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verapamil and Colitis

verapamil has been researched along with Colitis in 7 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.

Research Excerpts

ExcerptRelevanceReference
"The results of an open clinical trial carried out between 1985 and 1989, studying the effect of calcium antagonists, particularly verapamil, on chronic diarrhea of different etiologies, are presented."9.07[The therapeutic effects of the calcium blocker verapamil in chronic diarrhea. Preliminary communication]. ( Borsari, G, 1991)
"The initial use of verapamil for the symptomatic treatment of microscopic colitis is reported."7.71Use of verapamil for the symptomatic treatment of microscopic colitis. ( Meiselman, M; Scheidler, MD, 2001)
"In our study we have tried to compare the prophylactic effects of superoxide dismutase (SOD), SOD+catalase (CAT), desferrioxamine, verapamil and disulfiram, which are all free oxygen radical (FOR) scavengers, in an animal model of experimental acetic acid colitis."7.69The prophylactic effects of superoxide dismutase, catalase, desferrioxamine, verapamil and disulfiram in experimental colitis. ( Cokneşelí, B; Köksoy, FN; Köse, H; Soybír, GR; Yalçin, O, 1997)
" To examine the possibility that, because of differential regulation of arachidonic acid metabolism, calcium channel blockade might alter mucosal eicosanoid synthesis and accelerate healing during inflammatory bowel disease, we treated a 4% acetic acid-induced colitis model with verapamil and/or misoprostol and determined the effects on colonic macroscopic injury, mucosal inflammation as measured by myeloperoxidase activity, in vivo intestinal fluid absorption, and mucosal prostaglandin E2 and leukotriene B4 (LTB4) levels as measured by in vivo rectal dialysis."7.68Verapamil alters eicosanoid synthesis and accelerates healing during experimental colitis in rats. ( Empey, LR; Fedorak, RN; Walker, K, 1992)
"Acute colitis was induced in an isolated colonic segment by instillation of 4 per cent acetic acid for 15 s; this induces a uniform colitis after 4 days."5.29Effect of putative phospholipase A2 inhibitors on acetic acid-induced acute colitis in the rat. ( Andersson, R; Ar'Rajab, A; Bengmark, S; Fabia, R; Willén, R, 1993)
"The results of an open clinical trial carried out between 1985 and 1989, studying the effect of calcium antagonists, particularly verapamil, on chronic diarrhea of different etiologies, are presented."5.07[The therapeutic effects of the calcium blocker verapamil in chronic diarrhea. Preliminary communication]. ( Borsari, G, 1991)
"In this study two calcium channel blockers (CCB), diltiazem and verapamil, which demonstrate their effects on two different receptor blockage mechanisms, were assessed comparatively in an experimental colitis model regarding the local and systemic effect spectrum."3.72The comparative effects of calcium channel blockers in an experimental colitis model in rats. ( Akgün, E; Aynaci, M; Ersin, S; Firat, O; Içöz, G; Kiliç, M; Korkut, M; Ozütemiz, O; Zeytunlu, M, 2004)
"The initial use of verapamil for the symptomatic treatment of microscopic colitis is reported."3.71Use of verapamil for the symptomatic treatment of microscopic colitis. ( Meiselman, M; Scheidler, MD, 2001)
"In our study we have tried to compare the prophylactic effects of superoxide dismutase (SOD), SOD+catalase (CAT), desferrioxamine, verapamil and disulfiram, which are all free oxygen radical (FOR) scavengers, in an animal model of experimental acetic acid colitis."3.69The prophylactic effects of superoxide dismutase, catalase, desferrioxamine, verapamil and disulfiram in experimental colitis. ( Cokneşelí, B; Köksoy, FN; Köse, H; Soybír, GR; Yalçin, O, 1997)
" To examine the possibility that, because of differential regulation of arachidonic acid metabolism, calcium channel blockade might alter mucosal eicosanoid synthesis and accelerate healing during inflammatory bowel disease, we treated a 4% acetic acid-induced colitis model with verapamil and/or misoprostol and determined the effects on colonic macroscopic injury, mucosal inflammation as measured by myeloperoxidase activity, in vivo intestinal fluid absorption, and mucosal prostaglandin E2 and leukotriene B4 (LTB4) levels as measured by in vivo rectal dialysis."3.68Verapamil alters eicosanoid synthesis and accelerates healing during experimental colitis in rats. ( Empey, LR; Fedorak, RN; Walker, K, 1992)
"Acute colitis was induced in an isolated colonic segment by instillation of 4 per cent acetic acid for 15 s; this induces a uniform colitis after 4 days."1.29Effect of putative phospholipase A2 inhibitors on acetic acid-induced acute colitis in the rat. ( Andersson, R; Ar'Rajab, A; Bengmark, S; Fabia, R; Willén, R, 1993)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (57.14)18.2507
2000's3 (42.86)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zeytunlu, M1
Korkut, M1
Akgün, E1
Firat, O1
Aynaci, M1
Içöz, G1
Kiliç, M1
Ersin, S1
Ozütemiz, O1
Fabia, R1
Ar'Rajab, A1
Willén, R1
Andersson, R1
Bengmark, S1
Köksoy, FN1
Köse, H1
Soybír, GR1
Yalçin, O1
Cokneşelí, B1
Floch, MH1
Scheidler, MD1
Meiselman, M1
Fedorak, RN1
Empey, LR1
Walker, K1
Borsari, G1

Trials

1 trial available for verapamil and Colitis

ArticleYear
[The therapeutic effects of the calcium blocker verapamil in chronic diarrhea. Preliminary communication].
    Schweizerische medizinische Wochenschrift, 1991, Aug-31, Volume: 121, Issue:35

    Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Colitis; Diarrhea; Diverticulum, Colon; Dose-Respon

1991

Other Studies

6 other studies available for verapamil and Colitis

ArticleYear
The comparative effects of calcium channel blockers in an experimental colitis model in rats.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2004, Volume: 15, Issue:4

    Topics: Animals; Calcium Channel Blockers; Colitis; Diltiazem; Disease Models, Animal; Drug Administration S

2004
Effect of putative phospholipase A2 inhibitors on acetic acid-induced acute colitis in the rat.
    The British journal of surgery, 1993, Volume: 80, Issue:9

    Topics: Acetates; Acetic Acid; Acetophenones; Animals; Colitis; Colon; Enzyme Activation; Female; Intestinal

1993
The prophylactic effects of superoxide dismutase, catalase, desferrioxamine, verapamil and disulfiram in experimental colitis.
    Journal of the Royal College of Surgeons of Edinburgh, 1997, Volume: 42, Issue:1

    Topics: Acetic Acid; Animals; Calcium Channel Blockers; Catalase; Colitis; Colonic Diseases; Deferoxamine; D

1997
Use of verapamil in the treatment of diarrhea due to microscopic colitis.
    Journal of clinical gastroenterology, 2001, Volume: 32, Issue:4

    Topics: Calcium Channel Blockers; Colitis; Diarrhea; Humans; Verapamil

2001
Use of verapamil for the symptomatic treatment of microscopic colitis.
    Journal of clinical gastroenterology, 2001, Volume: 32, Issue:4

    Topics: Aged; Aged, 80 and over; Calcium Channel Blockers; Colitis; Diarrhea; Female; Humans; Male; Middle A

2001
Verapamil alters eicosanoid synthesis and accelerates healing during experimental colitis in rats.
    Gastroenterology, 1992, Volume: 102, Issue:4 Pt 1

    Topics: Animals; Colitis; Colon; Dinoprostone; Intestinal Absorption; Leukotriene B4; Male; Peroxidase; Rats

1992