verapamil has been researched along with Cardiac Toxicity in 8 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to investigate the potential role of co-treatment with doxorubicin (DOX) and verapamil (VRP) nanoparticles in experimentally induced hepatocellular carcinoma in mice and to investigate the possible mechanisms behind the potential favorable effect of the co-treatment." | 7.96 | Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Abo Mansour, HE; Abo-Elmatty, DM; Badawy, NS; El-Batsh, MM; Mehanna, ET; Mesbah, NM, 2020) |
| " Recently, we demonstrated that the antioxidant N-acetylcysteine (NAC) prevented ketamine-induced cardiotoxicity, developmental toxicity and neurotoxicity." | 7.96 | N-acetylcysteine prevents verapamil-induced cardiotoxicity with no effect on the noradrenergic arch-associated neurons in zebrafish. ( Gu, Q; Kanungo, J; Robinson, B; Rodgers, J, 2020) |
| "Significant AP prolongation (a pro-arrhythmia marker) was seen in response to quinidine and quinine." | 4.12 | An in silico-in vitro pipeline for drug cardiotoxicity screening identifies ionic pro-arrhythmia mechanisms. ( Christini, DJ; Clark, AP; Kalola, D; Krogh-Madsen, T; Wei, S, 2022) |
| "This study aimed to investigate the potential role of co-treatment with doxorubicin (DOX) and verapamil (VRP) nanoparticles in experimentally induced hepatocellular carcinoma in mice and to investigate the possible mechanisms behind the potential favorable effect of the co-treatment." | 3.96 | Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Abo Mansour, HE; Abo-Elmatty, DM; Badawy, NS; El-Batsh, MM; Mehanna, ET; Mesbah, NM, 2020) |
| " Recently, we demonstrated that the antioxidant N-acetylcysteine (NAC) prevented ketamine-induced cardiotoxicity, developmental toxicity and neurotoxicity." | 3.96 | N-acetylcysteine prevents verapamil-induced cardiotoxicity with no effect on the noradrenergic arch-associated neurons in zebrafish. ( Gu, Q; Kanungo, J; Robinson, B; Rodgers, J, 2020) |
| " Case reports suggest that ILE may reverse hypotension caused by acute poisoning with lipophilic drugs such as verapamil, but the mechanism remains unclear." | 3.83 | In Vitro Studies Indicate Intravenous Lipid Emulsion Acts as Lipid Sink in Verapamil Poisoning. ( Dawling, S; Knollmann, BC; Kryshtal, DO; Seger, D, 2016) |
| "Drug-induced cardiotoxicity is a potentially severe side effect that can alter the contractility and electrophysiology of the cardiomyocytes." | 1.72 | MEA-integrated cantilever platform for comparison of real-time change in electrophysiology and contractility of cardiomyocytes to drugs. ( Jeong, YJ; Kanade, PP; Kim, ES; Lee, BK; Lee, DW; Oyunbaatar, NE; Shanmugasundaram, A, 2022) |
| " There was no association by comparing the amount of insulin administered on adverse effects or glucose administered, suggesting higher doses of insulin are associated with no more adverse effects." | 1.48 | The safety of high-dose insulin euglycaemia therapy in toxin-induced cardiac toxicity. ( Isbister, GK; Page, CB; Ryan, NM, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 4 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clark, AP | 1 |
| Wei, S | 1 |
| Kalola, D | 1 |
| Krogh-Madsen, T | 1 |
| Christini, DJ | 1 |
| Kanade, PP | 1 |
| Oyunbaatar, NE | 2 |
| Shanmugasundaram, A | 2 |
| Jeong, YJ | 1 |
| Kim, ES | 2 |
| Lee, BK | 3 |
| Lee, DW | 3 |
| Dai, Y | 1 |
| Abo Mansour, HE | 1 |
| El-Batsh, MM | 1 |
| Badawy, NS | 1 |
| Mehanna, ET | 1 |
| Mesbah, NM | 1 |
| Abo-Elmatty, DM | 1 |
| Gu, Q | 1 |
| Rodgers, J | 1 |
| Robinson, B | 1 |
| Kanungo, J | 1 |
| Page, CB | 1 |
| Ryan, NM | 1 |
| Isbister, GK | 1 |
| Kryshtal, DO | 1 |
| Dawling, S | 1 |
| Seger, D | 1 |
| Knollmann, BC | 1 |
| Kim, JY | 1 |
| Choi, YS | 1 |
8 other studies available for verapamil and Cardiac Toxicity
| Article | Year |
|---|---|
An in silico-in vitro pipeline for drug cardiotoxicity screening identifies ionic pro-arrhythmia mechanisms.
Topics: Action Potentials; Arrhythmias, Cardiac; Cardiotoxicity; Cisapride; Drug Evaluation, Preclinical; HE | 2022 |
MEA-integrated cantilever platform for comparison of real-time change in electrophysiology and contractility of cardiomyocytes to drugs.
Topics: Animals; Biosensing Techniques; Cardiotoxicity; Cardiovascular Agents; Cells, Cultured; Induced Plur | 2022 |
Development of a Next-Generation Biosensing Platform for Simultaneous Detection of Mechano- and Electrophysiology of the Drug-Induced Cardiomyocytes.
Topics: Animals; Astemizole; Biosensing Techniques; Cardiotoxicity; Cardiotoxins; Cells, Cultured; Drug Eval | 2019 |
Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Calcium Channel Blockers; Carcinoma, Hepatocellular | 2020 |
N-acetylcysteine prevents verapamil-induced cardiotoxicity with no effect on the noradrenergic arch-associated neurons in zebrafish.
Topics: Acetylcysteine; Animals; Antioxidants; Calcium Channel Blockers; Cardiotoxicity; Cysteine; Dose-Resp | 2020 |
The safety of high-dose insulin euglycaemia therapy in toxin-induced cardiac toxicity.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Cardiotoxicity; Cardiotoxin | 2018 |
In Vitro Studies Indicate Intravenous Lipid Emulsion Acts as Lipid Sink in Verapamil Poisoning.
Topics: Absorption, Physicochemical; Animals; Calcium Channel Blockers; Calcium Signaling; Cardiotoxicity; C | 2016 |
Surface-patterned SU-8 cantilever arrays for preliminary screening of cardiac toxicity.
Topics: Animals; Astemizole; Biosensing Techniques; Cardiotoxicity; Cells, Cultured; Drug-Related Side Effec | 2016 |