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verapamil and Cirrhosis

verapamil has been researched along with Cirrhosis in 13 studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Research Excerpts

ExcerptRelevanceReference
"In previous work, we have shown that the chronic administration of verapamil, a calcium channel blocker, ameliorated the mortality, pathology, and biochemical alterations associated with acute murine Chagas' disease."5.28Effect of verapamil on the development of chronic experimental Chagas' disease. ( Bilezikian, JP; Factor, SM; Morris, SA; Tanowitz, HB; Weiss, LM; Wittner, M, 1989)
" To investigate the nature and the origin of the antihyperplastic effects, we tested topical pretreatment with pindolol, heptaminol, ATRA or verapamil against Balb/c mouse ear skin hyperplasia that was induced by TPA."3.83NO-dependent attenuation of TPA-induced immunoinflammatory skin changes in Balb/c mice by pindolol, heptaminol or ATRA, but not by verapamil. ( Cheon, SA; Chung, JF; Joo, MY; Kim, B; Kim, KH; Lee, SJ; Park, SH; Park, TJ; Seo, ES; Sood, AK; Yang, JS; Yoon, CJ, 2016)
"To investigate the effect of verapamil on the prevention of epidural fibrosis in laminectomy rats."3.80Calcium channel blockers in reduction of epidural fibrosis and dural adhesions in laminectomy rats. ( Liu, W; Wang, Y; Wang, Z; Xie, P; Zhang, S, 2014)
"These findings, consistent with a dilated cardiomyopathy, were ameliorated in the early but not in the late treatment group, demonstrating that late treatment with verapamil is ineffective in reversing the development of chagasic cardiomyopathy in chronically infected mice."1.32Effects of early and late verapamil administration on the development of cardiomyopathy in experimental chronic Trypanosoma cruzi (Brazil strain) infection. ( Chandra, M; De Souza, AP; Factor, SM; Huang, H; Jelicks, LA; Morris, SA; Shirani, J; Shtutin, V; Tanowitz, HB; Weiss, LM; Wittner, M, 2004)
"In previous work, we have shown that the chronic administration of verapamil, a calcium channel blocker, ameliorated the mortality, pathology, and biochemical alterations associated with acute murine Chagas' disease."1.28Effect of verapamil on the development of chronic experimental Chagas' disease. ( Bilezikian, JP; Factor, SM; Morris, SA; Tanowitz, HB; Weiss, LM; Wittner, M, 1989)
"The effects of cardiac hypertrophy on the structure, function and tolerance to ischemia of rat hearts have been investigated."1.27Assessment of hemodynamic function and tolerance to ischemia in the absence or presence of calcium antagonists in hearts of isoproterenol-treated, exercise-trained, and sedentary rats. ( Brinkman, CJ; Huysmans, HA; Kappetein, AP; Los, GJ; van der Laarse, A; Weening, JJ, 1988)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19903 (23.08)18.7374
1990's1 (7.69)18.2507
2000's6 (46.15)29.6817
2010's3 (23.08)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hammoud, SH1
Alkhansa, S1
Mahjoub, N1
Omar, AG1
El-Mas, MM1
Eid, AA1
Wang, Z1
Wang, Y1
Xie, P1
Liu, W1
Zhang, S1
Chung, JF1
Yoon, CJ1
Cheon, SA1
Seo, ES1
Park, SH1
Yang, JS1
Kim, B1
Joo, MY1
Park, TJ1
Kim, KH1
Sood, AK1
Lee, SJ1
Mazur, NA1
Khezheva, FM1
De Souza, AP1
Tanowitz, HB2
Chandra, M1
Shtutin, V1
Weiss, LM2
Morris, SA2
Factor, SM2
Huang, H1
Wittner, M2
Shirani, J1
Jelicks, LA1
Saggi, SJ1
Andoh, TF1
Safirstein, R1
Bennett, WM1
Stempien-Otero, A1
Plawman, A1
Meznarich, J1
Dyamenahalli, T1
Otsuka, G1
Dichek, DA1
Ziegelhöffer-Mihalovicova, B1
Arnold, N1
Marx, G1
Tannapfel, A1
Zimmer, HG1
Rassler, B1
Mantovani, F1
Patelli, E1
Colombo, F1
Sahin, M1
Başar, MM1
Bozdoğan, O1
Atan, A1
Bilezikian, JP1
Brinkman, CJ1
van der Laarse, A1
Los, GJ1
Kappetein, AP1
Weening, JJ1
Huysmans, HA1
Yamashita, T1
Kobayashi, A1
Yamazaki, N1
Miura, K1
Shirasawa, H1

