verapamil has been researched along with Cardiomegaly in 79 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Male Wistar rats were submitted to two kidneys, one clip (2K1C) model of hypertension or sham surgery and were treated with verapamil (VRP, 8 mg/kg/bid) by gavage from the second to tenth week post-surgery." | 7.96 | Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats. ( Blascke de Mello, MM; Castro, MM; Fazan, R; Mendes, AS; Neto-Neves, EM; Omoto, ACM; Parente, JM; Tanus-Santos, JE, 2020) |
| "The effects of propranolol and verapamil on contractile dysfunction, subcellular remodeling and changes in gene expression in cardiac hypertrophy due to pressure overload were examined." | 7.70 | Attenuation of changes in sarcoplasmic reticular gene expression in cardiac hypertrophy by propranolol and verapamil. ( Dhalla, NS; Elmoselhi, AB; Goel, R; Sentex, E; Takeo, S; Wang, J, 2000) |
| "We evaluated the effect of verapamil therapy on left ventricular hypertrophy and left ventricular diastolic function in 13 patients with mild to moderate hypertension." | 7.68 | Improvement in left ventricular hypertrophy and left ventricular diastolic function following verapamil therapy in mild to moderate hypertension. ( Conte, D; Douste-Blazy, MY; Galinier, F; Granier, P; Tredez, P, 1990) |
| "To assess the role of verapamil (VER)-sensitive calcium (Ca2+) channels in the regional development and pathogenesis of isoproterenol (ISO)-induced cardiac hypertrophy, male Fischer rats (150-175 g, N = 51) were divided into control (C) and ISO-treated (I) and VER (V1, 100 mg/L drinking water; V2, 10 mg/kg ip twice daily) and no-VER subgroups." | 7.68 | Verapamil does not prevent isoproterenol-induced cardiac hypertrophy. ( Allard, MF; Bishop, SP; Doss, LK, 1990) |
| "A case with a verapamil-sensitive ventricular tachycardia showing right bundle branch block pattern and left axis deviation is described." | 7.67 | Persistent ventricular tachycardia resulting in left ventricular dilatation treated with verapamil. ( Nieminen, M; Toivonen, L, 1986) |
| "The effects of long-term treatment with verapamil on blood pressure, cardiac hypertrophy and collagen content, collagen concentration and prolyl hydroxylase activity were studied in spontaneously hypertensive rats (SHR)." | 7.67 | Effects of long-term verapamil treatment on blood pressure, cardiac hypertrophy and collagen metabolism in spontaneously hypertensive rats. ( Ruskoaho, HJ; Savolainen, ER, 1985) |
| "Nifedipine was used successfully in nine patients with refractory hypertension and left ventricular hypertrophy who had symptoms of congestive heart failure despite preserved left ventricular systolic function." | 7.67 | Nifedipine in severely hypertensive patients with congestive heart failure and preserved ventricular systolic function. ( Dzau, VJ; Given, BD; Lee, TH; Stone, PH, 1985) |
| "Adult male Wistar rats were used for studying the effect of Ca2+ antagonist verapamil on pulmonary hypertension, right ventricular hypertrophy and the medial thickness of pulmonary arterioles, induced by intermittent high altitude (IHA) hypoxia." | 7.66 | Effect of verapamil on pulmonary hypertension and right ventricular hypertrophy induced in rats by intermittent high altitude hypoxia. ( Ostádal, B; Pelouch, V; Procházka, J; Ressl, J; Urbanová, D; Widimský, J, 1981) |
| " Verapamil heart tissue and plasma levels after intraperitoneal dosing of spontaneously hypertensive and normotensive rats were investigated." | 5.36 | Impaired tissue clearance of verapamil in rat cardiac hypertrophy results in transcriptional repression of ion channels. ( Borlak, J; Zwadlo, C, 2010) |
| "Treatment with Verapamil or aspirin reduced both chronic hypoxic pulmonary hypertension and the hypertrophy of the right ventricle." | 5.26 | Effects of verapamil and aspirin on experimental chronic hypoxic pulmonary hypertension and right ventricular hypertrophy in rats. ( Kentera, D; Susić, D; Zdravković, M, 1979) |
