verapamil has been researched along with Colonic Neoplasms in 76 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To establish a simple method for estimating residual peritoneal ascites in order to determine the optimum verapamil (VRP) initial concentration in the intraperitoneal perfusion chemotherapy." | 7.80 | Studies on assessment methods of malignant ascites residue and changes of verapamil concentration in intraperitoneal perfusion chemotherapy. ( Duan, Q; Fan, P; Jia, W; Liu, Y; Ma, K; Wen, C; Wu, Y; Zhang, T, 2014) |
| "Pretreatment of human colon cancer LoVo-H cells and human breast cancer ZR-75 1A cells with low doses of verapamil, a Ca2+ channel blocker, for 48 h has a slight growth stimulatory effect and substantially increases cell sensitivity to lymphokine-activated killer (LAK) mediated cytotoxicity in the standard 51Cr release assay." | 7.68 | Verapamil upregulates sensitivity of human colon and breast cancer cells to LAK-cytotoxicity in vitro. ( Bianco, AR; Celio, L; Correale, P; Genua, G; Montagnani, S; Tagliaferri, P, 1991) |
| "A subline of human colon carcinoma cells (WiDr/R) resistant to the cytotoxic effects of mitoxantrone in vitro, was developed by continuous exposure to increasing concentrations of drug." | 7.67 | Development of resistance and characteristics of a human colon carcinoma subline resistant to mitoxantrone in vitro. ( Durr, FE; Lindh, D; Wallace, RE, 1987) |
| "Verapamil (Ver) is a well known, worldwide used drug to correct cardiac arrhythmias." | 5.38 | Verapamil-induced autophagy-like process in colon adenocarcinoma COLO 205 cells; the ultrastructural studies. ( Gajkowska, B; Kania, E; Orzechowski, A; Pająk, B, 2012) |
| "To establish a simple method for estimating residual peritoneal ascites in order to determine the optimum verapamil (VRP) initial concentration in the intraperitoneal perfusion chemotherapy." | 3.80 | Studies on assessment methods of malignant ascites residue and changes of verapamil concentration in intraperitoneal perfusion chemotherapy. ( Duan, Q; Fan, P; Jia, W; Liu, Y; Ma, K; Wen, C; Wu, Y; Zhang, T, 2014) |
| " In this study, a colchicine resistant subline (HCA-2/1cch) was selected from a human colon adenocarcinoma after a short period of drug exposure, as an in vitro model of drug resistance selection." | 3.70 | Multidrug resistance increment in a human colon carcinoma cell line by colchicine. ( Gil, L; Martínez Morillo, M; Ruiz Gómez, MJ; Souviron, A, 2000) |
| "Pretreatment of human colon cancer LoVo-H cells and human breast cancer ZR-75 1A cells with low doses of verapamil, a Ca2+ channel blocker, for 48 h has a slight growth stimulatory effect and substantially increases cell sensitivity to lymphokine-activated killer (LAK) mediated cytotoxicity in the standard 51Cr release assay." | 3.68 | Verapamil upregulates sensitivity of human colon and breast cancer cells to LAK-cytotoxicity in vitro. ( Bianco, AR; Celio, L; Correale, P; Genua, G; Montagnani, S; Tagliaferri, P, 1991) |
| "Phenoxazine and seven other structurally related compounds were investigated to determine whether they would increase accumulation of Vinca alkaloids in multidrug-resistant (MDR) GC3/C1 (human colon adenocarcinoma) and KB-ChR-8-5 (HeLa variant) cell lines." | 3.68 | Structural determinants of phenoxazine type compounds required to modulate the accumulation of vinblastine and vincristine in multidrug-resistant cell lines. ( Beck, WT; Horton, JK; Houghton, JA; Houghton, PJ; Qian, XD; Thimmaiah, KN, 1990) |
| "A subline of human colon carcinoma cells (WiDr/R) resistant to the cytotoxic effects of mitoxantrone in vitro, was developed by continuous exposure to increasing concentrations of drug." | 3.67 | Development of resistance and characteristics of a human colon carcinoma subline resistant to mitoxantrone in vitro. ( Durr, FE; Lindh, D; Wallace, RE, 1987) |
