1
Burnett, JW1
Ruan, Y1
Wang, L1
Dumestre-Toulet, V1
Cirimele, V1
Gromb, S1
Belooussoff, T1
Lavault, D1
Ludes, B1
Kintz, P1
Björkander, I1
Ericson, M1
Kahan, T1
Sung, RJ1
Huycke, EC1
Ometto, R1
Corrado, D1
Vincenzi, M1
Rossi, L1
Mazur, NA1
Vasil'eva, NN1
Pavlova, TS1
Kul'ginskaia, IV1
Zhdanova, SM1
Tworek, DA1
Nazari, J1
Ezri, M1
Bauman, JL1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Metoprolol in Post Alcohol Septal Ablation Patients With Hypertrophic Cardiomyopathy[NCT04133532]Phase 422 participants (Actual)Interventional2020-03-05Completed
Correlation Between Myocardial Deformation and Coronary Artery Morphology in Patients With Hypertrophic Cardiomyopathy and Analysis of Genetic Factors:A Prospective, Single-center, Case-control Study[NCT04830787]302 participants (Actual)Observational2017-12-01Completed
Comparison of Two Macrolides, Azithromycin and Erythromycin, for Symptomatic Treatment of Gastroparesis[NCT01323582]Phase 226 participants (Actual)Interventional2009-02-28Terminated (stopped due to Original investigator left this institution, replacement investigator retired.)
Verapamil as Adjunctive Seizure Therapy for Children and Young Adults With Dravet Syndrome[NCT01607073]Phase 22 participants (Actual)Interventional2012-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Time to 50% Emptying: Post Test Less Baseline Pooled Over Orderings

Patients will be given a standardized meal enriched with a labeled material and the breath samples are then collected and analyzed. The estimated time to reaching 50% of the accumulated contents is recorded. (NCT01323582)
Timeframe: at baseline before initiation of the treatment and after completion of each treatment period.

Interventionminutes (Mean)
Azithromycin-15.0

Change in Time to 50% Gastric Emptying: Post Test Less Baseline Pooled Over Orderings

Patients will be given a standardized meal enriched with a labeled material and the breath samples are then collected and analyzed. The estimated time to reaching 50% of the accumulated contents is recorded. (NCT01323582)
Timeframe: Baseline and end of treatment period

InterventionMinutes (Mean)
Erythromycin-11.8

Does GCSI Score Improve (Lower) on Treatment, Pooling the AZ Patients Over Their Treatment Periods? Endpoint is Difference in Post-test Less Baseline

"This is a Validated instrument for measuring symptom severity in patients with gastroparesis. This scoring is based on a Likert Scale from (0-5) with zero being no symptom and five being very severe symptoms on 9 subscales, making the overall score range from 0-45. The higher the score, the more severe patient's symptoms are. The scale is reported in the references.~This is a calculation taken with GCSI score at end of treatment minus baseline. Negative value reflects this change." (NCT01323582)
Timeframe: Baseline and end of treatment period

Interventionunits on a scale (Median)
Azithromycin-6.40

Gastroparesis Cardinal Symptom Index (GCSI) Score

"This is a Validated instrument for measuring symptom severity in patients with gastroparesis. This scoring is based on a Likert Scale from (0-5) with zero being no symptoms and five being very severe symptoms on 9 subscales, making the overall score range from 0-45. The higher the score, the more severe patient's symptoms.~Reference for GCSI: Revicki DA, REntz AM, Dubois D, et al. Development and validation of a patient-assessed gastroparesis symptoms severity measure: the Gastroparesis Cardinal Symptom Index. Ailment Pharm Ther 2003; 18: 141:50.~Because the difference is RX-B -RX A in one group and RX A -RX B in the other, the difference between these two estimates twice the effect size. Hence the Half is applied, as is standard in the two sample method for crossover studies." (NCT01323582)
Timeframe: Weeks 4 and 11 (end of periods)

Interventionunits on a scale (Mean)
Erythromycin First Then Azithromycin-1.6
Azithromycin Then Erythromycin-2.9

Gastroparesis Cardinal Symptom Index (GCSI) Score Change From Baseline to Post Treatment

"This is a Validated instrument for measuring symptom severity in patients with gastroparesis. This scoring is based on a Likert Scale from (0-5) with zero being no symptom and five being very severe symptoms on 9 subscales, making the overall score range from 0-45. The higher the score, the more severe patient's symptoms are. The scale is reported in the references. The change was calculated by measuring the end of treatment minus baseline GCSI score.~Negative value reflects this change." (NCT01323582)
Timeframe: Baseline and end of treatment period