| "Male Wistar rats were submitted to two kidneys, one clip (2K1C) model of hypertension or sham surgery and were treated with verapamil (VRP, 8 mg/kg/bid) by gavage from the second to tenth week post-surgery." | 3.96 | Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats. ( Blascke de Mello, MM; Castro, MM; Fazan, R; Mendes, AS; Neto-Neves, EM; Omoto, ACM; Parente, JM; Tanus-Santos, JE, 2020) |
| " The pharmacokinetics of verapamil and of one of its metabolites, norverapamil, is changed after multiple oral dosing as has been described in patients with supraventricular tachyarrhythmias, angina pectoris or in patients with essential hypertension." | 3.76 | Pharmacokinetics of calcium channel blocking agents. ( Anderson, P, 1986) |
| "Both RyR2 and SERCA mRNA level in L-thyroxin-induced cardiac hypertrophy was over-expressed and propranolol or verapamil inhibited the alteration." | 3.72 | Propranolol and verapamil inhibit mRNA expression of RyR2 and SERCA in L-thyroxin-induced rat ventricular hypertrophy. ( Dai, DZ; Gao, F; Wu, XD; Zhang, QP, 2004) |
| "We investigated the potential of chronic administration of an oral daily dose (10 mg/kg) of the dietary flavonoid quercetin to prevent hypertension and oxidative stress induced by deoxycorticosterone acetate (DOCA)-salt in rats." | 3.72 | Effects of chronic quercetin treatment on antioxidant defence system and oxidative status of deoxycorticosterone acetate-salt-hypertensive rats. ( Duarte, J; Galisteo, M; García-Saura, MF; Jiménez, R; Vargas, F; Villar, IC; Zarzuelo, A, 2004) |
| "Calcium channel blockers, verapamil or felodipine, were given to genetically obese 6 and 11-month-old female SHHF/Mcc-facp (SHHF: Spontaneous Hypertension Heart Failure) rats for 8 weeks to investigate their effects on glucose and lipid metabolism and obesity." | 3.70 | Comparison of verapamil and felodipine treatment on lipid and glucose metabolism in obese female SHHF/Mcc-facp rats. ( Hoepf, T; McCune, SA; Park, SC; Radin, MJ, 1999) |
| "The effects of propranolol and verapamil on contractile dysfunction, subcellular remodeling and changes in gene expression in cardiac hypertrophy due to pressure overload were examined." | 3.70 | Attenuation of changes in sarcoplasmic reticular gene expression in cardiac hypertrophy by propranolol and verapamil. ( Dhalla, NS; Elmoselhi, AB; Goel, R; Sentex, E; Takeo, S; Wang, J, 2000) |
| "The aim of the present study was to define the protective effects of verapamil and nifedipine on mechanical performance and energy and substrate metabolism of the postischemically reperfused myocardium in a chronic pressure overload cardiac hypertrophy model." | 3.68 | Protective effects of calcium antagonists on energy and substrate metabolism during ischemia and reperfusion in hypertensive myocardial hypertrophy. ( Buser, PT; Higgins, CB; Wagner, S; Wikman-Coffelt, J; Wu, S, 1991) |
| "We evaluated the effect of verapamil therapy on left ventricular hypertrophy and left ventricular diastolic function in 13 patients with mild to moderate hypertension." | 3.68 | Improvement in left ventricular hypertrophy and left ventricular diastolic function following verapamil therapy in mild to moderate hypertension. ( Conte, D; Douste-Blazy, MY; Galinier, F; Granier, P; Tredez, P, 1990) |
| "To assess the role of verapamil (VER)-sensitive calcium (Ca2+) channels in the regional development and pathogenesis of isoproterenol (ISO)-induced cardiac hypertrophy, male Fischer rats (150-175 g, N = 51) were divided into control (C) and ISO-treated (I) and VER (V1, 100 mg/L drinking water; V2, 10 mg/kg ip twice daily) and no-VER subgroups." | 3.68 | Verapamil does not prevent isoproterenol-induced cardiac hypertrophy. ( Allard, MF; Bishop, SP; Doss, LK, 1990) |
| "A case with a verapamil-sensitive ventricular tachycardia showing right bundle branch block pattern and left axis deviation is described." | 3.67 | Persistent ventricular tachycardia resulting in left ventricular dilatation treated with verapamil. ( Nieminen, M; Toivonen, L, 1986) |
| "1 mg/kg verapamil on left ventricular (LV) diastolic mechanics was evaluated in ten patients with hypertrophic cardiomyopathy and 13 patients with aortic stenosis." | 3.67 | Influence of verapamil on diastolic left ventricular function in myocardial hypertrophy of different origin. ( Hess, OM; Krayenbühl, HP; Murakami, T, 1987) |