| "Verapamil, a calcium antagonist, inhibited both experimental (IV inoculation of tumor cells) and spontaneous metastasis (SC inoculation) of the highly metastatic B16 melanoma and colon adenocarcinoma 26 cell lines." | 3.67 | Inhibition of spontaneous and experimental tumor metastasis by the calcium antagonist verapamil. ( Iida, H; Kawabata, H; Makishima, F; Sakurai, Y; Tsukagoshi, S; Tsuruo, T; Yamori, T, 1985) |
| "Verapamil (Ver) is a well known, worldwide used drug to correct cardiac arrhythmias." | 1.38 | Verapamil-induced autophagy-like process in colon adenocarcinoma COLO 205 cells; the ultrastructural studies. ( Gajkowska, B; Kania, E; Orzechowski, A; Pająk, B, 2012) |
| "These data demonstrate that human colon cancer cells express L-type calcium channels that mediate calcium influx and apoptosis, which warrants further studies to determine whether calcium channel blockers may promote colon cancer growth." | 1.35 | Verapamil inhibits L-type calcium channel mediated apoptosis in human colon cancer cells. ( Jeppsson, B; Liu, Q; Melander, A; Thorlacius, H; Wang, Y; Zawadzki, A, 2008) |
| "Verapamil can inhibit proliferation of HCT cells via inducing cell apoptosis." | 1.33 | In vitro growth inhibition of human colonic tumor cells by Verapamil. ( Cao, QZ; Niu, G; Tan, HR, 2005) |
| "SJG-136 was highly potent in the colon cancer cell lines HCT-116, HT-29 and SW620 (IC50 0." | 1.33 | Influence of P-glycoprotein expression on in vitro cytotoxicity and in vivo antitumour activity of the novel pyrrolobenzodiazepine dimer SJG-136. ( Guichard, SM; Jodrell, DI; Macpherson, JS; Thurston, DE, 2005) |
| " Chronic use of Saint John's wort (SJW) has been shown to lower the bioavailability for a variety of co-administered drugs including indinavir, cyclosporin, and digoxin." | 1.31 | Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure. ( Greenblatt, DJ; Perloff, MD; Shader, RI; Störmer, E; von Moltke, LL, 2001) |
| "Mitomycin C pretreatment also significantly increased the sensitivity of cancer cells to subsequent killing by the P-glycoprotein substrate doxorubicin, decreasing the ED50 by 5- to 10-fold." | 1.30 | Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents. ( Blaxall, JR; Hamilton, JW; Ihnat, MA; La Ronde, N; Lariviere, JP; Pierre, KM; Turpie, BW; Warren, AJ, 1997) |
| "Our purpose was to investigate modulation of multidrug resistance by liposome-encapsulated vincristine (VCR) in a drug-resistant human colon cancer cell line HT-29mdr1 and the potentiation of this modulation in combination with monoclonal antibody MRK-16 or verapamil." | 1.29 | Reversal of multidrug resistance in human colon cancer cells expressing the human MDR1 gene by liposomes in combination with monoclonal antibody or verapamil. ( Husain, SR; Longo, DL; Pearson, JW; Rahman, A; Sela, S, 1995) |
| "Homoharringtonine (HHT) is a new drug with antileukemic activity which is currently tested for treatment of acute and chronic leukemias, either alone or in combination with other agents." | 1.29 | MDR-related P170-glycoprotein modulates cytotoxic activity of homoharringtonine. ( Baccarani, M; Candoni, A; Damiani, D; Marie, JP; Melli, C; Michelutti, A; Michieli, MG; Russo, D; Zhou, DC; Zittoun, R, 1995) |
| "Murine CT-26 colon cancer cells growing in continuous culture (parental cells) were harvested and injected subcutaneously into the lateral flank (to produce subcutaneous tumors) or the lateral tail vein (to produce experimental lung metastases) of 10 8-week-old syngeneic male BALB/c mice." | 1.29 | Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells. ( Bucana, CD; Dong, Z; Fan, D; Fidler, IJ; Radinsky, R; Tsan, R; Wilmanns, C, 1994) |
| "Verapamil (VRP) is an effective modulator of P170-associated multidrug resistance (MDR), but its clinical application is limited by cardiovascular side-effects." | 1.29 | D-verapamil downmodulates P170-associated resistance to doxorubicin, daunorubicin and idarubicin. ( Baccarani, M; Cerno, M; Damiani, D; Melli, C; Michelutti, A; Michieli, M, 1993) |
