verapamil has been researched along with Carcinoma, Small Cell in 27 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Verapamil has been shown to partially restore drug sensitivity in tumour cells rendered resistant in vitro." | 2.67 | A randomised clinical study of verapamil in addition to combination chemotherapy in small cell lung cancer. West of Scotland Lung Cancer Research Group, and the Aberdeen Oncology Group. ( Milroy, R, 1993) |
| " The potential for a pharmacokinetic interaction between the two drugs has therefore been investigated in five patients with small cell lung cancer treated with combination chemotherapy comprising adriamycin, VP16, vincristine and cyclophosphamide." | 2.66 | The effect of verapamil on the pharmacokinetics of adriamycin. ( Brodie, MJ; Cummings, J; Graham, J; Kaye, SB; Kerr, DJ; Morrison, JG; Thompson, GG, 1986) |
| "Studies were performed in rats bearing tumors bilaterally, a P-gp-negative small cell lung carcinoma (GLC4) and its P-gp-overexpressing subline (GLC4/P-gp)." | 1.30 | A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier. ( de Vries, EG; Eriks-Fluks, L; Franssen, EJ; Hendrikse, NH; Hospers, GA; Vaalburg, W; van der Graaf, WT; Willemsen, AT, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (22.22) | 18.7374 |
| 1990's | 20 (74.07) | 18.2507 |
| 2000's | 1 (3.70) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hendrikse, NH | 2 |
| Vaalburg, W | 2 |
| Binaschi, M | 1 |
| Supino, R | 1 |
| Gambetta, RA | 1 |
| Giaccone, G | 1 |
| Prosperi, E | 1 |
| Capranico, G | 1 |
| Cataldo, I | 1 |
| Zunino, F | 1 |
| Poupon, MF | 3 |
| Arvelo, F | 3 |
| Bourgeois, Y | 3 |
| Jacrot, M | 2 |
| Goguel, AF | 1 |
| Lizard, G | 1 |
| Arriagada, R | 1 |
| Le Chevalier, T | 2 |
| Kirk, J | 1 |
| Carmichael, J | 1 |
| Stratford, IJ | 1 |
| Harris, AL | 1 |
| Ohta, S | 1 |
| Nishio, K | 1 |
| Kubo, S | 1 |
| Nishio, M | 1 |
| Ohmori, T | 1 |
| Takahashi, T | 1 |
| Saijo, N | 1 |
| Milroy, R | 1 |
| Bichat, F | 1 |
| Grossin, F | 1 |
| Bastian, G | 1 |
| Zhan, Z | 1 |
| Sandor, VA | 1 |
| Gamelin, E | 1 |
| Regis, J | 1 |
| Dickstein, B | 1 |
| Wilson, W | 1 |
| Fojo, AT | 1 |
| Bates, SE | 1 |
| Cowie, FJ | 1 |
| Pritchard-Jones, K | 1 |
| Renshaw, J | 1 |
| Pinkerton, CR | 1 |
| Shrivastava, P | 1 |
| Hanibuchi, M | 1 |
| Yano, S | 1 |
| Parajuli, P | 1 |
| Tsuruo, T | 1 |
| Sone, S | 1 |
| Arbab, AS | 1 |
| Koizumi, K | 1 |
| Toyama, K | 1 |
| Arai, T | 1 |
| Araki, T | 1 |
| de Vries, EG | 2 |
| Eriks-Fluks, L | 1 |
| van der Graaf, WT | 1 |
| Hospers, GA | 1 |
| Willemsen, AT | 1 |
| Franssen, EJ | 1 |
| Pancrazio, JJ | 2 |
| Oie, HK | 1 |
| Kim, YI | 2 |
| Jensen, PB | 1 |
| Jensen, PS | 1 |
| Demant, EJ | 1 |
| Friche, E | 1 |
| Sørensen, BS | 1 |
| Sehested, M | 1 |
| Wassermann, K | 1 |
| Vindeløv, L | 1 |
| Westergaard, O | 1 |
| Hansen, HH | 1 |
| Nygren, P | 1 |
| Larsson, R | 1 |
| Gruber, A | 1 |
| Peterson, C | 1 |
| Bergh, J | 1 |
| Viglione, MP | 1 |
| Kleiman, RJ | 1 |
| de Jong, S | 1 |
| Zijlstra, JG | 1 |
| Mulder, NH | 1 |
| Sher, E | 1 |
| Pandiella, A | 1 |
| Clementi, F | 1 |
| Figueredo, A | 1 |
| Arnold, A | 1 |
| Goodyear, M | 1 |
| Findlay, B | 1 |
| Neville, A | 1 |
| Normandeau, R | 1 |
| Jones, A | 1 |
| Zacharski, LR | 1 |
| Moritz, TE | 1 |
| Haakenson, CM | 1 |
| O'Donnell, JF | 1 |
| Ballard, HS | 1 |
| Johnson, GJ | 1 |
| Ringenberg, QS | 1 |
| Schilsky, RL | 1 |
| Spaulding, MB | 1 |
| Tornyos, K | 1 |
| Coley, HM | 1 |
| Twentyman, PR | 3 |
| Workman, P | 1 |
| Banham, S | 1 |
| Dorward, A | 1 |
| Hutcheon, A | 1 |
| Ahmedzai, S | 1 |
| Cunningham, D | 1 |
| Burnett, A | 1 |
| Soukop, M | 1 |
| Lucie, N | 1 |
| Kaye, S | 1 |
| Chen, PH | 1 |
| Fox, NE | 2 |
| Wright, KA | 1 |
| Bleehen, NM | 2 |
| Kerr, DJ | 1 |
| Graham, J | 1 |
| Cummings, J | 1 |
| Morrison, JG | 1 |
| Thompson, GG | 1 |
| Brodie, MJ | 1 |
| Kaye, SB | 1 |
2 trials available for verapamil and Carcinoma, Small Cell
| Article | Year |
|---|---|
A randomised clinical study of verapamil in addition to combination chemotherapy in small cell lung cancer. West of Scotland Lung Cancer Research Group, and the Aberdeen Oncology Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Pressure; Carcinoma, Small Cell; | 1993 |
The effect of verapamil on the pharmacokinetics of adriamycin.