| "The effects of long-term treatment with verapamil on blood pressure, cardiac hypertrophy and collagen content, collagen concentration and prolyl hydroxylase activity were studied in spontaneously hypertensive rats (SHR)." | 3.67 | Effects of long-term verapamil treatment on blood pressure, cardiac hypertrophy and collagen metabolism in spontaneously hypertensive rats. ( Ruskoaho, HJ; Savolainen, ER, 1985) |
| "Nifedipine was used successfully in nine patients with refractory hypertension and left ventricular hypertrophy who had symptoms of congestive heart failure despite preserved left ventricular systolic function." | 3.67 | Nifedipine in severely hypertensive patients with congestive heart failure and preserved ventricular systolic function. ( Dzau, VJ; Given, BD; Lee, TH; Stone, PH, 1985) |
| "Adult male Wistar rats were used for studying the effect of Ca2+ antagonist verapamil on pulmonary hypertension, right ventricular hypertrophy and the medial thickness of pulmonary arterioles, induced by intermittent high altitude (IHA) hypoxia." | 3.66 | Effect of verapamil on pulmonary hypertension and right ventricular hypertrophy induced in rats by intermittent high altitude hypoxia. ( Ostádal, B; Pelouch, V; Procházka, J; Ressl, J; Urbanová, D; Widimský, J, 1981) |
| "Atenolol did not produce a reduction in the left-ventricular-mass index (109 +/- 9 g per square meter before treatment vs." | 2.67 | The effects of antihypertensive therapy on left ventricular mass in elderly patients. ( Becker, LC; Gerstenblith, G; Gottlieb, SO; Schulman, SP; Weisfeldt, ML; Weiss, JL; Woodruff, KM, 1990) |
| "Verapamil was discontinued in 2 patients who developed severe dyspnea at rest after 3-4 days of continued oral treatment." | 2.65 | Clinical use of calcium channel blockers as ventricular unloading agents. ( Agostoni, PG; Cipolla, C; Fabbiocchi, F; Guazzi, MD; Pepi, M; Sganzerla, P, 1983) |
| " Verapamil heart tissue and plasma levels after intraperitoneal dosing of spontaneously hypertensive and normotensive rats were investigated." | 1.36 | Impaired tissue clearance of verapamil in rat cardiac hypertrophy results in transcriptional repression of ion channels. ( Borlak, J; Zwadlo, C, 2010) |
| "Thus, the rapid development of cardiac hypertrophy in the norepinephrine model seems to be directly mediated by stimulation of myocardial alpha- and beta-adrenoceptors rather than by hemodynamic changes." | 1.28 | Significance of myocardial alpha- and beta-adrenoceptors in catecholamine-induced cardiac hypertrophy. ( Zierhut, W; Zimmer, HG, 1989) |
| "The effects of cardiac hypertrophy on the structure, function and tolerance to ischemia of rat hearts have been investigated." | 1.27 | Assessment of hemodynamic function and tolerance to ischemia in the absence or presence of calcium antagonists in hearts of isoproterenol-treated, exercise-trained, and sedentary rats. ( Brinkman, CJ; Huysmans, HA; Kappetein, AP; Los, GJ; van der Laarse, A; Weening, JJ, 1988) |
| "Treatment with Verapamil or aspirin reduced both chronic hypoxic pulmonary hypertension and the hypertrophy of the right ventricle." | 1.26 | Effects of verapamil and aspirin on experimental chronic hypoxic pulmonary hypertension and right ventricular hypertrophy in rats. ( Kentera, D; Susić, D; Zdravković, M, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (56.96) | 18.7374 |
| 1990's | 21 (26.58) | 18.2507 |
| 2000's | 8 (10.13) | 29.6817 |
| 2010's | 3 (3.80) | 24.3611 |
| 2020's | 2 (2.53) | 2.80 |
| Authors | Studies |
|---|---|
| De Jong, HN | 1 |
| Dewey, FE | 1 |
| Cordero, P | 1 |
| Victorio, RA | 1 |
| Kirillova, A | 1 |
| Huang, Y | 1 |
| Madhvani, R | 1 |
| Seo, K | 1 |
| Werdich, AA | 1 |
| Lan, F | 1 |
| Orcholski, M | 1 |
| Liu, WR | 1 |
| Erbilgin, A | 1 |
| Wheeler, MT | 1 |
| Chen, R | 1 |
| Pan, S | 1 |
| Kim, YM | 1 |
| Bommakanti, K | 1 |
| Marcou, CA | 1 |
| Bos, JM | 1 |
| Haddad, F | 1 |
| Ackerman, M | 1 |
| Vasan, RS | 1 |
| MacRae, C | 1 |
| Wu, JC | 1 |
| de Jesus Perez, V | 1 |
| Snyder, M | 1 |
| Parikh, VN | 1 |
| Ashley, EA | 1 |
| Mendes, AS | 1 |
| Blascke de Mello, MM | 1 |
| Parente, JM | 1 |
| Omoto, ACM | 1 |