| "Treatment with verapamil, tamoxifen, nicergoline or cyclosporin A only partially restores the activity of FCE 24517 against LoVo/24517 cells." | 1.29 | Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517). ( Broggini, M; Capolongo, L; Grandi, M; Melegaro, G; Mongelli, N, 1993) |
| "The potential for a pharmacokinetic interaction between epirubicin and the second-generation multidrug resistance modulating agent D-verapamil (DVPM) has been investigated in six patients with advanced colorectal cancer." | 1.29 | Pharmacokinetic interaction between epirubicin and the multidrug resistance reverting agent D-verapamil. ( Czejka, M; Scheithauer, W; Schenk, T, 1993) |
| "The expression of MRP gene in gastric cancer cell lines varied from a low to a high level, but mdrl was not detected in any of these cell lines." | 1.29 | The multidrug resistance-associated protein gene confers drug resistance in human gastric and colon cancers. ( Cowan, KH; Fukuda, M; Ikeda, K; Kohno, S; Matsuo, I; Nakano, R; Narasaki, F; Oka, M; Soda, H; Takatani, H; Terashi, K; Tomonaga, M, 1996) |
| "The sensitive/MDR human ovarian cancer cell line couple A2780/2780AD was used as a reference." | 1.28 | P-glycoprotein drug efflux pump involved in the mechanisms of intrinsic drug resistance in various colon cancer cell lines. Evidence for a saturation of active daunorubicin transport. ( Broxterman, HJ; Dekker, H; Lankelma, J; Schuurhuis, GJ; Spoelstra, EC, 1991) |
| "Four human colon cancer cell lines (SW620, LS 180, DLD-I, and HCT-15) and sub-lines isolated in vitro by selection with Adriamycin were studied for reversal of intrinsic and acquired Adriamycin resistance, using buthionine sulfoximine (BSO) to deplete cellular glutathione alone and in combination with the P-glycoprotein antagonist verapamil." | 1.28 | Contribution of glutathione and glutathione-dependent enzymes in the reversal of adriamycin resistance in colon carcinoma cell lines. ( Alvarez, MG; Bates, SE; Fojo, AT; Lai, GM; Moscow, JA, 1991) |
| "Four human colon cancer cell lines (SW620, LS 180, DLD-I, and HCT-15) and Adriamycin-resistant sub-lines with varying degrees of P-glycoprotein expression were studied to evaluate the reversibility of Adriamycin resistance in human colon cancer." | 1.28 | P-glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell lines. ( Bates, SE; Chen, YN; Fojo, AT; Lai, GM; Mickley, LA, 1991) |
| "Colon cancer is one of the tumors most refractory to treatment by chemotherapy, and this may be due to inherent phenotypic instability of such tumor cells with respect to the biochemical determinants of drug sensitivity." | 1.28 | Phenotypic instability of drug sensitivity in a human colon carcinoma cell line. ( Cheng, YC; Ferguson, PJ, 1989) |
| "When colon cancer cells were cultivated for 1 day or longer in adriamycin-containing medium no nuclear fluorescence was observed." | 1.27 | Cytofluorescence localization of adriamycin in resistant colon cancer cells. ( Caignard, A; Chauffert, B; Jeannin, JF; Leclerc, A; Martin, F, 1984) |
| "When verapamil was combined with DX it inhibited the rapid DX efflux from LoVo/DX and reversed the resistance in this cell line, but it had no significant activity on LoVo cells." | 1.27 | Intracellular doxorubicin concentrations and drug-induced DNA damage in a human colon adenocarcinoma cell line and in a drug-resistant subline. ( Broggini, M; D'Incalci, M; Geroni, C; Giuliani, FC; Grandi, M; Ubezio, P, 1988) |
| "Verapamil has been shown to reverse acquired drug resistance to Adriamycin (ADR) and vinblastine in the P388 leukemia and Ehrlich ascites carcinoma model systems." | 1.27 | Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells. ( Cox, TC; Crowley, J; Goodman, GE; Yen, YP, 1987) |
| "NL-44, however, did not form pulmonary metastasis even after the tumor cells had formed heterotypic aggregates with platelets, suggesting that tumor metastasis is dependent on the intrinsic nature of tumor cells." | 1.27 | [Tumor-induced platelet aggregation and growth-promoting factors as determinants of probable tumor metastasis]. ( Tsuruo, T, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (22.37) | 18.7374 |
