verapamil has been researched along with Cicatrization in 12 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Cicatrization: The formation of fibrous tissue in the place of normal tissue during the process of WOUND HEALING. It includes scar tissue formation occurring in healing internal organs as well as in the skin after surface injuries.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the anti-cicatricial and anti-restenosis effect of verapamil on anterior urethral stricture." | 9.27 | [Anti-cicatricial and anti-restenosis effect of verapamil on anterior urethral stricture: A randomized controlled clinical trial]. ( Liao, J; Tang, Z; Tian, T; Xue, R, 2018) |
| "A double-blind randomized controlled trial with a paired split-scar design compared verapamil, an L-type Ca2+ channel antagonist, and triamcinolone for prevention of keloid recurrence after excision." | 9.22 | Verapamil is Less Effective than Triamcinolone for Prevention of Keloid Scar Recurrence After Excision in a Randomized Controlled Trial. ( Alghamdi, M; Danielsen, PL; Fear, MW; Gankande, TU; Hool, LC; Manzur, M; Rea, SM; Stevenson, AW; Viola, HM; Wallace, HJ; Wood, FM, 2016) |
| "To evaluate the anti-cicatricial and anti-restenosis effect of verapamil on anterior urethral stricture." | 5.27 | [Anti-cicatricial and anti-restenosis effect of verapamil on anterior urethral stricture: A randomized controlled clinical trial]. ( Liao, J; Tang, Z; Tian, T; Xue, R, 2018) |
| "A double-blind randomized controlled trial with a paired split-scar design compared verapamil, an L-type Ca2+ channel antagonist, and triamcinolone for prevention of keloid recurrence after excision." | 5.22 | Verapamil is Less Effective than Triamcinolone for Prevention of Keloid Scar Recurrence After Excision in a Randomized Controlled Trial. ( Alghamdi, M; Danielsen, PL; Fear, MW; Gankande, TU; Hool, LC; Manzur, M; Rea, SM; Stevenson, AW; Viola, HM; Wallace, HJ; Wood, FM, 2016) |
| "The aim of this research was to investigate the impact of calcium channel blockers (verapamil) on the formation of scars in the sciatic nerve anastomosis after peripheral nerve injury." | 3.83 | Inhibition of Peripheral Nerve Scarring by Calcium Antagonists, Also Known as Calcium Channel Blockers. ( Jiang, YT; Jiao, JB; Li, CY; Ling, L; Liu, XF; Xue, JW; Yang, G; Yin, WT, 2016) |
| "To investigate the effect of verapamil on the prevention of epidural fibrosis in laminectomy rats." | 3.80 | Calcium channel blockers in reduction of epidural fibrosis and dural adhesions in laminectomy rats. ( Liu, W; Wang, Y; Wang, Z; Xie, P; Zhang, S, 2014) |
| "For atrophic scars, different types of lasers represent modern treatment modalities with satisfactory results." | 2.42 | Novel opportunities in the treatment and prevention of scarring. ( Berman, B; Ramirez, CC; Villa, AM, 2004) |
| "Treatment of verapamil inhibits TGF-β1 induced collagen production via inhibiting CaMK II." | 1.62 | Verapamil inhibits ureteral scar formation by regulating CaMK II-mediated Smad pathway. ( Gao, ZY; Guo, X; Li, YW; Lu, Q; Wang, JS; Xiao, W; Yang, K; Yuan, WX; Zeng, MQ, 2021) |
| "The formation of hypertrophic scaring (HSc) is an abnormal wound-healing response." | 1.46 | A Comparison of Gene Expression of Decorin and MMP13 in Hypertrophic Scars Treated With Calcium Channel Blocker, Steroid, and Interferon: A Human-Scar-Carrying Animal Model Study. ( Chuang, SS; Hsiao, YC; Yang, JY; Yang, SY, 2017) |
| "Autohemoperitoneum was simulated by intraperitoneal administration of autoblood (group 1)." | 1.36 | [Effect of verapamil on production of anti-inflammatory cytokines by peritoneal mononuclears]. ( Skal'skiĭ, SV, 2010) |
| "Scarring was documented in one patient." | 1.29 | Intracavernous self-injection of papaverine and verapamil: a clinical experience. ( Bolayir, K; Gökşin, N, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Zeng, MQ | 1 |
| Xiao, W | 1 |
| Yang, K | 1 |
| Gao, ZY | 1 |