| Neto-Neves, EM | 1 |
| Fazan, R | 1 |
| Tanus-Santos, JE | 1 |
| Castro, MM | 1 |
| Benhenda, N | 1 |
| Bernard-Brunet, A | 1 |
| Ferrandière, M | 1 |
| Salamé, E | 1 |
| Babuty, D | 1 |
| Carlson, C | 1 |
| Koonce, C | 1 |
| Aoyama, N | 1 |
| Einhorn, S | 1 |
| Fiene, S | 1 |
| Thompson, A | 1 |
| Swanson, B | 1 |
| Anson, B | 1 |
| Kattman, S | 1 |
| Zwadlo, C | 1 |
| Borlak, J | 1 |
| BIEHLER, W | 1 |
| Wu, XD | 1 |
| Dai, DZ | 1 |
| Zhang, QP | 1 |
| Gao, F | 1 |
| Galisteo, M | 1 |
| García-Saura, MF | 1 |
| Jiménez, R | 1 |
| Villar, IC | 1 |
| Zarzuelo, A | 1 |
| Vargas, F | 1 |
| Duarte, J | 1 |
| Frolov, VA | 1 |
| Drozdova, GA | 1 |
| Rieger, P | 1 |
| Blagonravov, M | 1 |
| Ziegelhöffer-Mihalovicova, B | 1 |
| Arnold, N | 1 |
| Marx, G | 1 |
| Tannapfel, A | 1 |
| Zimmer, HG | 2 |
| Rassler, B | 1 |
| Massie, BM | 1 |
| Hirsch, AT | 1 |
| Inouye, IK | 1 |
| Tubau, JF | 1 |
| Opie, LH | 1 |
| Lampa, E | 1 |
| Rossi, F | 1 |
| Aliperta, A | 1 |
| Giordano, L | 1 |
| Perna, D | 1 |
| Catena, E | 1 |
| Marmo, E | 1 |
| Sloan, RW | 1 |
| Karlsberg, RP | 1 |
| Aronow, WS | 1 |
| Guazzi, MD | 3 |
| Cipolla, C | 1 |
| Sganzerla, P | 1 |
| Agostoni, PG | 2 |
| Fabbiocchi, F | 1 |
| Pepi, M | 2 |
| Kuhn, H | 1 |
| Gietzen, F | 1 |
| Mercier, J | 1 |
| Lösse, B | 1 |
| Köhler, E | 1 |
| Schulte, HD | 1 |
| Bircks, W | 1 |
| Loogen, F | 1 |
| Fyke, FE | 1 |
| Vlietstra, RE | 1 |
| Danielson, GK | 1 |
| Beynen, FM | 1 |
| Loaldi, A | 1 |
| Fiorentini, C | 1 |
| Grazi, S | 1 |
| Della Bella, P | 1 |
| Dukes, ID | 1 |
| Vaughan Williams, EM | 1 |
| Kisliak, OA | 1 |
| Storozhakov, GI | 1 |
| Ewy, GA | 1 |
| Hanrath, P | 1 |
| Mathey, DG | 1 |
| Siegert, R | 1 |
| Bleifeld, W | 1 |
| Halawa, B | 1 |
| Mazurek, W | 1 |
| Ostádal, B | 2 |
| Widimský, J | 2 |
| Urbanová, D | 2 |
| Procházka, J | 2 |
| Pelouch, V | 2 |
| Ressl, J | 1 |
| Hope, RR | 1 |
| Lazzara, R | 1 |
| Hansen, JF | 1 |
| Johnson, PL | 1 |
| Bhattacharya, SK | 1 |
| Póvoa, R | 1 |
| Manzoli, MT | 1 |
| Ferreira, C | 2 |
| Murad, N | 1 |
| Simões, M | 1 |
| Luna, B | 1 |
| Park, SC | 1 |
| Radin, MJ | 1 |
| Hoepf, T | 1 |
| McCune, SA | 1 |
| Takeo, S | 1 |
| Elmoselhi, AB | 1 |
| Goel, R | 1 |
| Sentex, E | 1 |
| Wang, J | 2 |
| Dhalla, NS | 1 |
| Kodama-Takahashi, K | 1 |
| Ohshima, K | 1 |
| Yamamoto, K | 1 |
| Iwata, T | 1 |
| Pereira, LM | 1 |
| Mandarim-de-Lacerda, CA | 1 |
| Min, JY | 1 |
| Meissner, A | 1 |
| Morgan, JP | 1 |
| Lossnitzer, K | 1 |
| Konrad, A | 1 |
| Heine, HW | 1 |
| Ziegler, E | 1 |
| Stauch, M | 1 |
| Sekeff, JA | 1 |
| Perez, VP | 1 |
| Freitas, LB | 1 |
| Dohmann, HJ | 1 |
| Hasin, Y | 1 |
| Rod, JL | 1 |
| Friedman, G | 1 |
| Kentera, D | 1 |
| Susić, D | 1 |
| Zdravković, M | 1 |
| Witchitz, S | 1 |
| Haiat, R | 1 |
| Tarrade, T | 1 |
| Chiche, P | 1 |
| Huddleston, CB | 1 |
| Wareing, TH | 1 |
| Boucek, RJ | 1 |
| Hammon, JW | 1 |
| Kowey, PR | 1 |
| Friechling, TD | 1 |
| Sewter, J | 1 |
| Wu, Y | 1 |
| Sokil, A | 1 |
| Paul, J | 1 |
| Nocella, J | 1 |
| Buser, PT | 2 |
| Wagner, S | 2 |
| Wu, S | 1 |
| Higgins, CB | 2 |
| Wikman-Coffelt, J | 2 |
| Thom, CM | 1 |
| Angermann, CE | 1 |
| Spes, CH | 1 |
| Willems, S | 1 |
| Dominiak, P | 1 |
| Kemkes, BM | 1 |
| Theisen, K | 1 |
| Cuspidi, C | 1 |
| Sampieri, L | 1 |
| Boselli, L | 1 |
| Bragato, R | 1 |
| Lonati, L | 1 |
| Bocciolone, M | 1 |
| Leonetti, G | 1 |
| Zanchetti, A | 1 |
| Ianovskiĭ, GV | 1 |
| Golub', NS | 1 |
| Vysotskaia, ZhM | 1 |
| Stadniuk, LA | 1 |
| Kovtun, LI | 1 |
| Schulman, SP | 2 |
| Weiss, JL | 1 |
| Becker, LC | 1 |
| Gottlieb, SO | 1 |
| Woodruff, KM | 1 |
| Weisfeldt, ML | 1 |
| Gerstenblith, G | 3 |
| de la Morena Valenzuela, G | 1 |
| Ruipérez Abizanda, JA | 1 |
| Picó Aracil, F | 1 |
| García García, J | 1 |
| Jaén Armand, E | 1 |
| Salas Nieto, J | 1 |
| Penney, DG | 1 |
| Robinson, MC | 1 |
| Komissarov, VA | 1 |
| Granier, P | 1 |
| Douste-Blazy, MY | 1 |
| Tredez, P | 1 |
| Conte, D | 1 |
| Galinier, F | 1 |
| Nitta, Y | 1 |
| Shimizu, M | 1 |
| Kita, Y | 1 |
| Konishi, K | 1 |
| Kawagoshi, H | 1 |
| Umeda, K | 1 |
| Takeda, R | 1 |
| Bunko, H | 1 |
| Hisada, K | 1 |
| Genda, A | 1 |
| Allard, MF | 1 |
| Doss, LK | 1 |