| 1990's | 37 (48.68) | 18.2507 |
| 2000's | 11 (14.47) | 29.6817 |
| 2010's | 8 (10.53) | 24.3611 |
| 2020's | 3 (3.95) | 2.80 |
| Authors | Studies |
|---|---|
| Perloff, MD | 2 |
| von Moltke, LL | 2 |
| Fahey, JM | 1 |
| Daily, JP | 1 |
| Greenblatt, DJ | 2 |
| Dimmock, JR | 1 |
| Das, U | 1 |
| Gul, HI | 1 |
| Kawase, M | 1 |
| Sakagami, H | 1 |
| Baráth, Z | 1 |
| Ocsovsky, I | 1 |
| Molnár, J | 5 |
| Valente, I | 1 |
| Reis, M | 2 |
| Duarte, N | 2 |
| Serly, J | 1 |
| Ferreira, MJ | 2 |
| Matos, AM | 1 |
| Spengler, G | 4 |
| Gajdács, M | 2 |
| Sanmartín, C | 1 |
| Marć, MA | 1 |
| Handzlik, J | 1 |
| Domínguez-Álvarez, E | 1 |
| Vesci, L | 1 |
| Milazzo, FM | 1 |
| Stasi, MA | 1 |
| Pace, S | 1 |
| Manera, F | 1 |
| Tallarico, C | 1 |
| Cini, E | 1 |
| Petricci, E | 1 |
| Manetti, F | 1 |
| De Santis, R | 1 |
| Giannini, G | 1 |
| Mohamed, OG | 1 |
| Salim, AA | 2 |
| Khalil, ZG | 2 |
| Elbanna, AH | 1 |
| Bernhardt, PV | 2 |
| Capon, RJ | 2 |
| Wu, T | 1 |
| Cui, H | 1 |
| Silva, CD | 1 |
| Ramalhete, C | 1 |
| Mulhovo, S | 1 |
| Ferreira, MU | 1 |
| Wen, C | 1 |
| Duan, Q | 1 |
| Zhang, T | 1 |
| Liu, Y | 1 |
| Wu, Y | 1 |
| Ma, K | 1 |
| Fan, P | 1 |
| Jia, W | 1 |
| Takács, D | 1 |
| Csonka, Á | 1 |
| Horváth, Á | 1 |
| Windt, T | 1 |
| Riedl, Z | 1 |
| Hajós, G | 1 |
| Amaral, L | 1 |
| Zawadzki, A | 1 |
| Liu, Q | 1 |
| Wang, Y | 1 |
| Melander, A | 1 |
| Jeppsson, B | 1 |
| Thorlacius, H | 1 |
| Takakura, Y | 1 |
| Hinoi, T | 1 |
| Oue, N | 1 |
| Sasada, T | 1 |
| Kawaguchi, Y | 1 |
| Okajima, M | 1 |
| Akyol, A | 1 |
| Fearon, ER | 1 |
| Yasui, W | 1 |
| Ohdan, H | 1 |
| Pająk, B | 1 |
| Kania, E | 1 |
| Gajkowska, B | 1 |
| Orzechowski, A | 1 |
| Ma, Q | 1 |
| Zhang, ZS | 1 |
| Zhang, YL | 1 |
| Lai, ZS | 1 |
| Cao, QZ | 1 |
| Niu, G | 1 |
| Tan, HR | 1 |
| Guichard, SM | 1 |
| Macpherson, JS | 1 |
| Thurston, DE | 1 |
| Jodrell, DI | 1 |
| Chauffert, B | 3 |
| Martin, F | 3 |
| Caignard, A | 1 |
| Jeannin, JF | 1 |
| Leclerc, A | 1 |
| Tsuruo, T | 4 |
| Iida, H | 2 |
| Naganuma, K | 1 |
| Tsukagoshi, S | 2 |
| Sakurai, Y | 2 |
| Sela, S | 1 |
| Husain, SR | 1 |
| Pearson, JW | 1 |
| Longo, DL | 1 |
| Rahman, A | 1 |
| Alvarez, M | 1 |
| Paull, K | 1 |
| Monks, A | 1 |
| Hose, C | 1 |
| Lee, JS | 1 |
| Weinstein, J | 1 |
| Grever, M | 1 |
| Bates, S | 1 |
| Fojo, T | 1 |
| Ishizuka, J | 1 |
| Bold, RJ | 1 |
| Townsend, CM | 1 |
| Thompson, JC | 1 |
| Russo, D | 1 |
| Michelutti, A | 2 |
| Melli, C | 2 |
| Damiani, D | 2 |
| Michieli, MG | 1 |
| Candoni, A | 1 |
| Zhou, DC | 1 |
| Marie, JP | 1 |
| Zittoun, R | 1 |
| Baccarani, M | 2 |
| Dong, Z | 1 |
| Radinsky, R | 1 |
| Fan, D | 1 |
| Tsan, R | 1 |
| Bucana, CD | 1 |
| Wilmanns, C | 1 |
| Fidler, IJ | 1 |
| Kunzelmann, K | 1 |
| Slotki, IN | 1 |
| Klein, P | 1 |
| Koslowsky, T | 1 |
| Ausiello, DA | 1 |
| Greger, R | 1 |
| Cabantchik, ZI | 1 |
| Mazière, JC | 1 |
| Mora, L | 1 |
| Biade, S | 1 |
| Mazière, C | 1 |
| Santus, R | 1 |
| Michieli, M | 1 |
| Cerno, M | 1 |
| Van de Vrie, W | 1 |
| Gheuens, EE | 1 |
| Durante, NM | 1 |
| De Bruijn, EA | 1 |
| Marquet, RL | 1 |
| Van Oosterom, AT | 1 |
| Eggermont, AM | 1 |
| Capolongo, L | 1 |
| Melegaro, G | 1 |
| Broggini, M | 2 |
| Mongelli, N | 1 |
| Grandi, M | 3 |
| Hamilton, G | 1 |
| Cosentini, E | 1 |
| Teleky, B | 1 |
| Bischof, G | 1 |
| Koperna, T | 1 |
| Zacherl, J | 1 |
| Schiessel, R | 1 |
| Wenzl, E | 1 |
| Scheithauer, W | 1 |
| Schenk, T | 1 |
| Czejka, M | 1 |
| Matsumoto, J | 2 |
| Minami, T | 2 |
| Sato, T | 2 |
| Onodera, T | 2 |
| Toffoli, G | 3 |
| Tumiotto, L | 2 |
| Gigante, M | 3 |
| Dall'Arche, MG | 1 |
| Perin, T | 2 |
| Boiocchi, M | 3 |
| Biscontin, G | 1 |
| Quesada, AR | 2 |
| Barbacid, MM | 1 |
| Mira, E | 1 |
| Aracil, M | 1 |
| Márquez, G | 1 |