Topics: Administration, Oral; Carcinoma, Small Cell; Clinical Trials as Topic; Doxorubicin; Drug Interaction | 1986 |
25 other studies available for verapamil and Carcinoma, Small Cell
| Article | Year |
|---|---|
Dynamics of multidrug resistance: P-glycoprotein analyses with positron emission tomography.
Topics: Adult; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cell; Drug | 2002 |
MRP gene overexpression in a human doxorubicin-resistant SCLC cell line: alterations in cellular pharmacokinetics and in pattern of cross-resistance.
Topics: Carcinoma, Small Cell; Doxorubicin; Drug Resistance, Multiple; Gene Expression Regulation, Neoplasti | 1995 |
[Drug sensitivity of bronchial small cell cancers transplanted to nude mice. Expression of the mdr1 gene and correlation with clinical practice. Effects of antagonists].
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bronchial Neoplasms; Carcinoma, Sm | 1994 |
Response of a multidrug-resistant human small-cell lung cancer xenograft to chemotherapy.
Topics: Adult; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Su | 1993 |
Selective toxicity of TGF-alpha-PE40 to EGFR-positive cell lines: selective protection of low EGFR-expressing cell lines by EGF.
Topics: Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; Cell Line; C | 1994 |
Characterisation of a vindesine-resistant human small-cell lung cancer cell line.
Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Carcinoma, Small Cell; Cell Division; | 1993 |
Adding a reverser (verapamil) to combined chemotherapy overrides resistance in small cell lung cancer xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cisplatin; Cyclophos | 1995 |
Expression of the multidrug resistance-associated protein gene in refractory lymphoma: quantitation by a validated polymerase chain reaction assay.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Membe | 1997 |
Multidrug resistance modulation in rhabdomyosarcoma and neuroblastoma cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cel | 1998 |
Circumvention of multidrug resistance by a quinoline derivative, MS-209, in multidrug-resistant human small-cell lung cancer cells and its synergistic interaction with cyclosporin A or verapamil.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cel | 1998 |
Effects of ion channel modulators in the influx and efflux of Tc-99m-MIBI.
Topics: Adrenal Cortex Neoplasms; Amiloride; Calcium; Calcium Channel Blockers; Calcium Channels; Carcinoma, | 1999 |
A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood | 1999 |
Voltage-sensitive calcium channels in a human small-cell lung cancer cell line.
Topics: Calcium Channels; Carcinoma, Small Cell; Humans; Lambert-Eaton Myasthenic Syndrome; Lung Neoplasms; | 1992 |
Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: relationship to DNA integrity and topoisomerase II.
Topics: Aclarubicin; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ehrlich Tumor; Carc | 1991 |
Doxorubicin selected multidrug-resistant small cell lung cancer cell lines characterised by elevated cytoplasmic Ca2+ and resistance modulation by verapamil in absence of P-glycoprotein overexpression.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium; Carcinoma, Small Cell; Cell Surviv | 1991 |
Verapamil-induced blockade of voltage-activated K+ current in small-cell lung cancer cells.
Topics: Calcium; Carcinoma, Small Cell; Cell Division; Humans; Kinetics; Lung Neoplasms; Membrane Potentials | 1991 |
Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line.
Topics: Amsacrine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cell; Cell Cycl | 1990 |
Voltage-operated calcium channels in small cell lung carcinoma cell lines: pharmacological, functional, and immunological properties.
Topics: Binding Sites; Binding, Competitive; Calcium Channels; Carcinoma, Small Cell; Conotoxins; Humans; Lu | 1990 |
Addition of verapamil and tamoxifen to the initial chemotherapy of small cell lung cancer. A phase I/II study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Doxorubicin; Drug Administrat | 1990 |
Chronic calcium antagonist use in carcinoma of the lung and colon: a retrospective cohort observational study.
Topics: Calcium; Carcinoma, Small Cell; Cohort Studies; Colonic Neoplasms; Diltiazem; Humans; Lung Neoplasms | 1990 |
Identification of anthracyclines and related agents that retain preferential activity over adriamycin in multidrug-resistant cell lines, and further resistance modification by verapamil and cyclosporin A.
Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Small Cell; Cell Line; Coloring Agents; Cyclosporin | 1989 |
The role of VP-16 in the treatment of small-cell lung cancer: studies of the West of Scotland Lung Cancer Group.
Topics: Carcinoma, Small Cell; Cyclophosphamide; Drug Resistance; Drug Therapy, Combination; Etoposide; Fema | 1985 |
Multiform atrial tachycardia.
Topics: Aged; Carcinoma, Small Cell; Heart Atria; Humans; Lung Diseases, Obstructive; Lung Neoplasms; Male; | 1986 |
Derivation and preliminary characterisation of adriamycin resistant lines of human lung cancer cells.
Topics: Adenocarcinoma; Carcinoma, Small Cell; Cell Line; Cytological Techniques; Doxorubicin; Drug Resistan | 1986 |
Drug resistance in human lung cancer cell lines: cross-resistance studies and effects of the calcium transport blocker, verapamil.
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Small Cell; Cell Line; Drug Resistance; Humans; In | 1986 |