| Wang, JS | 1 |
| Lu, Q | 1 |
| Guo, X | 1 |
| Li, YW | 1 |
| Yuan, WX | 1 |
| Xue, R | 2 |
| Liao, J | 1 |
| Tian, T | 1 |
| Tang, Z | 2 |
| Zarbin, MA | 1 |
| Wang, Z | 1 |
| Wang, Y | 1 |
| Xie, P | 1 |
| Liu, W | 1 |
| Zhang, S | 1 |
| Xue, JW | 1 |
| Jiao, JB | 1 |
| Liu, XF | 1 |
| Jiang, YT | 1 |
| Yang, G | 1 |
| Li, CY | 1 |
| Yin, WT | 1 |
| Ling, L | 1 |
| Danielsen, PL | 1 |
| Rea, SM | 1 |
| Wood, FM | 1 |
| Fear, MW | 1 |
| Viola, HM | 1 |
| Hool, LC | 1 |
| Gankande, TU | 1 |
| Alghamdi, M | 1 |
| Stevenson, AW | 1 |
| Manzur, M | 1 |
| Wallace, HJ | 1 |
| Yang, SY | 1 |
| Yang, JY | 1 |
| Hsiao, YC | 1 |
| Chuang, SS | 1 |
| Zeng, M | 1 |
| Chen, J | 1 |
| Huang, L | 1 |
| Xiang, X | 1 |
| Zeng, F | 1 |
| Wang, G | 1 |
| Brock, G | 1 |
| Skal'skiĭ, SV | 1 |
| Berman, B | 1 |
| Villa, AM | 1 |
| Ramirez, CC | 1 |
| Bolayir, K | 1 |
| Gökşin, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intra-lesional ACE Inhibitor for Treatment of Hypertrophic Scars[NCT05259137] | Phase 2/Phase 3 | 30 participants (Anticipated) | Interventional | 2023-08-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for verapamil and Cicatrization
| Article | Year |
|---|---|
Novel opportunities in the treatment and prevention of scarring.
Topics: Bleomycin; Botulinum Toxins, Type A; Celecoxib; Cicatrix; Fluorouracil; Humans; Immunosuppressive Ag | 2004 |
2 trials available for verapamil and Cicatrization
| Article | Year |
|---|---|
[Anti-cicatricial and anti-restenosis effect of verapamil on anterior urethral stricture: A randomized controlled clinical trial].
Topics: Anastomosis, Surgical; Cicatrix; Dilatation; Humans; Male; Penis; Postoperative Complications; Secon | 2018 |
Verapamil is Less Effective than Triamcinolone for Prevention of Keloid Scar Recurrence After Excision in a Randomized Controlled Trial.
Topics: Adolescent; Adult; Cicatrix; Double-Blind Method; Female; Glucocorticoids; Humans; Injections, Intra | 2016 |
9 other studies available for verapamil and Cicatrization
| Article | Year |
|---|---|
Verapamil inhibits ureteral scar formation by regulating CaMK II-mediated Smad pathway.
Topics: Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Cicatrix; Collagen Type I; Coll | 2021 |
Combination therapy to reduce conjunctival scarring after glaucoma surgery.
Topics: Alkylating Agents; Apoptosis; Calcium Channel Blockers; Cicatrix; Conjunctival Diseases; Cyclosporin | 2013 |
Calcium channel blockers in reduction of epidural fibrosis and dural adhesions in laminectomy rats.
Topics: Animals; Calcium Channel Blockers; Cicatrix; Dura Mater; Epidural Space; Fibrosis; Hydroxyproline; I | 2014 |
Inhibition of Peripheral Nerve Scarring by Calcium Antagonists, Also Known as Calcium Channel Blockers.
Topics: Anastomosis, Surgical; Animals; Calcium Channel Blockers; Cicatrix; Collagen Type I; Male; Periphera | 2016 |
A Comparison of Gene Expression of Decorin and MMP13 in Hypertrophic Scars Treated With Calcium Channel Blocker, Steroid, and Interferon: A Human-Scar-Carrying Animal Model Study.
Topics: Adolescent; Adult; Animals; Burns; Calcium Channel Blockers; Child; Child, Preschool; Cicatrix; Cica | 2017 |
[Effect of calcium channel blockers on primary cultured human urethra scar fibroblasts].
Topics: Calcium Channel Blockers; Cell Proliferation; Cells, Cultured; Cicatrix; Fibroblasts; Humans; Matrix | 2016 |
Clinical case: 45-year-old male with penile pain (CME).
Topics: Anthropometry; Cicatrix; Erectile Dysfunction; Humans; Male; Middle Aged; Penile Induration; Phospho | 2009 |
[Effect of verapamil on production of anti-inflammatory cytokines by peritoneal mononuclears].
Topics: Animals; Calcium Channel Blockers; Cicatrix; Cytokines; Hemoperitoneum; Macrophages, Peritoneal; Mal | 2010 |
Intracavernous self-injection of papaverine and verapamil: a clinical experience.
Topics: Adult; Aged; Cicatrix; Drug Combinations; Erectile Dysfunction; Hematoma; Humans; Injections; Male; | 1994 |