| Baldini, N | 1 |
| Scotlandi, K | 1 |
| Serra, M | 1 |
| Shikita, T | 1 |
| Zini, N | 1 |
| Ognibene, A | 1 |
| Santi, S | 1 |
| Ferracini, R | 1 |
| Maraldi, NM | 1 |
| Schuetz, EG | 1 |
| Beck, WT | 2 |
| Schuetz, JD | 1 |
| Aherne, GW | 1 |
| Hardcastle, A | 1 |
| Valenti, M | 1 |
| Bryant, A | 1 |
| Rogers, P | 1 |
| Pettit, GR | 1 |
| Srirangam, JK | 1 |
| Kelland, LR | 1 |
| García Grávalos, MD | 1 |
| Fernández Puentes, JL | 1 |
| Pannocchia, A | 1 |
| Revelli, S | 1 |
| Tamponi, G | 1 |
| Giorgianni, A | 1 |
| Todde, R | 1 |
| Bosia, A | 1 |
| Ghigo, D | 1 |
| Corona, G | 1 |
| Tomonaga, M | 1 |
| Oka, M | 1 |
| Narasaki, F | 1 |
| Fukuda, M | 1 |
| Nakano, R | 1 |
| Takatani, H | 1 |
| Ikeda, K | 1 |
| Terashi, K | 1 |
| Matsuo, I | 1 |
| Soda, H | 1 |
| Cowan, KH | 1 |
| Kohno, S | 1 |
| Correale, P | 2 |
| Tagliaferri, P | 2 |
| Guarrasi, R | 1 |
| Caraglia, M | 1 |
| Giuliano, M | 1 |
| Marinetti, MR | 1 |
| Bianco, AR | 2 |
| Procopio, A | 1 |
| Ihnat, MA | 1 |
| Lariviere, JP | 1 |
| Warren, AJ | 1 |
| La Ronde, N | 1 |
| Blaxall, JR | 1 |
| Pierre, KM | 1 |
| Turpie, BW | 1 |
| Hamilton, JW | 1 |
| Berti, E | 1 |
| Carrara, M | 1 |
| Ragazzi, E | 1 |
| D'Ancona, S | 1 |
| Berti, T | 1 |
| Ruiz Gómez, MJ | 2 |
| Gil, L | 2 |
| Souviron, A | 2 |
| Martínez Morillo, M | 2 |
| Stephens, RH | 1 |
| O'Neill, CA | 1 |
| Warhurst, A | 1 |
| Carlson, GL | 1 |
| Rowland, M | 1 |
| Warhurst, G | 1 |
| Robey, RW | 1 |
| Honjo, Y | 1 |
| van de Laar, A | 1 |
| Miyake, K | 1 |
| Regis, JT | 1 |
| Litman, T | 1 |
| Bates, SE | 3 |
| Störmer, E | 1 |
| Shader, RI | 1 |
| Léonce, S | 1 |
| Pierré, A | 1 |
| Anstett, M | 1 |
| Pérez, V | 1 |
| Genton, A | 1 |
| Bizzari, JP | 1 |
| Atassi, G | 1 |
| Spoelstra, EC | 1 |
| Dekker, H | 1 |
| Schuurhuis, GJ | 1 |
| Broxterman, HJ | 1 |
| Lankelma, J | 1 |
| Hunter, J | 1 |
| Hirst, BH | 1 |
| Simmons, NL | 1 |
| Lai, GM | 2 |
| Moscow, JA | 1 |
| Alvarez, MG | 1 |
| Fojo, AT | 2 |
| Chen, YN | 1 |
| Mickley, LA | 1 |
| Celio, L | 1 |
| Genua, G | 1 |
| Montagnani, S | 1 |
| Rivoltini, L | 1 |
| Colombo, MP | 1 |
| Supino, R | 1 |
| Ballinari, D | 1 |
| Parmiani, G | 1 |
| Zacharski, LR | 1 |
| Moritz, TE | 1 |
| Haakenson, CM | 1 |
| O'Donnell, JF | 1 |
| Ballard, HS | 1 |
| Johnson, GJ | 1 |
| Ringenberg, QS | 1 |
| Schilsky, RL | 1 |
| Spaulding, MB | 1 |
| Tornyos, K | 1 |
| Pelletier, H | 1 |
| Corda, C | 1 |
| Solary, E | 1 |
| Bedenne, L | 1 |
| Caillot, D | 1 |
| Thimmaiah, KN | 1 |
| Horton, JK | 1 |
| Qian, XD | 1 |
| Houghton, JA | 1 |
| Houghton, PJ | 1 |
| Reinlib, L | 1 |
| Mikkelsen, R | 1 |
| Zahniser, D | 1 |
| Dharmsathaphorn, K | 1 |
| Donowitz, M | 1 |
| Ferguson, PJ | 1 |
| Cheng, YC | 1 |
| Soranzo, C | 1 |
| Ingrosso, A | 1 |
| Buffa, M | 1 |
| Della Torre, G | 1 |
| Gambetta, RA | 1 |
| Zunino, F | 1 |
| Giuliani, FC | 2 |
| Ubezio, P | 1 |
| Geroni, C | 1 |
| D'Incalci, M | 1 |
| Klohs, WD | 1 |
| Steinkampf, RW | 1 |
| Ince, P | 2 |
| Appleton, DR | 2 |
| Finney, KJ | 2 |
| Moorghen, M | 1 |
| Sunter, JP | 2 |
| Watson, AJ | 2 |
| Kramer, RA | 1 |
| Zakher, J | 1 |
| Kim, G | 1 |
| Wallace, RE | 1 |
| Lindh, D | 1 |
| Durr, FE | 1 |
| Goodman, GE | 1 |
| Yen, YP | 1 |
| Cox, TC | 1 |
| Crowley, J | 1 |
| Rey, D | 1 |
| Coudert, B | 1 |
| Dumas, M | 1 |
| Rubin, AS | 1 |
| Zablocki, AD | 1 |
| Makishima, F | 1 |
| Yamori, T | 1 |
| Kawabata, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast Cancer[NCT00001338] | Phase 3 | 65 participants | Interventional | 1993-06-30 | Completed | ||
| Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Adults and Children With Previously Untreated Patients With Aggressive Non-Hodgkin's Lymphoma[NCT00001337] | Phase 2 | 348 participants (Actual) | Interventional | 1993-05-08 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for verapamil and Colonic Neoplasms
| Article | Year |
|---|---|
Amiodarone is more efficient than verapamil in reversing resistance to anthracyclines in tumour cells.