Interventionunits on a scale (Mean)
Erythromycin-5.32

NDI Score

"Nepean Dyspepsia Index (NDI) is a measure of symptom status and quality of life in functional dyspepsia. This scale is scored using each subscale (Tension, interference with daily activities), Eating/drinking, Knowledge/control, work/study) and adding up the items for each of the five subscale score (2-10). Total score range would be 10-50).~For the NDI, a lower number is better meaning the symptom is not effecting quality of life and a higher score closer to 50 is worse meaning it is effecting patients quality of life.~Reference: Talley NJ, Verlinden M, Jones M. Quality of life in functional dyspepsia: responsiveness of the Nepean Dyspepsia Index and developement of a new 10-iten short form. Aliment Pharmacol Ther 2001: 15: 207-216.~Because the difference is RX-B -RX A in one group and RX A -RX B in the other, the difference between these two estimates twice the effect size. Hence the Half is applied, as is standard in the two sample method for crossover studies." (NCT01323582)
Timeframe: Weeks 4 and 11 (end of periods)

Interventionunits on a scale (Median)
Erythromycin First Then Azithromycin1.65
Azithromycin Then Erythromycin1.30

Time in Minutes for 50% of the Ingested Meal to Empty the Stomach With a Standardized Breath Test: Half the of the Week 11 Value (Period 2) Less Half the of the Week 4 Value (Period 1). This Estimates the Effect Size.

Patients will be given a standardized meal enriched with a labeled material and the breath samples are then collected and analyzed. The estimated time to empty 50% (t 1/2) of the accumulated contents is recorded. Because the difference is RX-B -RX A in one group and RX A -RX B in the other, the difference between these two estimates twice the effect size. Hence the Half is applied, as is standard in the two sample method for crossover studies. (NCT01323582)
Timeframe: Weeks 4 and 11 (end of periods)

InterventionMinutes (Mean)
Erythromycin First Then Azithromycin-1.6
Azithromycin Then Erythromycin-5.2

TLAG (Time From Ingestion of Meal to Start of Gastric Emptying)

This is defined as the time from ingestion of the meal to the beginning of the emptying process in minutes. Because the difference is RX-B -RX A in one group and RX A -RX B in the other, the difference between these two estimates twice the effect size. Hence the Half is applied, as is standard in the two sample method for crossover studies. (NCT01323582)
Timeframe: Weeks 4 and 11 (end of periods)

InterventionMinutes (Mean)
Erythromycin First Then Azithromycin-1.71
Azithromycin Then Erythromycin-0.22

Change in Number of Absence Seizures From Week 8 (Baseline) to Week 12

The secondary outcome measure is the change in number of absence seizures from Week 8 (Baseline) to Week 12 (NCT01607073)
Timeframe: Week 8 to Week 12

InterventionAbscence seizures (Number)
Week 8 Baseline165
Week 12 Verapamil 4mg/kg/Day101

Change in Number of General Tonic-clonic Seizures From Week 8 (Baseline) Visit to Week 12 Visit

The primary study endpoint is the change in number of seizures from baseline. Since we only had one participant finish the study, the endpoint was changed to Week 12 visit. Participants were on verapamil for 4 weeks at Week 12. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

InterventionGeneral tonic-clonic seizures (Number)
Week 8 Baseline39
Week 12 Verapamil 4mg/kg/Day14

Change in Number of Myoclonic Seizures From Week 8 (Baseline) to Week 12

The secondary outcome is the change in number of myoclonic seizures between baseline Week 8 visit and Week 12 visit. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

InterventionMyoclonic seizures (Number)
Week 8 Baseline116
Week 12 Verapamil 4mg/kg/Day175

Reviews

8 reviews available for verapamil and Death, Sudden, Cardiac

ArticleYear
    Proceedings. Mathematical, physical, and engineering sciences, 2019, Volume: 475, Issue:2227

    Topics: Acetylcholine; Acinetobacter baumannii; Actinobacteria; Action Potentials; Adalimumab; Adaptation, P

2019
Successful treatment of catecholaminergic polymorphic ventricular tachycardia with flecainide: a case report and review of the current literature.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2011, Volume: 13, Issue:6

    Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Calcium Channel Blockers; Child; Death, Sudden,

