verapamil has been researched along with Colitis in 7 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results of an open clinical trial carried out between 1985 and 1989, studying the effect of calcium antagonists, particularly verapamil, on chronic diarrhea of different etiologies, are presented." | 9.07 | [The therapeutic effects of the calcium blocker verapamil in chronic diarrhea. Preliminary communication]. ( Borsari, G, 1991) |
| "The initial use of verapamil for the symptomatic treatment of microscopic colitis is reported." | 7.71 | Use of verapamil for the symptomatic treatment of microscopic colitis. ( Meiselman, M; Scheidler, MD, 2001) |
| "In our study we have tried to compare the prophylactic effects of superoxide dismutase (SOD), SOD+catalase (CAT), desferrioxamine, verapamil and disulfiram, which are all free oxygen radical (FOR) scavengers, in an animal model of experimental acetic acid colitis." | 7.69 | The prophylactic effects of superoxide dismutase, catalase, desferrioxamine, verapamil and disulfiram in experimental colitis. ( Cokneşelí, B; Köksoy, FN; Köse, H; Soybír, GR; Yalçin, O, 1997) |
| " To examine the possibility that, because of differential regulation of arachidonic acid metabolism, calcium channel blockade might alter mucosal eicosanoid synthesis and accelerate healing during inflammatory bowel disease, we treated a 4% acetic acid-induced colitis model with verapamil and/or misoprostol and determined the effects on colonic macroscopic injury, mucosal inflammation as measured by myeloperoxidase activity, in vivo intestinal fluid absorption, and mucosal prostaglandin E2 and leukotriene B4 (LTB4) levels as measured by in vivo rectal dialysis." | 7.68 | Verapamil alters eicosanoid synthesis and accelerates healing during experimental colitis in rats. ( Empey, LR; Fedorak, RN; Walker, K, 1992) |
| "Acute colitis was induced in an isolated colonic segment by instillation of 4 per cent acetic acid for 15 s; this induces a uniform colitis after 4 days." | 5.29 | Effect of putative phospholipase A2 inhibitors on acetic acid-induced acute colitis in the rat. ( Andersson, R; Ar'Rajab, A; Bengmark, S; Fabia, R; Willén, R, 1993) |
| "The results of an open clinical trial carried out between 1985 and 1989, studying the effect of calcium antagonists, particularly verapamil, on chronic diarrhea of different etiologies, are presented." | 5.07 | [The therapeutic effects of the calcium blocker verapamil in chronic diarrhea. Preliminary communication]. ( Borsari, G, 1991) |
| "In this study two calcium channel blockers (CCB), diltiazem and verapamil, which demonstrate their effects on two different receptor blockage mechanisms, were assessed comparatively in an experimental colitis model regarding the local and systemic effect spectrum." | 3.72 | The comparative effects of calcium channel blockers in an experimental colitis model in rats. ( Akgün, E; Aynaci, M; Ersin, S; Firat, O; Içöz, G; Kiliç, M; Korkut, M; Ozütemiz, O; Zeytunlu, M, 2004) |
| "The initial use of verapamil for the symptomatic treatment of microscopic colitis is reported." | 3.71 | Use of verapamil for the symptomatic treatment of microscopic colitis. ( Meiselman, M; Scheidler, MD, 2001) |
| "In our study we have tried to compare the prophylactic effects of superoxide dismutase (SOD), SOD+catalase (CAT), desferrioxamine, verapamil and disulfiram, which are all free oxygen radical (FOR) scavengers, in an animal model of experimental acetic acid colitis." | 3.69 | The prophylactic effects of superoxide dismutase, catalase, desferrioxamine, verapamil and disulfiram in experimental colitis. ( Cokneşelí, B; Köksoy, FN; Köse, H; Soybír, GR; Yalçin, O, 1997) |
| " To examine the possibility that, because of differential regulation of arachidonic acid metabolism, calcium channel blockade might alter mucosal eicosanoid synthesis and accelerate healing during inflammatory bowel disease, we treated a 4% acetic acid-induced colitis model with verapamil and/or misoprostol and determined the effects on colonic macroscopic injury, mucosal inflammation as measured by myeloperoxidase activity, in vivo intestinal fluid absorption, and mucosal prostaglandin E2 and leukotriene B4 (LTB4) levels as measured by in vivo rectal dialysis." | 3.68 | Verapamil alters eicosanoid synthesis and accelerates healing during experimental colitis in rats. ( Empey, LR; Fedorak, RN; Walker, K, 1992) |
| "Acute colitis was induced in an isolated colonic segment by instillation of 4 per cent acetic acid for 15 s; this induces a uniform colitis after 4 days." | 1.29 | Effect of putative phospholipase A2 inhibitors on acetic acid-induced acute colitis in the rat. ( Andersson, R; Ar'Rajab, A; Bengmark, S; Fabia, R; Willén, R, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zeytunlu, M | 1 |
| Korkut, M | 1 |
| Akgün, E | 1 |
| Firat, O | 1 |
| Aynaci, M | 1 |
| Içöz, G | 1 |
| Kiliç, M | 1 |
| Ersin, S | 1 |
| Ozütemiz, O | 1 |
| Fabia, R | 1 |
| Ar'Rajab, A | 1 |
| Willén, R | 1 |
| Andersson, R | 1 |
| Bengmark, S | 1 |
| Köksoy, FN | 1 |
| Köse, H | 1 |
| Soybír, GR | 1 |
| Yalçin, O | 1 |
| Cokneşelí, B | 1 |
| Floch, MH | 1 |
| Scheidler, MD | 1 |
| Meiselman, M | 1 |
| Fedorak, RN | 1 |
| Empey, LR | 1 |
| Walker, K | 1 |
| Borsari, G | 1 |
1 trial available for verapamil and Colitis
| Article | Year |
|---|---|
[The therapeutic effects of the calcium blocker verapamil in chronic diarrhea. Preliminary communication].
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Colitis; Diarrhea; Diverticulum, Colon; Dose-Respon | 1991 |
6 other studies available for verapamil and Colitis
| Article | Year |
|---|---|
The comparative effects of calcium channel blockers in an experimental colitis model in rats.
Topics: Animals; Calcium Channel Blockers; Colitis; Diltiazem; Disease Models, Animal; Drug Administration S | 2004 |
Effect of putative phospholipase A2 inhibitors on acetic acid-induced acute colitis in the rat.
Topics: Acetates; Acetic Acid; Acetophenones; Animals; Colitis; Colon; Enzyme Activation; Female; Intestinal | 1993 |
The prophylactic effects of superoxide dismutase, catalase, desferrioxamine, verapamil and disulfiram in experimental colitis.
Topics: Acetic Acid; Animals; Calcium Channel Blockers; Catalase; Colitis; Colonic Diseases; Deferoxamine; D | 1997 |
Use of verapamil in the treatment of diarrhea due to microscopic colitis.
Topics: Calcium Channel Blockers; Colitis; Diarrhea; Humans; Verapamil | 2001 |
Use of verapamil for the symptomatic treatment of microscopic colitis.
Topics: Aged; Aged, 80 and over; Calcium Channel Blockers; Colitis; Diarrhea; Female; Humans; Male; Middle A | 2001 |
Verapamil alters eicosanoid synthesis and accelerates healing during experimental colitis in rats.
Topics: Animals; Colitis; Colon; Dinoprostone; Intestinal Absorption; Leukotriene B4; Male; Peroxidase; Rats | 1992 |