Topics: Adenocarcinoma; Amiodarone; Animals; Antibiotics, Antineoplastic; Cell Line; Colonic Neoplasms; Dose | 1987 |
75 other studies available for verapamil and Colonic Neoplasms
| Article | Year |
|---|---|
Induction of P-glycoprotein expression by HIV protease inhibitors in cell culture.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamates; Cell Line, Tran | 2000 |
3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Dru | 2005 |
Jatrophane diterpenes from Euphorbia mellifera and their activity as P-glycoprotein modulators on multidrug-resistant mouse lymphoma and human colon adenocarcinoma cells.
Topics: Algorithms; Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colonic Neo | 2012 |
Epoxylathyrol Derivatives: Modulation of ABCB1-Mediated Multidrug Resistance in Human Colon Adenocarcinoma and Mouse T-Lymphoma Cells.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP B | 2015 |
Selenoesters and selenoanhydrides as novel multidrug resistance reversing agents: A confirmation study in a colon cancer MDR cell line.
Topics: Anhydrides; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Cell Li | 2017 |
Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dos | 2018 |
Chrysosporazines F-M: P-Glycoprotein Inhibitory Phenylpropanoid Piperazines from an Australian Marine Fish Derived Fungus,
Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Australia; Chrysosporiu | 2020 |
Glenthenamines A-F: Enamine Pyranonaphthoquinones from the Australian Pasture Plant Derived
Topics: Animals; Australia; Colonic Neoplasms; Molecular Structure; Schiff Bases; Sheep; Streptomyces | 2022 |
Triterpenes from Momordica balsamina (African pumpkin): ABCB1 inhibition and synergistic interaction with doxorubicin in resistant cancer cells.
Topics: Adenocarcinoma; Animals; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Colonic Ne | 2022 |
Studies on assessment methods of malignant ascites residue and changes of verapamil concentration in intraperitoneal perfusion chemotherapy.
Topics: Aged; Ascites; Chromatography, Liquid; Colonic Neoplasms; Female; Humans; Infusions, Parenteral; Mal | 2014 |
Reversal of ABCB1-related Multidrug Resistance of Colonic Adenocarcinoma Cells by Phenothiazines.
Topics: Adenocarcinoma; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Colonic | 2015 |
Verapamil inhibits L-type calcium channel mediated apoptosis in human colon cancer cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member | 2010 |
Verapamil-induced autophagy-like process in colon adenocarcinoma COLO 205 cells; the ultrastructural studies.
Topics: Adenocarcinoma; Apoptosis; Autophagy; Cell Line, Tumor; Cell Membrane; Chromatin; Colonic Neoplasms; | 2012 |
[Relationship between multidrug resistance in human colon carcinoma LoVo/Adr cell line and intracellular calcium ion concentration].
Topics: Calcium; Colonic Neoplasms; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Human | 2002 |
In vitro growth inhibition of human colonic tumor cells by Verapamil.
Topics: Apoptosis; Calcium Channel Blockers; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Flow Cytome | 2005 |
Influence of P-glycoprotein expression on in vitro cytotoxicity and in vivo antitumour activity of the novel pyrrolobenzodiazepine dimer SJG-136.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodiazep | 2005 |
Cytofluorescence localization of adriamycin in resistant colon cancer cells.
Topics: Animals; Biological Transport, Active; Cell Line; Cell Nucleus; Cell Survival; Colonic Neoplasms; Cy | 1984 |
Promotion by verapamil of vincristine responsiveness in tumor cell lines inherently resistant to the drug.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Synergism; | 1983 |
Reversal of multidrug resistance in human colon cancer cells expressing the human MDR1 gene by liposomes in combination with monoclonal antibody or verapamil.
Topics: Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colonic Neoplasms; | 1995 |
Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cell Surv | 1995 |
Role of calcium in the regulation of ornithine decarboxylase enzyme activity in mouse colon cancer cells.