2011
The diagnosis and treatment of hypertrophic cardiomyopathy.
    Deutsches Arzteblatt international, 2011, Volume: 108, Issue:13

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Cardiac Surgical Procedures; Cardiomyopathy, Hypertr

2011
American College of Cardiology/European Society of Cardiology clinical expert consensus document on hypertrophic cardiomyopathy. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the European S
    Journal of the American College of Cardiology, 2003, Nov-05, Volume: 42, Issue:9

    Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Atrial Fibrillation; Cardiac Pacing, Artificial;

2003
American College of Cardiology/European Society of Cardiology clinical expert consensus document on hypertrophic cardiomyopathy. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the European S
    Journal of the American College of Cardiology, 2003, Nov-05, Volume: 42, Issue:9

    Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Atrial Fibrillation; Cardiac Pacing, Artificial;

2003
American College of Cardiology/European Society of Cardiology clinical expert consensus document on hypertrophic cardiomyopathy. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the European S
    Journal of the American College of Cardiology, 2003, Nov-05, Volume: 42, Issue:9

    Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Atrial Fibrillation; Cardiac Pacing, Artificial;

2003
American College of Cardiology/European Society of Cardiology clinical expert consensus document on hypertrophic cardiomyopathy. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the European S
    Journal of the American College of Cardiology, 2003, Nov-05, Volume: 42, Issue:9

    Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Atrial Fibrillation; Cardiac Pacing, Artificial;

2003
The management of hypertrophic cardiomyopathy.
    The New England journal of medicine, 1997, Mar-13, Volume: 336, Issue:11

    Topics: Adrenergic beta-Antagonists; Atrial Fibrillation; Cardiac Pacing, Artificial; Cardiomyopathy, Hypert

1997
Ventricular arrhythmias in the absence of organic heart disease.
    Cardiovascular clinics, 1992, Volume: 22, Issue:1

    Topics: Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Death, Sudden, Cardiac; Diagnosis, Computer-As

1992
Treatment with verapamil during and after an acute myocardial infarction: a review based on the Danish Verapamil Infarction Trials I and II. The Danish Study Group on Verapamil in Myocardial Infarction.
    Journal of cardiovascular pharmacology, 1991, Volume: 18 Suppl 6

    Topics: Arrhythmias, Cardiac; Blood Pressure; Death, Sudden, Cardiac; Denmark; Double-Blind Method; Female;

1991
Interference by antiarrhythmic agents with function of electrical cardiac devices.
    Clinical pharmacy, 1992, Volume: 11, Issue:1

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Death, Sudden, Cardiac; Digoxin; Drug Interactions; Ele

1992

Trials

6 trials available for verapamil and Death, Sudden, Cardiac

ArticleYear
Favourable long term prognosis in stable angina pectoris: an extended follow up of the angina prognosis study in Stockholm (APSIS).
    Heart (British Cardiac Society), 2006, Volume: 92, Issue:2

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Death, Sudden, Cardiac; Diab

2006
Postinfarct treatment with verapamil. Effect of verapamil in patients with hypertension.
    Drugs, 1993, Volume: 46 Suppl 2

    Topics: Cerebrovascular Disorders; Death, Sudden, Cardiac; Denmark; Double-Blind Method; Follow-Up Studies;

1993
Verapamil and circadian variation of sudden cardiac death.
    American heart journal, 1996, Volume: 131, Issue:2

    Topics: Calcium Channel Blockers; Circadian Rhythm; Death, Sudden, Cardiac; Double-Blind Method; Humans; Myo

1996
Prognostic implications of autonomic function assessed by analyses of catecholamines and heart rate variability in stable angina pectoris.
    Heart (British Cardiac Society), 2002, Volume: 87, Issue:5

    Topics: Adult; Aged; Angina Pectoris; Anti-Arrhythmia Agents; Autonomic Nervous System Diseases; Biomarkers;

2002
[Calcium antagonists. The prevention of a recurrent myocardial infarct and sudden death].
    Terapevticheskii arkhiv, 1992, Volume: 64, Issue:9

    Topics: Calcium Channel Blockers; Death, Sudden, Cardiac; Drug Therapy, Combination; Electrocardiography, Am

1992
Treatment with verapamil during and after an acute myocardial infarction: a review based on the Danish Verapamil Infarction Trials I and II. The Danish Study Group on Verapamil in Myocardial Infarction.
    Journal of cardiovascular pharmacology, 1991, Volume: 18 Suppl 6