Other Studies

13 other studies available for verapamil and Cirrhosis

ArticleYear
Molecular basis of the counteraction by calcium channel blockers of cyclosporine nephrotoxicity.
    American journal of physiology. Renal physiology, 2018, 09-01, Volume: 315, Issue:3

    Topics: Animals; Biomarkers; Blood Urea Nitrogen; Calcium Channel Blockers; Collagen Type IV; Creatinine; Cy

2018
Calcium channel blockers in reduction of epidural fibrosis and dural adhesions in laminectomy rats.
    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2014, Volume: 24 Suppl 1

    Topics: Animals; Calcium Channel Blockers; Cicatrix; Dura Mater; Epidural Space; Fibrosis; Hydroxyproline; I

2014
NO-dependent attenuation of TPA-induced immunoinflammatory skin changes in Balb/c mice by pindolol, heptaminol or ATRA, but not by verapamil.
    Oncotarget, 2016, Jul-26, Volume: 7, Issue:30

    Topics: Animals; Female; Fibrosis; Heptaminol; Hyperplasia; Killer Cells, Natural; Mice; Mice, Inbred BALB C

2016
[Effect of hypotensive therapy on metalloproteinase activity of the blood in patients with arterial hypertension].
    Kardiologiia, 2009, Volume: 49, Issue:2

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Enz

2009
Effects of early and late verapamil administration on the development of cardiomyopathy in experimental chronic Trypanosoma cruzi (Brazil strain) infection.
    Parasitology research, 2004, Volume: 92, Issue:6

    Topics: Animals; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Chagas Cardiomyopathy; Chagas Disease; Dis

2004
Cyclosporin induces renal proto-oncogene RNA message and increased transforming growth factor-beta prior to renal fibrosis: Modification by calcium channel blockade in the salt replete rat.
    Nephrology (Carlton, Vic.), 2004, Volume: 9, Issue:2

    Topics: Animals; Cyclosporine; DNA; DNA Fragmentation; Fibrosis; Gene Expression Regulation; Genes, Immediat

2004
Mechanisms of cardiac fibrosis induced by urokinase plasminogen activator.
    The Journal of biological chemistry, 2006, Jun-02, Volume: 281, Issue:22

    Topics: Animals; Fibrosis; Gelatinases; Heart; Humans; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout

2006
Effects of salt loading and various therapies on cardiac hypertrophy and fibrosis in young spontaneously hypertensive rats.
    Life sciences, 2006, Jul-24, Volume: 79, Issue:9

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Age

2006
[Correction of acquired penile curvatures].
    Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 1998, Volume: 70, Issue:5

    Topics: Calcinosis; Fibrosis; Humans; Male; Penile Induration; Penile Prosthesis; Penis; Prosthesis Design;

1998
Short-term histopathologic effects of different intracavernosal agents on corpus cavernosum and antifibrotic activity of intracavernosal verapamil: an experimental study.
    Urology, 2001, Volume: 58, Issue:3

    Topics: Alprostadil; Animals; Calcium Channel Blockers; Chemical and Drug Induced Liver Injury; Disease Mode

2001
Effect of verapamil on the development of chronic experimental Chagas' disease.
    The American journal of tropical medicine and hygiene, 1989, Volume: 41, Issue:6

    Topics: Adenylyl Cyclases; Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Models,

1989
Assessment of hemodynamic function and tolerance to ischemia in the absence or presence of calcium antagonists in hearts of isoproterenol-treated, exercise-trained, and sedentary rats.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 1988, Volume: 2, Issue:6

    Topics: Animals; Cardiomegaly; Cardioplegic Solutions; Creatine Kinase; Diltiazem; Fibrosis; Heart Arrest, I

1988
Effects of L-carnitine and verapamil on myocardial carnitine concentration and histopathology of Syrian hamster BIO 14.6.
    Cardiovascular research, 1986, Volume: 20, Issue:8

    Topics: Animals; Calcinosis; Cardiomyopathies; Carnitine; Cricetinae; Fibrosis; Mesocricetus; Myocardium; Ne

1986