Topics: Animals; Calcium; Calcium Channels; Calmodulin; Colonic Neoplasms; Ion Transport; Mice; Nifedipine; | 1995 |
MDR-related P170-glycoprotein modulates cytotoxic activity of homoharringtonine.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colonic Neoplasms; Cyclospo | 1995 |
Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Carrier Proteins; Colon | 1994 |
Effects of P-glycoprotein expression on cyclic AMP and volume-activated ion fluxes and conductances in HT-29 colon adenocarcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chlorides; Colforsin; Colon | 1994 |
[Potentiation of the photocytotoxic effect of photofrin II: synergistic action of verapamil and lovastatin].
Topics: Colonic Neoplasms; Dihematoporphyrin Ether; Drug Synergism; Humans; Lovastatin; Photochemotherapy; T | 1994 |
D-verapamil downmodulates P170-associated resistance to doxorubicin, daunorubicin and idarubicin.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Surv | 1993 |
In vitro and in vivo chemosensitizing effect of cyclosporin A on an intrinsic multidrug-resistant rat colon tumour.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transp | 1993 |
Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517).
Topics: Adenocarcinoma; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carr | 1993 |
Chemosensitisation effect of verapamil and cyclosporin A in vitro is reduced under acidic pH conditions.
Topics: Colonic Neoplasms; Cyclosporine; Drug Resistance; Humans; Hydrogen-Ion Concentration; Tumor Cells, C | 1993 |
Pharmacokinetic interaction between epirubicin and the multidrug resistance reverting agent D-verapamil.
Topics: Colonic Neoplasms; Drug Resistance; Epirubicin; Female; Half-Life; Humans; Male; Metabolic Clearance | 1993 |
[Hepatic arterial infusion chemotherapy combined with calcium antagonist for liver metastases].
Topics: Adult; Aged; Colonic Neoplasms; Doxorubicin; Female; Humans; Infusion Pumps, Implantable; Infusions, | 1993 |
Increased chemosensitivity to doxorubicin of intrinsically multidrug-resistant human colon carcinoma cells by prolonged exposure to verapamil.
Topics: Cell Survival; Colonic Neoplasms; Doxorubicin; Drug Resistance; Humans; Tumor Cells, Cultured; Verap | 1993 |
Doxorubicin, vincristine, and actinomycin-D, but not teniposide, require long-lasting uninterrupted verapamil pressure to overcome drug resistance in multidrug-resistant cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Dactinomycin; Doxorubi | 1993 |
Chemosensitization and drug accumulation assays as complementary methods for the screening of multidrug resistance reversal agents.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; ATP Binding C | 1996 |
Nuclear immunolocalization of P-glycoprotein in multidrug-resistant cell lines showing similar mechanisms of doxorubicin distribution.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Cel | 1995 |
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, No | 1996 |
Antitumour evaluation of dolastatins 10 and 15 and their measurement in plasma by radioimmunoassay.
Topics: Animals; Antineoplastic Agents; Carcinoma; Cell Division; Colonic Neoplasms; Cross Reactions; Depsip | 1996 |
Polyaromatic alkaloids from marine invertebrates as cytotoxic compounds and inhibitors of multidrug resistance caused by P-glycoprotein.
Topics: Adenocarcinoma; Alkaloids; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemoth | 1996 |
Reversal of doxorubicin resistance by the amiloride analogue EIPA in multidrug resistant human colon carcinoma cells.
Topics: Adenocarcinoma; Amiloride; Anti-Arrhythmia Agents; Antibiotics, Antineoplastic; Cell Division; Colon | 1996 |
Inhibition of Pgp activity and cell cycle-dependent chemosensitivity to doxorubicin in the multidrug-resistant LoVo human colon cancer cell line.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subf | 1996 |
The multidrug resistance-associated protein gene confers drug resistance in human gastric and colon cancers.
Topics: Antineoplastic Agents; Camptothecin; Cisplatin; Colonic Neoplasms; Doxorubicin; Etoposide; Genes, MD | 1996 |
Extracellular adenosine 5' triphosphate involvement in the death of LAK-engaged human tumor cells via P2X-receptor activation.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Apyrase; Calcium Channel B | 1997 |
Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter, | 1997 |
A comparison of the modulation of antiblastics cytotoxicity by verapamil and dipyridamole in a human colon carcinoma cell line.
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter | 1999 |
Multidrug resistance increment in a human colon carcinoma cell line by colchicine.
Topics: Adenocarcinoma; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colc | 2000 |
Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human intestinal epithelia.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 2001 |
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cass | 2001 |
Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure.
Topics: Adenocarcinoma; Anthracenes; Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily B, M | 2001 |
Verapamil sensitisation to alkaloids on colchicine-selected human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Cell Survival; Colchicine; Colonic Neoplasms; Dru | 2001 |
Effects of a new triazinoaminopiperidine derivative on adriamycin accumulation and retention in cells displaying P-glycoprotein-mediated multidrug resistance.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Membe | 1992 |
[A clinical trial of arterial infusion chemotherapy combined with calcium antagonist for liver metastases].