| Bishop, SP | 1 |
| Whelton, PK | 1 |
| Watson, AJ | 1 |
| Kone, B | 1 |
| Fortuin, NJ | 1 |
| Dillon, JS | 1 |
| Gu, XH | 1 |
| Nayler, WG | 1 |
| Lehmann, M | 1 |
| Dürr, H | 1 |
| Keul, J | 1 |
| Curtius, JM | 1 |
| Stoecker, J | 1 |
| Loesse, B | 1 |
| Welslau, R | 1 |
| Scholz, D | 1 |
| Alpert, NR | 1 |
| Blanchard, EM | 1 |
| Mulieri, LA | 1 |
| Nagai, R | 1 |
| Zarain-Herberg, A | 1 |
| Periasamy, M | 1 |
| French, WJ | 1 |
| Garner, D | 1 |
| Adomian, GE | 1 |
| Averill, W | 1 |
| Laks, MM | 1 |
| Wu, ST | 1 |
| Derugin, N | 1 |
| Parmley, WW | 1 |
| Zierhut, W | 1 |
| Colle, JP | 1 |
| Ohayon, J | 1 |
| Besse, P | 1 |
| Anderson, P | 1 |
| Hess, OM | 2 |
| Murakami, T | 2 |
| Krayenbuehl, HP | 1 |
| Toivonen, L | 1 |
| Nieminen, M | 1 |
| Kunkel, B | 1 |
| Schneider, M | 1 |
| Eisenmenger, A | 1 |
| Bergmann, B | 1 |
| Hopf, R | 1 |
| Kaltenbach, M | 1 |
| Krayenbühl, HP | 1 |
| Spacek, R | 1 |
| Kozák, P | 1 |
| Stárek, A | 1 |
| Hes, I | 1 |
| Skalníková, V | 1 |
| Huang, TF | 1 |
| Wu, ML | 1 |
| D'Ascia, C | 1 |
| Picardi, G | 1 |
| Picardi, A | 1 |
| Marullo, L | 1 |
| Romano, M | 1 |
| Vitagliano, G | 1 |
| Saccà, L | 1 |
| Hochhauser, E | 1 |
| Barak, Y | 1 |
| Einav, S | 1 |
| Cohen, S | 1 |
| Vidne, B | 1 |
| Brinkman, CJ | 1 |
| van der Laarse, A | 1 |
| Los, GJ | 1 |
| Kappetein, AP | 1 |
| Weening, JJ | 1 |
| Huysmans, HA | 1 |
| Ruskoaho, HJ | 1 |
| Savolainen, ER | 1 |
| Given, BD | 1 |
| Lee, TH | 1 |
| Stone, PH | 1 |
| Dzau, VJ | 1 |
5 reviews available for verapamil and Cardiomegaly
| Article | Year |
|---|---|
Calcium channel blockers as antihypertensive agents.
Topics: Blood Pressure; Calcium Channel Blockers; Cardiomegaly; Clinical Trials as Topic; Coronary Disease; | 1984 |
[Cardiomyopathies and their treatment].
Topics: Adult; Aged; Aortic Stenosis, Subvalvular; Cardiomegaly; Cardiomyopathies; Cardiomyopathy, Alcoholic | 1980 |
The clinical uses of calcium antagonists.
Topics: Angina Pectoris; Angina Pectoris, Variant; Animals; Arrhythmias, Cardiac; Calcium; Calcium Channel B | 1982 |
Changes of the degree of hypertrophy in hypertrophic obstructive cardiomyopathy under medical and surgical treatment.
Topics: Adolescent; Adult; Aged; Cardiomegaly; Cardiomyopathy, Hypertrophic; Child; Child, Preschool; Echoca | 1989 |
Pharmacokinetics of calcium channel blocking agents.
Topics: Administration, Oral; Angina Pectoris; Atrial Fibrillation; Biological Availability; Cardiomegaly; C | 1986 |
10 trials available for verapamil and Cardiomegaly
| Article | Year |
|---|---|
Calcium channel blockers as antihypertensive agents.
Topics: Blood Pressure; Calcium Channel Blockers; Cardiomegaly; Clinical Trials as Topic; Coronary Disease; | 1984 |
Calcium channel blockers: indications and limitations 2. Use in angina and other cardiac disorders.
Topics: Administration, Oral; Angina Pectoris; Angina Pectoris, Variant; Calcium Channel Blockers; Cardiomeg | 1982 |
Clinical use of calcium channel blockers as ventricular unloading agents.
Topics: Adult; Aged; Antihypertensive Agents; Calcium Channel Blockers; Cardiomegaly; Clinical Trials as Top | 1983 |
Calcium channel blocking agents.
Topics: Benzazepines; Calcium; Calcium Channel Blockers; Cardiomegaly; Clinical Trials as Topic; Coronary Di | 1981 |
[Evaluation of verapamil in the treatment of idiopathic cardiac hypertrophy].
Topics: Adult; Aortic Valve Stenosis; Cardiomegaly; Cardiomyopathies; Clinical Trials as Topic; Drug Evaluat | 1977 |
Cardiac structure and function before and after acute and chronic verapamil administration in hypertensive patients.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiomegaly; Echocardiography, Doppler; Female; Hemodyn | 1991 |
The effects of antihypertensive therapy on left ventricular mass in elderly patients.
Topics: Atenolol; Blood Pressure; Cardiomegaly; Double-Blind Method; Echocardiography; Gated Blood-Pool Imag | 1990 |
Influence of left ventricular mass regression on cardiac function in hypertensive elderly individuals.
Topics: Aged; Atenolol; Cardiomegaly; Double-Blind Method; Humans; Hypertension; Middle Aged; Physical Exert | 1990 |
Special considerations in the elderly patient.
