verapamil has been researched along with Chemical and Drug Induced Liver Injury in 29 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 56-year-old female patient on verapamil for hypertension experienced two episodes of jaundice, pruritus and upper abdominal pain with transaminase elevated up to six-fold and alkaline phosphatase up to four-fold when inadvertently re-challenged with the drug." | 3.67 | Liver injury due to verapamil. ( Abernethy, DR; Burgunder, JM; Lauterburg, BH, 1988) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "Verapamil treatment reversed the progesterone enhanced Cd cytolethality." | 1.32 | Involvement of calcium channels in the sexual dimorphism of cadmium-induced hepatotoxicity. ( Baker, TK; Carfagna, MA; Smith, WC; VanVooren, HB, 2003) |
| "Verapamil pretreatment increased the protein synthesis activity at both levels of granular endoplasmic reticulum and free polysomes in cytoplasm and decreased ATPase activity." | 1.31 | Evaluation of calcium channel blockers as potential hepatoprotective agents in oxidative stress injury of perfused hepatocytes. ( Farghali, H; Kmonícková, E; Lotková, H; Martínek, J, 2000) |
| "Pretreatment with verapamil reduced the increase of ALT in plasma and the morphological signs of necrosis induced by AA administration." | 1.29 | Effect of verapamil on allyl alcohol hepatotoxicity. ( Atzori, L; Congiu, L, 1996) |
| "Pretreatment of galactosamine/TNF-alpha-injured mice with 800 mg/kg uridine or with 6 mg/kg calmidazolium fully protected the animals, while administration of either verapamil or nifedipine (100 mg/kg, respectively) had no significant effect." | 1.28 | Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice. ( Tiegs, G; Wendel, A; Wolter, M, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (31.03) | 18.7374 |
| 1990's | 4 (13.79) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 10 (34.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 3 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Xie, SS | 1 |
| Lan, JS | 1 |
| Wang, XB | 1 |
| Jiang, N | 1 |
| Dong, G | 1 |
| Li, ZR | 1 |
| Wang, KD | 1 |
| Guo, PP | 1 |
| Kong, LY | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Mohamed, MZ | 1 |
| Hafez, HM | 1 |
| Hassan, M | 1 |
| Ibrahim, MA | 1 |
| He, K | 1 |
| Cai, L | 1 |
| Liu, H | 1 |
| Woolf, TF | 1 |
| Baker, TK | 1 |
| VanVooren, HB | 1 |
| Smith, WC | 1 |
| Carfagna, MA | 1 |
| Manov, I | 1 |
| Motanis, H | 1 |
| Frumin, I | 1 |
| Iancu, TC | 1 |
| Kaplan, N | 1 |
| Yagmurdur, H | 1 |
| Kilinc, K | 1 |
| Baltaci, B | 1 |
| Tezel, S | 1 |
| Kolts, BE | 1 |
| Langfitt, M | 1 |
| Guarascio, P | 1 |
| D'Amato, C | 1 |
| Sette, P | 1 |
| Conte, A | 1 |
| Visco, G | 1 |
| Nash, DT | 1 |
| Feer, TD | 1 |
| Stern, EH | 1 |
| Pitchon, R | 1 |
| King, BD | 1 |
| Wiener, I | 1 |
| Brodsky, SJ | 1 |
| Cutler, SS | 1 |
| Weiner, DA | 1 |
| Klein, MD | 1 |
| Kumar, KL | 1 |
| Colley, CA | 1 |
| de Arriba, G | 1 |
| Garcia-Martin, F | 1 |
| Sánchez-Heras, M | 1 |
| Aldeguer, M | 1 |
| Tejero, E | 1 |
| Jarillo, MD | 1 |
| Atzori, L | 1 |
| Congiu, L | 1 |
| Van Molle, W | 1 |
| Vanden Berghe, J | 1 |
| Brouckaert, P | 1 |
| Libert, C | 1 |
| Farghali, H | 1 |
| Kmonícková, E | 1 |
| Lotková, H | 1 |
| Martínek, J | 1 |
| Sahin, M | 1 |
| Başar, MM | 1 |
| Bozdoğan, O | 1 |
| Atan, A | 1 |
| Robles, NR | 1 |
| García Díaz, MC | 1 |
| Fernández Mora, G | 1 |
| Sánchez Casado, E | 1 |
| Tiegs, G | 1 |
| Wolter, M | 1 |
| Wendel, A | 1 |
| Burgunder, JM | 1 |
| Abernethy, DR | 1 |
| Lauterburg, BH | 1 |
| Veluvolu, P | 1 |
| Whalen, JP | 1 |
| Collier, BD | 1 |
| Friedman, B | 1 |
| Hare, DL | 1 |
| Horowitz, JD | 1 |
2 reviews available for verapamil and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Ster | 2006 |
27 other studies available for verapamil and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.