Topics: Adult; Aged; Clinical Trials as Topic; Colonic Neoplasms; Doxorubicin; Drug Synergism; Drug Therapy, | 1992 |
P-glycoprotein drug efflux pump involved in the mechanisms of intrinsic drug resistance in various colon cancer cell lines. Evidence for a saturation of active daunorubicin transport.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transpor | 1991 |
Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell | 1991 |
Contribution of glutathione and glutathione-dependent enzymes in the reversal of adriamycin resistance in colon carcinoma cell lines.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Division; Cell | 1991 |
P-glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell lines.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Colonic Neoplasms; Doxorubic | 1991 |
P-glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell lines.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Colonic Neoplasms; Doxorubic | 1991 |
P-glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell lines.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Colonic Neoplasms; Doxorubic | 1991 |
P-glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell lines.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Colonic Neoplasms; Doxorubic | 1991 |
Verapamil upregulates sensitivity of human colon and breast cancer cells to LAK-cytotoxicity in vitro.
Topics: Breast Neoplasms; Calcimycin; Calcium; Colonic Neoplasms; Cytotoxicity, Immunologic; Female; Humans; | 1991 |
Modulation of multidrug resistance by verapamil or mdr1 anti-sense oligodeoxynucleotide does not change the high susceptibility to lymphokine-activated killers in mdr-resistant human carcinoma (LoVo) line.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colonic Neoplasms; Doxorubi | 1990 |
Chronic calcium antagonist use in carcinoma of the lung and colon: a retrospective cohort observational study.
Topics: Calcium; Carcinoma, Small Cell; Cohort Studies; Colonic Neoplasms; Diltiazem; Humans; Lung Neoplasms | 1990 |
Potential usefulness of quinine to circumvent the anthracycline resistance in clinical practice.
Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Colonic Neoplasms; Drug Resistance; Drug Synerg | 1990 |
Structural determinants of phenoxazine type compounds required to modulate the accumulation of vinblastine and vincristine in multidrug-resistant cell lines.
Topics: Adenocarcinoma; Biological Transport; Cell Line; Colonic Neoplasms; Drug Resistance; HeLa Cells; Hum | 1990 |
Carbachol-induced cytosolic free Ca2+ increases in T84 colonic cells seen by microfluorimetry.
Topics: Atropine; Calcium; Carbachol; Cell Line; Colonic Neoplasms; Cytosol; Dantrolene; Egtazic Acid; Human | 1989 |
Phenotypic instability of drug sensitivity in a human colon carcinoma cell line.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colonic Neoplasms; Doxorubi | 1989 |
Changes in the three-dimensional organization of LoVo cells associated with resistance to doxorubicin.
Topics: Adenocarcinoma; Cell Aggregation; Cell Division; Colonic Neoplasms; Cyclosporins; Doxorubicin; Drug | 1989 |
Reduced cytotoxicity of tetracyclines to a multi-drug resistant human cell line.
Topics: Adenocarcinoma; Cell Division; Cell Survival; Colonic Neoplasms; Demeclocycline; Doxorubicin; Drug R | 1988 |
Intracellular doxorubicin concentrations and drug-induced DNA damage in a human colon adenocarcinoma cell line and in a drug-resistant subline.
Topics: Adenocarcinoma; Cell Line; Cell Survival; Cisplatin; Colonic Neoplasms; Cytarabine; Dactinomycin; DN | 1988 |
Possible link between the intrinsic drug resistance of colon tumors and a detoxification mechanism of intestinal cells.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Colonic Neoplasms; Drug Resistance; Drug S | 1988 |
Verapamil sensitizes normal and neoplastic rodent intestinal tissues to the stathmokinetic effect of vincristine in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dose-Response Relationsh | 1988 |
Role of the glutathione redox cycle in acquired and de novo multidrug resistance.
Topics: Animals; Carmustine; Colonic Neoplasms; Doxorubicin; Drug Resistance; Glutathione; Glutathione Perox | 1988 |
Development of resistance and characteristics of a human colon carcinoma subline resistant to mitoxantrone in vitro.
Topics: 2,4-Dinitrophenol; Carcinoma; Cell Nucleus; Colonic Neoplasms; Dinitrophenols; DNA, Neoplasm; Drug R | 1987 |
Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells.
Topics: Breast Neoplasms; Cell Survival; Clone Cells; Colonic Neoplasms; Doxorubicin; Drug Resistance; Esoph | 1987 |
[Tumor-induced platelet aggregation and growth-promoting factors as determinants of probable tumor metastasis].
Topics: Adenocarcinoma; Animals; Cell Line; Clone Cells; Colonic Neoplasms; Growth Substances; Lung Neoplasm | 1987 |
Hyperkalemia, verapamil, and dantrolene.
Topics: Colectomy; Colonic Neoplasms; Coronary Disease; Dantrolene; Drug Interactions; Humans; Hyperkalemia; | 1987 |
Verapamil increases the sensitivity of primary human colorectal carcinoma tissue to vincristine.
Topics: Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Humans; In Vit | 1986 |
Inhibition of spontaneous and experimental tumor metastasis by the calcium antagonist verapamil.
Topics: Animals; Colonic Neoplasms; Melanoma; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Metast | 1985 |