Topics: Age Factors; Aged; Aging; Atenolol; Blood Pressure; Cardiac Output; Cardiomegaly; Chlorthalidone; Do | 1990 |
Pharmacokinetics of calcium channel blocking agents.
Topics: Administration, Oral; Angina Pectoris; Atrial Fibrillation; Biological Availability; Cardiomegaly; C | 1986 |
66 other studies available for verapamil and Cardiomegaly
| Article | Year |
|---|---|
Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy.
Topics: Animals; Calcium; Cardiomegaly; Cardiomyopathy, Hypertrophic; Co-Repressor Proteins; Cytoskeletal Pr | 2022 |
Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats.
Topics: Animals; Calpain; Cardiomegaly; Gene Expression Regulation; Hypertension; Male; Matrix Metalloprotei | 2020 |
Fatal short-coupled torsade de pointes in a patient with primary oxalosis.
Topics: Anti-Arrhythmia Agents; Cardiomegaly; Defibrillators; Echocardiography; Fatal Outcome; Humans; Hyper | 2013 |
Phenotypic screening with human iPS cell-derived cardiomyocytes: HTS-compatible assays for interrogating cardiac hypertrophy.
Topics: Biomarkers; Calcium Channel Blockers; Cardiomegaly; Cell Differentiation; Cell Size; Cells, Cultured | 2013 |
Impaired tissue clearance of verapamil in rat cardiac hypertrophy results in transcriptional repression of ion channels.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calmodulin; Calsequestrin; Cardiomegaly; Cytosk | 2010 |
[ISOPTIN, A NEW CORONARY DILATOR].
Topics: Cardiomegaly; Coronary Disease; Drug Therapy; Humans; Vasodilator Agents; Verapamil | 1964 |
Propranolol and verapamil inhibit mRNA expression of RyR2 and SERCA in L-thyroxin-induced rat ventricular hypertrophy.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Calcium-Tran | 2004 |
Effects of chronic quercetin treatment on antioxidant defence system and oxidative status of deoxycorticosterone acetate-salt-hypertensive rats.
Topics: Administration, Oral; Animals; Blood Pressure; Cardiomegaly; Catalase; Desoxycorticosterone; Glutath | 2004 |
Changes in myocardial blood supply during experimental hypertension treated with verapamil in rabbits.
Topics: Animals; Calcium Channel Blockers; Capillaries; Cardiomegaly; Hypertension, Renovascular; Male; Rabb | 2005 |
Effects of salt loading and various therapies on cardiac hypertrophy and fibrosis in young spontaneously hypertensive rats.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Age | 2006 |
Drugs and the heart. III. Calcium antagonists.
Topics: Angina Pectoris; Aniline Compounds; Arrhythmias, Cardiac; Calcium; Cardiomegaly; Diuretics; Heart Di | 1980 |
A study on the effects of some drugs on DOCA induced hypertension in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Cardiomegaly; Desoxycorticosterone; Diuretics; H | 1980 |
Atrial fibrillation.
Topics: Age Factors; Aged; Atrial Fibrillation; Cardiomegaly; Digoxin; Electric Countershock; Electrocardiog | 1982 |
[Clinical aspects, course and prognosis of various forms of hypertrophic cardiomyopathy].
Topics: Adult; Blood Pressure; Cardiomegaly; Cardiomyopathy, Hypertrophic; Diagnosis, Differential; Electroc | 1983 |
Verapamil for refractory ventricular fibrillation during cardiac operations in patients with cardiac hypertrophy.
Topics: Adolescent; Aortic Valve Stenosis; Cardiomegaly; Cardiomyopathy, Hypertrophic; Child; Child, Prescho | 1983 |
Cardiac rhythm in hypertension assessed through 24 hour ambulatory electrocardiographic monitoring. Effects of load manipulation with atenolol, verapamil, and nifedipine.
Topics: Adult; Atenolol; Cardiomegaly; Echocardiography; Electrocardiography; Female; Heart Conduction Syste | 1983 |
Hypoxia-induced cardiac hypertrophy in rabbits treated with verapamil and nifedipine.
Topics: Animals; Cardiomegaly; Eating; Hypoxia; Nifedipine; Organ Size; Rabbits; Verapamil | 1983 |
[Experience with the treatment of patients with hypertrophic cardiomyopathy with obsidan and isoptin].
Topics: Adolescent; Adult; Cardiomegaly; Cardiomyopathy, Hypertrophic; Echocardiography; Female; Heart Septu | 1984 |
Left ventricular unloading with calcium antagonists.
Topics: Cardiac Output; Cardiomegaly; Drug Evaluation; Hemodynamics; Humans; Hypertension; Myocardial Contra | 1984 |
Left ventricular relaxation and filling pattern in different forms of left ventricular hypertrophy: an echocardiographic study.
Topics: Adolescent; Adult; Calcium; Cardiomegaly; Cardiomyopathy, Hypertrophic; Diastole; Echocardiography; | 1980 |
[Verapamil in rats exposed to intermittent altitude hypoxia. Its effect on pulmonary hypertension, right ventricular hypertrophy and myocardial necroses (author's transl)].
Topics: Animals; Cardiomegaly; Hypertension, Pulmonary; Hypoxia; Male; Myocardium; Necrosis; Rats; Rats, Inb | 1981 |
Effect of verapamil on pulmonary hypertension and right ventricular hypertrophy induced in rats by intermittent high altitude hypoxia.