Topics: Alzheimer Disease; Animals; Antioxidants; Biphenyl Compounds; Blood-Brain Barrier; Cell Survival; Ch | 2015 |
PI3K/Akt and Nrf2/HO-1 pathways involved in the hepatoprotective effect of verapamil against thioacetamide toxicity in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Calcium Channel Blockers; Chemical and Drug Induced | 2019 |
Inhibition of MDR3 Activity in Human Hepatocytes by Drugs Associated with Liver Injury.
Topics: ATP Binding Cassette Transporter, Subfamily B; Cells, Cultured; Chemical and Drug Induced Liver Inju | 2015 |
Involvement of calcium channels in the sexual dimorphism of cadmium-induced hepatotoxicity.
Topics: Algorithms; Animals; Cadmium Poisoning; Calcium Channel Blockers; Calcium Channels; Cell Death; Cell | 2003 |
The protective effects of intravenous anesthetics and verapamil in gut ischemia/reperfusion-induced liver injury.
Topics: Anesthetics, Intravenous; Animals; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination | 2007 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |
Liver damage from verapamil.
Topics: Angina Pectoris; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Humans; Male; Middle | 1984 |
Hepatic injury possibly induced by verapamil.
Topics: Alkaline Phosphatase; Chemical and Drug Induced Liver Injury; Female; Humans; Hypertension; Liver; L | 1983 |
Possible hepatitis from verapamil.
Topics: Chemical and Drug Induced Liver Injury; Humans; Male; Middle Aged; Verapamil | 1982 |
Hepatotoxicity due to treatment with verapamil.
Topics: Angina Pectoris; Chemical and Drug Induced Liver Injury; Double-Blind Method; Humans; Liver Function | 1981 |
Verapamil-induced hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Cluster Headache; Humans; Male; Middle Aged; Verapamil | 1994 |
Hepatotoxicity due to verapamil hydrochloride.
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Humans; Male; Middle Aged; Verapamil | 1993 |
Effect of verapamil on allyl alcohol hepatotoxicity.
Topics: 1-Propanol; Alanine Transaminase; Alcohol Dehydrogenase; Animals; Calcium Channel Blockers; Chemical | 1996 |
Tumor necrosis factor-induced lethal hepatitis: pharmacological intervention with verapamil, tannic acid, picotamide and K76COOH.
Topics: Alanine Transaminase; Animals; Apoptosis; Astringents; Chemical and Drug Induced Liver Injury; Compl | 2000 |
Evaluation of calcium channel blockers as potential hepatoprotective agents in oxidative stress injury of perfused hepatocytes.
Topics: Adenosine Triphosphatases; Animals; Calcium Channel Blockers; Chemical and Drug Induced Liver Injury | 2000 |
Short-term histopathologic effects of different intracavernosal agents on corpus cavernosum and antifibrotic activity of intracavernosal verapamil: an experimental study.
Topics: Alprostadil; Animals; Calcium Channel Blockers; Chemical and Drug Induced Liver Injury; Disease Mode | 2001 |
[Poisoning by delayed-release verapamil in an uremic patient].
Topics: Chemical and Drug Induced Liver Injury; Delayed-Action Preparations; Dose-Response Relationship, Dru | 1992 |
Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice.
Topics: Allopurinol; Animals; Chemical and Drug Induced Liver Injury; Eicosanoic Acids; Endotoxins; Epoprost | 1989 |
Liver injury due to verapamil.
Topics: Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Female; Humans; Hypertension; Mid | 1988 |
Scintigraphic demonstration of hepatocellular damage after verapamil toxicity.
Topics: Chemical and Drug Induced Liver Injury; Humans; Male; Middle Aged; Radionuclide Imaging; Verapamil | 1988 |
Verapamil hepatotoxicity: a hypersensitivity reaction.
Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Liver Diseases; | 1986 |