    Topics: Arrhythmias, Cardiac; Blood Pressure; Death, Sudden, Cardiac; Denmark; Double-Blind Method; Female;

1991

Other Studies

15 other studies available for verapamil and Death, Sudden, Cardiac

ArticleYear
[Drug treatment for hypertrophic cardiomyopathy].
    Presse medicale (Paris, France : 1983), 2009, Volume: 38, Issue:6

    Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Cardiomyop

2009
Catecholaminergic polymorphic ventricular tachycardia: electrocardiographic characteristics and optimal therapeutic strategies to prevent sudden death.
    Heart (British Cardiac Society), 2003, Volume: 89, Issue:1

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Catecholamines; Catheter Abl

2003
Sudden death due to atrial fibrillation in hypertrophic cardiomyopathy: a predictable event in a young patient.
    Pacing and clinical electrophysiology : PACE, 2003, Volume: 26, Issue:2 Pt 1

    Topics: Adult; Amiodarone; Atrial Fibrillation; Cardiomyopathy, Hypertrophic; Death, Sudden, Cardiac; Defibr

2003
Oral erythromycin and the risk of sudden death from cardiac causes.
    The New England journal of medicine, 2004, Sep-09, Volume: 351, Issue:11

    Topics: Administration, Oral; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases

2004
[Short coupled variant of torsade de pointes: our experience and review of the literature].
    La Tunisie medicale, 2004, Volume: 82, Issue:9

    Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Death, Sudden, Cardiac; Defibrillators, Implant

2004
Evidence that pharmacological strategies lack efficacy for the prevention of sudden death in hypertrophic cardiomyopathy.
    Heart (British Cardiac Society), 2007, Volume: 93, Issue:6

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiomyop

2007
Child with idiopathic ventricular tachycardia of prolonged duration.
    Annals of emergency medicine, 1995, Volume: 25, Issue:5

    Topics: Child, Preschool; Death, Sudden, Cardiac; Electric Countershock; Electrocardiography; Humans; Male;

1995
Short-coupled variant of torsade de pointes. A new electrocardiographic entity in the spectrum of idiopathic ventricular tachyarrhythmias.
    Circulation, 1994, Volume: 89, Issue:1

    Topics: Adult; Cardiac Pacing, Artificial; Death, Sudden, Cardiac; Defibrillators, Implantable; Electrocardi

1994
Verapamil prevents sudden death in patients with increased heart size after an acute myocardial infarction.
    Cardiovascular drugs and therapy, 1993, Volume: 7, Issue:3

    Topics: Cardiomegaly; Clinical Trials as Topic; Death, Sudden, Cardiac; Female; Humans; Male; Myocardial Inf

1993
Reversal of acute theophylline toxicity by calcium channel blockers in dogs and rats.
    Toxicology, 1996, Jun-17, Volume: 110, Issue:1-3

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bronchodilator Agents; Calcium; Calcium Channel Block

1996
[Value of calcium channel blockers in the prevention of ventricular fibrillation of ischemic etiology: experimental arguments].
    Bulletin de l'Academie nationale de medecine, 1996, Volume: 180, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Death, Sudden, Cardiac; Hemodynamics; Hum

1996
The case for the use of verapamil in alarming Chironex stings.
    Anaesthesia and intensive care, 1998, Volume: 26, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Antivenins; Bites and Stings; Calcium Channel Blockers; Cnidarian V

1998
Short-coupled variant of torsade de pointes.
    Journal of Tongji Medical University = Tong ji yi ke da xue xue bao, 2001, Volume: 21, Issue:1

    Topics: Adult; Anti-Arrhythmia Agents; Death, Sudden, Cardiac; Electrocardiography; Female; Follow-Up Studie

2001
Last performance with VIAGRA: post-mortem identification of sildenafil and its metabolites in biological specimens including hair sample.
    Forensic science international, 2002, Mar-28, Volume: 126, Issue:1

    Topics: Adult; Autopsy; Bromazepam; Cause of Death; Chromatography, Liquid; Death, Sudden, Cardiac; Drug Int

2002
Enhanced A-V nodal conduction (Lown-Ganong-Levine syndrome) by congenitally hypoplastic A-V node.
    European heart journal, 1992, Volume: 13, Issue:11

    Topics: Adult; Atrioventricular Node; Cardiac Pacing, Artificial; Death, Sudden, Cardiac; Electrocardiograph

1992