Topics: Altitude Sickness; Animals; Body Weight; Cardiomegaly; Hematocrit; Hemodynamics; Hemoglobins; Hypert | 1981 |
Verapamil prevents sudden death in patients with increased heart size after an acute myocardial infarction.
Topics: Cardiomegaly; Clinical Trials as Topic; Death, Sudden, Cardiac; Female; Humans; Male; Myocardial Inf | 1993 |
Regulation of membrane-mediated chronic muscle degeneration in dystrophic hamsters by calcium-channel blockers: diltiazem, nifedipine and verapamil.
Topics: Animals; Body Weight; Calcium; Calcium Channel Blockers; Cardiomegaly; Creatine Kinase; Cricetinae; | 1993 |
[Myocardial hypertrophy due to isoproterenol. The preventive action of verapamil].
Topics: Analysis of Variance; Animals; Calcium Channel Blockers; Cardiomegaly; Cardiotonic Agents; Drug Eval | 1995 |
Comparison of verapamil and felodipine treatment on lipid and glucose metabolism in obese female SHHF/Mcc-facp rats.
Topics: Age Factors; Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Calcium C | 1999 |
Attenuation of changes in sarcoplasmic reticular gene expression in cardiac hypertrophy by propranolol and verapamil.
Topics: Adenosine Triphosphatases; Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blotting, | 2000 |
[An elderly case of idiopathic dilatation of the right atrium in which right-sided heart failure was exacerbated by drug-induced bradyarrhythmia].
Topics: Aged; Aged, 80 and over; Atrial Fibrillation; Bradycardia; Cardiomegaly; Cardiotonic Agents; Dilatat | 2001 |
Stereology of cardiac hypertrophy induced by NO blockade in rats treated with enalapril and verapamil.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Apoptosis; Blood Pressur | 2001 |
Mibefradil improves beta-adrenergic responsiveness and intracellular Ca(2+) handling in hypertrophied rat myocardium.
Topics: Adrenergic beta-Agonists; Aequorin; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, T- | 2002 |
[Proceedings: Prevention of myocardial degeneration in a disease model of hereditary cardiomyopathy].
Topics: Animals; Calcium; Cardiomegaly; Cardiomyopathies; Cricetinae; Disease Models, Animal; Heart; Myocard | 1975 |
Co-existing aortic stenosis and secondary hypertrophic cardiomyopathy manifested by an hourglass left ventricle. Successful treatment with verapamil.
Topics: Aortic Valve Stenosis; Cardiomegaly; Cardiomyopathies; Heart Ventricles; Humans; Male; Middle Aged; | 1979 |
Effects of verapamil and aspirin on experimental chronic hypoxic pulmonary hypertension and right ventricular hypertrophy in rats.
Topics: Animals; Aspirin; Biological Transport; Calcium; Cardiomegaly; Chronic Disease; Female; Haplorhini; | 1979 |
[Cardiovascular complications during treatment by verapamil. A propos of 6 cases].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Arrhythmias, Cardiac; Cardiomegaly; Female; Glucagon; Hear | 1975 |
Response of the hypertrophied left ventricle to global ischemia. Comparison of hyperkalemic cardioplegic solution with and without verapamil.
Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Cardioplegic Solutions; Cardiopulmonary Bypass; Dogs; | 1992 |
Electrophysiological effects of left ventricular hypertrophy. Effect of calcium and potassium channel blockade.
Topics: Animals; Anti-Arrhythmia Agents; Calcium Channels; Cardiomegaly; Cats; Differential Threshold; Elect | 1991 |
Protective effects of calcium antagonists on energy and substrate metabolism during ischemia and reperfusion in hypertensive myocardial hypertrophy.
Topics: Adenosine Triphosphate; Animals; Calcium Channel Blockers; Cardiomegaly; Energy Metabolism; Hyperten | 1991 |
Verapamil and left ventricular hypertrophy.
Topics: Cardiomegaly; Humans; Hypertension; Verapamil | 1991 |
Regression of left ventricular hypertrophy in hypertensive heart transplant recipients treated with enalapril, furosemide, and verapamil.
Topics: Adult; Cardiomegaly; Echocardiography; Electrocardiography; Enalapril; Female; Furosemide; Heart Tra | 1991 |
[Left ventricular hypertrophy as an indication for the prescribing of calcium antagonists in patients with ischemic heart disease].
Topics: Adult; Calcium Channel Blockers; Cardiomegaly; Coronary Disease; Drug Evaluation; Hemodynamics; Huma | 1991 |
[Intravenous verapamil in hypertrophic myocardiopathy. A study using Doppler ultrasound].
Topics: Adolescent; Adult; Aged; Cardiomegaly; Child; Drug Evaluation; Echocardiography, Doppler; Female; Hu | 1990 |
Effects of verapamil and carbon monoxide on blood pressure and heart mass in the spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Carbon Monoxide; Cardiomegaly; Dose-Response Relationship, Drug; Heart; Hea | 1990 |
Left ventricular hypertrophy in hypertension.
Topics: Aged; Atenolol; Cardiomegaly; Humans; Hypertension; Middle Aged; Placebos; Verapamil | 1990 |
[Changes in the indicators of intracardiac hemodynamics in patients with post-infarction cardiosclerosis under the action of verapamil].
Topics: Cardiomegaly; Coronary Disease; Heart; Hemodynamics; Humans; Male; Middle Aged; Myocardial Contracti | 1990 |
Improvement in left ventricular hypertrophy and left ventricular diastolic function following verapamil therapy in mild to moderate hypertension.
Topics: Adult; Aged; Cardiomegaly; Diastole; Echocardiography, Doppler; Heart Septum; Humans; Hypertension; | 1990 |
[Washout rate in patients with hypertrophic cardiomyopathy and hypertensive cardiac hypertrophy].
Topics: Cardiomegaly; Cardiomyopathy, Hypertrophic; Echocardiography; Exercise Test; Female; Heart; Humans; | 1990 |
Verapamil does not prevent isoproterenol-induced cardiac hypertrophy.
Topics: Animals; Calcium Channels; Cardiomegaly; Isoproterenol; Male; Myocardium; Rats; Verapamil | 1990 |
Calcium channel blockade in dialysis patients with left ventricular hypertrophy and well-preserved systolic function.
Topics: Aged; Blood Pressure; Body Weight; Cardiomegaly; Cardiomyopathy, Dilated; Echocardiography; Female; | 1987 |
Effect of age and of hypertrophy on cardiac Ca2+ antagonist binding sites.
Topics: Aging; Animals; Blood Pressure; Body Weight; Calcium Channels; Cardiomegaly; Cell Membrane; Dihydrop | 1989 |
[Regression of hypertension-induced left heart enlargement in an endurance athlete treated with verapamil RR].
Topics: Blood Pressure; Cardiac Volume; Cardiomegaly; Echocardiography; Exercise Test; Follow-Up Studies; Hu | 1989 |
Genetic and non-genetic control of myocardial calcium.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Cardiomegaly; Male; Myocardial Contraction; Myocardi | 1989 |
Verapamil induced ventricular hypertrophy in conscious dogs.
Topics: Animals; Cardiomegaly; Dogs; Heart; Hemodynamics; Infusion Pumps, Implantable; Methoxamine; Myocardi | 1989 |
Verapamil preserves myocardial performance and energy metabolism in left ventricular hypertrophy following ischemia and reperfusion. Phosphorus 31 magnetic resonance spectroscopy study.
Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Coronary Circulation; Energy Metabolism; Magnetic Res | 1989 |
Significance of myocardial alpha- and beta-adrenoceptors in catecholamine-induced cardiac hypertrophy.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; DNA; Female; Myoca | 1989 |
[Effects of injectable calcium blockers on cardiac function and relaxation in left ventricular hypertrophy].
Topics: Adult; Arrhythmias, Cardiac; Calcium Channel Blockers; Cardiomegaly; Coronary Vessels; Diltiazem; He | 1985 |
Does verapamil improve left ventricular relaxation in patients with myocardial hypertrophy?
Topics: Adult; Aortic Valve Stenosis; Cardiomegaly; Diastole; Electrocardiography; Hemodynamics; Humans; Mid | 1986 |
Persistent ventricular tachycardia resulting in left ventricular dilatation treated with verapamil.
Topics: Adult; Cardiomegaly; Female; Humans; Tachycardia; Verapamil | 1986 |
Myocardial biopsy in patients with hypertrophic cardiomyopathy: correlations between morphologic and clinical parameters and development of myocardial hypertrophy under medical therapy.
Topics: Adult; Biopsy; Cardiomegaly; Cardiomyopathy, Hypertrophic; Cell Nucleus; Female; Humans; Male; Middl | 1987 |
Influence of verapamil on diastolic left ventricular function in myocardial hypertrophy of different origin.
Topics: Adult; Aortic Valve Stenosis; Cardiomegaly; Diastole; Echocardiography; Heart; Heart Ventricles; Hem | 1987 |
[Treatment of hypertension with a delayed-action form of verapamil and its effect on hypertrophy and function of the left ventricle].
Topics: Aged; Cardiomegaly; Delayed-Action Preparations; Female; Heart; Hemodynamics; Humans; Hypertension; | 1987 |
Electrophysiological study on hypertrophied and ischemic myocardial of rats.
Topics: Action Potentials; Animals; Calcium; Cardiomegaly; Coronary Disease; Electrophysiology; Female; Lana | 1987 |
[Protective effect of verapamil in myocardial hypertrophy due to aortic stenosis experimentally induced in the rat].
Topics: Animals; Aortic Valve Stenosis; Cardiomegaly; Hemodynamics; Male; Myocardial Contraction; Rats; Rats | 1988 |
Effect of experimental cardioplegia methods on normal and hypertrophied rat hearts.
Topics: Animals; Cardiomegaly; Cardioplegic Solutions; Coronary Circulation; Heart Arrest, Induced; Male; My | 1988 |
Assessment of hemodynamic function and tolerance to ischemia in the absence or presence of calcium antagonists in hearts of isoproterenol-treated, exercise-trained, and sedentary rats.
Topics: Animals; Cardiomegaly; Cardioplegic Solutions; Creatine Kinase; Diltiazem; Fibrosis; Heart Arrest, I | 1988 |
Effects of long-term verapamil treatment on blood pressure, cardiac hypertrophy and collagen metabolism in spontaneously hypertensive rats.
Topics: Animals; Aorta; Blood Pressure; Cardiomegaly; Collagen; Female; Heart; Hydroxyproline; Hypertension; | 1985 |
Nifedipine in severely hypertensive patients with congestive heart failure and preserved ventricular systolic function.
Topics: Aged; Cardiomegaly; Electrocardiography; Female; Heart Failure; Heart Ventricles; Humans; Hypertensi | 1985 |